Gene: Trpm8 (transient receptor potential cation channel, subfamily M, member 8) Rattus norvegicus

Analyze

Symbol:

Trpm8

Name:

transient receptor potential cation channel, subfamily M, member 8

RGD ID:

620762

Description:

Enables identical protein binding activity and monoatomic ion channel activity. Involved in calcium ion transmembrane transport and response to cold. Located in plasma membrane raft. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8); INTERACTS WITH ammonium chloride; bisphenol A; bisphenol AF.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CMR1; cold menthol receptor 1; cold/menthol receptor 1; transient receptor potential cation channel subfamily M member 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	96,315,567 - 96,437,959 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	96,351,681 - 96,436,617 (+)	Ensembl				GRCr8
mRatBN7.2	9	88,897,039 - 88,990,167 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	88,903,880 - 88,988,552 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	97,328,476 - 97,413,096 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	102,464,664 - 102,549,168 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	100,832,088 - 100,916,734 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	9	99,973,316 - 100,061,793 (+)	NCBI
Lyon_Normotensive	9	95,823,215 - 95,911,694 (+)	NCBI
Lyon_Hypertensive	9	95,947,425 - 96,035,894 (+)	NCBI
F344_StmMcwi	9	97,937,898 - 98,026,371 (+)	NCBI
Rnor_6.0	9	95,393,370 - 95,484,528 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	95,398,237 - 95,482,890 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	9	95,085,454 - 95,170,108 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	87,193,779 - 87,278,440 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	86,465,338 - 86,549,713 (+)	NCBI		Celera
RGSC_v3.1	9	87,380,876 - 87,465,529 (+)	NCBI
Cytogenetic Map	9	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (IEP)

cervical cancer (ISO)

cholangiocarcinoma (ISO)

colorectal cancer (ISO)

hepatocellular carcinoma (ISO)

melanoma (ISO)

migraine (ISO)

migraine without aura (ISO)

ovarian serous cystadenocarcinoma (ISO)

thymoma (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acetone (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

allyl isothiocyanate (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol AF (EXP)

Bromoenol lactone (EXP)

calcium atom (EXP,ISO)

calcium(0) (EXP,ISO)

cannabidiolic acid (ISO)

capsaicin (EXP,ISO)

capsazepine (EXP)

CGP 52608 (ISO)

citronellol acetate (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

dichloroacetic acid (ISO)

dorsomorphin (ISO)

enzalutamide (ISO)

fenvalerate (EXP)

flavonoids (EXP)

methanol (ISO)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

ochratoxin A (EXP)

okadaic acid (ISO)

p-menthan-3-ol (EXP,ISO)

paracetamol (ISO)

permethrin (EXP,ISO)

phenanthrolines (EXP)

phenobarbital (ISO)

phenylephrine (EXP)

pirinixic acid (ISO)

potassium chloride (EXP)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

testosterone (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

U-73122 (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion transmembrane transport (IBA,IDA)

calcium ion transport (ISO)

calcium-mediated signaling (IEA)

intracellular calcium ion homeostasis (ISO)

metal ion transport (IEA)

monoatomic cation transmembrane transport (IEA)

positive regulation of cold-induced thermogenesis (IBA,IEA,ISO,ISS)

response to cold (IDA,ISO)

response to temperature stimulus (ISO)

thermoception (IBA,ISO)

Cellular Component

endoplasmic reticulum membrane (ISO)

external side of plasma membrane (IEA,ISO)

membrane (IEA,ISO)

membrane raft (EXP,IEA,ISO)

plasma membrane (IBA,IEA,ISO,ISS)

plasma membrane raft (IDA)

Molecular Function

calcium channel activity (IEA,ISO)

identical protein binding (IDA,IEA,ISO)

ligand-gated calcium channel activity (IBA)

monoatomic ion channel activity (IDA,IEA,ISO)

