NPPC (natriuretic peptide C) - Rat Genome Database
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Gene: NPPC (natriuretic peptide C) Homo sapiens
Analyze
Symbol: NPPC
Name: natriuretic peptide C
RGD ID: 1351265
HGNC Page HGNC
Description: Exhibits hormone receptor binding activity. Involved in several processes, including cGMP biosynthetic process; negative regulation of oocyte maturation; and receptor guanylyl cyclase signaling pathway. Localizes to protein-containing complex. Implicated in hypertension. Biomarker of arteriosclerosis; end stage renal disease; hypertension; and toxic shock syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-type natriuretic peptide; CNP; CNP2; natriuretic peptide precursor C; natriuretic peptide precursor type C
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2231,921,809 - 231,926,396 (-)EnsemblGRCh38hg38GRCh38
GRCh382231,921,809 - 231,926,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372232,786,519 - 232,791,106 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372232,786,805 - 232,791,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,498,379 - 232,499,203 (-)NCBINCBI36hg18NCBI36
Build 342232,615,639 - 232,616,464NCBI
Celera2226,553,391 - 226,554,215 (-)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2224,637,737 - 224,641,970 (-)NCBIHuRef
CHM1_12232,792,756 - 232,797,065 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1309330   PMID:1339402   PMID:1472040   PMID:1660465   PMID:1672777   PMID:1855454   PMID:2018508   PMID:7698765   PMID:8330189   PMID:8353861   PMID:8586417   PMID:8674895  
PMID:9155593   PMID:9232196   PMID:11533490   PMID:12167597   PMID:12379507   PMID:12477932   PMID:12709393   PMID:12736257   PMID:14654233   PMID:15231517   PMID:15489334   PMID:15598085  
PMID:15815621   PMID:15911070   PMID:16006435   PMID:16109786   PMID:16179391   PMID:16777970   PMID:16870210   PMID:17289171   PMID:17487764   PMID:17951249   PMID:18280250   PMID:18391643  
PMID:18391951   PMID:19008326   PMID:19086053   PMID:19161538   PMID:19293575   PMID:19326473   PMID:19570815   PMID:19620509   PMID:19913121   PMID:20085572   PMID:20090473   PMID:20398908  
PMID:20551602   PMID:20553977   PMID:20628086   PMID:20700369   PMID:20721606   PMID:20797397   PMID:20802130   PMID:20832589   PMID:20881960   PMID:20934962   PMID:20947764   PMID:20966902  
PMID:21276798   PMID:21296556   PMID:21820448   PMID:21865234   PMID:21873635   PMID:22285383   PMID:22421372   PMID:22435455   PMID:22645228   PMID:22884919   PMID:22962429   PMID:23262354  
PMID:23542429   PMID:23732776   PMID:23911666   PMID:24099862   PMID:24845564   PMID:25096521   PMID:25387261   PMID:25429064   PMID:25728306   PMID:25808436   PMID:25811760   PMID:25926602  
PMID:26307537   PMID:26459742   PMID:26485840   PMID:26801306   PMID:26962968   PMID:26980729   PMID:27376982   PMID:27432908   PMID:28450398   PMID:28554303   PMID:28661490   PMID:28673612  
PMID:29367254   PMID:29506482   PMID:29987050   PMID:30232670   PMID:30335543   PMID:30566484   PMID:31072047   PMID:31075302   PMID:31431448   PMID:31893950  


Genomics

Comparative Map Data
NPPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2231,921,809 - 231,926,396 (-)EnsemblGRCh38hg38GRCh38
GRCh382231,921,809 - 231,926,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372232,786,519 - 232,791,106 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372232,786,805 - 232,791,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,498,379 - 232,499,203 (-)NCBINCBI36hg18NCBI36
Build 342232,615,639 - 232,616,464NCBI
Celera2226,553,391 - 226,554,215 (-)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2224,637,737 - 224,641,970 (-)NCBIHuRef
CHM1_12232,792,756 - 232,797,065 (-)NCBICHM1_1
Nppc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,594,015 - 86,598,295 (-)NCBIGRCm39mm39
GRCm38186,666,293 - 86,670,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,666,291 - 86,670,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,562,866 - 88,567,147 (-)NCBIGRCm37mm9NCBIm37
