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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:16990
Term: bilirubin IXalpha
Definition: A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
Chemical ID: MESH:D001663
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1increases glucuronidationEXP 6480464CTDUGT1A1 protein results in increased glucuronidation of BilirubinPMID:12153725 PMID:15921999 PMID:17599282
Ugt1a1multiple interactionsEXP 6480464CTD5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]PMID:17599282
Ugt1a1decreases activityISOUGT1A1 (Homo sapiens)6480464CTDBilirubin results in decreased activity of UGT1A1 proteinPMID:15334623
Ugt1a1decreases glucuronidationISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 gene mutant form results in decreased glucuronidation of BilirubinPMID:17898154
Ugt1a1increases expressionISOUGT1A1 (Homo sapiens)6480464CTDBilirubin results in increased expression of UGT1A1 mRNAPMID:15382119
Ugt1a1increases glucuronidationISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 protein results in increased glucuronidation of Bilirubin; UGT1A1 results in increased glucuronidation of BilirubinPMID:15988124 PMID:17599282 PMID:17898154 PMID:25370011
Ugt1a1increases metabolic processingISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 protein results in increased metabolism of BilirubinPMID:23401472 PMID:27060662
Ugt1a1multiple interactionsISOUGT1A1 (Homo sapiens)6480464CTD5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; Coumarins analog promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA]; imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of BilirubinPMID:10950852 PMID:15382119 PMID:15557560 PMID:17599282
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