Nppc (natriuretic peptide C) - Rat Genome Database

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Gene: Nppc (natriuretic peptide C) Rattus norvegicus
Analyze
Symbol: Nppc
Name: natriuretic peptide C
RGD ID: 620850
Description: Enables hormone activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cGMP-mediated signaling; and positive regulation of osteoblast differentiation. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in extracellular space and secretory granule. Biomarker of aortic valve stenosis and heart disease. Human ortholog(s) of this gene implicated in depressive disorder and hypertension. Orthologous to human NPPC (natriuretic peptide C); PARTICIPATES IN C-type natriuretic peptide signaling pathway; INTERACTS WITH 3',5'-cyclic GMP; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-type natriuretic peptide; natriuretic peptide precursor C; natriuretic peptide precursor type C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nppcem1Kyo   Nppcem2Kyo   Nppcem3Kyo   Nppcem4Kyo  
Genetic Models: F344-Nppcem1Kyo F344-Nppcem4Kyo F344-Nppcem3Kyo F344-Nppcem2Kyo
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,767,986 - 94,772,186 (-)NCBIGRCr8
mRatBN7.2987,320,051 - 87,324,251 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,320,051 - 87,324,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,736,538 - 95,740,736 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,864,694 - 100,868,893 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,248,353 - 99,252,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,731,436 - 93,735,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,458,753 - 93,462,953 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,434,254 - 85,438,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,617,672 - 85,621,873 (-)NCBI
Celera984,734,141 - 84,738,341 (-)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic GMP  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
ammonia  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
chloroquine  (EXP)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diiodine  (ISO)
dopamine  (EXP)
estriol  (ISO)
ethanol  (EXP)
fentanyl  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
nimodipine  (EXP)
Nutlin-3  (ISO)
ozone  (EXP)
paracetamol  (EXP)
parathion  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
terbufos  (ISO)
testosterone  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ development  (ISO)
blood vessel diameter maintenance  (IEA)
blood vessel remodeling  (ISO)
c-di-GMP signaling  (ISO)
cellular response to glycoprotein  (ISO)
cGMP biosynthetic process  (IBA,ISO)
cGMP-mediated signaling  (IDA)
chromosome organization  (ISO)
cumulus cell differentiation  (ISO)
gastric emptying  (ISO)
growth plate cartilage chondrocyte differentiation  (ISO,ISS)
growth plate cartilage chondrocyte proliferation  (ISO,ISS)
intracellular calcium ion homeostasis  (ISO)
meiotic cell cycle  (ISO)
meiotic cell cycle process involved in oocyte maturation  (ISO)
multicellular organismal locomotion  (ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of collagen biosynthetic process  (IDA)
negative regulation of DNA biosynthetic process  (IDA)
negative regulation of meiotic cell cycle  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oocyte maturation  (ISO)
oocyte development  (ISO)
ossification  (IEA)
ovarian follicle development  (ISO)
positive regulation of cGMP-mediated signaling  (IDA)
positive regulation of mast cell degranulation  (IDA)
positive regulation of osteoblast differentiation  (IDA)
positive regulation of uterine smooth muscle relaxation  (IDA)
post-embryonic development  (ISO)
protein folding  (ISO)
receptor guanylyl cyclase signaling pathway  (IBA,IDA,ISO,ISS)
regulation of multicellular organism growth  (ISO)
regulation of smooth muscle cell proliferation  (IEP)
response to axon injury  (ISO)
response to decreased oxygen levels  (ISO)
response to ethanol  (IEP)
response to hypoxia  (IEP)
response to ischemia  (ISO)
response to oxygen-glucose deprivation  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. Chauhan SD, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1426-31.
2. The natriuretic peptide (ovCNP-39) from platypus (Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release. de Plater GM, etal., Toxicon. 1998 Jun;36(6):847-57.
3. Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death. Fujii T, etal., PLoS One. 2018 Mar 22;13(3):e0194812. doi: 10.1371/journal.pone.0194812. eCollection 2018.
4. [Changes of plasma levels of type C natriuretic peptide in patients with pregnancy induced hypertension]. Gao Z, etal., Zhonghua Fu Chan Ke Za Zhi. 2000 Mar;35(3):139-41.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Alterations in brain levels of atrial and C-type natriuretic peptides after chronic moderate ethanol consumption in spontaneously hypertensive rats. Guillaume P, etal., Eur J Pharmacol. 1997 Jan 29;319(2-3):215-24.
7. Detection of C-type natriuretic peptide in human circulation and marked increase of plasma CNP level in septic shock patients. Hama N, etal., Biochem Biophys Res Commun. 1994 Feb 15;198(3):1177-82.
8. Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Hobbs A, etal., Circulation. 2004 Sep 7;110(10):1231-5. Epub 2004 Aug 30.
9. Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts. Horio T, etal., Endocrinology. 2003 Jun;144(6):2279-84.
10. C-type natriuretic peptide in chronic renal failure and its action in humans. Igaki T, etal., Kidney Int Suppl. 1996 Jun;55:S144-7.
11. The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging. Kaneki H, etal., J Cell Biochem. 2007 Jun 11;.
12. Cloning and sequence analysis of a cDNA encoding a precursor for rat C-type natriuretic peptide (CNP). Kojima M, etal., FEBS Lett 1990 Dec 10;276(1-2):209-13.
13. Forced homodimerization by site-directed mutagenesis alters guanylyl cyclase activity of natriuretic peptide receptor B. Langenickel T, etal., Hypertension. 2004 Feb;43(2):460-5. Epub 2003 Dec 22.
14. Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B. Langenickel TH, etal., Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4735-40. Epub 2006 Mar 14.
15. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, etal., Hum Mol Genet. 2022 Nov 10;31(22):3769-3776. doi: 10.1093/hmg/ddac129.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. Moffatt P, etal., J Biol Chem. 2007 Dec 14;282(50):36454-62. Epub 2007 Oct 19.
18. C-type natriuretic peptide in human coronary atherosclerotic lesions. Naruko T, etal., Circulation. 1996 Dec 15;94(12):3103-8.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension. Ono K, etal., Hypertens Res. 2002 Sep;25(5):727-30.
21. Distinct Downregulation of C-Type Natriuretic Peptide System in Human Aortic Valve Stenosis. Peltonen TO, etal., Circulation. 2007 Aug 20;.
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. [The expression and significance of urotensin II, nitric oxide, and C-type natriuretic peptide in hypoxia-induced pulmonary hypertension in rats] Sun DJ, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Mar;29(3):185-8.
25. Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alphaT3-1 and LbetaT2 gonadotroph cells. Thompson IR, etal., J Endocrinol. 2009 Nov;203(2):215-29. doi: 10.1677/JOE-09-0189. Epub 2009 Aug 7.
26. Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from pheochromocytoma (PC12) cells. Trachte GJ Endocrinology 2003 Jan;144(1):94-100.
27. Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. Villar IC, etal., Cardiovasc Res. 2007 Jun 1;74(3):515-25. Epub 2007 Mar 3.
28. Impaired angiotensin II regulation of renal C-type natriuretic peptide mRNA expression in experimental diabetes mellitus. Walther T, etal., Cardiovasc Res. 2001 Aug 15;51(3):562-6.
29. Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy. Walther T, etal., J Mol Endocrinol. 2000 Jun;24(3):391-5.
30. Expression and control of C-type natriuretic peptide in rat vascular smooth muscle cells. Woodard GE, etal., Am J Physiol Regul Integr Comp Physiol 2002 Jan;282(1):R156-65.
Additional References at PubMed
PMID:1660465   PMID:1672777   PMID:11259675   PMID:14514678   PMID:16870210   PMID:16888179   PMID:17360440   PMID:17439653   PMID:18222015   PMID:20438814   PMID:20947764   PMID:21170077  
PMID:21189408   PMID:21723350   PMID:21865266   PMID:23186653   PMID:23808942   PMID:24189506   PMID:24477916   PMID:24967686   PMID:25283078   PMID:25663771   PMID:26980729   PMID:27496871  
PMID:27557795   PMID:30235256   PMID:32517762   PMID:33970224   PMID:37493451  


