Gene: Trpm2 (transient receptor potential cation channel, subfamily M, member 2) Rattus norvegicus
Analyze
Symbol:
Trpm2
Name:
transient receptor potential cation channel, subfamily M, member 2
Description:
Predicted to have calcium ion binding activity; metal ion transmembrane transporter activity; and mono-ADP-D-ribose binding activity. Involved in several processes, including calcium ion import across plasma membrane; estrous cycle; and positive regulation of insulin secretion. Localizes to neuron projection; neuronal cell body; and plasma membrane. Biomarker of transient cerebral ischemia. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC294329; transient receptor potential cation channel subfamily M member 2; transient receptor potential melastatin family 2; Trpm2-predicted
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TRPM2 (transient receptor potential cation channel subfamily M member 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Trpm2 (transient receptor potential cation channel, subfamily M, member 2) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Trpm2 (transient receptor potential cation channel subfamily M member 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TRPM2 (transient receptor potential cation channel subfamily M member 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
LOC100855763 (transient receptor potential cation channel subfamily M member 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Trpm2 (transient receptor potential cation channel subfamily M member 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TRPM2 (transient receptor potential cation channel subfamily M member 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
TRPM2 (transient receptor potential cation channel subfamily M member 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Trpm2 (transient receptor potential cation channel subfamily M member 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TRPM8 (transient receptor potential cation channel subfamily M member 8) HGNC
OrthoMCL
Homo sapiens (human):
TRPM4 (transient receptor potential cation channel subfamily M member 4) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
TRPM2 (transient receptor potential cation channel subfamily M member 2)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Trpm2 (transient receptor potential cation channel, subfamily M, member 2)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
trpm2 (transient receptor potential cation channel, subfamily M, member 2)
Alliance
DIOPT (PANTHER|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
gtl-2
Alliance
DIOPT (OMA|TreeFam|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 11,434,062 - 11,482,880 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 11,436,267 - 11,482,051 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 20 13,604,119 - 13,652,782 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 11,053,301 - 11,099,740 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 11,053,527 - 11,099,966 (+) NCBI Celera 20 12,212,844 - 12,258,113 (+) NCBI Celera Cytogenetic Map 20 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
autistic disorder ISO RGD:1323582 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 autoimmune polyendocrine syndrome type 1 ISO RGD:1323582 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:28492532 Neurodevelopmental Disorders ISO RGD:1323582 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868
Imported Annotations - CTD
bipolar disorder ISO RGD:1323582 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23602965 Parkinson's disease ISO RGD:1323582 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27957685
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO RGD:1558477 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:27957685 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of TRPM2 mRNA CTD PMID:30723492 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:1558477 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TRPM2 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TRPM2 mRNA CTD PMID:21724226 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:21724226 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of TRPM2 mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNA CTD PMID:16158176 5-aza-2'-deoxycytidine decreases expression ISO RGD:1323582 6480464 Decitabine results in decreased expression of TRPM2 mRNA CTD PMID:19194470 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of TRPM2 mRNA CTD PMID:24780913 acetamide increases expression EXP 6480464 acetamide results in increased expression of TRPM2 mRNA CTD PMID:31881176 ADP-D-ribose multiple interactions ISO RGD:1323582 6480464 2-aminoethoxydiphenyl borate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] more ... CTD PMID:18204483 , PMID:22750002 ADP-D-ribose increases activity ISO RGD:1323582 6480464 Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein CTD PMID:18204483 , PMID:22750002 ADP-D-ribose multiple interactions ISO RGD:1558477 6480464 TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium] CTD PMID:20878536 ADP-D-ribose multiple interactions EXP 6480464 Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium] more ... CTD PMID:21900507 arsane affects methylation ISO RGD:1323582 6480464 Arsenic affects the methylation of TRPM2 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1323582 6480464 Arsenic affects the methylation of TRPM2 gene CTD PMID:25304211 bis(2-chloroethyl) sulfide affects response to substance ISO RGD:1323582 6480464 TRPM2 protein affects the susceptibility to Mustard Gas CTD PMID:22036725 bis(2-chloroethyl) sulfide multiple interactions ISO RGD:1323582 6480464 [Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium] more ... CTD PMID:22036725 bleomycin A2 multiple interactions ISO RGD:1558477 6480464 TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of CXCL1 protein] more ... CTD PMID:26600069 calcium atom multiple interactions EXP 6480464 Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium] more ... CTD PMID:21900507 calcium atom multiple interactions ISO RGD:1558477 6480464 TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium], TRPM2 protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium] CTD PMID:20878536 calcium atom multiple interactions ISO RGD:1323582 6480464 [Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium] more ... CTD PMID:22036725 calcium atom increases transport ISO RGD:1323582 6480464 TRPM2 protein results in increased transport of Calcium CTD PMID:12529379 calcium atom increases transport EXP 6480464 TRPM2 protein results in increased transport of Calcium CTD PMID:21900507 calcium(0) multiple interactions EXP 6480464 Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium] more ... CTD PMID:21900507 calcium(0) multiple interactions ISO RGD:1558477 6480464 TRPM2 protein promotes the reaction [Adenosine Diphosphate Ribose results in increased uptake of Calcium], TRPM2 protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium] CTD PMID:20878536 calcium(0) multiple interactions ISO RGD:1323582 6480464 [Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium] more ... CTD PMID:22036725 calcium(0) increases transport ISO RGD:1323582 6480464 TRPM2 protein results in increased transport of Calcium CTD PMID:12529379 calcium(0) increases transport EXP 6480464 TRPM2 protein results in increased transport of Calcium CTD PMID:21900507 clotrimazole multiple interactions EXP 6480464 Clotrimazole inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]] CTD PMID:21900507 clotrimazole multiple interactions ISO RGD:1323582 6480464 [Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium] CTD PMID:22036725 copper(II) sulfate multiple interactions ISO RGD:1323582 6480464 Copper Sulfate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] CTD PMID:22750002 econazole multiple interactions ISO RGD:1323582 6480464 [Econazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium] CTD PMID:22036725 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of TRPM2 mRNA CTD PMID:29391264 ethanol affects expression ISO RGD:1558477 6480464 Ethanol affects the expression of TRPM2 mRNA CTD PMID:30319688 flufenamic acid multiple interactions EXP 6480464 Flufenamic Acid inhibits the reaction [Adenosine Diphosphate Ribose promotes the reaction [TRPM2 protein results in increased transport of Calcium]] CTD PMID:21900507 hydrogen peroxide multiple interactions EXP 6480464 Calcium affects the reaction [Hydrogen Peroxide promotes the reaction [TRPM2 protein results in increased transport of Calcium]], Hydrogen Peroxide promotes the reaction [TRPM2 protein results in increased transport of Calcium] CTD PMID:21900507 hydrogen peroxide increases activity ISO RGD:1323582 6480464 Hydrogen Peroxide results in increased activity of TRPM2 protein CTD PMID:29658714 , PMID:30229906 hydrogen peroxide increases response to substance ISO RGD:1323582 6480464 TRPM2 protein results in increased susceptibility to Hydrogen Peroxide CTD PMID:29658714 , PMID:30625984 hydrogen peroxide multiple interactions ISO RGD:1558477 6480464 TRPM2 protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium] CTD PMID:20878536 iron dichloride multiple interactions ISO RGD:1323582 6480464 ferrous chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] CTD PMID:22750002 lead nitrate multiple interactions ISO RGD:1323582 6480464 lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] CTD PMID:22750002 lithium atom multiple interactions ISO RGD:1323582 6480464 Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form] CTD PMID:20799912 lithium hydride multiple interactions ISO RGD:1323582 6480464 Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form] CTD PMID:20799912 mercury dichloride multiple interactions ISO RGD:1323582 6480464 Mercuric Chloride inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] CTD PMID:22750002 miconazole multiple interactions ISO RGD:1323582 6480464 Miconazole inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] CTD PMID:18204483 monensin A decreases expression ISO RGD:1323582 6480464 Monensin results in decreased expression of TRPM2 protein alternative form CTD PMID:20799912 monensin A increases expression ISO RGD:1323582 6480464 Monensin results in increased expression of TRPM2 protein alternative form CTD PMID:20799912 monensin A multiple interactions ISO RGD:1323582 6480464 Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form] CTD PMID:20799912 N-(p-amylcinnamoyl)anthranilic acid multiple interactions ISO RGD:1323582 6480464 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein] CTD PMID:18204483 N-(p-amylcinnamoyl)anthranilic acid decreases activity ISO RGD:1323582 6480464 4-amylcinnamoylanthranilic acid results in decreased activity of TRPM2 protein CTD PMID:30229906 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1323582 6480464 TRPM2 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] more ... CTD PMID:27957685 N-methyl-4-phenylpyridinium increases expression ISO RGD:1323582 6480464 1-Methyl-4-phenylpyridinium results in increased expression of TRPM2 protein CTD PMID:27957685 N-nitrosodiethylamine multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNA CTD PMID:16158176 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of TRPM2 mRNA CTD PMID:23665939 pirinixic acid decreases expression ISO RGD:1558477 6480464 pirinixic acid results in decreased expression of TRPM2 mRNA CTD PMID:20813756 rotenone increases expression EXP 6480464 Rotenone results in increased expression of TRPM2 mRNA CTD PMID:23602965 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of TRPM2 mRNA CTD PMID:28374803 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of TRPM2 mRNA CTD PMID:31150632 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of TRPM2 mRNA CTD PMID:23411599 valproic acid increases methylation ISO RGD:1323582 6480464 Valproic Acid results in increased methylation of TRPM2 gene CTD PMID:29154799
Biological Process calcium ion import across plasma membrane IMP 9999433 RGD calcium ion import across plasma membrane ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calcium ion import across plasma membrane ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 calcium ion transmembrane import into cytosol ISO RGD:1323582 1624291 (PMID:19171771), (PMID:27068538) RGD PMID:19171771 , PMID:27068538 calcium ion transmembrane import into cytosol ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calcium ion transmembrane transport ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calcium ion transmembrane transport ISO RGD:1323582 1624291 (PMID:25620041), (PMID:27333281), (PMID:28775320), (PMID:29745897), (PMID:30467180) RGD PMID:25620041 more ... calcium-mediated signaling using intracellular calcium source ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 calcium-mediated signaling using intracellular calcium source ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to calcium ion ISO RGD:1323582 1624291 (PMID:19171771) RGD PMID:19171771 cellular response to calcium ion ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to hydrogen peroxide ISO RGD:1323582 1624291 (PMID:27068538) RGD PMID:27068538 cellular response to hydrogen peroxide ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to purine-containing compound ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 cellular response to purine-containing compound ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to temperature stimulus ISO RGD:1558477 1624291 (MGI:MGI:5795853, PMID:27562954) RGD MGI:MGI:5795853 , PMID:27562954 cellular response to temperature stimulus ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 dendritic cell chemotaxis ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 dendritic cell chemotaxis ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 dendritic cell differentiation ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 dendritic cell differentiation ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 estrous cycle IEP 9999435 RGD manganese ion transmembrane transport IEA GO:0005384 1600115 GO_REF:0000108 GOC GO_REF:0000108 manganese ion transport ISO RGD:1558477 1624291 (MGI:MGI:3798684, PMID:11804595) RGD MGI:MGI:3798684 , PMID:11804595 positive regulation of insulin secretion IMP 9999436 RGD positive regulation of