Chrng (cholinergic receptor nicotinic gamma subunit)

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Gene: Chrng (cholinergic receptor nicotinic gamma subunit) Rattus norvegicus

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Symbol:

Chrng

Name:

cholinergic receptor nicotinic gamma subunit

RGD ID:

2354

Description:

Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in contractures, pterygia, and spondylocarpotarsal fusion syndrome. Orthologous to human CHRNG (cholinergic receptor nicotinic gamma subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH acetylcholine; acrylamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

acetylcholine receptor subunit gamma; AChR gamma subunit; ACHRG; cholinergic receptor, nicotinic gamma; cholinergic receptor, nicotinic, gamma; cholinergic receptor, nicotinic, gamma (muscle); cholinergic receptor, nicotinic, gamma polypeptide

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	95,325,984 - 95,332,092 (+)	NCBI		GRCr8
mRatBN7.2	9	87,878,085 - 87,884,193 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	87,878,085 - 87,914,482 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	96,302,189 - 96,308,180 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	101,438,448 - 101,444,435 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	99,806,343 - 99,812,449 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	94,302,218 - 94,308,591 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	9	94,023,731 - 94,032,190 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	86,012,089 - 86,018,199 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	86,195,507 - 86,201,618 (+)	NCBI
Celera	9	85,291,469 - 85,297,460 (+)	NCBI		Celera
Cytogenetic Map	9	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arthrogryposis multiplex congenita (ISO)

bone development disease (ISO)

congenital myasthenic syndrome (ISO)

contractures, pterygia, and spondylocarpotarsal fusion syndrome (ISO)

contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B (ISO)

genetic disease (ISO)

Joubert syndrome 22 (ISO)

Multiple Pterygium Syndrome, Lethal Type (ISO)

neuropathy (ISO)

peripheral nervous system disease (ISO)

Perlman syndrome (ISO)

rheumatoid arthritis (ISO)

scoliosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

acetylcholine (EXP,ISO)

acrylamide (EXP,ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

C60 fullerene (EXP)

carmustine (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

diazinon (EXP)

epibatidine (EXP)

flavonoids (EXP)

Licochalcone B (ISO)

methylmercury chloride (ISO)

Muraglitazar (EXP)

paraquat (EXP)

pirinixic acid (ISO)

resveratrol (ISO)

sulfoxaflor (EXP)

Tesaglitazar (EXP)

thiram (ISO)

troglitazone (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine receptor signaling pathway (IBA)

excitatory postsynaptic potential (IEA)

membrane depolarization (IBA)

monoatomic cation transport (IDA)

monoatomic ion transmembrane transport (IEA)

regulation of membrane potential (ISO)

skeletal muscle contraction (IDA)

synaptic transmission, cholinergic (IEA)

translational initiation (IBA)

Cellular Component

acetylcholine-gated channel complex (IBA,IDA,ISO)

eukaryotic translation initiation factor 4F complex (IBA)

neuron projection (IBA)

plasma membrane (IBA,ISO)

postsynaptic membrane (IEA,ISO)

synapse (IBA)

Molecular Function

acetylcholine receptor activity (IBA)

acetylcholine-gated monoatomic cation-selective channel activity (IBA,IDA,IEA,ISO)

ligand-gated monoatomic ion channel activity (IDA)

protein binding (ISO)

RNA 7-methylguanosine cap binding (IBA)

translation initiation factor activity (IBA)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes.	Alberola-Die A, etal., J Neurochem. 2011 Jun;117(6):1009-19. doi: 10.1111/j.1471-4159.2011.07271.x. Epub 2011 May 10.
2.	Mammalian nicotinic acetylcholine receptors: from structure to function.	Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
9.	A novel mode-of-action mediated by the fetal muscle nicotinic acetylcholine receptor resulting in developmental toxicity in rats.	Rasoulpour RJ, etal., Toxicol Sci. 2012 Jun;127(2):522-34. doi: 10.1093/toxsci/kfs118. Epub 2012 Mar 29.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14.	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.	Unwin N, J Mol Biol. 2005 Mar 4;346(4):967-89. doi: 10.1016/j.jmb.2004.12.031. Epub 2005 Jan 25.
15.	Primary structure and functional expression of the alpha-, beta-, gamma-, delta- and epsilon-subunits of the acetylcholine receptor from rat muscle.	Witzemann V, etal., Eur J Biochem 1990 Dec 12;194(2):437-48.
16.	The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface.	Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.

