Nppc (natriuretic peptide C) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nppc (natriuretic peptide C) Rattus norvegicus
Analyze
Symbol: Nppc
Name: natriuretic peptide C
RGD ID: 620850
Description: Enables hormone activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cGMP-mediated signaling; and positive regulation of osteoblast differentiation. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in extracellular space and secretory granule. Biomarker of aortic valve stenosis and heart disease. Human ortholog(s) of this gene implicated in depressive disorder and hypertension. Orthologous to human NPPC (natriuretic peptide C); PARTICIPATES IN C-type natriuretic peptide signaling pathway; INTERACTS WITH 3',5'-cyclic GMP; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-type natriuretic peptide; natriuretic peptide precursor C; natriuretic peptide precursor type C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nppcem1Kyo   Nppcem2Kyo   Nppcem3Kyo   Nppcem4Kyo  
Genetic Models: F344-Nppcem1Kyo F344-Nppcem4Kyo F344-Nppcem3Kyo F344-Nppcem2Kyo
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,767,986 - 94,772,186 (-)NCBIGRCr8
mRatBN7.2987,320,051 - 87,324,251 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,320,051 - 87,324,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,736,538 - 95,740,736 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,864,694 - 100,868,893 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,248,353 - 99,252,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,731,436 - 93,735,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,458,753 - 93,462,953 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,434,254 - 85,438,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,617,672 - 85,621,873 (-)NCBI
Celera984,734,141 - 84,738,341 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRataortic valve stenosis  IEP 1642267mRNA:decreased expression:aortic valveRGD 
NppcRatarteriosclerosis  ISONPPC (Homo sapiens)1642296 RGD 
NppcRatdepressive disorder  ISONPPC (Homo sapiens)401854249DNA:SNP:CDS:multiple (human)RGD 
NppcRatend stage renal disease  ISONPPC (Homo sapiens)1580770protein:increased expression:plasma (human)RGD 
NppcRatend stage renal disease  ISONPPC (Homo sapiens)1642297protein:increased expression:plasmaRGD 
NppcRatheart disease  IEP 1642294associated with Diabetes Mellitus more ...RGD 
NppcRathypertension  ISONPPC (Homo sapiens)1580150 RGD 
NppcRathypertension severityISONPPC (Homo sapiens)1642292associated with Pregnancy Complications and protein:increased expression:plasmaRGD 
NppcRatHypoxia  IEP 1642268protein:increased expression:lung and plasmaRGD 
NppcRatMyocardial Reperfusion Injury  IDA 1580149 RGD 
NppcRattoxic shock syndrome  ISONPPC (Homo sapiens)1642297protein:increased expression:plasmaRGD 
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRatJoubert syndrome 22  ISONPPC (Homo sapiens)8554872ClinVar Annotator: match by term: Joubert syndrome 22ClinVarPMID:28492532
NppcRatosteochondrodysplasia  ISONPPC (Homo sapiens)8554872ClinVar Annotator: match by term: Skeletal dysplasiaClinVarPMID:25741868
NppcRatPerlman syndrome  ISONPPC (Homo sapiens)8554872ClinVar Annotator: match by term: Perlman syndromeClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRatbone development disease  ISONPPC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17676597
NppcRatcartilage disease  ISONPPC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17676597
NppcRatGrowth Disorders  ISONPPC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17676597
NppcRatHyperkinesis  ISONPPC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:11860464
NppcRatSkin Neoplasms  ISONPPC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:37352108
NppcRatureteral obstruction  ISONPPC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26207612
NppcRatWeight Loss  ISONPPC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:37352108
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRatachondroplasia  ISSNppc (Mus musculus)13592920OMIM:100800MouseDO 
NppcRatosteochondrodysplasia  ISSNppc (Mus musculus)13592920 MouseDO 

1 to 20 of 102 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRat17beta-estradiol multiple interactionsISONPPC (Homo sapiens)6480464ESR1 mutant form inhibits the reaction [Estradiol results in increased expression of NPPC mRNA]CTDPMID:25136773
NppcRat17beta-estradiol increases expressionISONppc (Mus musculus)6480464Estradiol results in increased expression of NPPC mRNA and Estradiol results in increased expression of NPPC proteinCTDPMID:9435603
NppcRat17beta-estradiol multiple interactionsISONppc (Mus musculus)6480464Dactinomycin inhibits the reaction [Estradiol results in increased expression of NPPC mRNA] more ...CTDPMID:9435603
NppcRat17beta-estradiol increases expressionISONPPC (Homo sapiens)6480464Estradiol results in increased expression of NPPC mRNACTDPMID:23019147 and PMID:25136773
NppcRat17beta-hydroxy-5alpha-androstan-3-one increases expressionISONPPC (Homo sapiens)6480464Dihydrotestosterone results in increased expression of NPPC mRNACTDPMID:29581250
NppcRat2-hydroxypropanoic acid increases expressionISONPPC (Homo sapiens)6480464Lactic Acid results in increased expression of NPPC mRNACTDPMID:30851411
NppcRat3',5'-cyclic GMP increases chemical synthesisEXP 6480464NPPC protein results in increased chemical synthesis of Cyclic GMPCTDPMID:18222015
NppcRat3',5'-cyclic GMP increases abundanceEXP 6480464NPPC protein results in increased abundance of Cyclic GMPCTDPMID:17629948
NppcRat3',5'-cyclic GMP multiple interactionsEXP 6480464Ammonia inhibits the reaction [NPPC protein results in increased chemical synthesis of Cyclic GMP] and Fluoroacetates inhibits the reaction [NPPC protein results in increased abundance of Cyclic GMP]CTDPMID:17629948 and PMID:18222015
NppcRat4,4'-sulfonyldiphenol increases expressionISONPPC (Homo sapiens)6480464bisphenol S results in increased expression of NPPC mRNACTDPMID:34831106
NppcRat4,4'-sulfonyldiphenol multiple interactionsISONPPC (Homo sapiens)6480464Fulvestrant inhibits the reaction [bisphenol S results in increased expression of NPPC mRNA]CTDPMID:34831106
NppcRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of NPPC mRNACTDPMID:24780913
NppcRat6-propyl-2-thiouracil multiple interactionsISONppc (Mus musculus)6480464[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of NPPC mRNACTDPMID:36706583
NppcRat7,12-dimethyltetraphene multiple interactionsISONppc (Mus musculus)6480464Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9 more ...CTDPMID:37352108
NppcRatacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of NPPC mRNACTDPMID:28959563
NppcRatactinomycin D multiple interactionsISONppc (Mus musculus)6480464Dactinomycin inhibits the reaction [Estradiol results in increased expression of NPPC mRNA]CTDPMID:9435603
NppcRatactinomycin D multiple interactionsISONPPC (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased expression of NPPC mRNACTDPMID:38460933
NppcRataflatoxin B1 increases expressionISONPPC (Homo sapiens)6480464Aflatoxin B1 results in increased expression of NPPC mRNACTDPMID:21641981
NppcRatalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of NPPC mRNACTDPMID:35163327
NppcRatalpha-Zearalanol decreases expressionEXP 6480464Zeranol results in decreased expression of NPPC mRNACTDPMID:35163327

