Trpm4 (transient receptor potential cation channel, subfamily M, member 4) - Rat Genome Database

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Gene: Trpm4 (transient receptor potential cation channel, subfamily M, member 4) Rattus norvegicus
Analyze
Symbol: Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
RGD ID: 620244
Description: Enables calcium-activated cation channel activity. Involved in several processes, including long-term memory; negative regulation of osteoblast differentiation; and regulation of blood circulation. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and neuronal cell body. Biomarker of cardiac arrest. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium-activated non-selective cation channel 1; long transient receptor potential channel 4; LTrpC-4; LTrpC4; melastatin like 2 protein; melastatin-like 2; Mls2s; transient receptor potential cation channel subfamily M member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,918,462 - 104,949,453 (-)NCBIGRCr8
mRatBN7.2195,781,805 - 95,812,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,782,000 - 95,812,532 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,167,413 - 101,197,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,640,086 - 109,669,864 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,930,482 - 102,960,268 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,293,300 - 101,323,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,293,409 - 101,323,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,357,043 - 102,387,010 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,773,485 - 95,803,542 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,851,812 - 95,863,602 (-)NCBI
Celera190,039,848 - 90,063,911 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-phenanthrol  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
ATP  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clofibric acid  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloroacetic acid  (ISO)
Dichloroacetonitrile  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flufenamic acid  (EXP,ISO)
folic acid  (ISO)
furan  (EXP)
glyburide  (EXP,ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
niclosamide  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium atom  (EXP,ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium atom  (EXP,ISO)
streptozocin  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
calcium ion transmembrane transport  (IEA)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA,ISO)
cellular response to ATP  (IEA,ISO)
dendritic cell chemotaxis  (IEA,ISO,ISS)
inorganic cation transmembrane transport  (ISO,ISS)
long-term memory  (IMP)
membrane depolarization during AV node cell action potential  (IEA,ISO)
membrane depolarization during bundle of His cell action potential  (IEA,ISO)
membrane depolarization during Purkinje myocyte cell action potential  (IEA,ISO)
metal ion transport  (IBA)
monoatomic cation transmembrane transport  (IBA,IEA)
negative regulation of bone mineralization  (IMP)
negative regulation of osteoblast differentiation  (IMP)
positive regulation of adipose tissue development  (IMP)
positive regulation of atrial cardiac muscle cell action potential  (IMP)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of fat cell differentiation  (IMP)
positive regulation of heart rate  (IMP)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization  (IMP)
positive regulation of vasoconstriction  (IMP)
protein homotetramerization  (IEA,ISO,ISS)
protein sumoylation  (IEA,ISO,ISS)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of T cell cytokine production  (IEA,ISO,ISS)
regulation of ventricular cardiac muscle cell action potential  (IEA,ISO)
sodium ion import across plasma membrane  (IEA,ISO)

Cellular Component
endoplasmic reticulum  (IDA,IEA,ISO)
Golgi apparatus  (IDA,IEA,ISO)
membrane  (IEA,ISO)
neuronal cell body  (IDA)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO,ISS)
sodium channel complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Disentangling the role of TRPM4 in hippocampus-dependent plasticity and learning: an electrophysiological, behavioral and FMRI approach. Bovet-Carmona M, etal., Brain Struct Funct. 2018 Nov;223(8):3557-3576. doi: 10.1007/s00429-018-1706-1. Epub 2018 Jul 3.
2. TRPM4 controls insulin secretion in pancreatic beta-cells. Cheng H, etal., Cell Calcium. 2007 Jan;41(1):51-61. Epub 2006 Jun 27.
3. Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells. Crnich R, etal., Am J Physiol Cell Physiol. 2010 Sep;299(3):C682-94. doi: 10.1152/ajpcell.00101.2010. Epub 2010 Jul 7.
4. Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Earley S, etal., Circ Res. 2004 Oct 29;95(9):922-9. Epub 2004 Oct 7.