MGSCv36188,497,462 - 88,501,743 (-)NCBImm8
Celera189,636,053 - 89,640,334 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.98NCBI
Nppc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2987,320,051 - 87,324,251 (-)NCBI
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0993,731,436 - 93,735,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0993,458,753 - 93,462,953 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,434,254 - 85,438,454 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1985,617,672 - 85,621,873 (-)NCBI
Celera984,734,141 - 84,738,341 (-)NCBICelera
Cytogenetic Map9q35NCBI
Nppc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554533,884,560 - 3,888,850 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554533,884,580 - 3,888,494 (+)NCBIChiLan1.0ChiLan1.0
NPPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B237,936,938 - 237,941,244 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,936,939 - 237,941,244 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B119,148,774 - 119,153,381 (-)NCBIMhudiblu_PPA_v0panPan3
NPPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2543,717,939 - 43,718,996 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12543,714,545 - 43,718,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nppc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365255,092,675 - 5,099,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15132,506,474 - 132,509,673 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115132,504,669 - 132,509,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215146,345,826 - 146,350,873 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,919,889 - 117,924,306 (-)NCBI
ChlSab1.1 Ensembl10117,919,760 - 117,924,273 (-)Ensembl
Nppc
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248434,869,278 - 4,873,444 (-)NCBI

Position Markers
NPPC  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372232,790,136 - 232,790,377UniSTSGRCh37
Build 362232,498,380 - 232,498,621RGDNCBI36
Celera2226,553,392 - 226,553,633RGD
HuRef2224,641,068 - 224,641,309UniSTS
UniSTS:483279  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372232,790,095 - 232,791,038UniSTSGRCh37
Celera2226,553,351 - 226,554,294UniSTS
HuRef2224,641,027 - 224,641,970UniSTS
UniSTS:480745  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372232,790,135 - 232,790,959UniSTSGRCh37
Celera2226,553,391 - 226,554,215UniSTS
HuRef2224,641,067 - 224,641,891UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:524
Count of miRNA genes:432
Interacting mature miRNAs:464
Transcripts:ENST00000295440, ENST00000409852
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 104 23 32 4 12 25 21 165 2 49 35 7 1 1
Low 1182 814 493 86 235 20 1155 1036 2762 102 715 438 66 189 611 1 1
Below cutoff 827 930 751 269 528 184 2101 907 687 206 591 697 93 615 1463 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000295440   ⟹   ENSP00000295440
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2231,925,385 - 231,926,328 (-)Ensembl
RefSeq Acc Id: ENST00000409852   ⟹   ENSP00000387159
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2231,921,809 - 231,926,396 (-)Ensembl
RefSeq Acc Id: NM_024409   ⟹   NP_077720
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382231,921,809 - 231,926,396 (-)NCBI
GRCh372232,786,805 - 232,791,038 (-)NCBI
Build 362232,498,379 - 232,499,203 (-)NCBI Archive
HuRef2224,637,737 - 224,641,970 (-)NCBI
CHM1_12232,792,756 - 232,797,065 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011511245   ⟹   XP_011509547
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382231,922,323 - 231,926,405 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077720   ⟸   NM_024409
- Peptide Label: preproprotein
- UniProtKB: P23582 (UniProtKB/Swiss-Prot),   E5LCN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011509547   ⟸   XM_011511245
- Peptide Label: isoform X1
