RGD Reference Report - Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver. - Rat Genome Database

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Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver.

Authors: Haberkorn, V  Heydel, JM  Mounie, J  Artur, Y  Goudonnet, H 
Citation: Haberkorn V, etal., Mol Cell Endocrinol 2002 Apr 25;190(1-2):167-75.
RGD ID: 634461
Pubmed: PMID:11997190   (View Abstract at PubMed)

We studied the influence of thyroid hormones and vitamin A status on the regulation of UDP-glucuronosyltransferase (UGT) expression and the glucuronidation of thyroid hormones by UGTs. For this, we used an original model of rats fed with different vitamin A diets and implanted subcutaneously by osmotic minipumps delivering vehicle or thyroid hormones, which permitted the control of plasma thyroid hormone concentrations. The activity and expression of family 1 UGTs are correlated and were significantly modified by both thyroid status and amounts of retinol in the diet. Dietary vitamin A did not perturbe the UGT1A expression in thyroidectomized animals. Thyroid hormones and dietary vitamin A did not affect the activity and expression of family 2 UGTs. We conclude that thyroid hormones and vitamin A are co-regulator of the UGT1 family expression, without affecting the UGT2 family; by modifying activity and expression of the bilirubin UOT isoform, a member of UGT1 family, thyroid hormone reduced the glucuronidation of T4 and rT3.



Objects referenced in this article
Gene Ugt1a1 UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus
Gene Ugt1a6 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus

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