monoatomic ion transmembrane transporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity.	Ma S, etal., J Mol Cell Biol. 2012 Apr;4(2):88-96. doi: 10.1093/jmcb/mjs001. Epub 2012 Jan 11.
3.	Identification of a cold receptor reveals a general role for TRP channels in thermosensation.	McKemy DD, etal., Nature 2002 Mar 7;416(6876):52-8.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Lipid raft segregation modulates TRPM8 channel activity.	Morenilla-Palao C, etal., J Biol Chem. 2009 Apr 3;284(14):9215-24. doi: 10.1074/jbc.M807228200. Epub 2009 Jan 27.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	AFM imaging reveals the tetrameric structure of the TRPM8 channel.	Stewart AP, etal., Biochem Biophys Res Commun. 2010 Apr 2;394(2):383-6. doi: 10.1016/j.bbrc.2010.03.027. Epub 2010 Mar 7.
11.	Activation of Cold-Sensitive Channels TRPM8 and TRPA1 Inhibits the Proliferative Airway Smooth Muscle Cell Phenotype.	Zhang L, etal., Lung. 2016 Aug;194(4):595-603. doi: 10.1007/s00408-016-9901-4. Epub 2016 May 28.
12.	Direct inhibition of the cold-activated TRPM8 ion channel by Gaq.	Zhang X, etal., Nat Cell Biol. 2012 Aug;14(8):851-8. doi: 10.1038/ncb2529. Epub 2012 Jul 1.

Additional References at PubMed

PMID:11893340	PMID:12634279	PMID:12654248	PMID:15194687	PMID:15893591	PMID:16304633	PMID:16595689	PMID:16675144	PMID:16831854	PMID:16846855	PMID:16920620	PMID:17015441
PMID:17317754	PMID:17481391	PMID:17481392	PMID:17517374	PMID:17538622	PMID:17548815	PMID:17712480	PMID:17908685	PMID:17932142	PMID:18077679	PMID:18534015	PMID:18562636
PMID:19158342	PMID:19363131	PMID:19371346	PMID:19622375	PMID:19812688	PMID:20110357	PMID:20844147	PMID:20934218	PMID:21150802	PMID:21598682	PMID:21684817	PMID:21906810
PMID:21947852	PMID:22111979	PMID:22571355	PMID:23001687	PMID:23092296	PMID:23132652	PMID:23293814	PMID:24269608	PMID:24358160	PMID:24472724	PMID:25157108	PMID:25352597
PMID:25539933	PMID:25559186	PMID:25843641	PMID:25944818	PMID:25978347	PMID:26014706	PMID:27051022	PMID:27329106	PMID:27712653	PMID:28038937	PMID:28138709	PMID:28626113
PMID:28867384	PMID:29054683	PMID:30046815	PMID:30488220	PMID:30567389	PMID:30942489	PMID:31002158	PMID:31310758	PMID:31340190	PMID:31703254	PMID:32277850	PMID:32391653
PMID:32929340	PMID:33037615	PMID:35489198	PMID:37542841	PMID:38574849

Genomics

Comparative Map Data

Trpm8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	96,315,567 - 96,437,959 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	96,351,681 - 96,436,617 (+)	Ensembl				GRCr8
mRatBN7.2	9	88,897,039 - 88,990,167 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	88,903,880 - 88,988,552 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	97,328,476 - 97,413,096 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	102,464,664 - 102,549,168 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	100,832,088 - 100,916,734 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	9	99,973,316 - 100,061,793 (+)	NCBI
Lyon_Normotensive	9	95,823,215 - 95,911,694 (+)	NCBI
Lyon_Hypertensive	9	95,947,425 - 96,035,894 (+)	NCBI
F344_StmMcwi	9	97,937,898 - 98,026,371 (+)	NCBI
Rnor_6.0	9	95,393,370 - 95,484,528 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	95,398,237 - 95,482,890 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	9	95,085,454 - 95,170,108 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	87,193,779 - 87,278,440 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	86,465,338 - 86,549,713 (+)	NCBI		Celera
RGSC_v3.1	9	87,380,876 - 87,465,529 (+)	NCBI
Cytogenetic Map	9	q35	NCBI

TRPM8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	233,917,373 - 234,019,522 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	233,917,373 - 234,019,522 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	2	234,826,018 - 234,928,166 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	234,490,782 - 234,592,905 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	234,608,042 - 234,710,165	NCBI
Celera	2	228,546,409 - 228,648,542 (+)	NCBI		Celera
Cytogenetic Map	2	q37.1	NCBI
HuRef	2	226,625,779 - 226,727,969 (+)	NCBI		HuRef
CHM1_1	2	234,831,850 - 234,933,975 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	234,406,317 - 234,508,483 (+)	NCBI		T2T-CHM13v2.0