5. Basal protein kinase Cdelta activity is required for membrane localization and activity of TRPM4 channels in cerebral artery smooth muscle cells. Garcia ZI, etal., Channels (Austin). 2011 May-Jun;5(3):210-4. Epub 2011 May 1.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Gerzanich V, etal., Nat Med. 2009 Feb;15(2):185-91. doi: 10.1038/nm.1899. Epub 2009 Jan 25.
8. Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle. Gonzales AL, etal., Am J Physiol Cell Physiol. 2010 Nov;299(5):C1195-202. doi: 10.1152/ajpcell.00269.2010. Epub 2010 Sep 8.
9. Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats. Guinamard R, etal., Hypertension. 2006 Oct;48(4):587-94. Epub 2006 Sep 11.
10. Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm. Hof T, etal., Heart Rhythm. 2013 Nov;10(11):1683-9. doi: 10.1016/j.hrthm.2013.08.014. Epub 2013 Aug 14.
11. Glibenclamide Improves Survival and Neurologic Outcome After Cardiac Arrest in Rats. Huang K, etal., Crit Care Med. 2015 Sep;43(9):e341-9. doi: 10.1097/CCM.0000000000001093.
12. 17ß-estradiol inhibits MMP-9 and SUR1/TrpM4 expression and activation and thereby attenuates BSCB disruption/hemorrhage after spinal cord injury in male rats. Lee JY, etal., Endocrinology. 2015 May;156(5):1838-50. doi: 10.1210/en.2014-1832. Epub 2015 Mar 12.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Identification and characterization of the murine TRPM4 channel. Murakami M, etal., Biochem Biophys Res Commun 2003 Aug 1;307(3):522-8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Transient receptor potential melastatin 4 channel controls calcium signals and dental follicle stem cell differentiation. Nelson P, etal., Stem Cells. 2013 Jan;31(1):167-77. doi: 10.1002/stem.1264.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Information Derived from GenBank Report RGD, Sept. 2003
22. Transient receptor potential channel m4 and m5 in magnocellular cells in rat supraoptic and paraventricular nuclei. Teruyama R, etal., J Neuroendocrinol. 2011 Dec;23(12):1204-13. doi: 10.1111/j.1365-2826.2011.02211.x.
23. Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage. Tosun C, etal., Stroke. 2013 Dec;44(12):3522-8. doi: 10.1161/STROKEAHA.113.002904. Epub 2013 Oct 10.
24. Cloning and characterization of rat transient receptor potential-melastatin 4 (TRPM4). Yoo JC, etal., Biochem Biophys Res Commun. 2010 Jan 1;391(1):806-11. doi: 10.1016/j.bbrc.2009.11.142. Epub 2009 Nov 27.
Additional References at PubMed
PMID:15030426   PMID:15057822   PMID:17188667   PMID:17293488   PMID:17585083   PMID:17712480   PMID:18758465   PMID:19063936   PMID:19726882   PMID:20427713   PMID:20625999   PMID:20656926  
PMID:22153976   PMID:23255597   PMID:23283997   PMID:24391909   PMID:25099756   PMID:25261791   PMID:25378404   PMID:25836769   PMID:26172285   PMID:27207958   PMID:28758259   PMID:29211714  
PMID:29211723   PMID:29217581   PMID:29390943   PMID:29435486   PMID:29569041   PMID:30553915   PMID:31022885   PMID:31664513   PMID:32147520   PMID:32619565   PMID:34144257   PMID:35099165  
PMID:35163382   PMID:37404129  


Genomics

Comparative Map Data
Trpm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,918,462 - 104,949,453 (-)NCBIGRCr8
mRatBN7.2195,781,805 - 95,812,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,782,000 - 95,812,532 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,167,413 - 101,197,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,640,086 - 109,669,864 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,930,482 - 102,960,268 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,293,300 - 101,323,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,293,409 - 101,323,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,357,043 - 102,387,010 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,773,485 - 95,803,542 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,851,812 - 95,863,602 (-)NCBI
Celera190,039,848 - 90,063,911 (-)NCBICelera
Cytogenetic Map1q22NCBI
TRPM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,157,792 - 49,211,836 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,157,741 - 49,211,836 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,661,049 - 49,715,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,352,864 - 54,406,905 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,352,863 - 54,406,903NCBI
