(-)-cotinine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Cotinine CTD PMID:14570768 , PMID:16141602 (5Z,8Z,11Z,13E)-15-HETE increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of 15-hydroxy-5 more ... CTD PMID:15231852 (S)-nicotine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 , PMID:16141602 (S)-nicotine decreases expression ISO RGD:1619654 6480464 Nicotine results in decreased expression of UGT1A5 mRNA CTD PMID:21955143 1-Hydroxypyrene increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1343519 6480464 Tetrachlorodibenzodioxin results in increased expression of UGT1A4 mRNA, Tetrachlorodibenzodioxin results in increased expression of UGT1A4 protein CTD PMID:16155002 , PMID:18433817 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1619654 6480464 Tetrachlorodibenzodioxin affects the expression of UGT1A5 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1619654 6480464 Tetrachlorodibenzodioxin results in increased expression of UGT1A5 mRNA CTD PMID:19474220 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1619654 6480464 [Tetrachlorodibenzodioxin co-treated with AHR protein mutant form] results in decreased expression of UGT1A5 mRNA, NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A5 mRNA] CTD PMID:19474220 , PMID:22496397 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO RGD:1343519 6480464 Tetrachlorodibenzodioxin results in increased activity of UGT1A4 protein CTD PMID:16155002 2,3,7,8-tetrachlorodibenzodioxine affects response to substance ISO RGD:1343519 6480464 UGT1A4 promoter SNP affects the susceptibility to Tetrachlorodibenzodioxin CTD PMID:18433817 20-HETE increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of 20-hydroxy-5 more ... CTD PMID:15231852 3-methylcholanthrene increases expression ISO RGD:1343519 6480464 Methylcholanthrene results in increased expression of UGT1A4 mRNA CTD PMID:19118567 4,4'-sulfonyldiphenol affects methylation ISO RGD:1619654 6480464 bis(4-hydroxyphenyl)sulfone affects the methylation of UGT1A5 gene CTD PMID:31683443 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 gene polymorphism results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, UGT1A4 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:14871856 , PMID:31307193 4-hydroxyphenytoin multiple interactions ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole increases expression ISO RGD:1343519 6480464 Omeprazole results in increased expression of UGT1A4 mRNA CTD PMID:19118567 Afloqualone increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of afloqualone CTD PMID:15475412 Afloqualone multiple interactions ISO RGD:1343519 6480464 Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone] CTD PMID:15475412 amentoflavone decreases activity ISO RGD:1343519 6480464 amentoflavone results in decreased activity of UGT1A4 protein CTD PMID:29470958 amphibole asbestos decreases expression ISO RGD:1343519 6480464 Asbestos, Amphibole results in decreased expression of UGT1A4 protein CTD PMID:20855422 androsterone increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein SNP results in increased glucuronidation of Androsterone analog CTD PMID:15708967 arachidonic acid increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Arachidonic Acid CTD PMID:15231852 Aroclor 1254 increases expression ISO RGD:1343519 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A4 mRNA CTD PMID:17851650 benzo[a]pyrene increases activity ISO RGD:1343519 6480464 Benzo(a)pyrene results in increased activity of UGT1A4 protein CTD PMID:17065433 benzo[a]pyrene decreases expression ISO RGD:1343519 6480464 Benzo(a)pyrene results in decreased expression of UGT1A4 mRNA CTD PMID:32234424 benzo[a]pyrene increases expression ISO RGD:1619654 6480464 Benzo(a)pyrene results in increased expression of UGT1A5 mRNA CTD PMID:20127859 , PMID:32417428 benzo[a]pyrene multiple interactions ISO RGD:1343519 6480464 Benzo(a)pyrene promotes the reaction [Butyric Acid results in increased expression of UGT1A4 mRNA] CTD PMID:30439556 benzo[a]pyrene increases expression ISO RGD:1343519 6480464 Benzo(a)pyrene results in increased expression of UGT1A4 mRNA CTD PMID:30439556 beta-naphthoflavone increases expression ISO RGD:1343519 6480464 beta-Naphthoflavone results in increased expression of UGT1A4 mRNA CTD PMID:19118567 beta-naphthoflavone increases expression ISO RGD:1619654 6480464 beta-Naphthoflavone results in increased expression of UGT1A5 mRNA CTD PMID:19144771 betulin increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of betulin CTD PMID:30776358 biphenyl-4-amine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of 4-biphenylamine CTD PMID:15840509 biphenyl-4-amine multiple interactions ISO RGD:1343519 6480464 [Alamethicin results in increased activity of UGT1A4 protein] which results in increased glucuronidation of 4-biphenylamine more ... CTD PMID:17080401 bisphenol A decreases expression ISO RGD:1343519 6480464 bisphenol A results in decreased expression of UGT1A4 mRNA CTD PMID:24214726 buta-1,3-diene increases expression ISO RGD:1619654 6480464 1, 3-butadiene results in increased expression of UGT1A5 mRNA CTD PMID:29038090 butyric acid increases expression ISO RGD:1343519 6480464 Butyric Acid results in increased expression of UGT1A4 mRNA CTD PMID:30439556 butyric acid multiple interactions ISO RGD:1343519 6480464 Benzo(a)pyrene promotes the reaction [Butyric Acid results in increased expression of UGT1A4 mRNA] CTD PMID:30439556 captan increases expression ISO RGD:1619654 6480464 Captan results in increased expression of UGT1A5 mRNA CTD PMID:31558096 clofibrate increases expression ISO RGD:1619654 6480464 Clofibrate results in increased expression of UGT1A5 mRNA CTD PMID:22496397 clozapine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein SNP results in increased glucuronidation of Clozapine CTD PMID:15708967 dibenzo[a,l]pyrene increases glycosylation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glycosylation of dibenzo(a, l)pyrene CTD PMID:21780761 dichloroacetic acid increases expression ISO RGD:1619654 6480464 Dichloroacetic Acid results in increased expression of UGT1A5 mRNA CTD PMID:28962523 diclofenac increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Diclofenac CTD PMID:15843492 dimethylarsinic acid multiple interactions ISO RGD:1619654 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of UGT1A5 mRNA CTD PMID:34876320 ethanol increases expression ISO RGD:1619654 6480464 Ethanol results in increased expression of UGT1A5 mRNA CTD PMID:21955143 ethoxyquin increases expression ISO RGD:1619654 6480464 Ethoxyquin results in increased expression of UGT1A5 mRNA CTD PMID:19144771 farnesol increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 fenthion increases expression ISO RGD:1619654 6480464 Fenthion results in increased expression of UGT1A5 mRNA CTD PMID:34813904 finasteride multiple interactions ISO RGD:1343519 6480464 Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine], Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine] CTD PMID:25448279 flurbiprofen increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Flurbiprofen CTD PMID:15843492 folpet increases expression ISO RGD:1619654 6480464 folpet results in increased expression of UGT1A5 mRNA CTD PMID:31558096 Hecogenin multiple interactions ISO RGD:1343519 6480464 [hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine more ... CTD PMID:17080401 more ... imipramine affects metabolic processing ISO RGD:1343519 6480464 UGT1A4 protein affects the metabolism of Imipramine CTD PMID:15286053 imipramine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Imipramine, UGT1A4 protein SNP results in increased glucuronidation of Imipramine CTD PMID:14570768 more ... imipramine multiple interactions ISO RGD:1343519 6480464 Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Imipramine] CTD PMID:25448279 indometacin increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Indomethacin CTD PMID:15843492 inulin multiple interactions ISO RGD:1619654 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of UGT1A5 mRNA CTD PMID:36331819 ketoprofen increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Ketoprofen CTD PMID:15843492 lamotrigine multiple interactions ISO RGD:1343519 6480464 [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine more ... CTD PMID:19845433 lamotrigine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of lamotrigine CTD PMID:17151188 , PMID:19845433 Licochalcone A multiple interactions ISO RGD:1343519 6480464 licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein] CTD PMID:26875642 lipopolysaccharide multiple interactions ISO RGD:1343519 6480464 [usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA CTD PMID:22777745 methotrexate increases expression ISO RGD:1343519 6480464 Methotrexate results in increased expression of UGT1A4 mRNA CTD PMID:20854796 methylarsonic acid multiple interactions ISO RGD:1619654 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of UGT1A5 mRNA CTD PMID:34876320 morphine increases expression ISO RGD:1619654 6480464 Morphine results in increased expression of UGT1A5 mRNA CTD PMID:21955143 N'-Nitrosoanabasine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of N'-nitrosoanabasine CTD PMID:18238858 N'-Nitrosoanatabine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of N'-nitrosoanatabine CTD PMID:18238858 N'-Nitrosonornicotine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of N'-nitrosonornicotine CTD PMID:18238858 N-hydroxy-PhIP multiple interactions ISO RGD:1343519 6480464 UGT1A4 protein promotes the reaction [2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine binds to Glucuronides] CTD PMID:15986396 N-hydroxy-PhIP increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine CTD PMID:15310245 N-hydroxy-PhIP increases metabolic processing ISO RGD:1343519 6480464 UGT1A4 protein results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4, 5-b)pyridine CTD PMID:15986396 N-Nitrosopyrrolidine decreases expression ISO RGD:1343519 6480464 N-Nitrosopyrrolidine results in decreased expression of UGT1A4 mRNA CTD PMID:32234424 nicotine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 , PMID:16141602 nicotine decreases expression ISO RGD:1619654 6480464 Nicotine results in decreased expression of UGT1A5 mRNA CTD PMID:21955143 Nor-9-carboxy-delta9-THC multiple interactions ISO RGD:1343519 6480464 [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of UGT1A4 gene CTD PMID:30521419 obeticholic acid decreases expression ISO RGD:1343519 6480464 obeticholic acid results in decreased expression of UGT1A4 mRNA CTD PMID:27939613 obeticholic acid increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of obeticholic acid CTD PMID:31299240 oltipraz increases expression ISO RGD:1619654 6480464 oltipraz results in increased expression of UGT1A5 mRNA CTD PMID:19144771 omeprazole increases expression ISO RGD:1343519 6480464 Omeprazole results in increased expression of UGT1A4 mRNA CTD PMID:19118567 perfluorodecanoic acid multiple interactions ISO RGD:1619654 6480464 PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA] CTD PMID:27344344 perfluorodecanoic acid increases expression ISO RGD:1619654 6480464 perfluorodecanoic acid results in increased expression of UGT1A5 mRNA CTD PMID:27344344 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:1619654 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of UGT1A5 mRNA CTD PMID:36331819 phenobarbital multiple interactions ISO RGD:1343519 6480464 [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine CTD PMID:19845433 phenobarbital increases activity ISO RGD:1343519 6480464 Phenobarbital results in increased activity of UGT1A4 protein CTD PMID:19845433 pirinixic acid increases activity ISO RGD:1343519 6480464 pirinixic acid results in increased activity of UGT1A4 protein CTD PMID:19845433 pirinixic acid increases expression ISO RGD:1343519 6480464 pirinixic acid results in increased expression of UGT1A4 mRNA, pirinixic acid results in increased expression of UGT1A4 protein CTD PMID:17151188 pirinixic acid multiple interactions ISO RGD:1343519 6480464 [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine CTD PMID:19845433 pregnenolone 16alpha-carbonitrile multiple interactions ISO RGD:1343519 6480464 [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine CTD PMID:19845433 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1619654 6480464 Pregnenolone Carbonitrile results in increased expression of UGT1A5 mRNA CTD PMID:22496397 pregnenolone 16alpha-carbonitrile multiple interactions ISO RGD:1619654 6480464 [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of UGT1A5 mRNA CTD PMID:22496397 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1343519 6480464 Pregnenolone Carbonitrile results in increased expression of UGT1A4 mRNA, Pregnenolone Carbonitrile results in increased expression of UGT1A4 protein CTD PMID:16155002 pregnenolone 16alpha-carbonitrile increases activity ISO RGD:1343519 6480464 Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein CTD PMID:16155002 , PMID:19845433 sarpogrelate increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 senecionine multiple interactions ISO RGD:1343519 6480464 [hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine CTD PMID:20092275 senecionine increases glycosylation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glycosylation of senecionine CTD PMID:20092275 sodium arsenate multiple interactions ISO RGD:1619654 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of UGT1A5 mRNA CTD PMID:34876320 sodium arsenite multiple interactions ISO RGD:1619654 6480464 [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of UGT1A5 mRNA CTD PMID:34876320 spironolactone increases expression ISO RGD:1619654 6480464 Spironolactone results in increased expression of UGT1A5 mRNA CTD PMID:19144771 sulindac increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 sulindac sulfone increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 tamoxifen increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Tamoxifen CTD PMID:15135306 triclocarban multiple interactions ISO RGD:1343519 6480464 NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA] CTD PMID:22761658 triclocarban increases expression ISO RGD:1343519 6480464 triclocarban results in increased expression of UGT1A4 mRNA CTD PMID:22761658 triclosan increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Triclosan CTD PMID:30776358 trifluoperazine increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Trifluoperazine CTD PMID:15135306 more ... trifluoperazine multiple interactions ISO RGD:1343519 6480464 Finasteride inhibits the reaction [UGT1A4 protein results in increased glucuronidation of Trifluoperazine] more ... CTD PMID:15475412 more ... trifluoperazine increases activity ISO RGD:1343519 6480464 Trifluoperazine results in increased activity of UGT1A4 protein CTD PMID:26875642 Triptolide decreases expression ISO RGD:1619654 6480464 triptolide results in decreased expression of UGT1A5 mRNA CTD PMID:32835833 troglitazone decreases expression ISO RGD:1343519 6480464 troglitazone results in decreased expression of UGT1A4 mRNA CTD PMID:19631733 troglitazone increases expression ISO RGD:1343519 6480464 troglitazone results in increased expression of UGT1A4 mRNA CTD PMID:19631733 ursodeoxycholic acid increases glucuronidation ISO RGD:1343519 6480464 UGT1A4 protein results in increased glucuronidation of Ursodeoxycholic Acid CTD PMID:31299240 usnic acid increases expression ISO RGD:1343519 6480464 usnic acid results in increased expression of UGT1A4 mRNA CTD PMID:21953288 , PMID:22777745 usnic acid multiple interactions ISO RGD:1343519 6480464 [usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA CTD PMID:22777745 valproic acid decreases methylation ISO RGD:1343519 6480464 Valproic Acid results in decreased methylation of UGT1A4 gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:1343519 6480464 Valproic Acid results in decreased expression of UGT1A4 mRNA CTD PMID:29501571 zinc molecular entity decreases expression ISO RGD:1343519 6480464 Zinc Compounds results in decreased expression of UGT1A4 mRNA CTD PMID:24035972
