Cnga3 (cyclic nucleotide gated channel subunit alpha 3) - Rat Genome Database

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Gene: Cnga3 (cyclic nucleotide gated channel subunit alpha 3) Rattus norvegicus
Analyze
Symbol: Cnga3
Name: cyclic nucleotide gated channel subunit alpha 3
RGD ID: 70948
Description: Enables several functions, including cGMP binding activity; cadherin binding activity; and intracellularly cGMP-activated cation channel activity. Involved in several processes, including inorganic cation import across plasma membrane; response to cAMP; and response to magnesium ion. Located in several cellular components, including axon initial segment; glial cell projection; and perikaryon. Human ortholog(s) of this gene implicated in achromatopsia 2 and color blindness. Orthologous to human CNGA3 (cyclic nucleotide gated channel subunit alpha 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; calcium transport pathway; visual phototransduction pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CNG channel alpha-3; CNG-3; CNG3; CNGgust; cone photoreceptor cGMP-gated channel subunit alpha-3; cyclic nucleotide gated channel alpha 3; cyclic nucleotide-gated cation channel alpha-3; cyclic nucleotide-gated channel alpha-3; gustatory cyclic nucleotide-gated cation channel
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,943,353 - 46,989,862 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl946,928,810 - 46,989,862 (+)EnsemblGRCr8
mRatBN7.2939,447,534 - 39,494,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl939,448,034 - 39,493,183 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx947,943,588 - 47,990,097 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0953,066,347 - 53,112,858 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0951,348,230 - 51,394,733 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd950,714,068 - 50,760,570 (+)NCBI
Lyon_Normotensive946,489,477 - 46,535,978 (+)NCBI
Lyon_Hypertensive946,624,825 - 46,671,327 (+)NCBI
F344_StmMcwi948,550,430 - 48,596,949 (+)NCBI
Rnor_6.0943,807,412 - 43,858,225 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl943,807,677 - 43,854,396 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0943,476,297 - 43,497,654 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4936,180,295 - 36,203,098 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera937,227,455 - 37,249,072 (+)NCBICelera
RGSC_v3.1936,181,708 - 36,204,512 (+)NCBI
Cytogenetic Map9q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Calcium signalling remodelling and disease. Berridge MJ Biochem Soc Trans. 2012 Apr;40(2):297-309. doi: 10.1042/BST20110766.
2. Functional expression of the heteromeric "olfactory" cyclic nucleotide-gated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons. Bradley J, etal., J Neurosci 1997 Mar 15;17(6):1993-2005.
3. Localization of olfactory cyclic nucleotide-gated channels in rat gonadotropin-releasing hormone neurons. El-Majdoubi M and Weiner RI, Endocrinology. 2002 Jun;143(6):2441-4.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Distribution of the A3 subunit of the cyclic nucleotide-gated ion channels in the main olfactory bulb of the rat. Gutierrez-Mecinas M, etal., Neuroscience. 2008 Jun 2;153(4):1164-76. Epub 2008 Mar 15.
7. Cyclic nucleotide-gated ion channels. Kaupp UB and Seifert R, Physiol Rev. 2002 Jul;82(3):769-824.
8. Electrophysiological characteristics of rat gustatory cyclic nucleotide--gated channel expressed in Xenopus oocytes. Lee HM, etal., J Neurophysiol. 2001 Jun;85(6):2335-49.
9. A cGMP-signaling pathway in a subset of olfactory sensory neurons. Meyer MR, etal., Proc Natl Acad Sci U S A 2000 Sep 12;97(19):10595-600.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Taste buds have a cyclic nucleotide-activated channel, CNGgust. Misaka T, etal., J Biol Chem 1997 Sep 5;272(36):22623-9.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Modulation of renal CNG-A3 sodium channel in rats subjected to low- and high-sodium diets. Novaira HJ, etal., Biochim Biophys Acta. 2004 Oct 11;1665(1-2):101-10.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Mutations in CNGA3 impair trafficking or function of cone cyclic nucleotide-gated channels, resulting in achromatopsia. Reuter P, etal., Hum Mutat. 2008 Oct;29(10):1228-36. doi: 10.1002/humu.20790.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Cyclic nucleotide-gated channel alpha-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransduction. Selvakumar D, etal., J Biol Chem. 2013 Mar 8;288(10):7215-29. doi: 10.1074/jbc.M112.443226. Epub 2013 Jan 17.
22. Extracellular proton sensing of the rat gustatory cyclic nucleotide-gated channel. Sugita M, etal., Biochem Biophys Res Commun. 2004 Jun 25;319(2):369-74. doi: 10.1016/j.bbrc.2004.05.009.
23. CNGA3 mutations in hereditary cone photoreceptor disorders. Wissinger B, etal., Am J Hum Genet 2001 Oct;69(4):722-37. Epub 2001 Aug 30.
Additional References at PubMed
PMID:10662822   PMID:10813773   PMID:15634774   PMID:21052544   PMID:22248097   PMID:24164424  


Genomics

Comparative Map Data
Cnga3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,943,353 - 46,989,862 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl946,928,810 - 46,989,862 (+)EnsemblGRCr8
mRatBN7.2939,447,534 - 39,494,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl939,448,034 - 39,493,183 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx947,943,588 - 47,990,097 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0953,066,347 - 53,112,858 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0951,348,230 - 51,394,733 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd950,714,068 - 50,760,570 (+)NCBI
Lyon_Normotensive946,489,477 - 46,535,978 (+)NCBI
Lyon_Hypertensive946,624,825 - 46,671,327 (+)NCBI
F344_StmMcwi948,550,430 - 48,596,949 (+)NCBI
Rnor_6.0943,807,412 - 43,858,225 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl943,807,677 - 43,854,396 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0943,476,297 - 43,497,654 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4936,180,295 - 36,203,098 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera937,227,455 - 37,249,072 (+)NCBICelera
RGSC_v3.1936,181,708 - 36,204,512 (+)NCBI
Cytogenetic Map9q21NCBI
CNGA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38298,346,456 - 98,398,601 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl298,346,188 - 98,399,797 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37298,962,919 - 99,015,064 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36298,329,050 - 98,381,496 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34298,444,917 - 98,473,581NCBI
Celera293,166,338 - 93,218,784 (+)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef292,727,722 - 92,780,234 (+)NCBIHuRef
CHM1_1298,966,936 - 99,019,379 (+)NCBICHM1_1
T2T-CHM13v2.0298,804,385 - 98,856,818 (+)NCBIT2T-CHM13v2.0
Cnga3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39137,257,317 - 37,302,465 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl137,253,515 - 37,304,128 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38137,218,241 - 37,263,384 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl137,214,434 - 37,263,384 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37137,276,106 - 37,320,229 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36137,163,807 - 37,207,930 (+)NCBIMGSCv36mm8
Celera136,995,421 - 37,043,436 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map115.46NCBI
Cnga3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554704,884,309 - 4,906,902 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554704,884,054 - 4,907,151 (+)NCBIChiLan1.0ChiLan1.0
CNGA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21230,043,405 - 30,074,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A30,046,167 - 30,077,672 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A100,911,053 - 100,962,278 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A99,259,808 - 99,308,524 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A99,259,808 - 99,308,517 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
CNGA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11044,232,716 - 44,278,555 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1044,234,004 - 44,260,746 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1044,156,508 - 44,183,215 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01045,105,862 - 45,150,463 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1045,104,784 - 45,151,081 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11044,817,459 - 44,844,164 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01045,108,283 - 45,135,227 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01045,284,117 - 45,310,870 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cnga3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11237,572,212 - 37,612,393 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440629284,246,488 - 84,286,560 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367441,514,821 - 1,540,580 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367441,499,431 - 1,537,784 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNGA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl355,874,250 - 55,922,979 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1355,872,607 - 55,936,516 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2358,478,654 - 58,496,156 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNGA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11499,091,254 - 99,177,199 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666041169,587,189 - 169,645,494 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1142,039,281 - 2,124,527 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl142,096,232 - 2,123,231 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Cnga3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247493,458,997 - 3,482,697 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247493,458,991 - 3,483,003 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Cnga3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14113,421,744 - 113,463,733 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Cnga3
370 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:53
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000059706
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
38 106 79 116 1806 91 780 13 19 86 19 27 653 390 99 1748 7 249 393 766 112 112

Sequence


Ensembl Acc Id: ENSRNOT00000081250   ⟹   ENSRNOP00000074533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,943,353 - 46,989,862 (+)Ensembl
mRatBN7.2 Ensembl939,448,034 - 39,492,895 (+)Ensembl
Rnor_6.0 Ensembl943,807,677 - 43,854,108 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081651   ⟹   ENSRNOP00000075614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,928,810 - 46,989,862 (+)Ensembl
mRatBN7.2 Ensembl939,448,034 - 39,492,895 (+)Ensembl
Rnor_6.0 Ensembl943,807,677 - 43,854,108 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084742   ⟹   ENSRNOP00000071309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,966,825 - 46,989,001 (+)Ensembl
mRatBN7.2 Ensembl939,471,007 - 39,493,183 (+)Ensembl
Rnor_6.0 Ensembl943,830,630 - 43,854,396 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085720   ⟹   ENSRNOP00000069613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,928,860 - 46,989,862 (+)Ensembl
mRatBN7.2 Ensembl939,473,956 - 39,493,183 (+)Ensembl
Rnor_6.0 Ensembl943,834,310 - 43,854,108 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089571   ⟹   ENSRNOP00000075524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl943,807,677 - 43,831,286 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139325   ⟹   ENSRNOP00000107668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,943,353 - 46,989,862 (+)Ensembl
RefSeq Acc Id: NM_001398686   ⟹   NP_001385615
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,943,353 - 46,989,862 (+)NCBI
mRatBN7.2939,447,534 - 39,494,044 (+)NCBI
Dahl_SR_JrHsd950,714,068 - 50,760,570 (+)NCBI
Lyon_Normotensive946,489,477 - 46,535,978 (+)NCBI
Lyon_Hypertensive946,624,825 - 46,671,327 (+)NCBI
F344_StmMcwi948,550,430 - 48,596,949 (+)NCBI
RefSeq Acc Id: NM_001398687   ⟹   NP_001385616
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,943,353 - 46,989,862 (+)NCBI
mRatBN7.2939,447,534 - 39,494,044 (+)NCBI
Dahl_SR_JrHsd950,714,068 - 50,760,570 (+)NCBI
Lyon_Normotensive946,489,477 - 46,535,978 (+)NCBI
Lyon_Hypertensive946,624,825 - 46,671,327 (+)NCBI
F344_StmMcwi948,550,430 - 48,596,949 (+)NCBI
Ensembl Acc Id: ENSRNOP00000071309   ⟸   ENSRNOT00000084742
Ensembl Acc Id: ENSRNOP00000075524   ⟸   ENSRNOT00000089571
Ensembl Acc Id: ENSRNOP00000075614   ⟸   ENSRNOT00000081651
Ensembl Acc Id: ENSRNOP00000069613   ⟸   ENSRNOT00000085720
Ensembl Acc Id: ENSRNOP00000074533   ⟸   ENSRNOT00000081250
RefSeq Acc Id: NP_001385615   ⟸   NM_001398686
- Peptide Label: isoform 1
- UniProtKB: Q9QWN7 (UniProtKB/Swiss-Prot),   Q9ER33 (UniProtKB/TrEMBL),   A0A0G2KB16 (UniProtKB/TrEMBL),   A0A0G2JVT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385616   ⟸   NM_001398687
- Peptide Label: isoform 2
- UniProtKB: Q9ER32 (UniProtKB/TrEMBL),   A0A0G2K8A7 (UniProtKB/TrEMBL),   A0A0G2K054 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107668   ⟸   ENSRNOT00000139325
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ER33-F1-model_v2 AlphaFold Q9ER33 1-670 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70948 AgrOrtholog
BioCyc Gene G2FUF-27791 BioCyc
Ensembl Genes ENSRNOG00000051950 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055018398 UniProtKB/Swiss-Prot
  ENSRNOG00060020621 UniProtKB/Swiss-Prot
  ENSRNOG00065029178 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000081250 ENTREZGENE
  ENSRNOT00000084742.3 UniProtKB/Swiss-Prot
  ENSRNOT00000139325 ENTREZGENE
  ENSRNOT00000139325.1 UniProtKB/Swiss-Prot
  ENSRNOT00055031261 UniProtKB/Swiss-Prot
  ENSRNOT00060035880 UniProtKB/Swiss-Prot
  ENSRNOT00065050478 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.5.300 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/Swiss-Prot
  Jelly Rolls UniProtKB/Swiss-Prot
InterPro CLZ_dom UniProtKB/Swiss-Prot
  CNG_Cation_Channel UniProtKB/Swiss-Prot
  cNMP-bd_CS UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  cNMP-bd_dom_sf UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report rno:85257 UniProtKB/Swiss-Prot
NCBI Gene 85257 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3 UniProtKB/Swiss-Prot
  CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A UniProtKB/Swiss-Prot
Pfam CLZ UniProtKB/Swiss-Prot
  cNMP_binding UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PhenoGen Cnga3 PhenoGen
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot
  CNMP_BINDING_2 UniProtKB/Swiss-Prot
  CNMP_BINDING_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051950 RatGTEx
  ENSRNOG00055018398 RatGTEx
  ENSRNOG00060020621 RatGTEx
  ENSRNOG00065029178 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
Superfamily-SCOP cAMP-binding domain-like UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0G2JVT7 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K054 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K8A7 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KB16 ENTREZGENE, UniProtKB/TrEMBL
  A0ACJ1MG87_RAT UniProtKB/TrEMBL
  CNGA3_RAT UniProtKB/Swiss-Prot
  Q9ER32 ENTREZGENE, UniProtKB/TrEMBL
  Q9ER33 ENTREZGENE
  Q9QWN7 ENTREZGENE
UniProt Secondary Q9QWN7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-02 Cnga3  cyclic nucleotide gated channel subunit alpha 3  Cnga3  cyclic nucleotide gated channel alpha 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cnga3  cyclic nucleotide gated channel alpha 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains six membrane-spanning segments,a pore-forming region that may determine ion permeability, and a cyclic nucleotide-binding domain 70687
gene_expression expressed in rat tongue epithelia 70687