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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sh3bp4 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SH3BP4 mRNA | CTD | PMID:22206623 | Sh3bp4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SH3BP4 mRNA | CTD | PMID:20106945 | Sh3bp4 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Sh3bp4 | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of SH3BP4 mRNA | CTD | PMID:18648102 | Sh3bp4 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | Fenretinide results in increased expression of SH3BP4 mRNA | CTD | PMID:28973697 | Sh3bp4 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of SH3BP4 mRNA | CTD | PMID:24780913 | Sh3bp4 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SH3BP4 mRNA | CTD | PMID:31881176 | Sh3bp4 | Rat | acrolein | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SH3BP4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of SH3BP4 mRNA | CTD | PMID:32699268 | Sh3bp4 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of SH3BP4 mRNA | CTD | PMID:28959563 | Sh3bp4 | Rat | afimoxifene | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | afimoxifene inhibits the reaction [Estrogens results in decreased expression of SH3BP4 mRNA] | CTD | PMID:21233418 | Sh3bp4 | Rat | aflatoxin B1 | decreases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of SH3BP4 mRNA | CTD | PMID:19770486 | Sh3bp4 | Rat | aflatoxin B1 | increases methylation | ISO | SH3BP4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SH3BP4 intron | CTD | PMID:30157460 | Sh3bp4 | Rat | aflatoxin B1 | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of SH3BP4 mRNA | CTD | PMID:22100608 | Sh3bp4 | Rat | all-trans-retinoic acid | decreases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SH3BP4 mRNA | CTD | PMID:21934132 | Sh3bp4 | Rat | alpha-pinene | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SH3BP4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of SH3BP4 mRNA | CTD | PMID:32699268 | Sh3bp4 | Rat | antirheumatic drug | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SH3BP4 mRNA | CTD | PMID:24449571 | Sh3bp4 | Rat | Aroclor 1254 | decreases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of SH3BP4 mRNA | CTD | PMID:16934159 | Sh3bp4 | Rat | atrazine | decreases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of SH3BP4 mRNA | CTD | PMID:22378314 | Sh3bp4 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of SH3BP4 gene | CTD | PMID:35440735 | Sh3bp4 | Rat | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of SH3BP4 mRNA | CTD | PMID:36841081 | Sh3bp4 | Rat | benzo[a]pyrene | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SH3BP4 mRNA | CTD | PMID:20106945 | Sh3bp4 | Rat | benzo[a]pyrene | affects methylation | ISO | SH3BP4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SH3BP4 5' UTR more ... | CTD | PMID:27901495 and PMID:30157460 | Sh3bp4 | Rat | benzo[a]pyrene | decreases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SH3BP4 mRNA | CTD | PMID:19770486 | Sh3bp4 | Rat | benzo[e]pyrene | increases methylation | ISO | SH3BP4 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of SH3BP4 intron | CTD | PMID:30157460 | Sh3bp4 | Rat | beta-lapachone | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of SH3BP4 mRNA | CTD | PMID:38218311 | Sh3bp4 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of SH3BP4 mRNA | CTD | PMID:39150890 | Sh3bp4 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SH3BP4 mRNA | CTD | PMID:25181051 and PMID:34947998 | Sh3bp4 | Rat | bisphenol A | increases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SH3BP4 mRNA | CTD | PMID:32156529 | Sh3bp4 | Rat | bisphenol A | increases methylation | ISO | SH3BP4 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of SH3BP4 gene | CTD | PMID:31601247 | Sh3bp4 | Rat | bisphenol A | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SH3BP4 gene | CTD | PMID:31601247 | Sh3bp4 | Rat | Butylbenzyl phthalate | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of SH3BP4 mRNA | CTD | PMID:39150890 | Sh3bp4 | Rat | cadmium atom | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SH3BP4 mRNA | CTD | PMID:35301059 | Sh3bp4 | Rat | cadmium dichloride | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SH3BP4 mRNA | CTD | PMID:35301059 | Sh3bp4 | Rat | CGP 52608 | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SH3BP4 gene] | CTD | PMID:28238834 | Sh3bp4 | Rat | chlordecone | increases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | Chlordecone results in increased expression of SH3BP4 mRNA | CTD | PMID:33711761 | Sh3bp4 | Rat | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of SH3BP4 mRNA | CTD | PMID:18668222 | Sh3bp4 | Rat | choline | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SH3BP4 mRNA | CTD | PMID:20938992 | Sh3bp4 | Rat | clobetasol | decreases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | Clobetasol results in decreased expression of SH3BP4 mRNA | CTD | PMID:27462272 | Sh3bp4 | Rat | cobalt dichloride | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of SH3BP4 mRNA | CTD | PMID:19376846 | Sh3bp4 | Rat | copper(II) sulfate | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SH3BP4 mRNA | CTD | PMID:19549813 | Sh3bp4 | Rat | coumarin | decreases phosphorylation | ISO | SH3BP4 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of SH3BP4 protein | CTD | PMID:35688186 | Sh3bp4 | Rat | coumestrol | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | Sh3bp4 | Rat | coumestrol | decreases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of SH3BP4 mRNA | CTD | PMID:19167446 | Sh3bp4 | Rat | crocidolite asbestos | decreases methylation | ISO | SH3BP4 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased methylation of SH3BP4 5' UTR | CTD | PMID:29523930 | Sh3bp4 | Rat | cyclosporin A | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SH3BP4 mRNA | CTD | PMID:20106945 | Sh3bp4 | Rat | dibutyl phthalate | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of SH3BP4 mRNA | CTD | PMID:39150890 | Sh3bp4 | Rat | dicrotophos | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of SH3BP4 mRNA | CTD | PMID:28302478 | Sh3bp4 | Rat | diethyl phthalate | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of SH3BP4 mRNA | CTD | PMID:39150890 | Sh3bp4 | Rat | diisobutyl phthalate | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of SH3BP4 mRNA | CTD | PMID:39150890 | Sh3bp4 | Rat | diisononyl phthalate | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of SH3BP4 mRNA | CTD | PMID:39150890 | Sh3bp4 | Rat | disodium selenite | decreases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Sodium Selenite results in decreased expression of SH3BP4 mRNA | CTD | PMID:18175754 | Sh3bp4 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of SH3BP4 mRNA | CTD | PMID:29391264 | Sh3bp4 | Rat | Enterolactone | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SH3BP4 mRNA | CTD | PMID:19167446 | Sh3bp4 | Rat | folic acid | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SH3BP4 mRNA | CTD | PMID:20938992 | Sh3bp4 | Rat | FR900359 | affects phosphorylation | ISO | SH3BP4 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of SH3BP4 protein | CTD | PMID:37730182 | Sh3bp4 | Rat | fulvestrant | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SH3BP4 gene | CTD | PMID:31601247 | Sh3bp4 | Rat | L-methionine | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SH3BP4 mRNA | CTD | PMID:20938992 | Sh3bp4 | Rat | leflunomide | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | leflunomide results in increased expression of SH3BP4 mRNA | CTD | PMID:28988120 | Sh3bp4 | Rat | methapyrilene | increases methylation | ISO | SH3BP4 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of SH3BP4 intron | CTD | PMID:30157460 | Sh3bp4 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of SH3BP4 gene | CTD | PMID:35440735 | Sh3bp4 | Rat | methylmercury chloride | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of SH3BP4 mRNA | CTD | PMID:28001369 | Sh3bp4 | Rat | N-methyl-4-phenylpyridinium | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SH3BP4 mRNA | CTD | PMID:24810058 | Sh3bp4 | Rat | ozone | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SH3BP4 mRNA more ... | CTD | PMID:32699268 | Sh3bp4 | Rat | paracetamol | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of SH3BP4 mRNA | CTD | PMID:29067470 | Sh3bp4 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Sh3bp4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of SH3BP4 mRNA | CTD | PMID:36331819 | Sh3bp4 | Rat | progesterone | decreases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Progesterone results in decreased expression of SH3BP4 mRNA | CTD | PMID:18037150 | Sh3bp4 | Rat | resveratrol | multiple interactions | ISO | SH3BP4 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in decreased expression of SH3BP4 mRNA | CTD | PMID:19167446 | Sh3bp4 | Rat | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of SH3BP4 mRNA | CTD | PMID:28374803 | Sh3bp4 | Rat | rotenone | increases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | Rotenone results in increased expression of SH3BP4 mRNA | CTD | PMID:32937126 | Sh3bp4 | Rat | silver atom | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Silver results in increased expression of SH3BP4 mRNA | CTD | PMID:26014281 and PMID:28959546 | Sh3bp4 | Rat | silver(0) | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Silver results in increased expression of SH3BP4 mRNA | CTD | PMID:26014281 and PMID:28959546 | Sh3bp4 | Rat | sodium arsenite | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SH3BP4 mRNA | CTD | PMID:38568856 | Sh3bp4 | Rat | sodium dodecyl sulfate | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Sodium Dodecyl Sulfate results in increased expression of SH3BP4 mRNA | CTD | PMID:31734321 | Sh3bp4 | Rat | temozolomide | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of SH3BP4 mRNA | CTD | PMID:31758290 | Sh3bp4 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SH3BP4 mRNA | CTD | PMID:31150632 | Sh3bp4 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SH3BP4 mRNA | CTD | PMID:23411599 | Sh3bp4 | Rat | titanium dioxide | decreases methylation | ISO | Sh3bp4 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of SH3BP4 gene | CTD | PMID:35295148 | Sh3bp4 | Rat | urethane | decreases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Urethane results in decreased expression of SH3BP4 mRNA | CTD | PMID:28818685 | Sh3bp4 | Rat | valproic acid | increases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of SH3BP4 mRNA | CTD | PMID:21427059 | Sh3bp4 | Rat | valproic acid | decreases expression | ISO | Sh3bp4 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of SH3BP4 mRNA | CTD | PMID:21427059 | Sh3bp4 | Rat | valproic acid | affects expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SH3BP4 mRNA | CTD | PMID:25979313 | Sh3bp4 | Rat | valproic acid | decreases methylation | ISO | SH3BP4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of SH3BP4 gene | CTD | PMID:29154799 | Sh3bp4 | Rat | valproic acid | increases expression | ISO | SH3BP4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SH3BP4 mRNA | CTD | PMID:23179753 and PMID:27188386 | Sh3bp4 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of SH3BP4 gene | CTD | PMID:31079544 | |