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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:9907
Term: ursodeoxycholic acid
Definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Chemical ID: MESH:D014580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1multiple interactionsEXP 6480464CTDUrsodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 protein]PMID:32198087
Ugt1a1increases expressionISOUgt1a1 (Mus musculus)6480464CTDUrsodeoxycholic Acid results in increased expression of UGT1A1 mRNAPMID:18687751
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