Ugt1a6 (UDP glucuronosyltransferase family 1 member A6) - Rat Genome Database

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Gene: Ugt1a6 (UDP glucuronosyltransferase family 1 member A6) Rattus norvegicus
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Symbol: Ugt1a6 (Ensembl: Ugt1a3)
Name: UDP glucuronosyltransferase family 1 member A6 (Ensembl:UDP glucuronosyltransferase family 1 member A1)
RGD ID: 620949
Description: Enables glucuronosyltransferase activity. Involved in several processes, including 4-chlorobiphenyl metabolic process; cellular response to glucocorticoid stimulus; and response to lipopolysaccharide. Located in intracellular membrane-bounded organelle. Part of protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human UGT1A6 (UDP glucuronosyltransferase family 1 member A6); PARTICIPATES IN paracetamol pharmacokinetics pathway; phenytoin pharmacodynamics pathway; ascorbate and aldarate metabolic pathway; INTERACTS WITH 1,7-phenanthroline; 1-naphthol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A1; MGC124929; P-nitrophenol specific; P-nitrophenol-specific UDPGT; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glucuronosyltransferase 1A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1A6; Udpgt; UDPGT 1-6; Ugt1; UGT1*6; UGT1-06; UGT1.6; Ugt1a7
RGD Orthologs
Human
Mouse
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,747,229 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx997,171,046 - 97,232,360 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09102,307,238 - 102,368,552 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.09100,675,406 - 100,736,659 (+)NCBIRnor_WKY
Rnor_6.0995,241,609 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0994,928,825 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,037,154 - 87,098,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1987,226,279 - 87,284,238 (+)NCBI
Celera986,308,548 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-cinnamyl alcohol  (ISO)
1,2-dimethylhydrazine  (ISO)
1,7-phenanthroline  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4,6-Triphenyl-1-hexene  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-Ethylphenol  (EXP)
3-methylcholanthrene  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxycoumarin  (EXP)
4-hydroxyphenytoin  (ISO)
4-methylumbelliferone  (EXP,ISO)
4-methylumbelliferone beta-D-glucuronide  (ISO)
4-nitrophenol  (EXP,ISO)
4-tert-butylphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinol  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
amentoflavone  (ISO)
aminoguanidine  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
antimonite  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Auriculasin  (ISO)
Bandrowski's base  (ISO)
belinostat  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
Benzyl viologen  (EXP)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
camptothecin  (ISO)
carbamazepine  (EXP)
carboplatin  (EXP)
cefaloridine  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorohydrocarbon  (EXP)
choline  (ISO)
chrysen-6-ol  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
Erucin  (EXP)
erythrosin B  (ISO)
etofenprox  (EXP)
eugenol  (ISO)
farnesol  (ISO)
felbamate  (EXP)
fenofibrate  (EXP)
fenthion  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hydroquinone  (EXP)
ibuprofen  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
indoxyl sulfate  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoeugenol  (ISO)
ketoprofen  (EXP,ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
Licochalcone A  (ISO)
lorcaserin  (ISO)
melatonin  (EXP)
menadione  (EXP)
metazachlor  (EXP)
methotrexate  (ISO)
methyl salicylate  (EXP)
methylmercury chloride  (EXP)
morin  (ISO)
morphine  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (EXP)
N-acetylserotonin  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naproxen  (ISO)
nefazodone  (EXP)
nickel atom  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
osimertinib  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
p-cresol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenanthrene  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenol  (EXP)
phenytoin  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrene  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rifampicin  (ISO)
rose bengal  (ISO)
rotenone  (ISO)
scopoletin  (ISO)
serotonin  (ISO)
sevoflurane  (EXP)
silibinin  (EXP,ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spermidine  (ISO)
spironolactone  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetracycline  (EXP)
tetraphene  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-isoeugenol  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
triclocarban  (ISO)
trifluralin  (EXP)
tungsten  (EXP)
umbelliferone  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
xanthenes  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats. Alkharfy KM, etal., Drug Metab Lett. 2008 Dec;2(4):248-55.