1 to 20 of 102 rows

Biological Process
1 to 20 of 82 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRatangiogenesis involved_inISONppc (Mus musculus)1624291MGI:5660304 PMID:30586761RGDPMID:30586761
NppcRatangiogenesis involved_inIEAUniProtKB:Q61839 and ensembl:ENSMUSP000000274491600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatanimal organ development acts_upstream_of_or_withinISONppc (Mus musculus)1624291MGI:2388899 PMID:17439653RGDPMID:17439653
NppcRatanimal organ development acts_upstream_of_or_withinIEAUniProtKB:Q61839 and ensembl:ENSMUSP000000274491600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatblood vessel diameter maintenance involved_inIEAUniProtKB-KW:KW-08381600115GO_REF:0000043UniProtGO_REF:0000043
NppcRatblood vessel remodeling involved_inISONppc (Mus musculus)1624291MGI:5660304 PMID:30586761RGDPMID:30586761
NppcRatblood vessel remodeling involved_inIEAUniProtKB:Q61839 and ensembl:ENSMUSP000000274491600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatc-di-GMP signaling involved_inIEAUniProtKB:Q61839 and ensembl:ENSMUSP000000274491600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatc-di-GMP signaling involved_inISONppc (Mus musculus)1624291 PMID:23127564RGDPMID:23127564
NppcRatcellular response to glycoprotein involved_inISONppc (Mus musculus)1624291 PMID:22987720RGDPMID:22987720
NppcRatcellular response to glycoprotein involved_inIEAUniProtKB:Q61839 and ensembl:ENSMUSP000000274491600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatcGMP biosynthetic process acts_upstream_ofISONPPC (Homo sapiens)1624291 PMID:1672777RGDPMID:1672777
NppcRatcGMP biosynthetic process acts_upstream_ofIEAUniProtKB:Q61839 and ensembl:ENSMUSP000000274491600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatcGMP biosynthetic process acts_upstream_ofIEAUniProtKB:P23582 and ensembl:ENSP000003871591600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatcGMP biosynthetic process acts_upstream_ofISONppc (Mus musculus)1624291 PMID:11259675RGDPMID:11259675
NppcRatcGMP biosynthetic process involved_inIBAMGI:97369 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
NppcRatcGMP-mediated signaling  IDA 1601491 RGD 
NppcRatchromosome organization involved_inISONppc (Mus musculus)1624291MGI:2388899 PMID:22696190RGDPMID:22696190
NppcRatchromosome organization involved_inIEAUniProtKB:Q61839 and ensembl:ENSMUSP000000274491600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatcumulus cell differentiation involved_inISONppc (Mus musculus)1624291MGI:2388899 PMID:22696190RGDPMID:22696190
1 to 20 of 82 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
NppcRatextracellular region located_inIEAInterPro:IPR000663 and InterPro:IPR0024061600115GO_REF:0000002InterProGO_REF:0000002
NppcRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
NppcRatextracellular space  IDA 1642268 RGD 
NppcRatprotein-containing complex part_ofISONPPC (Homo sapiens)1624291 PMID:16870210RGDPMID:16870210
NppcRatprotein-containing complex part_ofIEAUniProtKB:P23582 and ensembl:ENSP000003871591600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatsecretory granule  IDA 7327142 RGD 

