Strain Report - Rat Genome Database

Name: F344- Nppc em3Kyo
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Strain Registration

General

Strain: F344-Nppc^em3Kyo

Symbol:

F344-Nppc^em3Kyo

Strain:

F344-Nppc^em3

Substrain:

Kyo

RGD ID:

127284870

Citation ID:

RRID:RGD_127284870

Ontology ID:

RS:0004954

Alleles:

Nppc^em3Kyo

Also Known As:

delta 11 mutant; F344-Nppc^[em3Kyo]

Type:

mutant

Available Source:

National BioResource Project for the Rat in Japan

Origination:

National BioResource Project for the Rat in Japan

Description:

This strain was established by injecting Zinc-finger nucleases (ZFNs) to F344/Stm pronuclear stage embryos. Selected ZFNs were designed to target exon 1 of rat Nppc, which encodes the N-terminus of natriuretic peptide precursor C (target sequence: CGAAGCCAAGCCCGGGACaccaccGAAGGTGGGTGCTGTCGCG; nucleotides 179 - 221, NC_005108.4). The injected F344/Stm embryos were transferred into the oviducts of pseudopregnant rats. Four lines of knockout strains were estaglished. This F344-Nppc^em3Kyo strain ( delta 11)was deduced to generated a frame shift and a premature stop codon (at nucleotides 275 - 277, NM_053750.1)

Coat Color:

Albino

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	87,320,051 - 87,324,251	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	9	93,731,436 - 93,735,636	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	9	93,458,753 - 93,462,953	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	9	85,434,254 - 85,438,454	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased body length (IMP)

decreased body weight (IMP)

decreased cranium length (IMP)

decreased heart weight (IMP)

decreased kidney weight (IMP)

decreased width of hypertrophic chondrocyte zone (IMP)

short femur (IMP)

short radius (IMP)

short tibia (IMP)

small sacral vertebrae (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death.	Fujii T, etal., PLoS One. 2018 Mar 22;13(3):e0194812. doi: 10.1371/journal.pone.0194812. eCollection 2018.

Region

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: F344-Nppcem3Kyo

Mammalian Phenotype

Strain: F344-Nppc^em3Kyo