Ercc5 (ERCC excision repair 5, endonuclease) - Rat Genome Database

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Gene: Ercc5 (ERCC excision repair 5, endonuclease) Rattus norvegicus
Analyze
Symbol: Ercc5
Name: ERCC excision repair 5, endonuclease
RGD ID: 1586176
Description: Predicted to enable several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Predicted to be involved in DNA repair; negative regulation of apoptotic process; and response to UV-C. Predicted to act upstream of or within UV protection; determination of adult lifespan; and nucleotide-excision repair. Predicted to be part of DNA replication factor A complex and nucleotide-excision repair complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; melanoma; respiratory system cancer (multiple); stomach cancer; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; Ercc5_mapped; excision repair cross-complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped); Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum complementation group G (Cockayne syndrome)); excision repair cross-complementing rodent repair deficiency,complementation group 5; Xpg
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2946,309,477 - 46,354,478 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,309,389 - 46,354,472 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0950,928,847 - 50,970,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,925,619 - 50,970,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,591,955 - 50,637,694 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,248,023 - 43,293,196 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera944,012,579 - 44,057,619 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
daidzein  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dichromium trioxide  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
fenthion  (ISO)
fluvastatin  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
imiquimod  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lovastatin  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-nitrosodiethylamine  (ISO)
p-anisidine  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. Abbasi R, etal., Int J Cancer. 2009 Sep 15;125(6):1431-9. doi: 10.1002/ijc.24442.
2. Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. Cheng L, etal., Carcinogenesis. 2000 Aug;21(8):1527-30.
3. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM and Coin F, DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Complementary DNA sequence and chromosomal localization of xpg, the mouse counterpart of human repair gene XPG/ERCC5. Harada YN, etal., Genomics 1995 Jul 1;28(1):59-65.
6. Nucleotide excision repair: new tricks with old bricks. Kamileri I, etal., Trends Genet. 2012 Nov;28(11):566-73. doi: 10.1016/j.tig.2012.06.004. Epub 2012 Jul 22.
7. Role of XRCC1 and ERCC5 polymorphisms on clinical outcomes in advanced non-small cell lung cancer. Liu D, etal., Genet Mol Res. 2014 Apr 17;13(2):3100-7. doi: 10.4238/2014.April.17.6.
8. Polymorphisms of multiple genes involved in NER pathway predict prognosis of gastric cancer. Liu J, etal., Oncotarget. 2016 Jul 26;7(30):48130-48142. doi: 10.18632/oncotarget.10173.
9. Polymorphisms in DNA repair genes and risk of glioma and meningioma. Luo KQ, etal., Asian Pac J Cancer Prev. 2013;14(1):449-52. doi: 10.7314/apjcp.2013.14.1.449.
10. Prognostic Value of Excision Repair Cross-Complementing mRNA Expression in Gastric Cancer. Luo SS, etal., Biomed Res Int. 2018 Oct 17;2018:6204684. doi: 10.1155/2018/6204684. eCollection 2018.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. The multi-replication protein A (RPA) system--a new perspective. Sakaguchi K, etal., FEBS J. 2009 Feb;276(4):943-63. doi: 10.1111/j.1742-4658.2008.06841.x. Epub 2009 Jan 12.
19. ERCC5 p.Asp1104His and ERCC2 p.Lys751Gln polymorphisms are independent prognostic factors for the clinical course of melanoma. Schrama D, etal., J Invest Dermatol. 2011 Jun;131(6):1280-90. doi: 10.1038/jid.2011.35. Epub 2011 Mar 10.
20. Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. Shiomi N, etal., Mol Cell Biol. 2004 May;24(9):3712-9.
21. Single nucleotide polymorphisms of nucleotide excision repair pathway are significantly associated with outcomes of platinum-based chemotherapy in lung cancer. Song X, etal., Sci Rep. 2017 Sep 18;7(1):11785. doi: 10.1038/s41598-017-08257-7.
22. Association between single nucleotide polymorphisms (SNPs) and toxicity of advanced non-small-cell lung cancer patients treated with chemotherapy. Zhang L, etal., PLoS One. 2012;7(10):e48350. doi: 10.1371/journal.pone.0048350. Epub 2012 Oct 31.
Additional References at PubMed
PMID:7510366   PMID:7657672   PMID:7700386   PMID:8090225   PMID:8652557   PMID:8703115   PMID:8710877   PMID:10022922   PMID:10026181   PMID:11259578   PMID:12644470   PMID:16167068  
PMID:16246722   PMID:17208056  


Genomics

Comparative Map Data
Ercc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2946,309,477 - 46,354,478 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,309,389 - 46,354,472 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0950,928,847 - 50,970,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,925,619 - 50,970,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,591,955 - 50,637,694 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,248,023 - 43,293,196 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera944,012,579 - 44,057,619 (+)NCBICelera
Cytogenetic Map9q22NCBI
ERCC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,846,032 - 102,875,995 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13102,845,831 - 102,875,995 (+)EnsemblGRCh38hg38GRCh38
GRCh3713103,498,382 - 103,528,345 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,296,175 - 102,326,346 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413102,296,174 - 102,326,346NCBI
Celera1384,342,654 - 84,372,832 (+)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1384,090,418 - 84,120,587 (+)NCBIHuRef
CHM1_113103,467,640 - 103,497,809 (+)NCBICHM1_1
T2T-CHM13v2.013102,064,228 - 102,094,203 (+)NCBIT2T-CHM13v2.0
Ercc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,184,084 - 44,220,399 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,186,904 - 44,220,420 (+)EnsemblGRCm39 Ensembl
GRCm38144,146,948 - 44,181,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl144,147,744 - 44,181,260 (+)EnsemblGRCm38mm10GRCm38
MGSCv37144,204,589 - 44,238,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36144,092,393 - 44,125,806 (+)NCBIMGSCv36mm8
Celera144,491,664 - 44,523,751 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.55NCBI
Ercc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554048,294,346 - 8,321,112 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554048,294,506 - 8,321,505 (-)NCBIChiLan1.0ChiLan1.0
ERCC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan113103,033,007 - 103,063,245 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01384,005,950 - 84,036,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113103,142,508 - 103,173,022 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13103,096,344 - 103,174,182 (+)Ensemblpanpan1.1panPan2
ERCC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,339,011 - 52,372,618 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2252,118,439 - 52,152,268 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02252,786,543 - 52,820,389 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2252,786,765 - 52,820,387 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12252,438,966 - 52,472,791 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,455,293 - 52,489,134 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,496,357 - 52,530,203 (+)NCBIUU_Cfam_GSD_1.0
Ercc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,718,036 - 187,758,810 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364728,209,540 - 8,234,334 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364728,209,482 - 8,234,696 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERCC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1171,141,842 - 71,168,322 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11171,141,823 - 71,168,326 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ERCC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,406,103 - 81,441,422 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,405,872 - 81,436,040 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604637,942,886 - 37,972,889 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ercc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247938,632,471 - 8,657,346 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247938,632,581 - 8,657,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ercc5
203 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:132
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000059349
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat

Markers in Region
RH135251  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2946,308,996 - 46,309,185 (+)MAPPERmRatBN7.2
Rnor_6.0950,925,092 - 50,925,280NCBIRnor6.0
Rnor_5.0950,592,053 - 50,592,241UniSTSRnor5.0
RGSC_v3.4943,247,706 - 43,247,894UniSTSRGSC3.4
Celera944,012,229 - 44,012,417UniSTS
RH 3.4 Map9391.99UniSTS
Cytogenetic Map9q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 23 28 12 19 12 8 8 74 35 35 11 8
Low 1 20 29 29 29 3 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000059349   ⟹   ENSRNOP00000056107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,309,389 - 46,354,472 (+)Ensembl
Rnor_6.0 Ensembl950,925,620 - 50,970,854 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076248   ⟹   ENSRNOP00000068529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,311,526 - 46,354,472 (+)Ensembl
Rnor_6.0 Ensembl950,925,619 - 50,955,882 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076636   ⟹   ENSRNOP00000067938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl950,966,766 - 50,970,955 (+)Ensembl
RefSeq Acc Id: XM_017596798   ⟹   XP_017452287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,309,477 - 46,350,420 (+)NCBI
Rnor_6.0950,928,847 - 50,967,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596799   ⟹   XP_017452288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,309,477 - 46,350,422 (+)NCBI
Rnor_6.0950,928,847 - 50,967,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596800   ⟹   XP_017452289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,309,477 - 46,350,405 (+)NCBI
Rnor_6.0950,928,847 - 50,967,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084554   ⟹   XP_038940482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,309,477 - 46,354,478 (+)NCBI
RefSeq Acc Id: XM_039084555   ⟹   XP_038940483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,309,625 - 46,354,478 (+)NCBI
RefSeq Acc Id: XM_039084556   ⟹   XP_038940484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2946,309,477 - 46,349,995 (+)NCBI
RefSeq Acc Id: XP_017452289   ⟸   XM_017596800
- Peptide Label: isoform X5
- UniProtKB: A6INS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452287   ⟸   XM_017596798
- Peptide Label: isoform X4
- UniProtKB: A6INS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452288   ⟸   XM_017596799
- Peptide Label: isoform X4
- UniProtKB: A6INS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056107   ⟸   ENSRNOT00000059349
RefSeq Acc Id: ENSRNOP00000068529   ⟸   ENSRNOT00000076248
RefSeq Acc Id: ENSRNOP00000067938   ⟸   ENSRNOT00000076636
RefSeq Acc Id: XP_038940482   ⟸   XM_039084554
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038940484   ⟸   XM_039084556
- Peptide Label: isoform X3
- UniProtKB: A6INS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940483   ⟸   XM_039084555
- Peptide Label: isoform X2
- UniProtKB: A0A096MKI6 (UniProtKB/TrEMBL)
Protein Domains
XPG N-terminal   XPG-I