oxidative stress-induced neuron death IDA 9999433 RGD protein homotetramerization ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein homotetramerization ISO RGD:1323582 1624291 (PMID:30467180) RGD PMID:30467180 regulation of actin cytoskeleton reorganization ISO RGD:1323582 1624291 (PMID:27068538) RGD PMID:27068538 regulation of actin cytoskeleton reorganization ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of filopodium assembly ISO RGD:1323582 1624291 (PMID:27068538) RGD PMID:27068538 regulation of filopodium assembly ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 release of sequestered calcium ion into cytosol ISO RGD:1323582 1624291 (PMID:27068538) RGD PMID:27068538 release of sequestered calcium ion into cytosol ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 release of sequestered calcium ion into cytosol ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 response to heat ISO RGD:1558477 1624291 (MGI:MGI:5795853, PMID:27562954) RGD MGI:MGI:5795853 , PMID:27562954 response to hydroperoxide ISO RGD:1558477 1624291 (MGI:MGI:3798684, PMID:11804595) RGD MGI:MGI:3798684 , PMID:11804595 response to purine-containing compound ISO RGD:1323582 1624291 (PMID:19171771) RGD PMID:19171771 sodium ion transmembrane transport IEA GO:0005272 1600115 GO_REF:0000108 GOC GO_REF:0000108 temperature homeostasis ISO RGD:1558477 1624291 (MGI:MGI:5795853, PMID:27562954) RGD MGI:MGI:5795853 , PMID:27562954 temperature homeostasis ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 zinc ion transmembrane transport ISO RGD:1323582 1624291 (PMID:27068538) RGD PMID:27068538 zinc ion transmembrane transport ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Cellular Component cytoplasmic vesicle membrane ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 cytoplasmic vesicle membrane ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 integral component of plasma membrane ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 integral component of plasma membrane ISO RGD:1323582 1624291 (PMID:19171771), (PMID:30467180) RGD PMID:19171771 , PMID:30467180 integral component of plasma membrane ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 integral component of plasma membrane ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 lysosomal membrane ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 lysosomal membrane ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 lysosome ISO RGD:1323582 1624291 (PMID:27068538) RGD PMID:27068538 neuron projection IDA 9999433 RGD neuronal cell body IDA 9999433 RGD perikaryon IEA UniProtKB-SubCell:SL-0197 1600115 GO_REF:0000044 UniProt GO_REF:0000044 plasma membrane ISO RGD:1558477 1624291 (MGI:MGI:3798684, PMID:11804595) RGD MGI:MGI:3798684 , PMID:11804595 plasma membrane ISO RGD:1323582 1624291 (PMID:27333281) RGD PMID:27333281 plasma membrane IDA 9999433 RGD Molecular Function ADP-ribose diphosphatase activity NOT ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ADP-ribose diphosphatase activity NOT ISO RGD:1323582 1624291 (PMID:30467180) RGD PMID:30467180 calcium ion binding ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calcium ion binding ISO RGD:1323582 1624291 (PMID:19171771), (PMID:30467180) RGD PMID:19171771 , PMID:30467180 calcium-release channel activity ISO RGD:1323582 1624291 (PMID:27068538) RGD PMID:27068538 calcium-release channel activity ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cation channel activity ISO RGD:1323582 1624291 (PMID:27068538) RGD PMID:27068538 cation channel activity ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 hydrolase activity NOT ISO RGD:1323582 1624291 (PMID:27383051) RGD PMID:27383051 hydrolase activity NOT ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ligand-gated calcium channel activity ISO RGD:1558477 1624291 (MGI:MGI:5298324, PMID:21753080) RGD MGI:MGI:5298324 , PMID:21753080 ligand-gated calcium channel activity ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ligand-gated calcium channel activity ISS UniProtKB:Q91YD4 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ligand-gated calcium channel activity ISO RGD:1323582 1624291 (PMID:19171771), (PMID:25620041), (PMID:27333281), (PMID:28775320), (PMID:29745897), (PMID:30467180) RGD PMID:19171771 more ... manganese ion transmembrane transporter activity ISO RGD:1558477 1624291 (MGI:MGI:3798684, PMID:11804595) RGD MGI:MGI:3798684 , PMID:11804595 molecular_function ND 1598407 04/2015: no relevant rat data RGD mono-ADP-D-ribose binding ISS UniProtKB:O94759 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mono-ADP-D-ribose binding ISO RGD:1323582 1624291 (PMID:30467180) RGD PMID:30467180 sodium channel activity IEA UniProtKB-KW:KW-0894 1600115 GO_REF:0000043 UniProt GO_REF:0000043
Gene-Chemical Interaction Annotations