Additional References at PubMed

PMID:2383398	PMID:3666131	PMID:8798466	PMID:12388596	PMID:15883046

Genomics

Comparative Map Data

Chrng
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	95,325,984 - 95,332,092 (+)	NCBI		GRCr8
mRatBN7.2	9	87,878,085 - 87,884,193 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	87,878,085 - 87,914,482 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	96,302,189 - 96,308,180 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	101,438,448 - 101,444,435 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	99,806,343 - 99,812,449 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	94,302,218 - 94,308,591 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	9	94,023,731 - 94,032,190 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	86,012,089 - 86,018,199 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	86,195,507 - 86,201,618 (+)	NCBI
Celera	9	85,291,469 - 85,297,460 (+)	NCBI		Celera
Cytogenetic Map	9	q35	NCBI

CHRNG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	232,539,692 - 232,548,115 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	232,539,692 - 232,548,115 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	233,404,402 - 233,412,825 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	233,112,681 - 233,119,282 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	233,229,962 - 233,235,931	NCBI
Celera	2	227,168,752 - 227,175,352 (+)	NCBI		Celera
Cytogenetic Map	2	q37.1	NCBI
HuRef	2	225,255,337 - 225,261,938 (+)	NCBI		HuRef
CHM1_1	2	233,410,527 - 233,417,126 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	233,026,474 - 233,034,899 (+)	NCBI		T2T-CHM13v2.0

Chrng
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	87,133,533 - 87,139,365 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	87,132,379 - 87,140,416 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	87,205,811 - 87,211,835 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	87,204,657 - 87,212,694 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	89,102,386 - 89,108,410 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	89,036,981 - 89,042,806 (+)	NCBI		MGSCv36	mm8
Celera	1	90,178,869 - 90,184,965 (+)	NCBI		Celera
Cytogenetic Map	1	C5	NCBI
cM Map	1	44.07	NCBI

Chrng
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	3,425,603 - 3,432,695 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	3,425,603 - 3,432,695 (-)	NCBI	ChiLan1.0	ChiLan1.0

CHRNG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	135,143,072 - 135,155,792 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	135,158,037 - 135,166,019 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	119,770,636 - 119,779,332 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	238,689,935 - 238,696,526 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	238,689,935 - 238,696,526 (+)	Ensembl	panpan1.1		panPan2

CHRNG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	44,178,149 - 44,183,623 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	44,178,181 - 44,183,626 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	44,672,778 - 44,678,205 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	44,435,581 - 44,441,006 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	44,435,581 - 44,440,890 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	44,361,428 - 44,366,851 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	44,206,722 - 44,212,147 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	44,361,853 - 44,367,490 (+)	NCBI		UU_Cfam_GSD_1.0

Chrng
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	186,383,042 - 186,388,768 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936525	4,550,987 - 4,556,576 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936525	4,550,987 - 4,556,574 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	133,052,031 - 133,058,544 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	133,051,668 - 133,059,935 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	146,951,213 - 146,959,626 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHRNG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	118,558,688 - 118,566,449 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	118,559,230 - 118,565,610 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	80,935,848 - 80,941,756 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chrng
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624843	5,297,059 - 5,301,699 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624843	5,297,025 - 5,301,714 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Chrng
22 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	35
Interacting mature miRNAs:	38
Transcripts:	ENSRNOT00000026529
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
724547	Cm21	Cardiac mass QTL 21	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	79271511	102910209	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	64573531	109573531	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
2303178	Bp334	Blood pressure QTL 334	3.7	0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	79271511	91616855	Rat
61385	Edpm9	Estrogen-dependent pituitary mass QTL 9	3.43	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	63869687	108869687	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	62072275	96470995	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	61381434	104821652	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	75712843	111552878	Rat
4889852	Pur26	Proteinuria QTL 26	15	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	77813894	101597663	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	77813894	111552878	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	62072275	96470995	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	86369631	92058970	Rat

Markers in Region

D9Got109

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	87,881,222 - 87,881,453 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	94,305,356 - 94,305,586	NCBI	Rnor6.0
Rnor_5.0	9	94,028,948 - 94,029,178	UniSTS	Rnor5.0
RGSC_v3.4	9	86,015,225 - 86,015,457	RGD	RGSC3.4
RGSC_v3.4	9	86,015,227 - 86,015,457	UniSTS	RGSC3.4
RGSC_v3.1	9	86,198,644 - 86,198,876	RGD
Celera	9	85,294,488 - 85,294,718	UniSTS
RH 2.0 Map	9	849.4	RGD
Cytogenetic Map	9	q35	UniSTS

D9Wox27

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	87,881,304 - 87,881,532 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	94,305,438 - 94,305,665	NCBI	Rnor6.0
Rnor_5.0	9	94,029,030 - 94,029,257	UniSTS	Rnor5.0
RGSC_v3.4	9	86,015,309 - 86,015,536	UniSTS	RGSC3.4
Celera	9	85,294,570 - 85,294,797	UniSTS
Cytogenetic Map	9	q35	UniSTS

UniSTS:238129

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	87,883,252 - 87,884,005 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	94,307,651 - 94,308,403	NCBI	Rnor6.0
Rnor_5.0	9	94,031,243 - 94,031,995	UniSTS	Rnor5.0
RGSC_v3.4	9	86,017,259 - 86,018,011	UniSTS	RGSC3.4
Celera	9	85,296,520 - 85,297,272	UniSTS
Cytogenetic Map	9	q35	UniSTS

Chrng

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	9	85,292,457 - 85,294,126	UniSTS
Cytogenetic Map	9	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X06364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X74834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_019145 ⟹ NP_062018

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	95,325,984 - 95,332,092 (+)	NCBI
mRatBN7.2	9	87,878,085 - 87,884,193 (+)	NCBI
Rnor_6.0	9	94,302,218 - 94,308,591 (+)	NCBI
Rnor_5.0	9	94,023,731 - 94,032,190 (+)	NCBI
RGSC_v3.4	9	86,012,089 - 86,018,199 (+)	RGD
Celera	9	85,291,469 - 85,297,460 (+)	RGD

Sequence:

