Ugt1a1<sup>j</sup> (UDP glucuronosyltransferase family 1 member A1, jaundice mutant) - Rat Genome Database

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Gene: Ugt1a1j (UDP glucuronosyltransferase family 1 member A1, jaundice mutant) Rattus norvegicus
Analyze
Symbol: Ugt1a1j
Name: UDP glucuronosyltransferase family 1 member A1, jaundice mutant
RGD ID: 13432064
Description: A single guanosine (G) base deletion within the UGT1A1 gene causes the absence of hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin in a spontaneous mutant strain of Wistar rats.
ASSOCIATED WITH abnormal renal water reabsorption; decreased mean corpuscular volume; decreased urine osmolality; ASSOCIATED WITH bilirubin metabolic disorder; Jaundice; Polyuria
Type: allele  of Ugt1a1  
Previously known as: Ugt1a1j
Is Marker For: Strains:   Gunn-Ugt1a1j/BluHsd   Gunn-Ugt1a1j/Slc   Gunn-Ugt1a1j/BluHsdRrrc   SD.Gunn-Ugt1a1j/Aon   W.Gunn-Ugt1a1j/Aon  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin. Call NB and Tisher CC, J Clin Invest 1975 Feb;55(2):319-29.
2. Hereditary Acholuric Jaundice In The Rat Canadian Medical Association Journal
3. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation. Iyanagi T, etal., J Biol Chem 1989 Dec 15;264(35):21302-7.
4. Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector. Toietta G, etal., Proc Natl Acad Sci U S A 2005 Mar 15;102(11):3930-5. Epub 2005 Mar 7.
5. Successful treatment of UGT1A1 deficiency in a rat model of Crigler-Najjar disease by intravenous administration of a liver-specific lentiviral vector. van der Wegen P, etal., Mol Ther. 2006 Feb;13(2):374-81. Epub 2005 Dec 5.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ugt1a1j-var1 chr9 88805660 88805660 G - deletion mRatBN7.2
Ugt1a1j-var1 chr9 95300017 95300017 G - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Ugt1a1j


Expression


Sequence

Nucleotide Sequences


Additional Information