RGD Reference Report - Calcium signalling remodelling and disease. - Rat Genome Database

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Calcium signalling remodelling and disease.

Authors: Berridge, MJ 
Citation: Berridge MJ Biochem Soc Trans. 2012 Apr;40(2):297-309. doi: 10.1042/BST20110766.
RGD ID: 7204690
Pubmed: PMID:22435804   (View Abstract at PubMed)
DOI: DOI:10.1042/BST20110766   (Journal Full-text)

A wide range of Ca2+ signalling systems deliver the spatial and temporal Ca2+ signals necessary to control the specific functions of different cell types. Release of Ca2+ by InsP3 (inositol 1,4,5-trisphosphate) plays a central role in many of these signalling systems. Ongoing transcriptional processes maintain the integrity and stability of these cell-specific signalling systems. However, these homoeostatic systems are highly plastic and can undergo a process of phenotypic remodelling, resulting in the Ca2+ signals being set either too high or too low. Such subtle dysregulation of Ca2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CNGA1Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
CNGA2Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
CNGA3Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
CNGA4Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
CNGB1Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
CNGB3Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
Cnga1Ratcalcium/calcium-mediated signaling pathway   ISOCNGA1 (Homo sapiens) RGD 
Cnga1Mousecalcium/calcium-mediated signaling pathway   ISOCNGA1 (Homo sapiens) RGD 
Cnga2Ratcalcium/calcium-mediated signaling pathway   ISOCNGA2 (Homo sapiens) RGD 
Cnga2Mousecalcium/calcium-mediated signaling pathway   ISOCNGA2 (Homo sapiens) RGD 
Cnga3Ratcalcium/calcium-mediated signaling pathway   ISOCNGA3 (Homo sapiens) RGD 
Cnga3Mousecalcium/calcium-mediated signaling pathway   ISOCNGA3 (Homo sapiens) RGD 
Cnga4Ratcalcium/calcium-mediated signaling pathway   ISOCNGA4 (Homo sapiens) RGD 
Cnga4Mousecalcium/calcium-mediated signaling pathway   ISOCNGA4 (Homo sapiens) RGD 
Cngb1Ratcalcium/calcium-mediated signaling pathway   ISOCNGB1 (Homo sapiens) RGD 
Cngb1Mousecalcium/calcium-mediated signaling pathway   ISOCNGB1 (Homo sapiens) RGD 
Cngb3Mousecalcium/calcium-mediated signaling pathway   ISOCNGB3 (Homo sapiens) RGD 
Cngb3Ratcalcium/calcium-mediated signaling pathway   ISOCNGB3 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Cnga1  (cyclic nucleotide gated channel subunit alpha 1)
Cnga2  (cyclic nucleotide gated channel subunit alpha 2)
Cnga3  (cyclic nucleotide gated channel subunit alpha 3)
Cnga4  (cyclic nucleotide gated channel subunit alpha 4)
Cngb1  (cyclic nucleotide gated channel subunit beta 1)
Cngb3  (cyclic nucleotide gated channel subunit beta 3)

Genes (Mus musculus)
Cnga1  (cyclic nucleotide gated channel alpha 1)
Cnga2  (cyclic nucleotide gated channel alpha 2)
Cnga3  (cyclic nucleotide gated channel alpha 3)
Cnga4  (cyclic nucleotide gated channel alpha 4)
Cngb1  (cyclic nucleotide gated channel beta 1)
Cngb3  (cyclic nucleotide gated channel beta 3)

Genes (Homo sapiens)
CNGA1  (cyclic nucleotide gated channel subunit alpha 1)
CNGA2  (cyclic nucleotide gated channel subunit alpha 2)
CNGA3  (cyclic nucleotide gated channel subunit alpha 3)
CNGA4  (cyclic nucleotide gated channel subunit alpha 4)
CNGB1  (cyclic nucleotide gated channel subunit beta 1)
CNGB3  (cyclic nucleotide gated channel subunit beta 3)


Additional Information