RGD Reference Report - Hereditary Acholuric Jaundice In The Rat - Rat Genome Database

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Hereditary Acholuric Jaundice In The Rat

Authors: Charles Kenneth, GUNN  M.Sc., H  Ph.D.,  
Citation: Canadian Medical Association Journal
RGD ID: 1354701
Pubmed: PMID:20323028   (View Abstract at PubMed)
PMCID: PMC1581738   (View Article at PubMed Central)

1. A new mutant jaundice rat has been found among the rats of the breeding colony in the Connaught Laboratories. 2. The mutant rats regularly show bilirubinanemia (indirect van den Bergh reaction), jaundice, alcholuria, polyuria and subnormal growth rate. The occasionally show changed erythocyte fragility, microcytosis, and nervous symptoms. 3. Splenectomy does not alleviate the jaundiced condition in the mutant rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gunn-Ugt1a1j/BluHsdRatJaundice  IAGP  RGD 
UGT1A1HumanJaundice  ISOUgt1a1 (Rattus norvegicus) RGD 
Ugt1a1RatJaundice  IAGP  RGD 
Ugt1a1MouseJaundice  ISOUgt1a1 (Rattus norvegicus) RGD 
Ugt1a1jRatJaundice  IAGP  RGD 
Gunn-Ugt1a1j/BluHsdRatPolyuria  IAGP  RGD 
UGT1A1HumanPolyuria  ISOUgt1a1 (Rattus norvegicus) RGD 
Ugt1a1RatPolyuria  IAGP  RGD 
Ugt1a1MousePolyuria  ISOUgt1a1 (Rattus norvegicus) RGD 
Ugt1a1jRatPolyuria  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gunn-Ugt1a1j/BluHsdRatdecreased mean corpuscular volume  IAGP compared to Gunn ratsRGD 
Ugt1a1Ratdecreased mean corpuscular volume  IAGP compared to Gunn ratsRGD 
Ugt1a1jRatdecreased mean corpuscular volume  IAGP compared to Gunn ratsRGD 
Gunn-Ugt1a1j/BluHsdRatincreased circulating bilirubin level  IAGP compared to Gunn ratsRGD 
Ugt1a1Ratincreased circulating bilirubin level  IAGP compared to Gunn ratsRGD 
Ugt1a1jRatincreased circulating bilirubin level  IAGP compared to Gunn ratsRGD 
Gunn-Ugt1a1j/BluHsdRatreticulocytosis  IAGP compared to Gunn ratsRGD 
Ugt1a1Ratreticulocytosis  IAGP compared to Gunn ratsRGD 
Ugt1a1jRatreticulocytosis  IAGP compared to Gunn ratsRGD 
Gunn-Ugt1a1j/BluHsdRatslow postnatal weight gain  IAGP compared to Gunn ratsRGD 
Ugt1a1Ratslow postnatal weight gain  IAGP compared to Gunn ratsRGD 
Ugt1a1jRatslow postnatal weight gain  IAGP compared to Gunn ratsRGD 
Objects Annotated

Genes (Rattus norvegicus)
Ugt1a1  (UDP glucuronosyltransferase family 1 member A1)
Ugt1a1j  (UDP glucuronosyltransferase family 1 member A1, jaundice mutant)

Genes (Mus musculus)
Ugt1a1  (UDP glucuronosyltransferase 1 family, polypeptide A1)

Genes (Homo sapiens)
UGT1A1  (UDP glucuronosyltransferase family 1 member A1)

Strains
Gunn-Ugt1a1j/BluHsd  (Gunn rat)

Objects referenced in this article
Strain Gunn rats null Rattus norvegicus

Additional Information