TRPM8 (transient receptor potential cation channel subfamily M member 8) - Rat Genome Database

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Pathways
Gene: TRPM8 (transient receptor potential cation channel subfamily M member 8) Chlorocebus sabaeus
Analyze
Symbol: TRPM8
Name: transient receptor potential cation channel subfamily M member 8
RGD ID: 18599602
Description: ENCODES a protein that exhibits monoatomic ion channel activity (ortholog); INVOLVED IN calcium ion transport (ortholog); intracellular calcium ion homeostasis (ortholog); response to cold (ortholog); ASSOCIATED WITH asthma (ortholog); cervical cancer (ortholog); cholangiocarcinoma (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); plasma membrane raft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap110121,459,070 - 121,561,154 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366604079,436,945 - 79,536,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.110119,944,875 - 120,045,295 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10119,954,947 - 120,042,296 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
JBrowse:




References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TRPM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap110121,459,070 - 121,561,154 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366604079,436,945 - 79,536,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.110119,944,875 - 120,045,295 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10119,954,947 - 120,042,296 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
TRPM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,917,373 - 234,019,522 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,917,373 - 234,019,522 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh372234,826,018 - 234,928,166 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,490,782 - 234,592,905 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342234,608,042 - 234,710,165NCBI
Celera2228,546,409 - 228,648,542 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,625,779 - 226,727,969 (+)NCBIHuRef
CHM1_12234,831,850 - 234,933,975 (+)NCBICHM1_1
T2T-CHM13v2.02234,406,317 - 234,508,483 (+)NCBIT2T-CHM13v2.0
Trpm8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,234,457 - 88,318,909 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl188,205,383 - 88,317,015 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38188,306,735 - 88,388,853 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,277,661 - 88,389,293 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37190,203,287 - 90,285,426 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36190,134,453 - 90,220,022 (+)NCBIMGSCv36mm8
Celera191,265,235 - 91,346,306 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map144.57NCBI
Trpm8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,315,567 - 96,437,959 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl996,351,681 - 96,436,617 (+)EnsemblGRCr8
mRatBN7.2988,897,039 - 88,990,167 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,903,880 - 88,988,552 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx997,328,476 - 97,413,096 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,464,664 - 102,549,168 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,832,088 - 100,916,734 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd999,973,316 - 100,061,793 (+)NCBI
Lyon_Normotensive995,823,215 - 95,911,694 (+)NCBI
Lyon_Hypertensive995,947,425 - 96,035,894 (+)NCBI
F344_StmMcwi997,937,898 - 98,026,371 (+)NCBI
Rnor_6.0995,393,370 - 95,484,528 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,398,237 - 95,482,890 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0995,085,454 - 95,170,108 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4987,193,779 - 87,278,440 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera986,465,338 - 86,549,713 (+)NCBICelera
RGSC_v3.1987,380,876 - 87,465,529 (+)NCBI
Cytogenetic Map9q35NCBI
Trpm8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554532,185,534 - 2,265,261 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554532,185,534 - 2,265,261 (-)NCBIChiLan1.0ChiLan1.0
TRPM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213136,565,837 - 136,659,793 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B136,580,802 - 136,674,757 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B121,160,045 - 121,261,645 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B240,029,984 - 240,130,524 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B240,039,104 - 240,130,524 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
TRPM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12545,261,092 - 45,357,560 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2545,261,107 - 45,353,282 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2545,758,997 - 45,851,175 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02545,600,006 - 45,703,702 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2545,609,098 - 45,700,909 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12545,501,675 - 45,593,531 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02545,310,182 - 45,402,042 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02545,538,477 - 45,630,602 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trpm8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap17193,057,268 - 193,131,677 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_024405303187,447,832 - 187,530,684 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365253,413,747 - 3,491,815 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365253,413,730 - 3,491,815 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15134,145,943 - 134,267,970 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.115134,185,316 - 134,267,973 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215148,620,717 - 148,702,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Trpm8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624847180,040 - 320,494 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_004624847194,497 - 320,600 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl2541,145,813 - 41,280,936 (+)Ensembl
Trpm8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14160,348,136 - 160,434,008 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in TRPM8
3145 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
60 20 17 17 17 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000004274   ⟹   ENSCSAP00000002535
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl10119,954,947 - 120,042,296 (+)Ensembl
RefSeq Acc Id: XM_007966721   ⟹   XP_007964912
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap110121,459,070 - 121,561,154 (+)NCBI
Vero_WHO_p1.0NW_02366604079,436,945 - 79,536,853 (-)NCBI
ChlSab1.110119,944,875 - 120,045,295 (+)NCBI
Sequence:
RefSeq Acc Id: XM_073020148   ⟹   XP_072876249
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap110121,474,172 - 121,484,208 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007964912 (Get FASTA)   NCBI Sequence Viewer  
  XP_072876249 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000002535.1
RefSeq Acc Id: XP_007964912   ⟸   XM_007966721
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R1P6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000002535   ⟸   ENSCSAT00000004274
RefSeq Acc Id: XP_072876249   ⟸   XM_073020148
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006269 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004274.1 UniProtKB/TrEMBL
InterPro TRPM UniProtKB/TrEMBL
  TRPM-like UniProtKB/TrEMBL
  TRPM_SLOG UniProtKB/TrEMBL
  YVC1_C UniProtKB/TrEMBL
NCBI Gene TRPM8 ENTREZGENE
PANTHER PTHR13800:SF9 UniProtKB/TrEMBL
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 UniProtKB/TrEMBL
Pfam LSDAT_euk UniProtKB/TrEMBL
  TRPM2 UniProtKB/TrEMBL
  YVC1_C UniProtKB/TrEMBL
UniProt A0A0D9R1P6 ENTREZGENE, UniProtKB/TrEMBL