Celera1946,527,963 - 46,581,978 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,037,071 - 46,092,109 (+)NCBIHuRef
CHM1_11949,662,673 - 49,716,555 (+)NCBICHM1_1
T2T-CHM13v2.01952,152,347 - 52,209,191 (+)NCBIT2T-CHM13v2.0
Trpm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,952,579 - 44,983,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,952,056 - 44,983,204 (-)EnsemblGRCm39 Ensembl
GRCm38745,303,155 - 45,334,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,302,632 - 45,333,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,558,525 - 52,589,150 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,170,674 - 45,201,784 (-)NCBIMGSCv36mm8
Celera740,759,067 - 40,790,038 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.24NCBI
Trpm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,546,365 - 1,581,712 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,539,036 - 1,581,800 (-)NCBIChiLan1.0ChiLan1.0
TRPM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,272,183 - 55,328,155 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,191,713 - 57,248,153 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,168,301 - 46,224,726 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,095,029 - 55,150,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,095,029 - 55,150,464 (+)Ensemblpanpan1.1panPan2
TRPM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,261,760 - 107,304,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,261,756 - 107,303,346 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,849,462 - 106,891,183 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,786,342 - 107,828,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,678,345 - 107,828,249 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,454,730 - 107,496,450 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,100,989 - 107,142,706 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,938,110 - 107,978,274 (-)NCBIUU_Cfam_GSD_1.0
Trpm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,474,889 - 21,506,283 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,093,367 - 3,124,117 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,093,258 - 3,124,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,342,784 - 54,377,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,342,774 - 54,377,557 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,975,735 - 49,985,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,379,534 - 42,424,721 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,379,659 - 42,424,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,272,664 - 22,341,345 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,902,659 - 4,936,926 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,902,335 - 4,937,806 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trpm4
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:463
Count of miRNA genes:232
Interacting mature miRNAs:276
Transcripts:ENSRNOT00000041513
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat

Markers in Region
RH133941  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,803,951 - 95,804,147 (+)MAPPERmRatBN7.2
Rnor_6.01101,315,365 - 101,315,560NCBIRnor6.0
Rnor_5.01102,378,888 - 102,379,083UniSTSRnor5.0
RGSC_v3.4195,795,720 - 95,795,915UniSTSRGSC3.4
Celera190,061,722 - 90,061,917UniSTS
RH 3.4 Map1910.1UniSTS
Cytogenetic Map1q22UniSTS
AI234615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,782,252 - 95,782,461 (+)MAPPERmRatBN7.2
Rnor_6.01101,293,553 - 101,293,761NCBIRnor6.0
Rnor_5.01102,357,296 - 102,357,504UniSTSRnor5.0
RGSC_v3.4195,773,738 - 95,773,946UniSTSRGSC3.4
Celera190,040,101 - 90,040,309UniSTS
RH 3.4 Map1908.89UniSTS
Cytogenetic Map1q22UniSTS
Trpm4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,782,428 - 95,782,510 (+)MAPPERmRatBN7.2
Rnor_6.01101,293,729 - 101,293,810NCBIRnor6.0
Rnor_5.01102,357,472 - 102,357,553UniSTSRnor5.0
Celera190,040,277 - 90,040,358UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000041513   ⟹   ENSRNOP00000041387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,782,000 - 95,812,532 (-)Ensembl
