NPPC (natriuretic peptide C) - Rat Genome Database

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Gene: NPPC (natriuretic peptide C) Canis lupus familiaris
Analyze
Symbol: NPPC
Name: natriuretic peptide C
RGD ID: 12207930
Description: ENCODES a protein that exhibits hormone activity (ortholog); INVOLVED IN animal organ development (ortholog); cGMP biosynthetic process (ortholog); cGMP-mediated signaling (ortholog); PARTICIPATES IN C-type natriuretic peptide signaling pathway; ASSOCIATED WITH achondroplasia (ortholog); aortic valve stenosis (ortholog); arteriosclerosis (ortholog); FOUND IN extracellular space (ortholog); secretory granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C-type natriuretic peptide; natriuretic peptide precursor C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,714,545 - 43,718,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,717,939 - 43,718,996 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,207,480 - 44,212,095 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,970,614 - 43,975,231 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,971,109 - 43,975,418 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,897,765 - 43,902,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02543,741,734 - 43,746,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,896,748 - 43,901,364 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
animal organ development  (IEA,ISO)
blood vessel diameter maintenance  (IEA)
blood vessel remodeling  (IEA)
c-di-GMP signaling  (IEA)
cellular response to glycoprotein  (IEA)
cGMP biosynthetic process  (IEA,ISO)
cGMP-mediated signaling  (ISO)
chromosome organization  (IEA)
cumulus cell differentiation  (IEA)
gastric emptying  (IEA)
growth plate cartilage chondrocyte differentiation  (IEA)
growth plate cartilage chondrocyte proliferation  (IEA)
intracellular calcium ion homeostasis  (IEA)
meiotic cell cycle  (IEA,ISO)
meiotic cell cycle process involved in oocyte maturation  (IEA)
multicellular organismal locomotion  (IEA)
negative regulation of cell population proliferation  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of meiotic cell cycle  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA)
negative regulation of oocyte maturation  (IEA,ISO)
oocyte development  (IEA)
ovarian follicle development  (IEA)
positive regulation of cGMP-mediated signaling  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of uterine smooth muscle relaxation  (ISO)
post-embryonic development  (IEA,ISO)
protein folding  (IEA)
receptor guanylyl cyclase signaling pathway  (IEA,ISO)
regulation of multicellular organism growth  (IEA,ISO)
regulation of smooth muscle cell proliferation  (ISO)
reproductive process  (IEA,ISO)
response to axon injury  (IEA)
response to decreased oxygen levels  (IEA)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to ischemia  (IEA)
response to oxygen-glucose deprivation  (IEA)
response to wounding  (IEA)
response to xenobiotic stimulus  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NPPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,714,545 - 43,718,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,717,939 - 43,718,996 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,207,480 - 44,212,095 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02543,970,614 - 43,975,231 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2543,971,109 - 43,975,418 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12543,897,765 - 43,902,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02543,741,734 - 43,746,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02543,896,748 - 43,901,364 (-)NCBIUU_Cfam_GSD_1.0
NPPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,921,809 - 231,926,396 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,921,809 - 231,926,396 (-)EnsemblGRCh38hg38GRCh38
GRCh372232,786,519 - 232,791,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,498,379 - 232,499,203 (-)NCBINCBI36Build 36hg18NCBI36
Build 342232,615,639 - 232,616,464NCBI
Celera2226,553,391 - 226,554,215 (-)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2224,637,737 - 224,641,970 (-)NCBIHuRef
CHM1_12232,792,757 - 232,796,990 (-)NCBICHM1_1
T2T-CHM13v2.02232,408,446 - 232,413,033 (-)NCBIT2T-CHM13v2.0
Nppc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,594,015 - 86,598,295 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,594,013 - 86,598,293 (-)EnsemblGRCm39 Ensembl
GRCm38186,666,293 - 86,670,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,666,291 - 86,670,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,562,866 - 88,567,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36188,497,462 - 88,501,743 (-)NCBIMGSCv36mm8
Celera189,636,053 - 89,640,334 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.98NCBI
Nppc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8994,767,986 - 94,772,186 (-)NCBIGRCr8
mRatBN7.2987,320,051 - 87,324,251 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,320,051 - 87,324,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx995,736,538 - 95,740,736 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09100,864,694 - 100,868,893 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,248,353 - 99,252,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0993,731,436 - 93,735,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,458,753 - 93,462,953 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,434,254 - 85,438,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1985,617,672 - 85,621,873 (-)NCBI
Celera984,734,141 - 84,738,341 (-)NCBICelera
Cytogenetic Map9q35NCBI
Nppc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554533,884,560 - 3,888,850 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554533,884,580 - 3,888,494 (+)NCBIChiLan1.0ChiLan1.0
NPPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213134,521,303 - 134,525,907 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B134,536,268 - 134,540,875 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B119,148,774 - 119,153,381 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B237,936,938 - 237,941,244 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,936,939 - 237,941,244 (-)Ensemblpanpan1.1panPan2
Nppc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,842,468 - 185,847,056 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365255,092,635 - 5,099,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365255,092,675 - 5,099,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15132,506,474 - 132,509,673 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115132,504,669 - 132,509,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215146,345,826 - 146,350,873 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,919,889 - 117,924,306 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10117,919,760 - 117,924,273 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604081,519,481 - 81,524,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nppc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248434,869,614 - 4,873,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248434,869,278 - 4,873,444 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NPPC
48 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 1 6
Low 2 1 5 6 5 3 6 4
Below cutoff 3 4 11 6 6 3 8 6 6

