Trpm8 (transient receptor potential cation channel, subfamily M, member 8) - Rat Genome Database

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Gene: Trpm8 (transient receptor potential cation channel, subfamily M, member 8) Rattus norvegicus
Analyze
Symbol: Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
RGD ID: 620762
Description: Enables monoatomic ion channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including intracellular calcium ion homeostasis; response to cold; and thermoception. Predicted to be located in external side of plasma membrane. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8); INTERACTS WITH ammonium chloride; bisphenol A; Bromoenol lactone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CMR1; cold menthol receptor 1; cold/menthol receptor 1; transient receptor potential cation channel subfamily M member 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,897,039 - 88,990,167 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,903,880 - 88,988,552 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx997,328,476 - 97,413,096 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,464,664 - 102,549,168 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,832,088 - 100,916,734 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,393,370 - 95,484,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,398,237 - 95,482,890 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0995,085,454 - 95,170,108 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,193,779 - 87,278,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1987,380,876 - 87,465,529 (+)NCBI
Celera986,465,338 - 86,549,713 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. Ma S, etal., J Mol Cell Biol. 2012 Apr;4(2):88-96. doi: 10.1093/jmcb/mjs001. Epub 2012 Jan 11.
3. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. McKemy DD, etal., Nature 2002 Mar 7;416(6876):52-8.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Direct inhibition of the cold-activated TRPM8 ion channel by Gaq. Zhang X, etal., Nat Cell Biol. 2012 Aug;14(8):851-8. doi: 10.1038/ncb2529. Epub 2012 Jul 1.
Additional References at PubMed
PMID:11893340   PMID:12634279   PMID:12654248   PMID:15194687   PMID:15893591   PMID:16304633   PMID:16595689   PMID:16675144   PMID:16831854   PMID:16846855   PMID:16920620   PMID:17015441  
PMID:17317754   PMID:17481391   PMID:17481392   PMID:17517374   PMID:17538622   PMID:17548815   PMID:17712480   PMID:17908685   PMID:17932142   PMID:18077679   PMID:18534015   PMID:18562636  
PMID:19158342   PMID:19363131   PMID:19371346   PMID:19622375   PMID:19812688   PMID:20110357   PMID:20214891   PMID:20844147   PMID:20934218   PMID:21150802   PMID:21598682   PMID:21684817  
PMID:21906810   PMID:21947852   PMID:22111979   PMID:22571355   PMID:23001687   PMID:23092296   PMID:23132652   PMID:23293814   PMID:24269608   PMID:24358160   PMID:24472724   PMID:25157108  
PMID:25352597   PMID:25539933   PMID:25559186   PMID:25843641   PMID:25944818   PMID:25978347   PMID:26014706   PMID:27051022   PMID:27236325   PMID:27329106   PMID:27712653   PMID:28038937  
PMID:28138709   PMID:28626113   PMID:28867384   PMID:29054683   PMID:30046815   PMID:30488220   PMID:30567389   PMID:30942489   PMID:31002158   PMID:31310758   PMID:31340190   PMID:31703254  
PMID:32277850   PMID:32391653   PMID:32929340   PMID:33037615   PMID:35489198   PMID:37542841  