Rnor_6.0 Ensembl1101,293,409 - 101,323,960 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099429   ⟹   ENSRNOP00000082333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,782,211 - 95,812,532 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100339   ⟹   ENSRNOP00000089776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,782,211 - 95,812,532 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107811   ⟹   ENSRNOP00000082706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,782,723 - 95,812,532 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113541   ⟹   ENSRNOP00000090318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,782,000 - 95,811,382 (-)Ensembl
RefSeq Acc Id: NM_001136229   ⟹   NP_001129701
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,462 - 104,948,236 (-)NCBI
mRatBN7.2195,782,000 - 95,811,746 (-)NCBI
Rnor_6.01101,293,300 - 101,323,187 (-)NCBI
Rnor_5.01102,357,043 - 102,387,010 (-)NCBI
RGSC_v3.4195,773,485 - 95,803,542 (-)RGD
Celera190,039,848 - 90,063,911 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088263   ⟹   XP_038944191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,925,950 - 104,949,453 (-)NCBI
mRatBN7.2195,789,489 - 95,812,095 (-)NCBI
RefSeq Acc Id: XR_001835352
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,672 - 104,949,431 (-)NCBI
mRatBN7.2195,781,805 - 95,812,094 (-)NCBI
Rnor_6.01101,293,513 - 101,323,484 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005491008
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,672 - 104,948,244 (-)NCBI
mRatBN7.2195,781,805 - 95,811,754 (-)NCBI
RefSeq Acc Id: XR_005491011
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,672 - 104,942,567 (-)NCBI
mRatBN7.2195,781,805 - 95,806,104 (-)NCBI
RefSeq Acc Id: XR_005491013
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,923,746 - 104,949,441 (-)NCBI
mRatBN7.2195,787,280 - 95,812,094 (-)NCBI
RefSeq Acc Id: XR_005491016
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,918,672 - 104,937,066 (-)NCBI
mRatBN7.2195,781,805 - 95,800,604 (-)NCBI
RefSeq Acc Id: NP_001129701   ⟸   NM_001136229
- UniProtKB: Q9ESQ5 (UniProtKB/Swiss-Prot),   A0A0H2UHX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041387   ⟸   ENSRNOT00000041513
RefSeq Acc Id: XP_038944191   ⟸   XM_039088263
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000082706   ⟸   ENSRNOT00000107811
Ensembl Acc Id: ENSRNOP00000089776   ⟸   ENSRNOT00000100339
Ensembl Acc Id: ENSRNOP00000082333   ⟸   ENSRNOT00000099429
Ensembl Acc Id: ENSRNOP00000090318   ⟸   ENSRNOT00000113541
Protein Domains
Ion transport   TRPM SLOG

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESQ5-F1-model_v2 AlphaFold Q9ESQ5 1-1208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690033
Promoter ID:EPDNEW_R558
Type:single initiation site
Name:Trpm4_1
Description:transient receptor potential cation channel, subfamily M, member4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,323,972 - 101,324,032EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620244 AgrOrtholog
BioCyc Gene G2FUF-59695 BioCyc
Ensembl Genes ENSRNOG00000020714 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041513.5 UniProtKB/TrEMBL
  ENSRNOT00000099429.1 UniProtKB/TrEMBL
  ENSRNOT00000100339.1 UniProtKB/TrEMBL
  ENSRNOT00000107811.1 UniProtKB/TrEMBL
  ENSRNOT00000113541.1 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPM_SLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171143 UniProtKB/Swiss-Prot
NCBI Gene 171143 ENTREZGENE
PANTHER PTHR13800:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LSDAT_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpm4 PhenoGen
RatGTEx ENSRNOG00000020714 RatGTEx
Superfamily-SCOP Pseudo ankyrin repeat-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHX0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVE9_RAT UniProtKB/TrEMBL
  A0A8I5ZWN0_RAT UniProtKB/TrEMBL
  A0A8I6A802_RAT UniProtKB/TrEMBL
  A0A8I6AAJ1_RAT UniProtKB/TrEMBL
  A6JB05_RAT UniProtKB/TrEMBL
  A6JB06_RAT UniProtKB/TrEMBL
  A7L639_RAT UniProtKB/TrEMBL
  Q9ESQ5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Trpm4  transient receptor potential cation channel, subfamily M, member 4  Mls2s  melastatin like 2 protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Mls2s  melastatin like 2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL