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Gene: Myo7a (myosin VIIA) Rattus norvegicus
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Symbol: Myo7a
Name: myosin VIIA
Description: Exhibits several functions, including adenyl ribonucleotide binding activity; calmodulin binding activity; and nucleoside-triphosphatase activity. Involved in actin filament-based movement. Localizes to several cellular components, including the microvillus; myosin VII complex; and upper tip-link density. Used to study Usher syndrome. Human ortholog(s) of this gene implicated in Usher syndrome (multiple); auditory system disease (multiple); and eye disease (multiple). Orthologous to human MYO7A (myosin VIIA); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)); myosin-VIIa; unconventional myosin-VIIa
Orthologs:
Homo sapiens (human) : MYO7A (myosin VIIA)  HGNC  Alliance
Mus musculus (house mouse) : Myo7a (myosin VIIA)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myo7a (myosin VIIA)
Pan paniscus (bonobo/pygmy chimpanzee) : MYO7A (myosin VIIA)
Canis lupus familiaris (dog) : MYO7A (myosin VIIA)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myo7a (myosin VIIA)
Sus scrofa (pig) : MYO7A (myosin VIIA)
more info ...
Allele / Splice: Myo7atnd/Hubr  
Genetic Models: W-Myo7atnd/Hubr
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01163,001,313 - 163,071,545 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01169,206,150 - 169,276,706 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,292,620 - 155,362,698 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11155,371,025 - 155,441,104 (-)NCBI
Celera1150,435,342 - 150,505,024 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Myo7a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628830
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.