2. An alternative promoter contributes to tissue- and inducer-specific expression of the rat UDP-glucuronosyltransferase 1A6 gene. Auyeung DJ, etal., Toxicol Appl Pharmacol 2001 Jul 1;174(1):60-8.
3. UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat. Daidoji T, etal., Drug Metab Dispos. 2005 Oct;33(10):1466-76. Epub 2005 Jul 8.
4. Regulation of the rat UGT1A6 by glucocorticoids involves a cryptic glucocorticoid response element. Falkner KC, etal., Drug Metab Dispos. 2008 Feb;36(2):409-17. Epub 2007 Nov 26.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract. Grams B, etal., Arch Biochem Biophys. 2000 May 15;377(2):255-65.
8. Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver. Haberkorn V, etal., Mol Cell Endocrinol 2002 Apr 25;190(1-2):167-75.
9. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
10. Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6. Ikushiro S, etal., Biochemistry 2002 Oct 22;41(42):12813-20.
11. Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex. Ishii Y, etal., Drug Metab Pharmacokinet. 2007 Oct;22(5):367-76.
12. A critical amino acid residue, asp446, in UDP-glucuronosyltransferase. Iwano H, etal., Biochem J 1997 Aug 1;325 ( Pt 3):587-91.
13. Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase. Iyanagi T, etal., J Biol Chem 1986 Nov 25;261(33):15607-14.
14. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation. Iyanagi T, etal., J Biol Chem 1989 Dec 15;264(35):21302-7.
15. Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Kessler FK, etal., Drug Metab Dispos 2002 Mar;30(3):324-30.
16. Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Kishi M, etal., Biochem Biophys Res Commun. 2008 Dec 19;377(3):815-9. Epub 2008 Oct 18.
17. The effect of hormones on the expression of five isoforms of UDP-glucuronosyltransferase in primary cultures of rat hepatocytes. Li YQ, etal., Pharm Res. 1999 Feb;16(2):191-7.
18. Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver. Luquita MG, etal., J Pharmacol Exp Ther. 2001 Jul;298(1):49-56.
19. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Vansell NR and Klaassen CD, Drug Metab Dispos. 2002 Mar;30(3):240-6.
26. Dysregulations of intestinal and colonic UDP-glucuronosyltransferases in rats with type 2 diabetes. Xie H, etal., Drug Metab Pharmacokinet. 2013;28(5):427-34. Epub 2013 Apr 2.
27. Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat. Yokota H, etal., J Biochem (Tokyo) 2002 Aug;132(2):265-70.
28. Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China. Zhang C, etal., J Int Med Res. 2018 Feb;46(2):739-751. doi: 10.1177/0300060517730174. Epub 2017 Sep 20.
29. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
Additional References at PubMed
PMID:1748678   PMID:3141926   PMID:7608130   PMID:12477932   PMID:16141793   PMID:17179145   PMID:19023562   PMID:20308471   PMID:20610558   PMID:22579593   PMID:22846377   PMID:23376485  
PMID:24694608   PMID:26725430   PMID:29131354  


Genomics

Comparative Map Data
Ugt1a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,747,229 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx997,171,046 - 97,232,360 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09102,307,238 - 102,368,552 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.09100,675,406 - 100,736,659 (+)NCBIRnor_WKY
Rnor_6.0995,241,609 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0994,928,825 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,037,154 - 87,098,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1987,226,279 - 87,284,238 (+)NCBI
Celera986,308,548 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
UGT1A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,691,702 - 233,773,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2233,691,607 - 233,773,300 (+)EnsemblGRCh38hg38GRCh38
GRCh372234,600,348 - 234,681,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,265,060 - 234,346,690 (+)NCBINCBI36Build 36hg18NCBI36
Build 342234,382,320 - 234,463,945NCBI
Celera2228,320,943 - 228,402,583 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,400,315 - 226,481,785 (+)NCBIHuRef
CHM1_12234,606,135 - 234,682,899 (+)NCBICHM1_1
T2T-CHM13v2.02234,180,351 - 234,261,929 (+)NCBIT2T-CHM13v2.0
Ugt1a6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,030,979 - 88,146,720 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl188,030,974 - 88,146,725 (+)EnsemblGRCm39 Ensembl
GRCm38188,103,257 - 88,218,998 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,103,252 - 88,219,003 (+)EnsemblGRCm38mm10GRCm38
MGSCv37189,999,832 - 90,115,573 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36189,966,005 - 90,050,148 (+)NCBIMGSCv36mm8
Celera191,064,552 - 91,180,057 (+)NCBICelera
Cytogenetic Map1DNCBI
UGT1A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12545,081,655 - 45,161,584 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2545,032,130 - 45,160,941 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2545,612,859 - 45,657,873 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02545,428,478 - 45,508,428 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2545,313,739 - 45,508,426 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12545,355,559 - 45,400,594 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02545,168,630 - 45,209,045 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02545,397,783 - 45,437,778 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Ugt1a6
283 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat

Markers in Region
D9Mco15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,786,718 - 88,787,007 (+)MAPPERmRatBN7.2
Rnor_6.0995,281,097 - 95,281,383NCBIRnor6.0
Rnor_5.0994,968,312 - 94,968,598UniSTSRnor5.0
RGSC_v3.4987,076,637 - 87,076,923UniSTSRGSC3.4
Celera986,348,016 - 86,348,299UniSTS
Cytogenetic Map9q35UniSTS
D9Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,786,755 - 88,786,956 (+)MAPPERmRatBN7.2
Rnor_6.0995,281,134 - 95,281,332NCBIRnor6.0
Rnor_5.0994,968,349 - 94,968,547UniSTSRnor5.0
RGSC_v3.4987,076,674 - 87,076,872UniSTSRGSC3.4
Celera986,348,053 - 86,348,248UniSTS
Cytogenetic Map9q35UniSTS
RH130767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,795,599 - 88,795,779 (+)MAPPERmRatBN7.2
Rnor_6.0995,289,976 - 95,290,155NCBIRnor6.0
Rnor_5.0994,977,191 - 94,977,370UniSTSRnor5.0
RGSC_v3.4987,085,516 - 87,085,695UniSTSRGSC3.4
Celera986,356,892 - 86,357,071UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS
RH94830  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,808,140 - 88,808,341 (+)MAPPERmRatBN7.2
Rnor_6.0995,302,498 - 95,302,698NCBIRnor6.0
Rnor_5.0994,989,713 - 94,989,913UniSTSRnor5.0
RGSC_v3.4987,098,038 - 87,098,238UniSTSRGSC3.4
Celera986,369,232 - 86,369,432UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 31 31 1 31 25 7
Low 43 26 10 18 10 8 11 74 10 34 11 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_057105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC092531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF359279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF359280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF461737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY435133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D38061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D63585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S70355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000025045   ⟹   ENSRNOP00000025045
