Nppc (natriuretic peptide type C) - Rat Genome Database

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Gene: Nppc (natriuretic peptide type C) Mus musculus
Analyze
Symbol: Nppc
Name: natriuretic peptide type C
RGD ID: 1551929
MGI Page MGI
Description: Enables signaling receptor binding activity. Involved in growth plate cartilage chondrocyte differentiation and growth plate cartilage chondrocyte proliferation. Acts upstream of or within several processes, including negative regulation of meiotic cell cycle; negative regulation of oocyte maturation; and regulation of growth. Predicted to be located in extracellular space and secretory granule. Predicted to be part of protein-containing complex. Is expressed in central nervous system and vertebral cartilage condensation. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C; C-type natriuretic peptide; CNP; lb; lbab; MGC130574; natriuretic peptide precursor C; natriuretic peptide precursor type C
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,594,015 - 86,598,295 (-)NCBIGRCm39mm39
GRCm39 Ensembl186,594,013 - 86,598,293 (-)Ensembl
GRCm38186,666,293 - 86,670,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,666,291 - 86,670,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,562,866 - 88,567,147 (-)NCBIGRCm37mm9NCBIm37
MGSCv36188,497,462 - 88,501,743 (-)NCBImm8
Celera189,636,053 - 89,640,334 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7698765   PMID:7769089   PMID:8097440   PMID:8182124   PMID:8603590   PMID:8751373   PMID:8897953   PMID:9119363   PMID:9510554   PMID:10349636   PMID:11042159   PMID:11076861  
PMID:11225057   PMID:11259675   PMID:11870417   PMID:12193576   PMID:12434160   PMID:12475749   PMID:12477932   PMID:12637561   PMID:14514678   PMID:14613785   PMID:15093694   PMID:15196958  
PMID:15327393   PMID:15550520   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16716628   PMID:17116261   PMID:17439653   PMID:17640987   PMID:17951249   PMID:18554750   PMID:18752656  
PMID:18775416   PMID:19282381   PMID:19805191   PMID:19805384   PMID:19808910   PMID:20555027   PMID:20610569   PMID:20947764   PMID:21267068   PMID:21873635   PMID:22271248   PMID:22595960  
PMID:22696190   PMID:22933780   PMID:22987720   PMID:23127564   PMID:23274904   PMID:24099862   PMID:24431432   PMID:24449577   PMID:24804968   PMID:25105365   PMID:25784544   PMID:25860030  
PMID:26263678   PMID:28054671   PMID:28277543   PMID:28346477   PMID:28852070   PMID:28990933   PMID:29251627   PMID:29273600   PMID:29501420   PMID:29535265   PMID:29962937   PMID:30586761  
PMID:30767584   PMID:30817314   PMID:31893950   PMID:34376651  


