Rab17 (RAB17, member RAS oncogene family) - Rat Genome Database

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Gene: Rab17 (RAB17, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab17
Name: RAB17, member RAS oncogene family
RGD ID: 1562478
Description: Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in several processes, including immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; plasma membrane bounded cell projection assembly; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynapse. Orthologous to human RAB17 (RAB17, member RAS oncogene family); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC503269; ras-related protein Rab-17; RGD1562478; similar to RAB17, member RAS oncogene family
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2991,552,924 - 91,566,759 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,553,464 - 91,566,451 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx999,980,262 - 99,993,254 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09105,116,022 - 105,129,014 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.09103,481,328 - 103,494,316 (-)NCBIRnor_WKY
Rnor_6.0998,118,907 - 98,131,883 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,118,908 - 98,131,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0997,800,064 - 97,813,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,159,592 - 90,198,282 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera989,097,774 - 89,109,527 (-)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8486736   PMID:9490718   PMID:9624171   PMID:12477932   PMID:17646400   PMID:19056867   PMID:20937701   PMID:21291502   PMID:22291024   PMID:24895134   PMID:30256711  


Genomics

Comparative Map Data
Rab17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2991,552,924 - 91,566,759 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,553,464 - 91,566,451 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx999,980,262 - 99,993,254 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.09105,116,022 - 105,129,014 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.09103,481,328 - 103,494,316 (-)NCBIRnor_WKY
Rnor_6.0998,118,907 - 98,131,883 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,118,908 - 98,131,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0997,800,064 - 97,813,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,159,592 - 90,198,282 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera989,097,774 - 89,109,527 (-)NCBICelera
Cytogenetic Map9q36NCBI
RAB17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,574,326 - 237,590,734 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2237,574,322 - 237,601,614 (-)EnsemblGRCh38hg38GRCh38
GRCh372238,482,969 - 238,499,377 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,147,704 - 238,177,653 (-)NCBINCBI36Build 36hg18NCBI36
Build 342238,264,964 - 238,281,736NCBI
Celera2232,196,815 - 232,213,528 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,273,094 - 230,289,898 (-)NCBIHuRef
CHM1_12238,488,032 - 238,504,837 (-)NCBICHM1_1
T2T-CHM13v2.02238,064,233 - 238,080,663 (-)NCBIT2T-CHM13v2.0
Rab17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39190,885,855 - 90,897,395 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl190,885,855 - 90,897,383 (-)EnsemblGRCm39 Ensembl
GRCm38190,958,133 - 90,969,673 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl190,958,133 - 90,969,661 (-)EnsemblGRCm38mm10GRCm38
MGSCv37192,854,710 - 92,866,197 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36192,788,541 - 92,800,026 (-)NCBIMGSCv36mm8
Celera193,903,499 - 93,914,395 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map145.84NCBI
Rab17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555422,751,953 - 2,759,661 (+)NCBIChiLan1.0ChiLan1.0
RAB17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B243,654,176 - 243,671,003 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B243,654,176 - 243,671,003 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B124,802,789 - 124,820,775 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RAB17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,181,557 - 48,220,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,188,085 - 48,203,149 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2548,678,331 - 48,717,616 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02548,566,563 - 48,606,048 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2548,573,948 - 48,588,458 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,442,454 - 48,482,046 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,230,979 - 48,270,251 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,462,757 - 48,502,042 (-)NCBIUU_Cfam_GSD_1.0
Rab17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,174,049 - 190,221,710 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525748,600 - 765,642 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936525748,851 - 765,636 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,235,936 - 137,261,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115137,232,781 - 137,255,884 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215151,631,277 - 151,635,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110123,579,771 - 123,603,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10123,580,621 - 123,594,374 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604075,803,128 - 75,824,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Rab17
93 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:385
Count of miRNA genes:221
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000026918
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat

Markers in Region
RH132977  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2991,553,531 - 91,553,719 (+)MAPPERmRatBN7.2
Rnor_6.0998,118,976 - 98,119,163NCBIRnor6.0
Rnor_5.0997,800,133 - 97,800,320UniSTSRnor5.0
RGSC_v3.4990,159,661 - 90,159,848UniSTSRGSC3.4
Celera989,097,843 - 89,098,030UniSTS
Cytogenetic Map9q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 23 23 23 31 2
Low 20 18 2 18 4 26 11
Below cutoff 18 12 14 4 4 5 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079446   ⟹   ENSRNOP00000068669
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,553,464 - 91,566,451 (-)Ensembl
Rnor_6.0 Ensembl998,118,908 - 98,131,883 (-)Ensembl
RefSeq Acc Id: NM_001109363   ⟹   NP_001102833
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2991,553,463 - 91,566,451 (-)NCBI
Rnor_6.0998,118,907 - 98,131,883 (-)NCBI
Rnor_5.0997,800,064 - 97,813,040 (-)NCBI
RGSC_v3.4990,159,592 - 90,198,282 (-)RGD
Celera989,097,774 - 89,109,527 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084134   ⟹   XP_038940062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2991,552,924 - 91,566,759 (-)NCBI
RefSeq Acc Id: XM_039084135   ⟹   XP_038940063
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2991,552,924 - 91,566,759 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001102833   ⟸   NM_001109363
- UniProtKB: B2RZ46 (UniProtKB/TrEMBL),   A0A0G2JTD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068669   ⟸   ENSRNOT00000079446
RefSeq Acc Id: XP_038940062   ⟸   XM_039084134
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940063   ⟸   XM_039084135
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTD9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTD9-F1-model_v2 AlphaFold A0A0G2JTD9 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696852
Promoter ID:EPDNEW_R7377
Type:single initiation site
Name:Rab17_1
Description:RAB17, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,131,866 - 98,131,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562478 AgrOrtholog
BioCyc Gene G2FUF-26731 BioCyc
Ensembl Genes ENSRNOG00000052979 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068669 ENTREZGENE
  ENSRNOP00000068669.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079446 ENTREZGENE
  ENSRNOT00000079446.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126868 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report rno:503269 UniProtKB/TrEMBL
MGC_CLONE MGC:189241 IMAGE-MGC_LOAD
NCBI Gene 503269 ENTREZGENE
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rab17 PhenoGen
PROSITE RAS UniProtKB/TrEMBL
SMART RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
TIGRFAMs Small_GTP UniProtKB/TrEMBL
UniProt A0A0G2JTD9 ENTREZGENE
  B2RZ46 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2JTD9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Rab17  RAB17, member RAS oncogene family  RGD1562478_predicted  similar to RAB17, member RAS oncogene family (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562478_predicted  similar to RAB17, member RAS oncogene family (predicted)  LOC503269  similar to RAB17, member RAS oncogene family  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC503269  similar to RAB17, member RAS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL