Gene: Iqca1 (IQ motif containing with AAA domain 1) Rattus norvegicus
Analyze
Symbol:
Iqca1
Name:
IQ motif containing with AAA domain 1
RGD ID:
1305311
Description:
Orthologous to human IQCA1 (IQ motif containing with AAA domain 1); INTERACTS WITH bisphenol A; fenvalerate; vinclozolin.
Type:
protein-coding
RefSeq Status:
MODEL
Also known as:
dynein regulatory complex protein 11; IQ and AAA domain-containing protein 1; LOC316616; RGD1305311; similar to hypothetical protein FLJ22527
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
IQCA1 (IQ motif containing with AAA domain 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Iqca (IQ motif containing with AAA domain) HGNC
Treefam, NCBI, OMA, HomoloGene, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Iqca1 (IQ motif containing with AAA domain 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
IQCA1 (IQ motif containing with AAA domain 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
IQCA1 (IQ motif containing with AAA domain 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Iqca1 (IQ motif containing with AAA domain 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
IQCA1 (IQ motif containing with AAA domain 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
IQCA1 (IQ motif containing with AAA domain 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Iqca1 (IQ motif containing with AAA domain 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
IQCA1 (IQ motif containing with AAA domain 1)
Alliance
DIOPT (HGNC)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 9 90,626,735 - 90,742,563 (-) NCBI Rnor_6.0 9 97,190,240 - 97,298,760 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 9 96,873,940 - 96,989,685 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 89,153,670 - 89,273,101 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 9 89,335,555 - 89,537,162 (-) NCBI Celera 9 88,175,143 - 88,290,699 (-) NCBI Celera Cytogenetic Map 9 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1553411 6480464 [Tetrachlorodibenzodioxin affects the methylation of IQCA intron] which results in decreased expression of IQCA mRNA CTD PMID:33017471 4,4'-sulfonyldiphenol increases expression ISO RGD:1553411 6480464 bis4-hydroxyphenylsulfone results in increased expression of IQCA mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide increases expression ISO RGD:1553411 6480464 Fenretinide results in increased expression of IQCA1 mRNA CTD PMID:28973697 acrolein multiple interactions ISO RGD:1349054 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of IQCA1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of IQCA1 mRNA CTD PMID:32699268 aflatoxin B2 decreases methylation ISO RGD:1349054 6480464 aflatoxin B2 results in decreased methylation of IQCA1 intron CTD PMID:30157460 all-trans-retinoic acid increases expression ISO RGD:1349054 6480464 Tretinoin results in increased expression of IQCA1 mRNA CTD PMID:21934132 alpha-pinene multiple interactions ISO RGD:1349054 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of IQCA1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of IQCA1 mRNA CTD PMID:32699268 benzo[a]pyrene increases methylation ISO RGD:1553411 6480464 Benzoapyrene results in increased methylation of IQCA intron CTD PMID:27901495 benzo[a]pyrene increases methylation ISO RGD:1349054 6480464 Benzoapyrene results in increased methylation of IQCA1 3' UTR CTD PMID:27901495 benzo[e]pyrene decreases methylation ISO RGD:1349054 6480464 benzoepyrene results in decreased methylation of IQCA1 intron CTD PMID:30157460 benzo[e]pyrene increases methylation ISO RGD:1349054 6480464 benzoepyrene results in increased methylation of IQCA1 promoter CTD PMID:30157460 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IQCA1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1553411 6480464 bisphenol A results in increased expression of IQCA mRNA CTD PMID:30951980 bisphenol A increases expression ISO RGD:1349054 6480464 bisphenol A results in increased expression of IQCA1 mRNA CTD PMID:27685785 bisphenol F increases expression ISO RGD:1553411 6480464 bisphenol F results in increased expression of IQCA mRNA CTD PMID:30951980 calcitriol increases expression ISO RGD:1349054 6480464 Calcitriol results in increased expression of IQCA mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1349054 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of IQCA mRNA CTD PMID:21592394 carbon nanotube decreases expression ISO RGD:1553411 6480464 Nanotubes more ... CTD PMID:25554681 dorsomorphin multiple interactions ISO RGD:1349054 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 doxorubicin increases expression ISO RGD:1553411 6480464 Doxorubicin results in increased expression of IQCA mRNA CTD PMID:28608983 entinostat multiple interactions ISO RGD:1349054 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of IQCA1 mRNA CTD PMID:27188386 entinostat increases expression ISO RGD:1349054 6480464 entinostat results in increased expression of IQCA1 mRNA CTD PMID:27188386 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of IQCA1 mRNA CTD PMID:30307764 lithium chloride increases expression ISO RGD:1349054 6480464 Lithium Chloride results in increased expression of IQCA mRNA CTD PMID:23527032 methapyrilene increases methylation ISO RGD:1349054 6480464 Methapyrilene results in increased methylation of IQCA1 promoter CTD PMID:30157460 methapyrilene decreases methylation ISO RGD:1349054 6480464 Methapyrilene results in decreased methylation of IQCA1 intron CTD PMID:30157460 methylmercury chloride decreases expression ISO RGD:1349054 6480464 methylmercuric chloride results in decreased expression of IQCA1 mRNA CTD PMID:23179753 , PMID:28001369 N-methyl-4-phenylpyridinium increases expression ISO RGD:1349054 6480464 1-Methyl-4-phenylpyridinium results in increased expression of IQCA1 mRNA CTD PMID:24810058 ozone multiple interactions ISO RGD:1349054 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of IQCA1 mRNA more ... CTD PMID:32699268 panobinostat multiple interactions ISO RGD:1349054 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of IQCA1 mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:1349054 6480464 panobinostat results in increased expression of IQCA1 mRNA CTD PMID:26272509 pirinixic acid multiple interactions ISO RGD:1553411 6480464 [pirinixic acid co-treated with PPARA] results in increased expression of IQCA mRNA CTD PMID:20813756 pirinixic acid increases expression ISO RGD:1553411 6480464 pirinixic acid results in increased expression of IQCA mRNA CTD PMID:20813756 potassium dichromate decreases expression ISO RGD:1553411 6480464 Potassium Dichromate results in decreased expression of IQCA mRNA CTD PMID:23608068 rifampicin decreases expression ISO RGD:1349054 6480464 Rifampin results in decreased expression of IQCA1 mRNA CTD PMID:24552687 SB 431542 multiple interactions ISO RGD:1349054 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 sodium arsenite decreases expression ISO RGD:1349054 6480464 sodium arsenite results in decreased expression of IQCA1 mRNA CTD PMID:22714537 sunitinib decreases expression ISO RGD:1349054 6480464 Sunitinib results in decreased expression of IQCA1 mRNA CTD PMID:31533062 testosterone decreases expression ISO RGD:1349054 6480464 Testosterone results in decreased expression of IQCA mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:1349054 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of IQCA mRNA CTD PMID:21592394 titanium dioxide decreases expression ISO RGD:1553411 6480464 titanium dioxide results in decreased expression of IQCA mRNA CTD PMID:23557971 trichostatin A increases expression ISO RGD:1349054 6480464 trichostatin A results in increased expression of IQCA1 mRNA CTD PMID:24935251 valproic acid affects expression ISO RGD:1349054 6480464 Valproic Acid affects the expression of IQCA1 mRNA CTD PMID:25979313 valproic acid increases methylation ISO RGD:1349054 6480464 Valproic Acid results in increased methylation of IQCA1 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1349054 6480464 Valproic Acid results in increased expression of IQCA1 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1349054 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of IQCA1 mRNA CTD PMID:27188386 vinclozolin decreases methylation EXP 6480464 vinclozolin results in decreased methylation of IQCA1 gene CTD PMID:31079544 vinclozolin increases methylation EXP 6480464 vinclozolin results in increased methylation of IQCA gene CTD PMID:31079544
References
Additional References at PubMed
Genomics
Comparative Map Data
Iqca1 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 9 90,626,735 - 90,742,563 (-) NCBI Rnor_6.0 9 97,190,240 - 97,298,760 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 9 96,873,940 - 96,989,685 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 9 89,153,670 - 89,273,101 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 9 89,335,555 - 89,537,162 (-) NCBI Celera 9 88,175,143 - 88,290,699 (-) NCBI Celera Cytogenetic Map 9 q36 NCBI
IQCA1 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38.p13 Ensembl 2 236,324,147 - 236,507,535 (-) Ensembl GRCh38 hg38 GRCh38 GRCh38 2 236,324,147 - 236,507,476 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 2 237,232,794 - 237,416,119 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 GRCh37 2 237,232,790 - 237,416,178 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 2 236,897,533 - 237,080,831 (-) NCBI NCBI36 hg18 NCBI36 Build 34 2 237,014,793 - 237,198,092 NCBI Celera 2 230,945,804 - 231,128,787 (-) NCBI Cytogenetic Map 2 q37.2-q37.3 NCBI HuRef 2 229,027,057 - 229,210,048 (-) NCBI HuRef CHM1_1 2 237,238,581 - 237,421,557 (-) NCBI CHM1_1
Iqca Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 1 89,969,854 - 90,081,158 (-) NCBI GRCm39 mm39 GRCm38 1 90,042,132 - 90,153,436 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 1 90,042,132 - 90,153,401 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 1 91,938,707 - 92,049,976 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 1 91,938,707 - 92,049,976 (-) NCBI mm8 Celera 1 92,983,783 - 93,096,895 (-) NCBI Celera Cytogenetic Map 1 D NCBI
Iqca1 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955453 291,334 - 416,529 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955453 282,601 - 416,715 (+) NCBI ChiLan1.0 ChiLan1.0
IQCA1 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl PanPan1.1 2B 242,416,200 - 242,593,852 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 2B 242,416,200 - 242,593,852 (-) Ensembl panpan1.1 panPan2 Mhudiblu_PPA_v0 2B 123,555,491 - 123,735,660 (-) NCBI Mhudiblu_PPA_v0 panPan3
IQCA1
Iqca1
IQCA1 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 15 136,153,545 - 136,321,647 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 15 136,153,182 - 136,322,725 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 15 150,587,819 - 150,757,656 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
IQCA1 Vervet Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 10 122,335,436 - 122,500,848 (-) NCBI ChlSab1.1 Ensembl 10 122,335,980 - 122,500,711 (-) Ensembl
Iqca1 Molerat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HetGla 1.0 NW_004624847 2,008,479 - 2,128,737 (-) NCBI
Position Markers
D9Got111
Rat Assembly Chr Position (strand) Source JBrowse Rnor_6.0 9 97,276,144 - 97,276,310 NCBI Rnor6.0 Rnor_5.0 9 96,967,774 - 96,967,940 UniSTS Rnor5.0 RGSC_v3.4 9 89,249,726 - 89,249,893 RGD RGSC3.4 RGSC_v3.4 9 89,249,727 - 89,249,893 UniSTS RGSC3.4 RGSC_v3.1 9 89,454,495 - 89,454,662 RGD Celera 9 88,267,055 - 88,267,221 UniSTS RH 2.0 Map 9 927.4 RGD Cytogenetic Map 9 q35 UniSTS
BE102230
Rat Assembly Chr Position (strand) Source JBrowse Rnor_6.0 9 97,245,661 - 97,245,876 NCBI Rnor6.0 Rnor_5.0 9 96,937,629 - 96,937,844 UniSTS Rnor5.0 RGSC_v3.4 9 89,218,735 - 89,218,950 UniSTS RGSC3.4 Celera 9 88,236,574 - 88,236,789 UniSTS Cytogenetic Map 9 q35 UniSTS
BE110326
Rat Assembly Chr Position (strand) Source JBrowse Rnor_6.0 9 97,182,810 - 97,182,968 NCBI Rnor6.0 Rnor_5.0 9 96,873,536 - 96,873,694 UniSTS Rnor5.0 RGSC_v3.4 9 89,153,266 - 89,153,424 UniSTS RGSC3.4 Celera 9 88,175,196 - 88,175,354 UniSTS RH 3.4 Map 9 784.08 UniSTS Cytogenetic Map 9 q35 UniSTS
RH140487
Rat Assembly Chr Position (strand) Source JBrowse Rnor_6.0 9 97,220,053 - 97,220,213 NCBI Rnor6.0 Rnor_5.0 9 96,911,877 - 96,912,037 UniSTS Rnor5.0 RGSC_v3.4 9 89,191,558 - 89,191,718 UniSTS RGSC3.4 Celera 9 88,211,684 - 88,211,844 UniSTS Cytogenetic Map 9 q35 UniSTS
QTLs in Region (Rnor_6.0)
724544 Uae9 Urinary albumin excretion QTL 9 4.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 9 29075079 122095297 Rat 731164 Uae25 Urinary albumin excretion QTL 25 3.5 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 29466970 107878528 Rat 8662828 Vetf6 Vascular elastic tissue fragility QTL 6 3.9 artery integrity trait (VT:0010639) patent ductus arteriosus score (CMO:0002566) 9 41261034 98606834 Rat 2290450 Scl57 Serum cholesterol level QTL 57 4.15 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 9 41261034 102531865 Rat 631656 Bp108 Blood pressure QTL 108 5.97 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 54177542 99177542 Rat 1578760 Cm53 Cardiac mass QTL 53 3.3 0.0001 heart mass (VT:0007028) heart wet weight (CMO:0000069) 9 61186278 106186278 Rat 724515 Uae16 Urinary albumin excretion QTL 16 8 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 63270073 107878387 Rat 1300134 Bp185 Blood pressure QTL 185 3.73 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 66757444 112943287 Rat 1581580 Uae34 Urinary albumin excretion QTL 34 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 9 67451664 99920892 Rat 1578757 Pur6 Proteinuria QTL 6 3.3 0.005 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 9 67451664 99920892 Rat 61385 Edpm9 Estrogen-dependent pituitary mass QTL 9 3.43 0.05 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) 9 70241351 115241351 Rat 731171 Glom6 Glomerulus QTL 6 2.8 0.0003 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) 9 70942881 115942881 Rat 1354626 Bvd1 Brain ventricular dilatation QTL 1 3.73 0.001 brain ventricle morphology trait (VT:0000822) hydrocephalus severity score (CMO:0001881) 9 81411073 119983851 Rat 2303178 Bp334 Blood pressure QTL 334 3.7 0.01 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 9 83686153 98164303 Rat 2303178 Bp334 Blood pressure QTL 334 3.7 0.01 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 9 83686153 98164303 Rat 2303178 Bp334 Blood pressure QTL 334 3.7 0.01 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 9 83686153 98164303 Rat 724547 Cm21 Cardiac mass QTL 21 2.7 heart mass (VT:0007028) calculated heart weight (CMO:0000073) 9 83686153 111609081 Rat 4889852 Pur26 Proteinuria QTL 26 15 0.001 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 9 90024661 107199079 Rat 7794784 Mcs31 Mammary carcinoma susceptibility QTL 31 2.98 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) 9 90024661 119983851 Rat 4889943 Bss90 Bone structure and strength QTL 90 4.1 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) 9 92741297 98606834 Rat 11353957 Bmd92 Bone mineral density QTL 92 0.01 tibia mineral mass (VT:1000283) volumetric bone mineral density (CMO:0001553) 9 95430880 97679852 Rat 
