Cnga1 (cyclic nucleotide gated channel subunit alpha 1) - Rat Genome Database

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Gene: Cnga1 (cyclic nucleotide gated channel subunit alpha 1) Rattus norvegicus
Symbol: Cnga1
Name: cyclic nucleotide gated channel subunit alpha 1
RGD ID: 621815
Description: Enables cGMP binding activity and intracellular cGMP-activated cation channel activity. Involved in membrane depolarization; regulation of cytosolic calcium ion concentration; and spermatogenesis. Located in terminal bouton. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 49. Orthologous to human CNGA1 (cyclic nucleotide gated channel subunit alpha 1); PARTICIPATES IN altered visual phototransduction pathway; calcium/calcium-mediated signaling pathway; retinitis pigmentosa pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cGMP-gated cation channel alpha-1; Cncg; CNG channel alpha-1; CNG-1; CNG1; cyclic nucleotide gated channel alpha 1; cyclic nucleotide-gated cation channel; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel alpha-1; cyclic nucleotide-gated channel, photoreceptor; HCN; rod photoreceptor cGMP-gated channel subunit alpha
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81435,920,948 - 35,959,065 (+)NCBIGRCr8
mRatBN7.21435,566,947 - 35,605,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,567,125 - 35,605,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1435,932,350 - 35,970,416 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,237,096 - 37,275,170 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,725,471 - 35,763,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,155,771 - 38,171,107 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,155,759 - 38,171,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01437,966,503 - 37,981,839 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41438,017,762 - 38,033,098 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11438,021,111 - 38,036,448 (+)NCBI
Celera1434,842,269 - 34,857,640 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Calcium signalling remodelling and disease. Berridge MJ Biochem Soc Trans. 2012 Apr;40(2):297-309. doi: 10.1042/BST20110766.
2. Functional expression of the heteromeric "olfactory" cyclic nucleotide-gated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons. Bradley J, etal., J Neurosci 1997 Mar 15;17(6):1993-2005.
3. Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. Brewster A, etal., J Neurosci 2002 Jun 1;22(11):4591-9.
4. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
5. Cloning and widespread distribution of the rat rod-type cyclic nucleotide-gated cation channel. Ding C, etal., Am J Physiol 1997 Apr;272(4 Pt 1):C1335-44.
6. Expression of subunits for the cAMP-sensitive 'olfactory' cyclic nucleotide-gated ion channel in the cochlea: implications for signal transduction. Drescher MJ, etal., Brain Res Mol Brain Res 2002 Jan 31;98(1-2):1-14.
7. Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa. Dryja TP, etal., Proc Natl Acad Sci U S A 1995 Oct 24;92(22):10177-81.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Cyclic nucleotide-gated ion channels. Kaupp UB and Seifert R, Physiol Rev. 2002 Jul;82(3):769-824.
11. Functional cGMP-gated channels in cerebellar granule cells. Lopez-Jimenez ME, etal., J Cell Physiol. 2012 May;227(5):2252-63. doi: 10.1002/jcp.22964.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Functional role of cyclic nucleotide-gated channels in rat medial vestibular nucleus neurons. Podda MV, etal., J Physiol. 2008 Feb 1;586(3):803-15. Epub 2007 Nov 29.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. NO activates the olfactory cyclic nucleotide-gated conductance independent from cGMP in isolated rat olfactory receptor neurons. Schmachtenberg O, etal., Brain Res 2003 Aug 1;980(1):146-50.
21. Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis. Shi F, etal., J Androl. 2005 Mar-Apr;26(2):258-63.
22. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, etal., Nat Rev Genet. 2010 Apr;11(4):273-84. doi: 10.1038/nrg2717.
23. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry. Zhong H, etal., Nature 2002 Nov 14;420(6912):193-8.
Additional References at PubMed
PMID:8860239   PMID:10725384   PMID:14681019   PMID:15634774   PMID:16272883   PMID:16940558   PMID:18565991   PMID:18654668   PMID:18850083   PMID:20592197   PMID:20890309   PMID:21559843  
PMID:22759964   PMID:23032687   PMID:25633097   PMID:37889366  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81435,920,948 - 35,959,065 (+)NCBIGRCr8
mRatBN7.21435,566,947 - 35,605,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1435,567,125 - 35,605,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1435,932,350 - 35,970,416 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,237,096 - 37,275,170 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01435,725,471 - 35,763,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,155,771 - 38,171,107 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,155,759 - 38,171,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01437,966,503 - 37,981,839 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41438,017,762 - 38,033,098 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11438,021,111 - 38,036,448 (+)NCBI
Celera1434,842,269 - 34,857,640 (+)NCBICelera
Cytogenetic Map14p11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38447,935,977 - 48,016,681 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl447,935,977 - 48,016,681 (-)EnsemblGRCh38hg38GRCh38
GRCh37447,937,994 - 48,018,698 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36447,632,751 - 47,649,483 (-)NCBINCBI36Build 36hg18NCBI36
Build 34447,778,958 - 47,824,359NCBI
Celera448,386,872 - 48,463,813 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef447,257,564 - 47,334,503 (-)NCBIHuRef
CHM1_1447,937,102 - 48,014,053 (-)NCBICHM1_1
T2T-CHM13v2.0447,903,221 - 47,983,754 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39572,761,039 - 72,800,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl572,761,039 - 72,801,618 (-)EnsemblGRCm39 Ensembl
GRCm38572,603,696 - 72,642,752 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl572,603,696 - 72,644,275 (-)EnsemblGRCm38mm10GRCm38
MGSCv37572,994,935 - 73,033,991 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36572,882,866 - 72,898,284 (-)NCBIMGSCv36mm8
Celera569,852,095 - 69,891,530 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.44NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955443639,096 - 649,606 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955443615,061 - 649,693 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2379,844,967 - 79,929,771 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1480,106,473 - 80,186,832 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0474,196,877 - 74,213,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1484,865,999 - 84,945,692 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl484,910,653 - 84,945,248 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11343,831,159 - 43,864,276 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1343,831,163 - 43,864,276 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1343,783,705 - 43,816,818 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01344,430,864 - 44,464,133 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1344,430,868 - 44,464,133 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11344,108,422 - 44,141,536 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01343,640,294 - 43,673,581 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01344,523,433 - 44,556,694 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440528532,190,442 - 32,206,819 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648214,091,913 - 14,107,787 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648214,091,343 - 14,107,793 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl837,896,459 - 37,969,344 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1837,896,460 - 37,968,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2839,950,659 - 39,971,201 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1272,273,540 - 2,313,083 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl272,293,765 - 2,312,761 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604748,276,917 - 48,325,283 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476118,992,384 - 19,004,202 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476118,992,372 - 19,004,247 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cnga1
372 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:24
Interacting mature miRNAs:25
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,589,400 - 35,590,305 (+)MAPPERmRatBN7.2
Rnor_6.01438,155,781 - 38,156,685NCBIRnor6.0
Rnor_5.01437,966,513 - 37,967,417UniSTSRnor5.0
RGSC_v3.41438,017,772 - 38,018,676UniSTSRGSC3.4
Celera1434,842,279 - 34,843,183UniSTS
Cytogenetic Map14p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21435,604,683 - 35,604,880 (+)MAPPERmRatBN7.2
Rnor_6.01438,171,063 - 38,171,259NCBIRnor6.0
Rnor_5.01437,981,795 - 37,981,991UniSTSRnor5.0
RGSC_v3.41438,033,054 - 38,033,250UniSTSRGSC3.4
Celera1434,857,596 - 34,857,792UniSTS
Cytogenetic Map14p11UniSTS