Sequence


RefSeq Acc Id: ENSCAFT00000017709   ⟹   ENSCAFP00000016394
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2543,717,939 - 43,718,996 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845043436   ⟹   ENSCAFP00845034030
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2543,971,109 - 43,975,418 (-)Ensembl
RefSeq Acc Id: XM_038434640   ⟹   XP_038290568
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02543,970,614 - 43,975,231 (-)NCBI
RefSeq Acc Id: XM_038511053   ⟹   XP_038366981
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12543,897,765 - 43,902,381 (-)NCBI
RefSeq Acc Id: XM_038573084   ⟹   XP_038429012
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02543,896,748 - 43,901,364 (-)NCBI
RefSeq Acc Id: XM_038637326   ⟹   XP_038493254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02543,741,734 - 43,746,352 (-)NCBI
RefSeq Acc Id: XM_847591   ⟹   XP_852684
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12543,714,545 - 43,718,969 (-)NCBI
Dog10K_Boxer_Tasha2544,207,480 - 44,212,095 (-)NCBI
Sequence:
RefSeq Acc Id: XP_852684   ⟸   XM_847591
- UniProtKB: A0A8C0LBU4 (UniProtKB/TrEMBL),   A0A8C0NT34 (UniProtKB/TrEMBL),   A0A8I3Q3C1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000016394   ⟸   ENSCAFT00000017709
RefSeq Acc Id: XP_038366981   ⟸   XM_038511053
RefSeq Acc Id: XP_038493254   ⟸   XM_038637326
RefSeq Acc Id: XP_038290568   ⟸   XM_038434640
- UniProtKB: A0A8C0LBU4 (UniProtKB/TrEMBL),   A0A8C0NT34 (UniProtKB/TrEMBL),   A0A8I3Q3C1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038429012   ⟸   XM_038573084
RefSeq Acc Id: ENSCAFP00845034030   ⟸   ENSCAFT00845043436

Promoters
RGD ID:13687821
Promoter ID:EPDNEW_C5891
Type:multiple initiation site
Name:NPPC_1
Description:natriuretic peptide C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12543,718,760 - 43,718,820EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011135 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017671 UniProtKB/TrEMBL
  ENSCAFG00040024429 UniProtKB/TrEMBL
  ENSCAFG00845024603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017709.3 UniProtKB/TrEMBL
  ENSCAFT00030032541.1 UniProtKB/TrEMBL
  ENSCAFT00040045502.1 UniProtKB/TrEMBL
  ENSCAFT00845043436 ENTREZGENE
  ENSCAFT00845043436.1 UniProtKB/TrEMBL
InterPro C_natriurtcpep UniProtKB/TrEMBL
  Natr_peptide UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/TrEMBL
KEGG Report cfa:610169 UniProtKB/TrEMBL
NCBI Gene NPPC ENTREZGENE
PANTHER C-TYPE NATRIURETIC PEPTIDE UniProtKB/TrEMBL
  C-TYPE NATRIURETIC PEPTIDE UniProtKB/TrEMBL
Pfam ANP UniProtKB/TrEMBL
PRINTS CNATPEPTIDE UniProtKB/TrEMBL
  NATPEPTIDES UniProtKB/TrEMBL
PROSITE NATRIURETIC_PEPTIDE UniProtKB/TrEMBL
SMART NAT_PEP UniProtKB/TrEMBL
UniProt A0A8C0LBU4 ENTREZGENE
  A0A8C0NT34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q3C1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43927 ENTREZGENE