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Strain: Gunn-Ugt1a1j/BluHsd

Symbol: Gunn-Ugt1a1j/BluHsd
Strain: Gunn-Ugt1a1j
Substrain: BluHsd
Full Name: Gunn rat
RGD ID: 1357186
Citation ID: RRID:RGD_1357186
Ontology ID: RS:0001319
Alleles: Ugt1a1j
Also Known As: Gunn-Ugt1a1j; Gunn-Ugt1a1j/BluHsd; Gunn-Ugt1a1^[j]/BluHsd
Type: mutant
Available Source: Harlan
Description: This mutation was first observed in normal Wistar albino rats in a breeding colony at Cannaught Laboratories in 1934. Jaundice was evident at birth or shortly after and was persistant throughout life.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,805,660 - 88,805,660RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0995,300,017 - 95,300,017RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0994,982,916 - 94,990,037RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4987,091,241 - 87,098,362RGD_MAPPER_PIPELINERGSC3.4

Mutant Strains
Gunn-Ugt1a1j/BluHsdRrrc




Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin. Call NB and Tisher CC, J Clin Invest 1975 Feb;55(2):319-29.
2. Hereditary Acholuric Jaundice In The Rat Canadian Medical Association Journal
3. Defective function of a microsomal UDP-glucuronyltransferase in Gunn rats. Nakata D, etal., Proc Natl Acad Sci U S A 1976 Feb;73(2):289-92.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Isolation of multiple normal and functionally defective forms of uridine diphosphate-glucuronosyltransferase from inbred Gunn rats. Roy Chowdhury N, etal., J Clin Invest 1987 Feb;79(2):327-34.
6. A difference in mortality between two strains of jaundiced rats. Stobie PE, etal., Pediatrics 1991 Jan;87(1):88-93.
7. Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector. Toietta G, etal., Proc Natl Acad Sci U S A 2005 Mar 15;102(11):3930-5. Epub 2005 Mar 7.
8. Successful treatment of UGT1A1 deficiency in a rat model of Crigler-Najjar disease by intravenous administration of a liver-specific lentiviral vector. van der Wegen P, etal., Mol Ther. 2006 Feb;13(2):374-81. Epub 2005 Dec 5.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ugt1a1j-var1 chr9 88805660 88805660 G - deletion mRatBN7.2
Ugt1a1j-var1 chr9 95300017 95300017 G - deletion Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These have jaundice with a yellow coloration of the skin and serum. 1354701
strain_life_disease Long-term correction of unconjugated hyperbilirubinemia can be achieved by one injection of HD-Ad vector with negligible chronic toxicity. 1354702
strain_phys_biochem There is absence of bile in the urine of these animals. 1354701
strain_phys_biochem Kidneys have persistent deposition of bilirubin in the papilla and inner medula along with varying degree of parenchymatous damage. 1354700

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-15 Gunn-Ugt1a1j/BluHsd  Gunn rat  Gunn-Ugt1a1jBluHsd  Gunn rat  Symbol updated 68687 APPROVED
2010-06-08 Gunn-Ugt1a1jBluHsd  Gunn rat  Gunn-Ugt1a1j/BluHsd  Gunn rat  Symbol and/or name change 68913 APPROVED