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRathormone activity  IDA 1580115 RGD 
NppcRathormone activity enablesIEAInterPro:IPR000663 and InterPro:IPR0024061600115GO_REF:0000002InterProGO_REF:0000002
NppcRathormone activity enablesIEAUniProtKB-KW:KW-03721600115GO_REF:0000043UniProtGO_REF:0000043
NppcRathormone activity enablesIBAPANTHER:PTN002638244 and Nppc (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
NppcRathormone activity  IDA 1601491 RGD 
NppcRathormone receptor binding enablesISONPPC (Homo sapiens)1624291UniProtKB:P20594 and PMID:1660465RGDPMID:1660465
NppcRathormone receptor binding enablesIEAUniProtKB:P23582 and ensembl:ENSP000003871591600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRathormone receptor binding enablesIBAPANTHER:PTN002638244 and UniProtKB:P235821600115GO_REF:0000033GO_CentralGO_REF:0000033
NppcRatsignaling receptor binding enablesISONPPC (Homo sapiens)1624291UniProtKB:P17342 more ...RGDPMID:1672777 more ...
NppcRatsignaling receptor binding enablesIEAUniProtKB:P23582 and ensembl:ENSP000003871591600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatsignaling receptor binding enablesIEAUniProtKB:Q61839 and ensembl:ENSMUSP000000274491600115GO_REF:0000107EnsemblGO_REF:0000107
NppcRatsignaling receptor binding enablesISONppc (Mus musculus)1624291 PMID:14514678RGDPMID:14514678
1 to 12 of 12 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRatC-type natriuretic peptide signaling pathway  IMP 1580149 RGD 
NppcRatC-type natriuretic peptide signaling pathway  TAS 1601488 RGD 
1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NppcRatdecreased body length  IMP 127284867compared to wild typeRGD 
NppcRatdecreased body weight  IMP 127284867compared to wild typeRGD 
NppcRatdecreased cranium length  IMP 127284867compared to wild typeRGD 
NppcRatdecreased heart weight  IMP 127284867compared to wild typeRGD 
NppcRatdecreased kidney weight  IMP 127284867compared to wild typeRGD 
NppcRatdecreased width of hypertrophic chondrocyte zone  IMP 127284867compared to wild typeRGD 
NppcRatshort femur  IMP 127284867compared to wild typeRGD 
NppcRatshort radius  IMP 127284867compared to wild typeRGD 
NppcRatshort tibia  IMP 127284867compared to wild typeRGD 
NppcRatsmall sacral vertebrae  IMP 127284867compared to wild typeRGD 
1 to 10 of 10 rows

1 to 20 of 30 rows
#
Reference Title
Reference Citation
1. Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. Chauhan SD, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1426-31.
2. The natriuretic peptide (ovCNP-39) from platypus (Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release. de Plater GM, etal., Toxicon. 1998 Jun;36(6):847-57.
3. Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death. Fujii T, etal., PLoS One. 2018 Mar 22;13(3):e0194812. doi: 10.1371/journal.pone.0194812. eCollection 2018.
4. [Changes of plasma levels of type C natriuretic peptide in patients with pregnancy induced hypertension]. Gao Z, etal., Zhonghua Fu Chan Ke Za Zhi. 2000 Mar;35(3):139-41.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Alterations in brain levels of atrial and C-type natriuretic peptides after chronic moderate ethanol consumption in spontaneously hypertensive rats. Guillaume P, etal., Eur J Pharmacol. 1997 Jan 29;319(2-3):215-24.
7. Detection of C-type natriuretic peptide in human circulation and marked increase of plasma CNP level in septic shock patients. Hama N, etal., Biochem Biophys Res Commun. 1994 Feb 15;198(3):1177-82.
8. Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Hobbs A, etal., Circulation. 2004 Sep 7;110(10):1231-5. Epub 2004 Aug 30.
9. Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts. Horio T, etal., Endocrinology. 2003 Jun;144(6):2279-84.
10. C-type natriuretic peptide in chronic renal failure and its action in humans. Igaki T, etal., Kidney Int Suppl. 1996 Jun;55:S144-7.
11. The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging. Kaneki H, etal., J Cell Biochem. 2007 Jun 11;.
12. Cloning and sequence analysis of a cDNA encoding a precursor for rat C-type natriuretic peptide (CNP). Kojima M, etal., FEBS Lett 1990 Dec 10;276(1-2):209-13.
13. Forced homodimerization by site-directed mutagenesis alters guanylyl cyclase activity of natriuretic peptide receptor B. Langenickel T, etal., Hypertension. 2004 Feb;43(2):460-5. Epub 2003 Dec 22.
14. Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B. Langenickel TH, etal., Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4735-40. Epub 2006 Mar 14.
15. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. Moffatt P, etal., J Biol Chem. 2007 Dec 14;282(50):36454-62. Epub 2007 Oct 19.
18. C-type natriuretic peptide in human coronary atherosclerotic lesions. Naruko T, etal., Circulation. 1996 Dec 15;94(12):3103-8.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension. Ono K, etal., Hypertens Res. 2002 Sep;25(5):727-30.
1 to 20 of 30 rows
PMID:1660465   PMID:1672777   PMID:11259675   PMID:14514678   PMID:16870210   PMID:16888179   PMID:17360440   PMID:17439653   PMID:18222015   PMID:20438814   PMID:20947764   PMID:21170077  
PMID:21189408   PMID:21723350   PMID:21865266   PMID:23186653   PMID:23808942   PMID:24189506   PMID:24477916   PMID:24967686   PMID:25283078   PMID:25663771   PMID:26980729   PMID:27496871  
PMID:27557795   PMID:30235256   PMID:32517762   PMID:33970224   PMID:37493451  