Genomics

Comparative Map Data
Trpm8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2988,897,039 - 88,990,167 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,903,880 - 88,988,552 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx997,328,476 - 97,413,096 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,464,664 - 102,549,168 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,832,088 - 100,916,734 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,393,370 - 95,484,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,398,237 - 95,482,890 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0995,085,454 - 95,170,108 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,193,779 - 87,278,440 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1987,380,876 - 87,465,529 (+)NCBI
Celera986,465,338 - 86,549,713 (+)NCBICelera
Cytogenetic Map9q35NCBI
TRPM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,917,373 - 234,019,522 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,917,373 - 234,019,522 (+)EnsemblGRCh38hg38GRCh38
GRCh372234,826,018 - 234,928,166 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,490,782 - 234,592,905 (+)NCBINCBI36Build 36hg18NCBI36
Build 342234,608,042 - 234,710,165NCBI
Celera2228,546,409 - 228,648,542 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,625,779 - 226,727,969 (+)NCBIHuRef
CHM1_12234,831,850 - 234,933,975 (+)NCBICHM1_1
T2T-CHM13v2.02234,406,317 - 234,508,483 (+)NCBIT2T-CHM13v2.0
Trpm8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,234,457 - 88,318,909 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl188,205,383 - 88,317,015 (+)EnsemblGRCm39 Ensembl
GRCm38188,306,735 - 88,388,853 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,277,661 - 88,389,293 (+)EnsemblGRCm38mm10GRCm38
MGSCv37190,203,287 - 90,285,426 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36190,134,453 - 90,220,022 (+)NCBIMGSCv36mm8
Celera191,265,235 - 91,346,306 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map144.57NCBI
Trpm8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554532,185,534 - 2,265,261 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554532,185,534 - 2,265,261 (-)NCBIChiLan1.0ChiLan1.0
TRPM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B136,580,802 - 136,674,757 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B121,160,045 - 121,261,645 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B240,029,984 - 240,130,524 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B240,039,104 - 240,130,524 (+)Ensemblpanpan1.1panPan2
TRPM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12545,261,092 - 45,357,560 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2545,261,107 - 45,353,282 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2545,758,997 - 45,851,175 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02545,600,006 - 45,703,702 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2545,609,098 - 45,700,909 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12545,501,675 - 45,593,531 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02545,310,182 - 45,402,042 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02545,538,477 - 45,630,602 (+)NCBIUU_Cfam_GSD_1.0
Trpm8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303187,447,832 - 187,530,684 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365253,413,747 - 3,491,815 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365253,413,730 - 3,491,815 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15134,145,943 - 134,267,970 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115134,185,316 - 134,267,973 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215148,620,717 - 148,702,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRPM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110119,944,875 - 120,045,295 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10119,954,947 - 120,042,296 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604079,436,945 - 79,536,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpm8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624847194,497 - 320,600 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624847180,040 - 320,494 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trpm8
727 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:341
Count of miRNA genes:186
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000025879
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 2 1 1 41 18 28
Below cutoff 2 34 17 5 17 5 3 3 33 15 10 11 3

Sequence


RefSeq Acc Id: ENSRNOT00000025879   ⟹   ENSRNOP00000025879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,903,880 - 88,988,552 (+)Ensembl
Rnor_6.0 Ensembl995,398,237 - 95,482,890 (+)Ensembl
RefSeq Acc Id: NM_134371   ⟹   NP_599198
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2988,903,882 - 88,988,562 (+)NCBI
Rnor_6.0995,398,239 - 95,482,900 (+)NCBI
Rnor_5.0995,085,454 - 95,170,108 (+)NCBI
RGSC_v3.4987,193,779 - 87,278,440 (+)RGD
Celera986,465,338 - 86,549,713 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082997   ⟹   XP_038938925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2988,897,039 - 88,990,167 (+)NCBI
RefSeq Acc Id: XM_039082998   ⟹   XP_038938926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2988,897,039 - 88,990,167 (+)NCBI
RefSeq Acc Id: NP_599198   ⟸   NM_134371
- UniProtKB: Q8R455 (UniProtKB/Swiss-Prot),   A6JQJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025879   ⟸   ENSRNOT00000025879
RefSeq Acc Id: XP_038938926   ⟸   XM_039082998
- Peptide Label: isoform X1
- UniProtKB: Q8R455 (UniProtKB/Swiss-Prot),   A6JQJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938925   ⟸   XM_039082997
- Peptide Label: isoform X1
- UniProtKB: Q8R455 (UniProtKB/Swiss-Prot),   A6JQJ1 (UniProtKB/TrEMBL)
Protein Domains
Ion transport   TRPM SLOG

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R455-F1-model_v2 AlphaFold Q8R455 1-1104 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620762 AgrOrtholog
BioCyc Gene G2FUF-26803 BioCyc
Ensembl Genes ENSRNOG00000019035 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010822 UniProtKB/Swiss-Prot
  ENSRNOG00060010558 UniProtKB/Swiss-Prot
  ENSRNOG00065021562 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025879 ENTREZGENE
  ENSRNOT00000025879.5 UniProtKB/Swiss-Prot
  ENSRNOT00055018309 UniProtKB/Swiss-Prot
  ENSRNOT00060017862 UniProtKB/Swiss-Prot
  ENSRNOT00065036644 UniProtKB/Swiss-Prot
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPM_SLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171384 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171384 ENTREZGENE
PANTHER PTHR13800:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LSDAT_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpm8 PhenoGen
RatGTEx ENSRNOG00000019035 RatGTEx
  ENSRNOG00055010822 RatGTEx
  ENSRNOG00060010558 RatGTEx
  ENSRNOG00065021562 RatGTEx
UniProt A6JQJ1 ENTREZGENE, UniProtKB/TrEMBL
  Q8R455 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Trpm8  transient receptor potential cation channel, subfamily M, member 8  CMR1  cold/menthol receptor 1  Symbol and Name updated 1299863 APPROVED
2002-08-07 CMR1  cold/menthol receptor 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in trigeminal sensory neurons 632416