Trpm8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	88,234,457 - 88,318,909 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	88,205,383 - 88,317,015 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	88,306,735 - 88,388,853 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	88,277,661 - 88,389,293 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	1	90,203,287 - 90,285,426 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	90,134,453 - 90,220,022 (+)	NCBI		MGSCv36	mm8
Celera	1	91,265,235 - 91,346,306 (+)	NCBI		Celera
Cytogenetic Map	1	D	NCBI
cM Map	1	44.57	NCBI

Trpm8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	2,185,534 - 2,265,261 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955453	2,185,534 - 2,265,261 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRPM8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	136,565,837 - 136,659,793 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	136,580,802 - 136,674,757 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	121,160,045 - 121,261,645 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	240,029,984 - 240,130,524 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	240,039,104 - 240,130,524 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

TRPM8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	45,261,092 - 45,357,560 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	45,261,107 - 45,353,282 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	45,758,997 - 45,851,175 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	45,600,006 - 45,703,702 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	45,609,098 - 45,700,909 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	45,501,675 - 45,593,531 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	45,310,182 - 45,402,042 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	45,538,477 - 45,630,602 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Trpm8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	7	193,057,268 - 193,131,677 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405303	187,447,832 - 187,530,684 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936525	3,413,747 - 3,491,815 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936525	3,413,730 - 3,491,815 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRPM8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	134,145,943 - 134,267,970 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	15	134,185,316 - 134,267,973 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	148,620,717 - 148,702,575 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRPM8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	10	121,459,070 - 121,561,154 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666040	79,436,945 - 79,536,853 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	10	119,944,875 - 120,045,295 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	119,954,947 - 120,042,296 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Trpm8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624847	180,040 - 320,494 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624847	194,497 - 320,600 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	25	41,145,813 - 41,280,936 (+)	Ensembl

Trpm8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	160,348,136 - 160,434,008 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in Trpm8
1640 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	341
Count of miRNA genes:	186
Interacting mature miRNAs:	213
Transcripts:	ENSRNOT00000025879
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56047863	101047863	Rat
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
724547	Cm21	Cardiac mass QTL 21	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	86720043	110356905	Rat
2303178	Bp334	Blood pressure QTL 334	3.7	0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	86720043	121768150	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	83161999	118999486	Rat
4889852	Pur26	Proteinuria QTL 26	15	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	85262459	109044727	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	85262459	118999486	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	54506504	99506504	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
193	106	351	1141	3644	379	857	103	249	253	234	130	3424	1807	390	3574	36	1143	647	661	150	148

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_134371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC095563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC120922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY072788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025879 ⟹ ENSRNOP00000025879

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	96,351,681 - 96,436,335 (+)	Ensembl
mRatBN7.2 Ensembl	9	88,903,880 - 88,988,552 (+)	Ensembl
Rnor_6.0 Ensembl	9	95,398,237 - 95,482,890 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000159170 ⟹ ENSRNOP00000101005

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	96,351,681 - 96,436,617 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000169836 ⟹ ENSRNOP00000102466

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	96,351,681 - 96,436,617 (+)	Ensembl

RefSeq Acc Id:

NM_134371 ⟹ NP_599198

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	96,351,683 - 96,436,345 (+)	NCBI
mRatBN7.2	9	88,903,882 - 88,988,562 (+)	NCBI
Dahl_SR_JrHsd	9	99,973,316 - 100,061,793 (+)	NCBI
Lyon_Normotensive	9	95,823,215 - 95,911,694 (+)	NCBI
Lyon_Hypertensive	9	95,947,425 - 96,035,894 (+)	NCBI
F344_StmMcwi	9	97,937,898 - 98,026,371 (+)	NCBI
Rnor_6.0	9	95,398,239 - 95,482,900 (+)	NCBI
Rnor_5.0	9	95,085,454 - 95,170,108 (+)	NCBI
RGSC_v3.4	9	87,193,779 - 87,278,440 (+)	RGD
Celera	9	86,465,338 - 86,549,713 (+)	RGD

