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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1decreases expressionISOUGT1A1 (Homo sapiens)6480464CTDOxygen deficiency results in decreased expression of UGT1A1 mRNAPMID:19695866
Ugt1a1increases expressionISOUGT1A1 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of UGT1A1 mRNAPMID:33811995
Ugt1a1multiple interactionsISOUGT1A1 (Homo sapiens)6480464CTD[Acetaminophen co-treated with Oxygen deficiency] results in decreased expression of UGT1A1 mRNA; Oxygen deficiency inhibits the reaction [Acetaminophen results in increased expression of UGT1A1 mRNA]; Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of UGT1A1 mRNA]; Oxygen deficiency promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA]PMID:33811995
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