Genomics

Comparative Map Data
Nppc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,767,986 - 94,772,186 (-)NCBIGRCr8
mRatBN7.2987,320,051 - 87,324,251 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,320,051 - 87,324,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,736,538 - 95,740,736 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,864,694 - 100,868,893 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,248,353 - 99,252,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,731,436 - 93,735,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,458,753 - 93,462,953 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,434,254 - 85,438,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,617,672 - 85,621,873 (-)NCBI
Celera984,734,141 - 84,738,341 (-)NCBICelera
Cytogenetic Map9q35NCBI
NPPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,921,809 - 231,926,396 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,921,809 - 231,926,396 (-)EnsemblGRCh38hg38GRCh38
GRCh372232,786,519 - 232,791,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,498,379 - 232,499,203 (-)NCBINCBI36Build 36hg18NCBI36
Build 342232,615,639 - 232,616,464NCBI
Celera2226,553,391 - 226,554,215 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2224,637,737 - 224,641,970 (-)NCBIHuRef
CHM1_12232,792,757 - 232,796,990 (-)NCBICHM1_1
T2T-CHM13v2.02232,408,446 - 232,413,033 (-)NCBIT2T-CHM13v2.0
Nppc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,594,015 - 86,598,295 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,594,013 - 86,598,293 (-)EnsemblGRCm39 Ensembl
GRCm38186,666,293 - 86,670,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,666,291 - 86,670,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,562,866 - 88,567,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,497,462 - 88,501,743 (-)NCBIMGSCv36mm8
Celera189,636,053 - 89,640,334 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.98NCBI
Nppc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554533,884,560 - 3,888,850 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554533,884,580 - 3,888,494 (+)NCBIChiLan1.0ChiLan1.0
NPPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213134,521,303 - 134,525,907 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B134,536,268 - 134,540,875 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B119,148,774 - 119,153,381 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B237,936,938 - 237,941,244 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,936,939 - 237,941,244 (-)Ensemblpanpan1.1panPan2
NPPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,714,545 - 43,718,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,717,939 - 43,718,996 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,207,480 - 44,212,095 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,970,614 - 43,975,231 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,971,109 - 43,975,418 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,897,765 - 43,902,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02543,741,734 - 43,746,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,896,748 - 43,901,364 (-)NCBIUU_Cfam_GSD_1.0
Nppc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,842,468 - 185,847,056 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365255,092,635 - 5,099,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365255,092,675 - 5,099,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15132,506,474 - 132,509,673 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115132,504,669 - 132,509,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215146,345,826 - 146,350,873 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,919,889 - 117,924,306 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10117,919,760 - 117,924,273 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604081,519,481 - 81,524,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nppc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248434,869,614 - 4,873,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248434,869,278 - 4,873,444 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nppc
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:172
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000025582
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat

Markers in Region
Nppc  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2987,323,441 - 87,324,246 (+)MAPPERmRatBN7.2
Rnor_6.0993,734,827 - 93,735,631NCBIRnor6.0
Rnor_5.0993,462,144 - 93,462,948UniSTSRnor5.0
RGSC_v3.4985,437,645 - 85,438,449UniSTSRGSC3.4
Celera984,737,532 - 84,738,336UniSTS
Cytogenetic Map9q35UniSTS


Genetic Models
This gene Nppc is modified in the following models/strains:
F344-Nppcem1Kyo     F344-Nppcem4Kyo     F344-Nppcem3Kyo     F344-Nppcem2Kyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 46 110 54 50 25 18 25 5 155 85 93 29 60 25