Nppc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,767,986 - 94,772,186 (-)NCBIGRCr8
mRatBN7.2987,320,051 - 87,324,251 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,320,051 - 87,324,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,736,538 - 95,740,736 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,864,694 - 100,868,893 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,248,353 - 99,252,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,731,436 - 93,735,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,458,753 - 93,462,953 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,434,254 - 85,438,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,617,672 - 85,621,873 (-)NCBI
Celera984,734,141 - 84,738,341 (-)NCBICelera
Cytogenetic Map9q35NCBI
NPPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,921,809 - 231,926,396 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,921,809 - 231,926,396 (-)EnsemblGRCh38hg38GRCh38
GRCh372232,786,519 - 232,791,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,498,379 - 232,499,203 (-)NCBINCBI36Build 36hg18NCBI36
Build 342232,615,639 - 232,616,464NCBI
Celera2226,553,391 - 226,554,215 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2224,637,737 - 224,641,970 (-)NCBIHuRef
CHM1_12232,792,757 - 232,796,990 (-)NCBICHM1_1
T2T-CHM13v2.02232,408,446 - 232,413,033 (-)NCBIT2T-CHM13v2.0
Nppc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,594,015 - 86,598,295 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,594,013 - 86,598,293 (-)EnsemblGRCm39 Ensembl
GRCm38186,666,293 - 86,670,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,666,291 - 86,670,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,562,866 - 88,567,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,497,462 - 88,501,743 (-)NCBIMGSCv36mm8
Celera189,636,053 - 89,640,334 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.98NCBI
Nppc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554533,884,560 - 3,888,850 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554533,884,580 - 3,888,494 (+)NCBIChiLan1.0ChiLan1.0
NPPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213134,521,303 - 134,525,907 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B134,536,268 - 134,540,875 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B119,148,774 - 119,153,381 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B237,936,938 - 237,941,244 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,936,939 - 237,941,244 (-)Ensemblpanpan1.1panPan2
NPPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,714,545 - 43,718,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,717,939 - 43,718,996 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,207,480 - 44,212,095 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,970,614 - 43,975,231 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,971,109 - 43,975,418 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,897,765 - 43,902,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02543,741,734 - 43,746,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,896,748 - 43,901,364 (-)NCBIUU_Cfam_GSD_1.0
Nppc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,842,468 - 185,847,056 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365255,092,635 - 5,099,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365255,092,675 - 5,099,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15132,506,474 - 132,509,673 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115132,504,669 - 132,509,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215146,345,826 - 146,350,873 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,919,889 - 117,924,306 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10117,919,760 - 117,924,273 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604081,519,481 - 81,524,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nppc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248434,869,614 - 4,873,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248434,869,278 - 4,873,444 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Nppc
9 total Variants

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:172
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000025582
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat

1 to 10 of 22 rows
Nppc  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2987,323,441 - 87,324,246 (+)MAPPERmRatBN7.2
Rnor_6.0993,734,827 - 93,735,631NCBIRnor6.0
Rnor_5.0993,462,144 - 93,462,948UniSTSRnor5.0
RGSC_v3.4985,437,645 - 85,438,449UniSTSRGSC3.4
Celera984,737,532 - 84,738,336UniSTS
Cytogenetic Map9q35UniSTS