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,801,339 - 88,808,465 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000025291   ⟹   ENSRNOP00000025292
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,762,249 - 88,808,465 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000025652   ⟹   ENSRNOP00000025652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,739,577 - 88,808,465 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000032634   ⟹   ENSRNOP00000030374
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,747,213 - 88,808,463 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000045163   ⟹   ENSRNOP00000046507
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,780,328 - 88,808,465 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000063853   ⟹   ENSRNOP00000062958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,791,216 - 88,808,465 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066839   ⟹   ENSRNOP00000063634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071200   ⟹   ENSRNOP00000066773
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,727,092 - 88,808,453 (+)Ensembl
RefSeq Acc Id: NM_001039691   ⟹   NP_001034780
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2988,747,229 - 88,808,465 (+)NCBI
Rnor_6.0995,241,609 - 95,302,822 (+)NCBI
Rnor_5.0994,928,825 - 94,990,037 (+)NCBI
RGSC_v3.4987,037,154 - 87,098,362 (+)RGD
Celera986,308,548 - 86,369,556 (+)NCBI
Sequence:
RefSeq Acc Id: NM_057105   ⟹   NP_476446
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2988,750,940 - 88,808,465 (+)NCBI
Rnor_6.0995,245,318 - 95,302,822 (+)NCBI
Rnor_5.0994,928,825 - 94,990,037 (+)NCBI
RGSC_v3.4987,037,154 - 87,098,362 (+)RGD
Celera986,312,240 - 86,369,556 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001034780   ⟸   NM_001039691
- Peptide Label: precursor
- UniProtKB: P08430 (UniProtKB/Swiss-Prot),   Q63662 (UniProtKB/TrEMBL),   Q6T5E9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_476446   ⟸   NM_057105
- Peptide Label: precursor
- UniProtKB: Q6T5E9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062958   ⟸   ENSRNOT00000063853
RefSeq Acc Id: ENSRNOP00000063634   ⟸   ENSRNOT00000066839
RefSeq Acc Id: ENSRNOP00000046507   ⟸   ENSRNOT00000045163
RefSeq Acc Id: ENSRNOP00000030374   ⟸   ENSRNOT00000032634
RefSeq Acc Id: ENSRNOP00000066773   ⟸   ENSRNOT00000071200
RefSeq Acc Id: ENSRNOP00000025292   ⟸   ENSRNOT00000025291
RefSeq Acc Id: ENSRNOP00000025045   ⟸   ENSRNOT00000025045
RefSeq Acc Id: ENSRNOP00000025652   ⟸   ENSRNOT00000025652
Protein Domains
UDPGT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08430-F1-model_v2 AlphaFold P08430 1-529 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696843
Promoter ID:EPDNEW_R7367
Type:initiation region
Name:Ugt1a7c_1
Description:UDP glucuronosyltransferase 1 family, polypeptide A7C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7366  EPDNEW_R7368  EPDNEW_R7370  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0995,241,625 - 95,241,685EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620949 AgrOrtholog
BioCyc Gene G2FUF-26825 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
  PWY-6313 [serotonin degradation] BioCyc
  PWY-6398 [melatonin degradation I] BioCyc
Ensembl Genes ENSRNOG00000018740 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000030374 ENTREZGENE
  ENSRNOP00000030374.4 UniProtKB/TrEMBL
  ENSRNOP00000063634.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032634 ENTREZGENE
  ENSRNOT00000032634.7 UniProtKB/TrEMBL
  ENSRNOT00000066839.5 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126208 IMAGE-MGC_LOAD
InterPro UDP_glucos_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:113992 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  rno:301595 UniProtKB/TrEMBL
MGC_CLONE MGC:124929 IMAGE-MGC_LOAD
NCBI Gene 113992 ENTREZGENE
Pfam UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UGT1A6 RGD
PhenoGen Ugt1a6 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7EKA4_RAT UniProtKB/TrEMBL
  P08430 ENTREZGENE
  Q63662 ENTREZGENE, UniProtKB/TrEMBL
  Q6T5E9 ENTREZGENE, UniProtKB/TrEMBL
  Q91Y43_RAT UniProtKB/TrEMBL
  Q925F8_RAT UniProtKB/TrEMBL
  UD16_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-02 Ugt1a6  UDP glucuronosyltransferase family 1 member A6  Ugt1a6  UDP glucuronosyltransferase 1 family, polypeptide A6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Ugt1a6  UDP glucuronosyltransferase 1 family, polypeptide A6  Ugt1a6  UDP glycosyltransferase 1 family, polypeptide A6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ugt1a6  UDP glycosyltransferase 1 family, polypeptide A6      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ugt1a6        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is decreased 1.8 and 1.9 fold in SHR compared with WKY rats 1357414
gene_regulation expression increased 10- to 15-fold by 3-methylcholanthrene 634456