- UniProtKB: P23582 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000295440   ⟸   ENST00000295440
RefSeq Acc Id: ENSP00000387159   ⟸   ENST00000409852

Promoters
RGD ID:6863076
Promoter ID:EPDNEW_H4703
Type:multiple initiation site
Name:NPPC_1
Description:natriuretic peptide C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382231,926,396 - 231,926,456EPDNEW
RGD ID:6797299
Promoter ID:HG_KWN:37727
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Lymphoblastoid
Transcripts:ENST00000295440,   ENST00000409852
Position:
Human AssemblyChrPosition (strand)Source
Build 362232,499,081 - 232,499,581 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q37.1-37.3(chr2:231770279-242126245)x1 copy number loss See cases [RCV000050304] Chr2:231770279..242126245 [GRCh38]
Chr2:232634989..243059659 [GRCh37]
Chr2:232343233..242717069 [NCBI36]
Chr2:2q37.1-37.3
pathogenic
GRCh38/hg38 2q32.3-37.3(chr2:194898783-236473913)x3 copy number gain See cases [RCV000051119] Chr2:194898783..236473913 [GRCh38]
Chr2:195763507..237382556 [GRCh37]
Chr2:195471752..237047295 [NCBI36]
Chr2:2q32.3-37.3
pathogenic
GRCh38/hg38 2q37.1-37.3(chr2:231375505-242065208)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052639]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052639]|See cases [RCV000052639] Chr2:231375505..242065208 [GRCh38]
Chr2:232240216..243007359 [GRCh37]
Chr2:231948460..242656032 [NCBI36]
Chr2:2q37.1-37.3
pathogenic
GRCh38/hg38 2q36.3-37.3(chr2:226978129-236886599)x1 copy number loss See cases [RCV000052637] Chr2:226978129..236886599 [GRCh38]
Chr2:227842845..237795242 [GRCh37]
Chr2:227551089..237459981 [NCBI36]
Chr2:2q36.3-37.3
pathogenic
GRCh38/hg38 2q36.3-37.2(chr2:227343278-235339168)x1 copy number loss See cases [RCV000052638] Chr2:227343278..235339168 [GRCh38]
Chr2:228207994..236247812 [GRCh37]
Chr2:227916238..235912551 [NCBI36]
Chr2:2q36.3-37.2
pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:188818195-242065208)x3 copy number gain See cases [RCV000052958] Chr2:188818195..242065208 [GRCh38]
Chr2:189682921..243007359 [GRCh37]
Chr2:189391166..242656032 [NCBI36]
Chr2:2q32.2-37.3
pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:190310736-241892770)x3 copy number gain See cases [RCV000052959] Chr2:190310736..241892770 [GRCh38]
Chr2:191175462..242834921 [GRCh37]
Chr2:190883707..242483594 [NCBI36]
Chr2:2q32.2-37.3
pathogenic
GRCh38/hg38 2q32.3-37.3(chr2:193122313-241074980)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]|See cases [RCV000052960] Chr2:193122313..241074980 [GRCh38]
Chr2:193987039..242014395 [GRCh37]
Chr2:193695284..241663068 [NCBI36]
Chr2:2q32.3-37.3
pathogenic
GRCh38/hg38 2q36.1-37.3(chr2:223992431-242126245)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052972]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052972]|See cases [RCV000052972] Chr2:223992431..242126245 [GRCh38]
Chr2:224857148..243059659 [GRCh37]
Chr2:224565392..242717069 [NCBI36]
Chr2:2q36.1-37.3
pathogenic
GRCh38/hg38 2q36.3-37.3(chr2:227803148-242086301)x3 copy number gain See cases [RCV000052973] Chr2:227803148..242086301 [GRCh38]
Chr2:228667864..243028452 [GRCh37]
Chr2:228376108..242677125 [NCBI36]
Chr2:2q36.3-37.3
pathogenic
GRCh38/hg38 2q37.1(chr2:231892041-232652305)x1 copy number loss See cases [RCV000133712] Chr2:231892041..232652305 [GRCh38]
Chr2:232756751..233517015 [GRCh37]
Chr2:232464995..233225259 [NCBI36]
Chr2:2q37.1
pathogenic
GRCh38/hg38 2q36.3-37.3(chr2:228723579-241404867)x3 copy number gain See cases [RCV000134169] Chr2:228723579..241404867 [GRCh38]
Chr2:229588295..242344282 [GRCh37]
Chr2:229296539..241992955 [NCBI36]
Chr2:2q36.3-37.3
pathogenic
GRCh38/hg38 2q34-37.3(chr2:210579676-242126245)x3 copy number gain See cases [RCV000135934] Chr2:210579676..242126245 [GRCh38]
Chr2:211444400..243059659 [GRCh37]
Chr2:211152645..242717069 [NCBI36]
Chr2:2q34-37.3
pathogenic
GRCh38/hg38 2q36.3-37.2(chr2:228014149-234976424)x3 copy number gain See cases [RCV000136967] Chr2:228014149..234976424 [GRCh38]