Sequence:

show sequence

GTGCTCTAAAGAGAAGCTCTTGGCTGTTTGAGCAGCTCCACGGCAAGATGTCCTTCGAGGGAGC
CAGGCTCAGCATGAGGAGCCGCAGAAATGGAACTCTGGGCAGCACCCGGACCCTGTACTCCAGC
GTGTCTCGGAGCACAGACGTGTCCTACAGTGAAAGTGATTTGGTGAATTTTATTCAGGCAAATT
TTAAAAAACGAGAATGCGTCTTCTTTACCAGAGACTCCAAGGCCATGGAGAGCATATGCAAGTG
TGGTTATGCCCAGAGCCAGCATATCGAAGGCACCCAGATCAACCAAAATGAGAAGTGGAACTAC
AAAAAACACACCAAGGAGTTTCCAACAGACGCCTTTGGGGACATTCAGTTTGAGACTCTGGGGA
AGAAAGGCAAGTACTTACGCTTATCCTGTGACACGGACTCTGAAACCCTCTACGAACTGCTGAC
CCAGCACTGGCACCTCAAAACACCCAACCTGGTCATCTCAGTGACGGGTGGAGCCAAAAACTTT
GCTTTGAAGCCACGCATGCGCAAAATCTTCAGTCGGCTGATCTACATCGCTCAGTCTAAAGGGG
CATGGATTCTTACCGGAGGCACTCATTACGGTCTGATGAAGTACATAGGTGAAGTGGTGAGGGA
TAACACCATCAGCAGGAACTCGGAAGAGAACATCGTGGCCATTGGCATAGCGGCCTGGGGCATG
GTCTCCAACAGGGACACCCTCATCAGGAATTGTGATGATGAGGGACATTTTTCAGCTCAATATA
TCATGGATGACTTCATGAGAGATCCTCTCTACATCCTGGACAACAATCATACCCACCTGCTGCT
TGTGGACAACGGTTGTCATGGACACCCCACGGTGGAAGCCAAACTTCGGAATCAGCTGGAGAAG
TACATCTCTGAGCGCACCAGTCAAGATTCCAACTATGGTGGTAAGATCCCCATCGTGTGTTTTG
CCCAGGGAGGTGGAAGAGAAACTTTGAAAGCCATCAACACCTCTGTCAAAAGTAAGATCCCCTG
TGTGGTGGTGGAAGGCTCGGGGCAGATTGCCGATGTGATTGCCAGCCTGGTGGAGGTAGAGGAT
GTTTTAACCTCTTCCATGGTCAAAGAGAAGCTGGTACGGTTTTTACCCCGCACTGTGTCCCGGC
TGCCTGAAGAGGAGATTGAGAGCTGGATCAAATGGCTCAAAGAAATTCTTGAGAGCCCCCACCT
CCTCACGGTCATCAAGATGGAGGAGGCTGGAGACGAGGTCGTGAGCAGCGCCATTTCCTACGCG
CTGTACAAAGCCTTCAGCACTAATGAACAAGACAAGGACAACTGGAACGGACAGCTGAAGCTTC
TGCTGGAGTGGAACCAACTGGACCTTGCCAGTGATGAGATCTTCACCAATGACCGCCGCTGGGA
GTCTGCCGACCTTCAGGAAGTCATGTTCACGGCCCTCATAAAGGACAGGCCCAAGTTTGTCCGC
CTCTTCCTGGAGAATGGCCTCAACCTGCAGAAGTTCCTCACCAATGAAGTCCTCACGGAGCTCT
TCTCCACCCACTTCAGCACCCTAGTGTACCGGAACCTGCAGATCGCCAAGAACTCCTACAACGA
TGCACTCCTTACCTTTGTCTGGAAGTTGGTGGCAAACTTCCGTAGAAGCTTCTGGAAAGAGGAC
AGAAGCAGCAGGGAGGACTTGGATGTGGAACTCCATGATGCATCTCTCACCACCCGGCACCCCC
TGCAGGCTCTTTTCATCTGGGCCATTCTTCAGAACAAGAAGGAACTCTCCAAGGTCATCTGGGA
GCAAACCAAAGGCTGTACTCTGGCCGCCTTGGGGGCCAGCAAACTTCTGAAGACCCTGGCCAAA
GTTAAGAATGATATCAACGCAGCTGGGGAATCTGAGGAACTGGCTAATGAGTATGAGACCCGAG
CAGTGGAGTTGTTCACTGAGTGTTACAGCAGTGATGAGGACTTGGCAGAACAGCTACTGGTCTA
CTCTTGTGAAGCCTGGGGTGGGAGCAACTGTCTGGAGCTGGCGGTGGAGGCTACGGACCAGCAT
TTCATTGCTCAGCCTGGGGTCCAGAATTTCCTTTCTAAGCAATGGTATGGAGAGATTTCCCGAG