show sequence

CTGGTGGGGCCTGATAGAGCTGGCAGGGTTGGCTGGGAGGGGCGTGTAGGCTGACACAGGACAC
TCCAACCCCCCAACCCCAAGACCTGTAAAGCTACTGTCCTACTCATCACTGGGCAGAACTGAGG
CACCATGCACGGGGGCCAGGGACCTCAGCTCCTCTTGCTGCTGCTGGCTACCTGCCTGGGGGCC
CAGAGCCGCAACCAAGAGGAGCGGCTGCTTGCGGACCTGATGCGCAACTACGACCCCCATCTGC
GGCCGGCTGAGCGTGACTCAGATGTGGTTAATGTCAGCCTGAAGCTTACCTTAACCAACCTCAT
CTCCCTTAATGAGCGAGAGGAGGCCCTCACGACTAATGTCTGGATAGAAATGCAATGGTGCGAC
TATCGCCTACGCTGGGACCCGAAAGACTACGAAGGCCTGTGGATATTGAGGGTGCCATCTACCA
TGGTCTGGCAGCCCGATATCGTGCTGGGAAACAATGTGGACGGTGTCTTCGAGGTGGCGCTCTA
CTGCAATGTGCTCGTGTCCCCTGATGGTTGTATCTACTGGCTGCCGCCTGCCATCTTCCGCTCC
TCCTGCTCCATCTCTGTCACCTACTTCCCCTTCGATTGGCAGAACTGCTCCCTCGTCTTCCAGT
CCCAGACTTACAGCACCAGCGAGATCAACTTGCAGCTGAGCCAGGAGGATGGGCAAGCCATTGA
GTGGATCTTCATTGACCCCGAGGCTTTCACAGAGAATGGGGAATGGGCCATCCGGCATCGACCA
GCCAAAATGCTACTGGATCCTGTGACTCCAGCAGAGGAGGCAGGCCACCAGAAGGTGGTGTTCT
ACCTGCTCATCCAACGCAAGCCCCTCTTCTATGTCATCAACATCATCGTCCCCTGTGTGCTCAT
CTCCTCAGTTGCGATCCTCATCTACTTCCTTCCTGCCAAGGCGGGCGGCCAGAAGTGCACAGTG
GCCACCAACGTGCTCCTGGCCCAGACCGTCTTCCTTTTCCTCGTGGCTAAGAAGGTGCCTGAGA
CCTCCCAGGCAGTGCCGCTCATCAGCAAGTACCTGACCTTCCTCATGGTGGTGACCATCCTCAT
CGTTGTGAACTCTGTGGTCGTGCTCAATGTGTCCTTGAGGTCCCCACACACACACTCCATGGCC
CGGGGGGTCCGCAAGGTGTTTTTGAGGCTCCTGCCCCAGCTGTTACGGATGCATGTGCATCCTC
GGGCTCCTGCTGCTGTCCAGGATGCCCGGCTGCGACTCCAGAATGGCTCTTCCTCAGGGTGGCC
CATCATGACTCGAGAGGAAGGGGACCTCTGTTTGCCTCGAAGCGAACTCCTCTTTAGGCAAAGG
CAGCGCAATGGATTGGTGCAGGCAGTACTGGAGAAGTTAGAGAATGGTCCAGAAATGAGGCAGA
GCCAGGAGTTCTGTGGCAGCCTGAAGCAAGCCTCCCCGGCCATCCAGGCCTGTGTGGATGCCTG
TAACCTCATGGCGCGTGCCCGACACCAGCAAAGTCACTTTGACAGTGGGAATGAGGAGTGGTTG
CTGGTGGGCCGAGTGCTGGACCGAGTCTGTTTCCTAGCCATGCTCTCCCTCTTCATCTGCGGCA
CTGCTGGCATCTTCCTCATGGCCCACTACAACCAGGTGCCTGACCTGCCATTCCCTGGAGACCC
CCGCCCCTACTTGCCTTTGCCAGACTGAGCCAACCAATCACTCCTGCGCCCTGGAGTCAGCCAT
GTGGGTCATGCTGTTTATGGAGCTGTATTCTCTGTTGATCCTGATGGGCTCCTGGGGAGCAATC
ATTCTTGGGAGAAGATAGAGGAATAAAGGAATAGGAATAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_062018	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA29662	(Get FASTA)	NCBI Sequence Viewer
	CAA52828	(Get FASTA)	NCBI Sequence Viewer
	EDL75621	(Get FASTA)	NCBI Sequence Viewer
	EDL75622	(Get FASTA)	NCBI Sequence Viewer
	EDL75623	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068342.2
	ENSRNOP00000074842.2
	ENSRNOP00000075812.2
	ENSRNOP00000075858.2
	ENSRNOP00000077974.1
	ENSRNOP00000085634.1
GenBank Protein	P18916	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_062018 ⟸ NM_019145
- Peptide Label:	precursor
- UniProtKB:	P18916 (UniProtKB/Swiss-Prot), A0A8I6A2R4 (UniProtKB/TrEMBL), A6JWL3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHGGQGPQLLLLLLATCLGAQSRNQEERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLIS LNEREEALTTNVWIEMQWCDYRLRWDPKDYEGLWILRVPSTMVWQPDIVLGNNVDGVFEVALYC NVLVSPDGCIYWLPPAIFRSSCSISVTYFPFDWQNCSLVFQSQTYSTSEINLQLSQEDGQAIEW IFIDPEAFTENGEWAIRHRPAKMLLDPVTPAEEAGHQKVVFYLLIQRKPLFYVINIIVPCVLIS SVAILIYFLPAKAGGQKCTVATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIV VNSVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVHPRAPAAVQDARLRLQNGSSSGWPI MTREEGDLCLPRSELLFRQRQRNGLVQAVLEKLENGPEMRQSQEFCGSLKQASPAIQACVDACN LMARARHQQSHFDSGNEEWLLVGRVLDRVCFLAMLSLFICGTAGIFLMAHYNQVPDLPFPGDPR PYLPLPD hide sequence

