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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of NCK2 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1314307 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of NCK2 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | RGD:1314306 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of NCK2 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of NCK2 mRNA | CTD | PMID:22298810 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of NCK2 mRNA | CTD | PMID:30071829 | 3-methylcholanthrene | decreases expression | ISO | RGD:1314307 | 6480464 | Methylcholanthrene results in decreased expression of NCK2 mRNA | CTD | PMID:20713471 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:1314307 | 6480464 | 4, 4'-diaminodiphenylmethane results in decreased expression of NCK2 mRNA | CTD | PMID:18648102 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1314307 | 6480464 | Fenretinide results in increased expression of NCK2 mRNA | CTD | PMID:28973697 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of NCK2 mRNA | CTD | PMID:23630614, PMID:25378103 | aflatoxin B1 | increases methylation | ISO | RGD:1314306 | 6480464 | Aflatoxin B1 results in increased methylation of NCK2 gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | RGD:1314306 | 6480464 | Tretinoin results in decreased expression of NCK2 mRNA | CTD | PMID:33167477 | aristolochic acid A | multiple interactions | ISO | RGD:1314306 | 6480464 | aristolochic acid I inhibits the reaction [SLIT2 protein results in increased expression of NCK2 mRNA] more ... | CTD | PMID:30381256 | Aroclor 1254 | decreases expression | ISO | RGD:1314307 | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of NCK2 mRNA | CTD | PMID:23650126 | benzene-1,2,4-triol | increases expression | ISO | RGD:1314306 | 6480464 | hydroxyhydroquinone results in increased expression of NCK2 mRNA | CTD | PMID:17572062 | benzo[a]pyrene | decreases methylation | ISO | RGD:1314306 | 6480464 | Benzo(a)pyrene results in decreased methylation of NCK2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RGD:1314306 | 6480464 | Benzo(a)pyrene affects the methylation of NCK2 5' UTR | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | RGD:1314306 | 6480464 | benzo(e)pyrene results in increased methylation of NCK2 intron | CTD | PMID:30157460 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of NCK2 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | RGD:1314306 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of NCK2 gene | CTD | PMID:31601247 | bisphenol A | affects methylation | ISO | RGD:1314306 | 6480464 | bisphenol A affects the methylation of NCK2 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of NCK2 mRNA | CTD | PMID:30816183, PMID:34947998 | cadmium atom | multiple interactions | ISO | RGD:1314306 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NCK2 mRNA | CTD | PMID:35301059 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of NCK2 promoter | CTD | PMID:22457795 | cadmium dichloride | multiple interactions | ISO | RGD:1314306 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of NCK2 mRNA | CTD | PMID:35301059 | camptothecin | decreases expression | ISO | RGD:1314306 | 6480464 | Camptothecin results in decreased expression of NCK2 mRNA | CTD | PMID:17374387 | CGP 52608 | multiple interactions | ISO | RGD:1314306 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to NCK2 gene] | CTD | PMID:28238834 | cisplatin | decreases expression | ISO | RGD:1314306 | 6480464 | Cisplatin results in decreased expression of NCK2 mRNA | CTD | PMID:27392435 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of NCK2 mRNA | CTD | PMID:26577399 | cyclosporin A | increases expression | ISO | RGD:1314306 | 6480464 | Cyclosporine results in increased expression of NCK2 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:1314306 | 6480464 | Cyclosporine results in decreased expression of NCK2 mRNA | CTD | PMID:27989131 | daunorubicin | decreases expression | ISO | RGD:1314306 | 6480464 | Daunorubicin results in decreased expression of NCK2 mRNA | CTD | PMID:17374387 | doxorubicin | decreases expression | ISO | RGD:1314306 | 6480464 | Doxorubicin results in decreased expression of NCK2 mRNA | CTD | PMID:29803840 | etoposide | decreases expression | ISO | RGD:1314306 | 6480464 | Etoposide results in decreased expression of NCK2 mRNA | CTD | PMID:17374387 | fulvestrant | multiple interactions | ISO | RGD:1314306 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of NCK2 gene | CTD | PMID:31601247 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of NCK2 gene | CTD | PMID:22079235 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of NCK2 mRNA | CTD | PMID:33387578 | hydrazine | decreases expression | ISO | RGD:1314307 | 6480464 | hydrazine results in decreased expression of NCK2 mRNA | CTD | PMID:15282401 | hydrogen peroxide | multiple interactions | ISO | RGD:1314306 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NCK2 protein | CTD | PMID:18951874 | methapyrilene | increases methylation | ISO | RGD:1314306 | 6480464 | Methapyrilene results in increased methylation of NCK2 intron | CTD | PMID:30157460 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of NCK2 mRNA | CTD | PMID:25729387 | p-toluidine | decreases expression | EXP | | 6480464 | 4-toluidine results in decreased expression of NCK2 mRNA | CTD | PMID:27638505 | paracetamol | affects expression | ISO | RGD:1314307 | 6480464 | Acetaminophen affects the expression of NCK2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1314306 | 6480464 | Acetaminophen results in increased expression of NCK2 mRNA | CTD | PMID:29067470 | perfluorononanoic acid | increases expression | ISO | RGD:1314306 | 6480464 | perfluoro-n-nonanoic acid results in increased expression of NCK2 mRNA | CTD | PMID:32588087 | phenacetin | decreases expression | EXP | | 6480464 | Phenacetin results in decreased expression of NCK2 mRNA | CTD | PMID:17082564 | phenylhydrazine | decreases expression | EXP | | 6480464 | phenylhydrazine results in decreased expression of NCK2 mRNA | CTD | PMID:17082564 | pirinixic acid | multiple interactions | ISO | RGD:1314307 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NCK2 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | RGD:1314307 | 6480464 | pirinixic acid results in increased expression of NCK2 mRNA | CTD | PMID:18301758, PMID:23811191 | rotenone | increases expression | ISO | RGD:1314307 | 6480464 | Rotenone results in increased expression of NCK2 mRNA | CTD | PMID:32937126 | sodium arsenite | affects methylation | ISO | RGD:1314306 | 6480464 | sodium arsenite affects the methylation of NCK2 gene | CTD | PMID:28589171 | temozolomide | decreases expression | ISO | RGD:1314306 | 6480464 | Temozolomide results in decreased expression of NCK2 mRNA | CTD | PMID:31758290 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of NCK2 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of NCK2 mRNA] | CTD | PMID:31150632 | theophylline | multiple interactions | ISO | RGD:1314306 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NCK2 protein | CTD | PMID:18951874 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of NCK2 mRNA | CTD | PMID:23411599 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of NCK2 mRNA | CTD | PMID:25729387 | triptonide | decreases expression | ISO | RGD:1314307 | 6480464 | triptonide results in decreased expression of NCK2 mRNA | CTD | PMID:33045310 | urethane | increases expression | ISO | RGD:1314306 | 6480464 | Urethane results in increased expression of NCK2 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | RGD:1314307 | 6480464 | Valproic Acid affects the expression of NCK2 mRNA | CTD | PMID:17963808 | valproic acid | affects expression | ISO | RGD:1314306 | 6480464 | Valproic Acid affects the expression of NCK2 mRNA | CTD | PMID:25979313 | |