Cnga4 (cyclic nucleotide gated channel subunit alpha 4) - Rat Genome Database

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Gene: Cnga4 (cyclic nucleotide gated channel subunit alpha 4) Rattus norvegicus
Analyze
Symbol: Cnga4
Name: cyclic nucleotide gated channel subunit alpha 4
RGD ID: 619844
Description: Enables cGMP binding activity; intracellular cAMP-activated cation channel activity; and intracellular cGMP-activated cation channel activity. Predicted to be involved in monoatomic cation transmembrane transport. Predicted to act upstream of or within sensory perception of smell. Located in perikaryon and plasma membrane. Part of intracellular cyclic nucleotide activated cation channel complex. Orthologous to human CNGA4 (cyclic nucleotide gated channel subunit alpha 4); PARTICIPATES IN calcium/calcium-mediated signaling pathway; calcium transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cgn2; CNCalpha4, CNG5; CNG channel alpha-4; CNG-4; CNG4; cyclic nucleotide gated cation channel; cyclic nucleotide gated channel alpha 4; cyclic nucleotide-gated cation channel alpha 4; cyclic nucleotide-gated cation channel alpha-4; cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated olfactory channel subunit OCNC2; olfactory cyclic nucleotide-gated channel; rOCNC2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Gluco13  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21159,752,357 - 159,756,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,752,357 - 159,756,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1167,773,767 - 167,777,745 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01174,959,758 - 174,963,736 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01167,855,020 - 167,858,998 (+)NCBIRnor_WKY
Rnor_6.01170,238,959 - 170,246,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,242,846 - 170,246,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,245,757 - 177,253,787 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,137,544 - 163,141,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,233,020 - 163,237,158 (+)NCBI
Celera1157,687,159 - 157,691,171 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Calcium signalling remodelling and disease. Berridge MJ Biochem Soc Trans. 2012 Apr;40(2):297-309. doi: 10.1042/BST20110766.
2. Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Bradley J, etal., Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8890-4.
3. Nomenclature for ion channel subunits. Bradley J, etal., Science 2001 Dec 7;294(5549):2095-6.
4. Localization of olfactory cyclic nucleotide-gated channels in rat gonadotropin-releasing hormone neurons. El-Majdoubi M and Weiner RI, Endocrinology. 2002 Jun;143(6):2441-4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Cyclic nucleotide-gated ion channels. Kaupp UB and Seifert R, Physiol Rev. 2002 Jul;82(3):769-824.
7. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Liman ER and Buck LB, Neuron 1994 Sep;13(3):611-21.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels. Nache V, etal., Sci Signal. 2012 Jul 10;5(232):ra48. doi: 10.1126/scisignal.2003110.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry. Zhong H, etal., Nature 2002 Nov 14;420(6912):193-8.
Additional References at PubMed
PMID:9045728   PMID:11739959   PMID:12649326  


Genomics

Comparative Map Data
Cnga4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21159,752,357 - 159,756,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,752,357 - 159,756,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1167,773,767 - 167,777,745 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01174,959,758 - 174,963,736 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01167,855,020 - 167,858,998 (+)NCBIRnor_WKY
Rnor_6.01170,238,959 - 170,246,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,242,846 - 170,246,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,245,757 - 177,253,787 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,137,544 - 163,141,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,233,020 - 163,237,158 (+)NCBI
Celera1157,687,159 - 157,691,171 (+)NCBICelera
Cytogenetic Map1q32NCBI
CNGA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,234,793 - 6,244,976 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl116,234,765 - 6,244,479 (+)EnsemblGRCh38hg38GRCh38
GRCh37116,260,319 - 6,265,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,216,910 - 6,222,235 (+)NCBINCBI36Build 36hg18NCBI36
Celera116,379,405 - 6,384,782 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef115,920,393 - 5,925,778 (+)NCBIHuRef
CHM1_1116,259,550 - 6,264,935 (+)NCBICHM1_1
T2T-CHM13v2.0116,297,536 - 6,302,926 (+)NCBIT2T-CHM13v2.0
Cnga4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,049,247 - 105,057,981 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7105,053,775 - 105,057,949 (+)EnsemblGRCm39 Ensembl
GRCm387105,400,024 - 105,408,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,404,568 - 105,408,742 (+)EnsemblGRCm38mm10GRCm38
MGSCv377112,553,082 - 112,557,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,278,389 - 105,282,559 (+)NCBIMGSCv36mm8
Celera7105,676,665 - 105,680,835 (+)NCBICelera
Cytogenetic Map7E3NCBI
Cnga4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541421,977,996 - 21,986,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541421,977,996 - 21,986,349 (+)NCBIChiLan1.0ChiLan1.0
CNGA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,051,091 - 6,061,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,051,091 - 6,061,550 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0116,368,768 - 6,378,976 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CNGA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,575,140 - 29,581,721 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,575,578 - 29,580,616 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,273,213 - 29,293,243 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02130,397,346 - 30,417,377 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2130,402,030 - 30,407,489 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12129,722,659 - 29,738,374 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02129,884,350 - 29,904,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02130,078,976 - 30,098,988 (+)NCBIUU_Cfam_GSD_1.0
Cnga4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494756,360,294 - 56,369,005 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936842310,741 - 314,754 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936842310,741 - 314,754 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNGA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,431,340 - 3,442,426 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,430,995 - 3,438,411 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.294,133,006 - 4,138,939 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNGA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,581,702 - 58,592,733 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,582,175 - 58,588,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038156,418,620 - 156,428,468 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnga4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248177,719,332 - 7,737,336 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248177,716,951 - 7,732,177 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnga4
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:155
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000023751
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383635Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat

Markers in Region
D1Wox52  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21159,755,864 - 159,756,222 (+)MAPPERmRatBN7.2
Rnor_6.01170,246,354 - 170,246,711NCBIRnor6.0
Rnor_5.01177,253,180 - 177,253,537UniSTSRnor5.0
RGSC_v3.41163,141,052 - 163,141,409UniSTSRGSC3.4
Celera1157,690,667 - 157,691,024UniSTS
Cytogenetic Map1q33UniSTS
RH135288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21159,756,488 - 159,756,674 (+)MAPPERmRatBN7.2
Rnor_6.01170,246,978 - 170,247,163NCBIRnor6.0
Rnor_5.01177,253,804 - 177,253,989UniSTSRnor5.0
RGSC_v3.41163,141,676 - 163,141,861UniSTSRGSC3.4
Celera1157,691,291 - 157,691,476UniSTS
RH 3.4 Map11296.3UniSTS
Cytogenetic Map1q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 1 1 14 14 1 10 4 15 10
Below cutoff 2 12 12 10 5 10 8 9 4 7 11 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023751   ⟹   ENSRNOP00000023751
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1159,752,357 - 159,756,375 (+)Ensembl
Rnor_6.0 Ensembl1170,242,846 - 170,246,858 (+)Ensembl
RefSeq Acc Id: NM_053496   ⟹   NP_445948
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21159,752,357 - 159,756,369 (+)NCBI
Rnor_6.01170,242,846 - 170,246,858 (+)NCBI
Rnor_5.01177,245,757 - 177,253,787 (+)NCBI
RGSC_v3.41163,137,544 - 163,141,556 (+)RGD
Celera1157,687,159 - 157,691,171 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445948   ⟸   NM_053496
- UniProtKB: Q64359 (UniProtKB/Swiss-Prot),   G3V898 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023751   ⟸   ENSRNOT00000023751
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64359-F1-model_v2 AlphaFold Q64359 1-575 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619844 AgrOrtholog
BioCyc Gene G2FUF-58022 BioCyc
Ensembl Genes ENSRNOG00000017609 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023751 ENTREZGENE
  ENSRNOP00000023751.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023751 ENTREZGENE
  ENSRNOT00000023751.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CLZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85258 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 85258 ENTREZGENE
Pfam CLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnga4 PhenoGen
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CNGA4_RAT UniProtKB/Swiss-Prot
  G3V898 ENTREZGENE, UniProtKB/TrEMBL
  Q64359 ENTREZGENE
UniProt Secondary Q6Q2I4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-02 Cnga4  cyclic nucleotide gated channel subunit alpha 4  Cnga4  cyclic nucleotide gated channel alpha 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Cnga4  cyclic nucleotide gated channel alpha 4  rOCNC2  hypothetical gene supported by NM_053496  Data Merged 1643240 APPROVED
2006-11-19 rOCNC2  hypothetical gene supported by NM_053496      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Cnga4  cyclic nucleotide gated channel alpha 4  Cgn2  cyclic nucleotide gated cation channel  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cgn2        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation must be coexpressed with cyclic nucleotide-gated (CNG) ion channel subunit CNC1 for channel activity 632401