This gene Nppc is modified in the following models/strains:
F344-Nppcem1Kyo     F344-Nppcem4Kyo     F344-Nppcem3Kyo     F344-Nppcem2Kyo    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 46 110 54 50 25 18 25 5 155 85 93 29 60 25



Ensembl Acc Id: ENSRNOT00000025582   ⟹   ENSRNOP00000025582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl987,320,051 - 87,324,251 (-)Ensembl
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)Ensembl
RefSeq Acc Id: NM_053750   ⟹   NP_446202
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,767,986 - 94,772,186 (-)NCBI
mRatBN7.2987,320,051 - 87,324,251 (-)NCBI
Rnor_6.0993,731,436 - 93,735,636 (-)NCBI
Rnor_5.0993,458,753 - 93,462,953 (-)NCBI
RGSC_v3.4985,434,254 - 85,438,454 (-)RGD
Celera984,734,141 - 84,738,341 (-)RGD
Sequence:
Protein RefSeqs NP_446202 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AIZ76564 (Get FASTA)   NCBI Sequence Viewer  
  BAA14250 (Get FASTA)   NCBI Sequence Viewer  
  EDL75605 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025582
  ENSRNOP00000025582.1
GenBank Protein P55207 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446202   ⟸   NM_053750
- Peptide Label: precursor
- UniProtKB: P55207 (UniProtKB/Swiss-Prot),   A6JWJ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025582   ⟸   ENSRNOT00000025582

Name Modeler Protein Id AA Range Protein Structure
AF-P55207-F1-model_v2 AlphaFold P55207 1-126 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696828
Promoter ID:EPDNEW_R7352
Type:single initiation site
Name:Nppc_1
Description:natriuretic peptide C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0993,735,655 - 93,735,715EPDNEW


1 to 20 of 20 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-26861 BioCyc
Ensembl Genes ENSRNOG00000018854 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025582 ENTREZGENE
  ENSRNOT00000025582.3 UniProtKB/Swiss-Prot
InterPro C_natriurtcpep UniProtKB/Swiss-Prot
  Natr_peptide UniProtKB/Swiss-Prot
  Natr_peptide_CS UniProtKB/Swiss-Prot
KEGG Report rno:114593 UniProtKB/Swiss-Prot
NCBI Gene 114593 ENTREZGENE
PANTHER C-TYPE NATRIURETIC PEPTIDE UniProtKB/Swiss-Prot
  C-TYPE NATRIURETIC PEPTIDE UniProtKB/Swiss-Prot
Pfam ANP UniProtKB/Swiss-Prot
PhenoGen Nppc PhenoGen
PRINTS CNATPEPTIDE UniProtKB/Swiss-Prot
  NATPEPTIDES UniProtKB/Swiss-Prot
PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018854 RatGTEx
SMART NAT_PEP UniProtKB/Swiss-Prot
UniProt A6JWJ7 ENTREZGENE, UniProtKB/TrEMBL
  ANFC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Nppc  natriuretic peptide C  Nppc  natriuretic peptide precursor C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Nppc  natriuretic peptide precursor C  Nppc  natriuretic peptide precursor type C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nppc  natriuretic peptide precursor type C    natriuretic peptide precursor C  Name updated 1299863 APPROVED
2002-08-07 Nppc  natriuretic peptide precursor C      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression mainly distributed in the central nervous system 70639
gene_expression produced and secreted by the endothelium 70639
gene_expression expressed in vascular smooth muscle cells in the absence of endothelium and independently of endothelial regulation 70639
gene_function binds to natriuretic peptide receptor 70639
gene_process potent inhibitor of growth and proliferation in vascular smooth muscle cells 70639
gene_product member of the natriuretic peptide family 70639
gene_product 22 or 53 amino acids 70639
gene_protein 126-residue peptide 728923
gene_regulation stimulated by TGF-b, but inhibited by basic FGF 70639