Genomics

Comparative Map Data
Nppc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,594,015 - 86,598,295 (-)NCBIGRCm39mm39
GRCm39 Ensembl186,594,013 - 86,598,293 (-)Ensembl
GRCm38186,666,293 - 86,670,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,666,291 - 86,670,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv37188,562,866 - 88,567,147 (-)NCBIGRCm37mm9NCBIm37
MGSCv36188,497,462 - 88,501,743 (-)NCBImm8
Celera189,636,053 - 89,640,334 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.98NCBI
NPPC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2231,921,809 - 231,926,396 (-)EnsemblGRCh38hg38GRCh38
GRCh382231,921,809 - 231,926,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372232,786,519 - 232,791,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362232,498,379 - 232,499,203 (-)NCBINCBI36hg18NCBI36
Build 342232,615,639 - 232,616,464NCBI
Celera2226,553,391 - 226,554,215 (-)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2224,637,737 - 224,641,970 (-)NCBIHuRef
CHM1_12232,792,757 - 232,796,990 (-)NCBICHM1_1
Nppc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2987,320,051 - 87,324,251 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl987,320,051 - 87,324,251 (-)Ensembl
Rnor_6.0993,731,436 - 93,735,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl993,731,436 - 93,735,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,458,753 - 93,462,953 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,434,254 - 85,438,454 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1985,617,672 - 85,621,873 (-)NCBI
Celera984,734,141 - 84,738,341 (-)NCBICelera
Cytogenetic Map9q35NCBI
Nppc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554533,884,560 - 3,888,850 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554533,884,580 - 3,888,494 (+)NCBIChiLan1.0ChiLan1.0
NPPC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B237,936,938 - 237,941,244 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B237,936,939 - 237,941,244 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B119,148,774 - 119,153,381 (-)NCBIMhudiblu_PPA_v0panPan3
NPPC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12543,714,545 - 43,718,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2543,717,939 - 43,718,996 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2544,207,480 - 44,212,095 (-)NCBI
ROS_Cfam_1.02543,970,614 - 43,975,231 (-)NCBI
UMICH_Zoey_3.12543,897,765 - 43,902,381 (-)NCBI
UNSW_CanFamBas_1.02543,741,734 - 43,746,352 (-)NCBI
UU_Cfam_GSD_1.02543,896,748 - 43,901,364 (-)NCBI
Nppc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303185,842,468 - 185,847,056 (-)NCBI
SpeTri2.0NW_0049365255,092,675 - 5,099,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15132,506,474 - 132,509,673 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115132,504,669 - 132,509,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215146,345,826 - 146,350,873 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110117,919,889 - 117,924,306 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl10117,919,760 - 117,924,273 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604081,519,481 - 81,524,437 (+)NCBIVero_WHO_p1.0
Nppc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248434,869,278 - 4,873,444 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Nppc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38186,669,743 - 86,670,549UniSTSGRCm38
MGSCv37188,566,318 - 88,567,124UniSTSGRCm37
Celera189,639,505 - 89,640,311UniSTS
Cytogenetic Map1DUniSTS
cM Map154.0UniSTS
cM Map154.0UniSTS
cM Map154.0UniSTS
cM Map154.0UniSTS
Nppc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1DUniSTS
cM Map154.0UniSTS
Nppc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38186,671,022 - 86,671,363UniSTSGRCm38
MGSCv37188,567,597 - 88,567,938UniSTSGRCm37
Celera189,640,784 - 89,641,121UniSTS
Cytogenetic Map1DUniSTS
cM Map154.0UniSTS
Nppc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38186,671,205 - 86,671,363UniSTSGRCm38
MGSCv37188,567,780 - 88,567,938UniSTSGRCm37
Celera189,640,967 - 89,641,121UniSTS
Cytogenetic Map1DUniSTS
cM Map154.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162907596120601949Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16584984788568379Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170205811104211835Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173227055108910684Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73687970107688108Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173687970107688108Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174952818133363199Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17557254793013355Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)176000000128600000Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)176000000148900000Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177146478110608345Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17750000095900000Mouse
14696691Malq1_mmean attack latency QTL 1 (mouse)17800000088000000Mouse
14696693Avd2q1_mattack value day 2 QTL 1 (mouse)17900000091000000Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179930958113931066Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179930958113931066Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180267876126458780Mouse
1302029Sst1_msusceptibility to tuberculosis 1 (mouse)Not determined18167439987203100Mouse
14696692Tavq1_mtotal attack value QTL 1 (mouse)18200000088500000Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782314261147249632Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182665468135687641Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182904910116904910Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182904910116904910Mouse
25394564Skmw49_mskeletal muscle weight 49, TA (mouse)18344239888624908Mouse
25394563Skmw48_mskeletal muscle weight 48, EDL (mouse)18555028587395436Mouse
11667074Led2_mlate embryonic death 2 (mouse)185768306117267351Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186556204120556204Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:140
Interacting mature miRNAs:146
Transcripts:ENSMUST00000027449
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000027449   ⟹   ENSMUSP00000027449
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl186,594,013 - 86,598,293 (-)Ensembl
GRCm38.p6 Ensembl186,666,291 - 86,670,571 (-)Ensembl
RefSeq Acc Id: NM_010933   ⟹   NP_035063
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39186,594,015 - 86,598,295 (-)NCBI
GRCm38186,666,293 - 86,670,573 (-)ENTREZGENE
MGSCv37188,562,866 - 88,567,147 (-)RGD
Celera189,636,055 - 89,640,335 (-)ENTREZGENE
cM Map1 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035063   ⟸   NM_010933
- Peptide Label: preproprotein
- UniProtKB: Q61839 (UniProtKB/Swiss-Prot),   Q544K5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027449   ⟸   ENSMUST00000027449

Promoters
RGD ID:6874338
Promoter ID:EPDNEW_M620
Type:single initiation site
Name:Nppc_1
Description:Mus musculus natriuretic peptide type C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38186,670,573 - 86,670,633EPDNEW
RGD ID:6818181
Promoter ID:MM_KWN:1487
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Liver
Transcripts:NM_010933
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36188,566,814 - 88,567,314 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97369 AgrOrtholog
Ensembl Genes ENSMUSG00000026241 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000027449 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027449 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro C_natriurtcpep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18159 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97369 ENTREZGENE
NCBI Gene 18159 ENTREZGENE
Pfam ANP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nppc PhenoGen
PRINTS CNATPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NATPEPTIDES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NAT_PEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ANFC_MOUSE UniProtKB/Swiss-Prot
  Q544K5 ENTREZGENE, UniProtKB/TrEMBL
  Q61839 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-17 Nppc  natriuretic peptide type C  Nppc  natriuretic peptide type C  Symbol and/or name change 5135510 APPROVED
2011-07-27 Nppc  natriuretic peptide type C  Nppc  natriuretic peptide precursor type C  Symbol and/or name change 5135510 APPROVED