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTV2-F1-model_v2 AlphaFold D3ZTV2 1-1166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586176 AgrOrtholog
BioCyc Gene G2FUF-27650 BioCyc
Ensembl Genes ENSRNOG00000022812 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059349 ENTREZGENE
  ENSRNOT00000059349.5 UniProtKB/TrEMBL
  ENSRNOT00000076248 ENTREZGENE
  ENSRNOT00000076248.3 UniProtKB/TrEMBL
Gene3D-CATH 5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
  5'-nuclease UniProtKB/TrEMBL
InterPro 5-3_exonuclease_C_sf UniProtKB/TrEMBL
  HhH2 UniProtKB/TrEMBL
  PIN_domain-like UniProtKB/TrEMBL
  XPG-I_dom UniProtKB/TrEMBL
  XPG/Rad2 UniProtKB/TrEMBL
  XPG_CS UniProtKB/TrEMBL
  XPG_DNA_repair_N UniProtKB/TrEMBL
  XPGC_DNA_repair UniProtKB/TrEMBL
NCBI Gene 301382 ENTREZGENE
PANTHER DNA EXCISION REPAIR PROTEIN ERCC-5 UniProtKB/TrEMBL
  DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED UniProtKB/TrEMBL
Pfam XPG_I UniProtKB/TrEMBL
  XPG_N UniProtKB/TrEMBL
PhenoGen Ercc5 PhenoGen
PRINTS XPGRADSUPER UniProtKB/TrEMBL
  XRODRMPGMNTG UniProtKB/TrEMBL
PROSITE XPG_1 UniProtKB/TrEMBL
  XPG_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022812 RatGTEx
SMART HhH2 UniProtKB/TrEMBL
  XPGI UniProtKB/TrEMBL
  XPGN UniProtKB/TrEMBL
Superfamily-SCOP SSF47807 UniProtKB/TrEMBL
  SSF88723 UniProtKB/TrEMBL
UniProt A0A096MKI6 ENTREZGENE, UniProtKB/TrEMBL
  A6INS6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTV2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Ercc5  ERCC excision repair 5, endonuclease  Ercc5  excision repair cross-complementation group 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-12 Ercc5  excision repair cross-complementation group 5  Ercc5  excision repair cross-complementing rodent repair deficiency, complementation group 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   excision repair cross-complementing rodent repair deficiency, complementation group 5  Ercc5  excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped)  Name updated 737654 APPROVED
2007-04-11 Ercc5  excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped)  Ercc5_mapped  excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped)  Data merged from RGD:2562 737654 APPROVED
2006-11-19 Ercc5  excision repair cross-complementing rodent repair deficiency, complementation group 5 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Ercc5_mapped  excision repair cross-complementing rodent repair deficiency,complementation group 5 (mapped)  Ercc5  excision repair cross-complementing rodent repair deficiency,complementation group 5  Symbol and Name updated 1556543 APPROVED
2002-11-06 Ercc5  excision repair cross-complementing rodent repair deficiency,complementation group 5    Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum complementation group G (Cockayne syndrome))  Name updated 625702 APPROVED
2002-06-10 Ercc5  Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum complementation group G (Cockayne syndrome))      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may be involved in DNA repair 1302205
gene_homology shares homology with mouse ercc5 located on mouse chromosome 1 1302205