ACACGAAGAACTGGAAGATTATCCTGTGTCTGTTCATCATCCCCCTGGTGGGCTGTGGCCTCGT
ATCGTTTAGGAAGAAGCCCATTGACAAGCACAAGAAGCTGCTCTGGTACTACGTGGCCTTCTTC
ACTTCGCCCTTCGTGGTCTTCTCCTGGAACGTGGTCTTCTACATCGCCTTCCTCCTGCTGTTTG
CGTATGTGCTGCTCATGGACTTCCACTCGGTGCCACACACCCCCGAGCTGATCCTCTATGCCCT
GGTCTTCGTCCTCTTCTGTGATGAAGTGAGGCAGTGGTACATGAACGGAGTGAATTATTTCACC
GACCTATGGAACGTTATGGACACACTGGGACTTTTCTACTTCATAGCGGGTATTGTATTCCGGC
TTCACTCTTCAAATAAAAGCTCTTTGTACTCCGGGCGAGTCATTTTCTGTCTGGATTACATTAT
ATTCACTCTAAGGCTCATCCACATTTTCACCGTGAGCAGGAACCTGGGACCCAAGATTATAATG
CTGCAGCGGATGCTCATCGACGTTTTCTTCTTCTTGTTTCTCTTTGCTGTGTGGATGGTGGCCT
TCGGCGTAGCCAGACAGGGGATCCTTAGGCAAAATGAACAGCGCTGGAGGTGGATCTTCCGCTC
TGTCATCTATGAGCCCTACCTGGCCATGTTTGGCCAGGTGCCCAGTGATGTGGACAGTACCACA
TATGACTTCTCCCACTGCACCTTCTCGGGAAATGAGTCCAAGCCACTGTGCGTGGAGCTAGATG
AATACAATCTGCCCCGCTTCCCTGAGTGGATCACCATCCCACTAGTGTGCATCTACATGCTCTC
CACCAACATCCTTCTGGTCAATCTCCTGGTCGCCATGTTTGGCTACACGGTGGGCATTGTGCAG
GAGAACAACGATCAGGTCTGGAAGTTCCAGCGGTACTTCCTGGTGCAGGAGTACTGCAACCGCC
TCAACATCCCCTTCCCCTTCGTCGTCTTCGCTTACTTCTACATGGTGGTCAAGAAGTGTTTCAA
ATGCTGCTGTAAAGAGAAGAACACGGAGTCTTCTGCCTGCTGTTTCAGAAATGAGGACAACGAG
ACTTTGGCGTGGGAGGGCGTCATGAAGGAGAATTACCTTGTCAAGATCAACACGAAGGCCAACG
ACAACGCAGAGGAGATGAGGCATCGGTTCAGACAACTGGACACAAAGCTTAATGATCTCAAAGG
TCTTCTGAAAGAGATTGCTAATAAAATCAAATAAGGCAGGCGACTGCTCATGGAGAGAAGTCAA
ATTGCAATAAGATCAAATCAAACACCTGGATTTGGAGGCTCGTGGGACTCTGATAAACAATACT
GCTATTGACTTCTAAAGGAGACATTTCCAGGTCCCTGGGCACAAAGTGGATGAGTCATAGTCAC
CCTCAAGGGCATAGGTCAGGGACCAAAGTGTACAGAGAACTGTGCACAAGAAGAGGAGTGCAAA
GGTTCCTCCATGAAGGTGCCTGTGCTGTCTGCATCTCGGAGCCTTGAACTGATGCTGAAGGTTT
AAGTGATGACACACCTTTCCCACCCTCGTCTCATGCACCTCCCATGACTGTGACCCTGGCCCTG
ATTTTACACCTACACTGCTATTGTGTTTATTTCCTACTGTCCCCTTTCTGCATTGTATGATGAA
TTCATCGACATAGGTCAGAGTCCTACACCACCCCAAAGAAAAGTCAGGCCGGATGCTAAAATAC
CCTGGGGCAACCTCTCCTTTCTCACATGTCAAACGTGGGAGGTGTGTGTGTGGGGGGGGCACAC
GGAGGCAGTGACTTCTTTCTCTGGGGCTCTCCAGGACTCCTGCTGAAGGAACCCTTGAGAGCCG
TACCTTGCTCCTTTTGTTTTTGGGAGTGTGCCTCTCCTCCATTCTCTCATTATTTCCCCATTGA
GAATAGCAAATGGATCTCACAGGAGGTTAGAGGAGCACAAAAATGTATGGAAACGGCCTCCCAC
TCACAGCCCTTGCTCACACTTCCGTGTGTTTGCTCAATCCCAGCCTTTTCTATGCATGCTACAC
TTCACTTTTAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039082997 ⟹ XP_038938925

