RGD Reference Report - Hereditary Acholuric Jaundice In The Rat - Rat Genome Database

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Hereditary Acholuric Jaundice In The Rat

Authors: Charles Kenneth, GUNN  M.Sc., H  Ph.D.,  
Citation: Canadian Medical Association Journal
RGD ID: 1354701
Pubmed: PMID:20323028   (View Abstract at PubMed)
PMCID: PMC1581738   (View Article at PubMed Central)

1. A new mutant jaundice rat has been found among the rats of the breeding colony in the Connaught Laboratories. 2. The mutant rats regularly show bilirubinanemia (indirect van den Bergh reaction), jaundice, alcholuria, polyuria and subnormal growth rate. The occasionally show changed erythocyte fragility, microcytosis, and nervous symptoms. 3. Splenectomy does not alleviate the jaundiced condition in the mutant rats.



Disease Annotations    
Jaundice  (IAGP,ISO)
Polyuria  (IAGP,ISO)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

Genes (Rattus norvegicus)
Ugt1a1  (UDP glucuronosyltransferase family 1 member A1)
Ugt1a1j  (UDP glucuronosyltransferase family 1 member A1, jaundice mutant)

Genes (Mus musculus)
Ugt1a1  (UDP glucuronosyltransferase 1 family, polypeptide A1)

Genes (Homo sapiens)
UGT1A1  (UDP glucuronosyltransferase family 1 member A1)

Strains
Gunn-Ugt1a1j/BluHsd  (Gunn rat)

Objects referenced in this article
Strain Gunn rats null Rattus norvegicus

Additional Information