Sequence


Ensembl Acc Id: ENSRNOT00000025582   ⟹   ENSRNOP00000025582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl987,320,051 - 87,324,251 (-)Ensembl
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)Ensembl
RefSeq Acc Id: NM_053750   ⟹   NP_446202
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8994,767,986 - 94,772,186 (-)NCBI
mRatBN7.2987,320,051 - 87,324,251 (-)NCBI
Rnor_6.0993,731,436 - 93,735,636 (-)NCBI
Rnor_5.0993,458,753 - 93,462,953 (-)NCBI
RGSC_v3.4985,434,254 - 85,438,454 (-)RGD
Celera984,734,141 - 84,738,341 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446202 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AIZ76564 (Get FASTA)   NCBI Sequence Viewer  
  BAA14250 (Get FASTA)   NCBI Sequence Viewer  
  EDL75605 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025582.1
  ENSRNOP00055011064
  ENSRNOP00060011782
  ENSRNOP00065024077
GenBank Protein P55207 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446202   ⟸   NM_053750
- Peptide Label: precursor
- UniProtKB: P55207 (UniProtKB/Swiss-Prot),   A6JWJ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025582   ⟸   ENSRNOT00000025582

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55207-F1-model_v2 AlphaFold P55207 1-126 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696828
Promoter ID:EPDNEW_R7352
Type:single initiation site
Name:Nppc_1
Description:natriuretic peptide C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0993,735,655 - 93,735,715EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620850 AgrOrtholog
BioCyc Gene G2FUF-26861 BioCyc
Ensembl Genes ENSRNOG00000018854 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055008145 UniProtKB/Swiss-Prot
  ENSRNOG00060009041 UniProtKB/Swiss-Prot
  ENSRNOG00065018088 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025582.3 UniProtKB/Swiss-Prot
  ENSRNOT00055013776 UniProtKB/Swiss-Prot
  ENSRNOT00060015157 UniProtKB/Swiss-Prot
  ENSRNOT00065030296 UniProtKB/Swiss-Prot
InterPro C_natriurtcpep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114593 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114593 ENTREZGENE
PANTHER C-TYPE NATRIURETIC PEPTIDE UniProtKB/Swiss-Prot
  C-TYPE NATRIURETIC PEPTIDE UniProtKB/Swiss-Prot
  C-TYPE NATRIURETIC PEPTIDE UniProtKB/TrEMBL
  C-TYPE NATRIURETIC PEPTIDE UniProtKB/TrEMBL
Pfam ANP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nppc PhenoGen
PRINTS CNATPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NATPEPTIDES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018854 RatGTEx
  ENSRNOG00055008145 RatGTEx
  ENSRNOG00060009041 RatGTEx
  ENSRNOG00065018088 RatGTEx
SMART NAT_PEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JWJ7 ENTREZGENE, UniProtKB/TrEMBL
  ANFC_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Nppc  natriuretic peptide C  Nppc  natriuretic peptide precursor C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Nppc  natriuretic peptide precursor C  Nppc  natriuretic peptide precursor type C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nppc  natriuretic peptide precursor type C    natriuretic peptide precursor C  Name updated 1299863 APPROVED
2002-08-07 Nppc  natriuretic peptide precursor C      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mainly distributed in the central nervous system 70639
gene_expression produced and secreted by the endothelium 70639
gene_expression expressed in vascular smooth muscle cells in the absence of endothelium and independently of endothelial regulation 70639
gene_function binds to natriuretic peptide receptor 70639
gene_process potent inhibitor of growth and proliferation in vascular smooth muscle cells 70639
gene_product member of the natriuretic peptide family 70639
gene_product 22 or 53 amino acids 70639
gene_protein 126-residue peptide 728923
gene_regulation stimulated by TGF-b, but inhibited by basic FGF 70639