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	96,315,567 - 96,437,959 (+)	NCBI
mRatBN7.2	9	88,897,039 - 88,990,167 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_599198	(Get FASTA)	NCBI Sequence Viewer
	XP_038938925	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL68394	(Get FASTA)	NCBI Sequence Viewer
	EDL92094	(Get FASTA)	NCBI Sequence Viewer
	EDL92095	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025879
	ENSRNOP00000025879.4
	ENSRNOP00055014718
	ENSRNOP00060013870
	ENSRNOP00065029493
GenBank Protein	Q8R455	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_599198 ⟸ NM_134371

- UniProtKB:

Q8R455 (UniProtKB/Swiss-Prot), A0ABK0LGB2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSESDLVNFIQANFKKRECVFFTRDSKAM
ESICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYLRLSCDTDSET
LYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYI
GEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRNCDDEGHFSAQYIMDDFMRDPLYILDNN
HTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSV
KSKIPCVVVEGSGQIADVIASLVEVEDVLTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEI
LESPHLLTVIKMEEAGDEVVSSAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFT
NDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIA
KNSYNDALLTFVWKLVANFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFIWAILQNKKEL
SKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLA
EQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPL
VGCGLVSFRKKPIDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPE
LILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIF
CLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRW
RWIFRSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMV
VKKCFKCCCKEKNTESSACCFRNEDNETLAWEGVMKENYLVKINTKANDNAEEMRHRFRQLDTK
LNDLKGLLKEIANKIK

hide sequence

Ensembl Acc Id:

ENSRNOP00000025879 ⟸ ENSRNOT00000025879

RefSeq Acc Id:	XP_038938925 ⟸ XM_039082997
- Peptide Label:	isoform X1
- UniProtKB:	Q8R455 (UniProtKB/Swiss-Prot), A0ABK0LGB2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000102466 ⟸ ENSRNOT00000169836

Ensembl Acc Id:

ENSRNOP00000101005 ⟸ ENSRNOT00000159170

Protein Domains

Calcium channel YVC1-like C-terminal transmembrane TRPM SLOG TRPM-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R455-F1-model_v2	AlphaFold	Q8R455	1-1104	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620762	AgrOrtholog
BioCyc Gene	G2FUF-26803	BioCyc
Ensembl Genes	ENSRNOG00000019035	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055010822	UniProtKB/Swiss-Prot
	ENSRNOG00060010558	UniProtKB/Swiss-Prot
	ENSRNOG00065021562	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025879	ENTREZGENE
	ENSRNOT00000025879.6	UniProtKB/Swiss-Prot
	ENSRNOT00055018309	UniProtKB/Swiss-Prot
	ENSRNOT00060017862	UniProtKB/Swiss-Prot
	ENSRNOT00065036644	UniProtKB/Swiss-Prot
InterPro	TRPM	UniProtKB/Swiss-Prot
	TRPM-like	UniProtKB/Swiss-Prot
	TRPM_SLOG	UniProtKB/Swiss-Prot
	YVC1_C	UniProtKB/Swiss-Prot
KEGG Report	rno:171384	UniProtKB/Swiss-Prot
NCBI Gene	171384	ENTREZGENE
PANTHER	PTHR13800:SF9	UniProtKB/Swiss-Prot
	TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6	UniProtKB/Swiss-Prot
Pfam	LSDAT_euk	UniProtKB/Swiss-Prot
	TRPM2	UniProtKB/Swiss-Prot
	YVC1_C	UniProtKB/Swiss-Prot
PhenoGen	Trpm8	PhenoGen
RatGTEx	ENSRNOG00000019035	RatGTEx
	ENSRNOG00055010822	RatGTEx
	ENSRNOG00060010558	RatGTEx
	ENSRNOG00065021562	RatGTEx
UniProt	A0ABK0LD04_RAT	UniProtKB/TrEMBL
	A0ABK0LGB2	ENTREZGENE, UniProtKB/TrEMBL
	Q8R455	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Trpm8	transient receptor potential cation channel, subfamily M, member 8	CMR1	cold/menthol receptor 1	Symbol and Name updated	1299863	APPROVED
2002-08-07	CMR1	cold/menthol receptor 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in trigeminal sensory neurons	632416

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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