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K933-F1-model_v2	AlphaFold	A0A0G2K933	1-256	view protein structure
AF-P18916-F1-model_v2	AlphaFold	P18916	1-519	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2354	AgrOrtholog
BioCyc Gene	G2FUF-26849	BioCyc
Ensembl Genes	ENSRNOG00000019634	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000077005.2	UniProtKB/TrEMBL
	ENSRNOT00000085476.2	UniProtKB/TrEMBL
	ENSRNOT00000092493.2	UniProtKB/TrEMBL
	ENSRNOT00000092534.2	UniProtKB/TrEMBL
	ENSRNOT00000106438.1	UniProtKB/TrEMBL
	ENSRNOT00000114104.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.390	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.70.170.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.760.10	UniProtKB/TrEMBL
InterPro	Neur_chan_lig-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Neur_chan_lig-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Neur_channel	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Neuro-gated_channel_TM_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Neuro_actylchol_rec	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Neurotrans-gated_channel_TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Neurotransmitter_ion_chnl_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nicotinic_acetylcholine_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TIF_eIF4e-like	UniProtKB/TrEMBL
	TIF_eIF_4E	UniProtKB/TrEMBL
	TIF_eIF_4E_CS	UniProtKB/TrEMBL
KEGG Report	rno:25753	UniProtKB/Swiss-Prot
NCBI Gene	25753	ENTREZGENE
PANTHER	ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2	UniProtKB/TrEMBL
	PTHR11960	UniProtKB/TrEMBL
	PTHR18945	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	IF4E	UniProtKB/TrEMBL
	Neur_chan_LBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Neur_chan_memb	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Chrng	PhenoGen
PRINTS	NICOTINICR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NRIONCHANNEL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	IF4E	UniProtKB/TrEMBL
	NEUROTR_ION_CHANNEL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019634	RatGTEx
Superfamily-SCOP	SSF55418	UniProtKB/TrEMBL
	SSF63712	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF90112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC226750
UniProt	A0A096MK14_RAT	UniProtKB/TrEMBL
	A0A0G2K933_RAT	UniProtKB/TrEMBL
	A0A0U1RRU1_RAT	UniProtKB/TrEMBL
	A0A0U1RRY1_RAT	UniProtKB/TrEMBL
	A0A8I5YC42_RAT	UniProtKB/TrEMBL
	A0A8I6A2R4	ENTREZGENE, UniProtKB/TrEMBL
	A6JWL3	ENTREZGENE, UniProtKB/TrEMBL
	A6JWL4_RAT	UniProtKB/TrEMBL
	A6JWL5_RAT	UniProtKB/TrEMBL
	ACHG_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	D4A174	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Chrng	cholinergic receptor nicotinic gamma subunit	Chrng	cholinergic receptor, nicotinic gamma	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-12-09	Chrng	cholinergic receptor, nicotinic gamma	Chrng	cholinergic receptor, nicotinic, gamma (muscle)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-16	Chrng	cholinergic receptor, nicotinic, gamma (muscle)	Chrng	cholinergic receptor, nicotinic, gamma	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-29	Chrng	cholinergic receptor, nicotinic, gamma	Chrng	cholinergic receptor, nicotinic, gamma polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Chrng	cholinergic receptor, nicotinic, gamma polypeptide			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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