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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1increases expressionEXP 6480464CTDCisplatin results in increased expression of UGT1A1 mRNA; Cisplatin results in increased expression of UGT1A1 proteinPMID:18289764 PMID:22023808
Ugt1a1affects response to substanceISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 protein affects the susceptibility to CisplatinPMID:16217747
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