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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620762
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Acc ID: CHEBI:32588
Term: potassium chloride
Definition: A metal chloride salt with a K(+) counterion.
Chemical ID: MESH:D011189
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trpm8increases activityEXP 6480464CTDPotassium Chloride results in increased activity of TRPM8 proteinPMID:19363131
Trpm8multiple interactionsEXP 6480464CTDcapsazepine inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]; icilin inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]; Menthol inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]; Phenanthrolines inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]PMID:19363131
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