Chr2:228878865..235885068 [GRCh37]
Chr2:228587109..235549807 [NCBI36]
Chr2:2q36.3-37.2
pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:189436149-241841232)x3 copy number gain See cases [RCV000142307] Chr2:189436149..241841232 [GRCh38]
Chr2:190300875..242783384 [GRCh37]
Chr2:190009120..242432057 [NCBI36]
Chr2:2q32.2-37.3
pathogenic
GRCh38/hg38 2q35-37.3(chr2:218101759-242126245)x3 copy number gain See cases [RCV000143216] Chr2:218101759..242126245 [GRCh38]
Chr2:218966482..243059659 [GRCh37]
Chr2:218674727..242717069 [NCBI36]
Chr2:2q35-37.3
pathogenic
GRCh38/hg38 2q37.1-37.3(chr2:231770279-242126245)x1 copy number loss See cases [RCV000148260] Chr2:231770279..242126245 [GRCh38]
Chr2:232634989..243059659 [GRCh37]
Chr2:232343233..242717069 [NCBI36]
Chr2:2q37.1-37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q37.1(chr2:232215111-235593473)x1 copy number loss See cases [RCV000446723] Chr2:232215111..235593473 [GRCh37]
Chr2:2q37.1
likely pathogenic
GRCh37/hg19 2q35-37.3(chr2:219966808-237815985)x3 copy number gain See cases [RCV000448049] Chr2:219966808..237815985 [GRCh37]
Chr2:2q35-37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q36.1-37.3(chr2:222077224-239394441)x3 copy number gain See cases [RCV000511816] Chr2:222077224..239394441 [GRCh37]
Chr2:2q36.1-37.3
pathogenic
GRCh37/hg19 2q34-37.3(chr2:213518431-242783384)x3 copy number gain See cases [RCV000512009] Chr2:213518431..242783384 [GRCh37]
Chr2:2q34-37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q35-37.3(chr2:219225872-242016876)x3 copy number gain not provided [RCV000682170] Chr2:219225872..242016876 [GRCh37]
Chr2:2q35-37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q37.1(chr2:232550626-233171039)x1 copy number loss not provided [RCV000740949] Chr2:232550626..233171039 [GRCh37]
Chr2:2q37.1
uncertain significance
Single allele deletion Skeletal dysplasia [RCV000787429] Chr2:232647812..232930068 [GRCh37]
Chr2:2q37.1
uncertain significance
GRCh37/hg19 2q34-37.3(chr2:210779657-239879183)x3 copy number gain See cases [RCV000790568] Chr2:210779657..239879183 [GRCh37]
Chr2:2q34-37.3
pathogenic
GRCh37/hg19 2q37.1(chr2:232550626-232968158)x3 copy number gain See cases [RCV000790573] Chr2:232550626..232968158 [GRCh37]
Chr2:2q37.1
uncertain significance
GRCh37/hg19 2q36.3-37.3(chr2:230814690-242783384)x3 copy number gain not provided [RCV001007519] Chr2:230814690..242783384 [GRCh37]
Chr2:2q36.3-37.3
pathogenic
NM_024409.4(NPPC):c.52C>T (p.Leu18Phe) single nucleotide variant not provided [RCV000950649] Chr2:231926198 [GRCh38]
Chr2:232790908 [GRCh37]
Chr2:2q37.1
benign
GRCh37/hg19 2q31.2-37.3(chr2:178397959-243007457)x3 copy number gain See cases [RCV001263052] Chr2:178397959..243007457 [GRCh37]
Chr2:2q31.2-37.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7941 AgrOrtholog
COSMIC NPPC COSMIC
Ensembl Genes ENSG00000163273 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000295440 UniProtKB/Swiss-Prot
  ENSP00000387159 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000295440 UniProtKB/Swiss-Prot
  ENST00000409852 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000163273 GTEx
HGNC ID HGNC:7941 ENTREZGENE
Human Proteome Map NPPC Human Proteome Map
InterPro C_natriurtcpep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4880 ENTREZGENE
OMIM 600296 OMIM
Pfam ANP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31735 PharmGKB
PRINTS CNATPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NATPEPTIDES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NAT_PEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ANFC_HUMAN UniProtKB/Swiss-Prot
  E5LCN7 ENTREZGENE, UniProtKB/TrEMBL
  P23582 ENTREZGENE
UniProt Secondary Q4ZG41 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-13 NPPC  natriuretic peptide C  NPPC  natriuretic peptide C  Symbol and/or name change 5135510 APPROVED
2011-07-27 NPPC  natriuretic peptide C  NPPC  natriuretic peptide precursor C  Symbol and/or name change 5135510 APPROVED