Related Rat Strains
The following Strains have been annotated to Cnga1


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
Medium 7
Low 1 14 8 45 20 1
Below cutoff 2 2 10 23 15 10 6


RefSeq Acc Id: ENSRNOT00000006469   ⟹   ENSRNOP00000006469
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1435,567,125 - 35,605,065 (+)Ensembl
Rnor_6.0 Ensembl1438,155,759 - 38,171,010 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104815   ⟹   ENSRNOP00000079731
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1435,567,125 - 35,605,065 (+)Ensembl
RefSeq Acc Id: NM_053497   ⟹   NP_445949
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81435,920,948 - 35,959,065 (+)NCBI
mRatBN7.21435,566,947 - 35,605,065 (+)NCBI
Rnor_6.01438,155,771 - 38,171,107 (+)NCBI
Rnor_5.01437,966,503 - 37,981,839 (+)NCBI
RGSC_v3.41438,017,762 - 38,033,098 (+)RGD
Celera1434,842,269 - 34,857,640 (+)RGD
RefSeq Acc Id: XM_039092516   ⟹   XP_038948444
Rat AssemblyChrPosition (strand)Source
GRCr81435,942,894 - 35,959,060 (+)NCBI
mRatBN7.21435,589,082 - 35,605,065 (+)NCBI
RefSeq Acc Id: NP_445949   ⟸   NM_053497
- UniProtKB: Q62927 (UniProtKB/Swiss-Prot),   O08659 (UniProtKB/Swiss-Prot),   F1LQN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006469   ⟸   ENSRNOT00000006469
RefSeq Acc Id: XP_038948444   ⟸   XM_039092516
- Peptide Label: isoform X1
- UniProtKB: Q62927 (UniProtKB/Swiss-Prot),   O08659 (UniProtKB/Swiss-Prot),   F1LQN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079731   ⟸   ENSRNOT00000104815
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62927-F1-model_v2 AlphaFold Q62927 1-683 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621815 AgrOrtholog
BioCyc Gene G2FUF-15851 BioCyc
Ensembl Genes ENSRNOG00000004778 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006469 ENTREZGENE
  ENSRNOT00000006469.5 UniProtKB/TrEMBL
  ENSRNOT00000104815.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CLZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85259 UniProtKB/Swiss-Prot
  PTHR45638:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnga1 PhenoGen
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004778 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZP66_RAT UniProtKB/TrEMBL
  CNGA1_RAT UniProtKB/Swiss-Prot
UniProt Secondary O08659 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-02 Cnga1  cyclic nucleotide gated channel subunit alpha 1  Cnga1  cyclic nucleotide gated channel alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cnga1  cyclic nucleotide gated channel alpha 1    cyclic nucleotide-gated cation channel  Name updated 1299863 APPROVED
2004-09-10 Cnga1  cyclic nucleotide-gated cation channel  Cncg    Symbol and Name updated 1299863 APPROVED
2002-08-07 Cncg  cyclic nucleotide-gated cation channel      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease contains a leucine-zipper-homology domain named CLZ and mediates an inter-subunit interaction 632402
gene_disease associated with febrile seizures and limbic epilepsy 625755
gene_expression mRNA and protein expression seen early on postnatal day 2 and showed age specific changes in hippocampus and during the developmental phase of hippocampal connectivity 625755
gene_expression expressed in neurons of brain, hippocampus and heart 625755
gene_expression mRNA and proteins are expressed in isoform specific and neuron selective manner 625755
gene_process role in mediation of hyperpolarization-activated currents, mediates neuronal membrane potential involved in pacemaker activity, and promotes synchronization of thalamus and hippocampal neuronal networks 625755
gene_regulation regulated by constant hippocampal circuit activity in a duration dependent manner 625755
gene_regulation transcriptional regulation is associated with excitability of the hippocampal network and in heart is regulated by thyroid hormone 625755