Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Plcd4 | Rat | (S)-nicotine | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Nicotine results in decreased expression of PLCD4 mRNA | CTD | PMID:21955143 | Plcd4 | Rat | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PLCD4 mRNA | CTD | PMID:27840820 | Plcd4 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PLCD4 mRNA | CTD | PMID:17942748 | Plcd4 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Plcd4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLCD4 mRNA | CTD | PMID:17942748 | Plcd4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Plcd4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLCD4 mRNA | CTD | PMID:17942748 | Plcd4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLCD4 mRNA | CTD | PMID:33387578 | Plcd4 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Plcd4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PLCD4 mRNA | CTD | PMID:20188158 | Plcd4 | Rat | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of PLCD4 mRNA | CTD | PMID:18648102 | Plcd4 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of PLCD4 mRNA | CTD | PMID:30951980 | Plcd4 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PLCD4 mRNA | CTD | PMID:25825206 | Plcd4 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of PLCD4 mRNA | CTD | PMID:31881176 | Plcd4 | Rat | acetylsalicylic acid | increases expression | EXP | | 6480464 | Aspirin results in increased expression of PLCD4 mRNA | CTD | PMID:12800193 | Plcd4 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of PLCD4 mRNA | CTD | PMID:28959563 | Plcd4 | Rat | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of PLCD4 mRNA | CTD | PMID:23630614 | Plcd4 | Rat | Aflatoxin B2 alpha | decreases methylation | ISO | PLCD4 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of PLCD4 intron | CTD | PMID:30157460 | Plcd4 | Rat | alpha-Zearalanol | decreases expression | EXP | | 6480464 | Zeranol results in decreased expression of PLCD4 mRNA | CTD | PMID:35163327 | Plcd4 | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PLCD4 mRNA | CTD | PMID:35163327 | Plcd4 | Rat | amitriptyline | decreases expression | EXP | | 6480464 | Amitriptyline results in decreased expression of PLCD4 mRNA | CTD | PMID:22341215 | Plcd4 | Rat | anthocyanin | increases expression | EXP | | 6480464 | Anthocyanins results in increased expression of PLCD4 mRNA | CTD | PMID:18803703 | Plcd4 | Rat | aristolochic acid A | increases expression | ISO | PLCD4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of PLCD4 mRNA | CTD | PMID:33212167 | Plcd4 | Rat | arsane | multiple interactions | ISO | Plcd4 (Mus musculus) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PLCD4 mRNA | CTD | PMID:32045263 | Plcd4 | Rat | arsenic atom | multiple interactions | ISO | Plcd4 (Mus musculus) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PLCD4 mRNA | CTD | PMID:32045263 | Plcd4 | Rat | atrazine | decreases expression | ISO | PLCD4 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of PLCD4 mRNA | CTD | PMID:22378314 | Plcd4 | Rat | benzo[a]pyrene | increases mutagenesis | ISO | PLCD4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of PLCD4 gene | CTD | PMID:25435355 | Plcd4 | Rat | benzo[a]pyrene | increases methylation | ISO | PLCD4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PLCD4 5' UTR | CTD | PMID:27901495 | Plcd4 | Rat | benzo[a]pyrene | affects methylation | ISO | PLCD4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PLCD4 intron | CTD | PMID:30157460 | Plcd4 | Rat | benzo[a]pyrene | decreases methylation | ISO | Plcd4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of PLCD4 intron | CTD | PMID:27901495 | Plcd4 | Rat | benzo[a]pyrene | multiple interactions | ISO | Plcd4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCD4 mRNA | CTD | PMID:27858113 | Plcd4 | Rat | benzo[a]pyrene | increases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PLCD4 mRNA | CTD | PMID:22610609 | Plcd4 | Rat | benzo[b]fluoranthene | increases expression | ISO | Plcd4 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of PLCD4 mRNA | CTD | PMID:26377693 | Plcd4 | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Plcd4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCD4 mRNA | CTD | PMID:27858113 | Plcd4 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PLCD4 mRNA | CTD | PMID:25181051 more ... | Plcd4 | Rat | bisphenol A | decreases methylation | ISO | PLCD4 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of PLCD4 gene | CTD | PMID:31601247 | Plcd4 | Rat | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of PLCD4 gene | CTD | PMID:28505145 | Plcd4 | Rat | bisphenol F | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of PLCD4 mRNA | CTD | PMID:30951980 | Plcd4 | Rat | butanal | decreases expression | ISO | PLCD4 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of PLCD4 mRNA | CTD | PMID:26079696 | Plcd4 | Rat | cadmium atom | multiple interactions | ISO | PLCD4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PLCD4 mRNA | CTD | PMID:35301059 | Plcd4 | Rat | cadmium dichloride | increases expression | ISO | PLCD4 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of PLCD4 mRNA | CTD | PMID:38568856 | Plcd4 | Rat | cadmium dichloride | multiple interactions | ISO | PLCD4 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PLCD4 mRNA | CTD | PMID:35301059 | Plcd4 | Rat | chlordecone | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Chlordecone results in decreased expression of PLCD4 mRNA | CTD | PMID:29980752 | Plcd4 | Rat | chrysene | multiple interactions | ISO | Plcd4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCD4 mRNA | CTD | PMID:27858113 | Plcd4 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of PLCD4 mRNA | CTD | PMID:26033743 | Plcd4 | Rat | copper atom | multiple interactions | ISO | PLCD4 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of PLCD4 mRNA | CTD | PMID:30911355 | Plcd4 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of PLCD4 mRNA | CTD | PMID:26033743 | Plcd4 | Rat | copper(0) | multiple interactions | ISO | PLCD4 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of PLCD4 mRNA | CTD | PMID:30911355 | Plcd4 | Rat | dexamethasone | decreases expression | EXP | | 6480464 | Dexamethasone results in decreased expression of PLCD4 mRNA | CTD | PMID:14618091 | Plcd4 | Rat | dibenz[a,h]anthracene | increases expression | ISO | Plcd4 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | Plcd4 | Rat | Dibutyl phosphate | affects expression | ISO | PLCD4 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PLCD4 mRNA | CTD | PMID:37042841 | Plcd4 | Rat | dichloroacetic acid | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Dichloroacetic Acid results in decreased expression of PLCD4 mRNA | CTD | PMID:28962523 | Plcd4 | Rat | dicrotophos | increases expression | ISO | PLCD4 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of PLCD4 mRNA | CTD | PMID:28302478 | Plcd4 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron metabolite results in decreased expression of PLCD4 mRNA | CTD | PMID:24172598 | Plcd4 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of PLCD4 mRNA | CTD | PMID:29391264 | Plcd4 | Rat | ethanol | increases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Ethanol results in increased expression of PLCD4 mRNA | CTD | PMID:21955143 and PMID:30319688 | Plcd4 | Rat | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of PLCD4 mRNA | CTD | PMID:30307764 | Plcd4 | Rat | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of PLCD4 mRNA | CTD | PMID:18035473 | Plcd4 | Rat | folic acid | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PLCD4 mRNA | CTD | PMID:25629700 | Plcd4 | Rat | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of PLCD4 gene | CTD | PMID:22079235 | Plcd4 | Rat | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of PLCD4 mRNA | CTD | PMID:21782745 | Plcd4 | Rat | genistein | increases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Genistein results in increased expression of PLCD4 mRNA | CTD | PMID:32186404 | Plcd4 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PLCD4 mRNA | CTD | PMID:33387578 | Plcd4 | Rat | glufosinate | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | phosphinothricin results in decreased expression of PLCD4 mRNA | CTD | PMID:34597628 | Plcd4 | Rat | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of PLCD4 mRNA | CTD | PMID:20080153 | Plcd4 | Rat | morphine | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Morphine results in decreased expression of PLCD4 mRNA | CTD | PMID:21955143 | Plcd4 | Rat | N-Nitrosopyrrolidine | increases expression | ISO | PLCD4 (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in increased expression of PLCD4 mRNA | CTD | PMID:32234424 | Plcd4 | Rat | nicotine | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | Nicotine results in decreased expression of PLCD4 mRNA | CTD | PMID:21955143 | Plcd4 | Rat | paracetamol | increases expression | ISO | PLCD4 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PLCD4 mRNA | CTD | PMID:26690555 | Plcd4 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PLCD4 mRNA | CTD | PMID:33387578 | Plcd4 | Rat | perfluorooctane-1-sulfonic acid | decreases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased expression of PLCD4 mRNA | CTD | PMID:20136073 | Plcd4 | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PLCD4 mRNA | CTD | PMID:35163327 | Plcd4 | Rat | pirinixic acid | multiple interactions | ISO | PLCD4 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLCD4 mRNA | CTD | PMID:19710929 | Plcd4 | Rat | pirinixic acid | increases expression | ISO | Plcd4 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PLCD4 mRNA | CTD | PMID:20813756 | Plcd4 | Rat | resveratrol | multiple interactions | ISO | PLCD4 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of PLCD4 mRNA | CTD | PMID:23557933 | Plcd4 | Rat | silicon dioxide | decreases expression | ISO | PLCD4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of PLCD4 mRNA | CTD | PMID:25895662 | Plcd4 | Rat | sodium arsenite | multiple interactions | ISO | Plcd4 (Mus musculus) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PLCD4 mRNA | CTD | PMID:32045263 | Plcd4 | Rat | sodium arsenite | decreases expression | ISO | Plcd4 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of PLCD4 mRNA | CTD | PMID:37682722 | Plcd4 | Rat | tetraphene | multiple interactions | ISO | Plcd4 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCD4 mRNA | CTD | PMID:27858113 | Plcd4 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PLCD4 mRNA | CTD | PMID:34492290 | Plcd4 | Rat | topiramate | decreases expression | EXP | | 6480464 | topiramate results in decreased expression of PLCD4 mRNA | CTD | PMID:16979414 | Plcd4 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of PLCD4 mRNA | CTD | PMID:33387578 | Plcd4 | Rat | triptonide | increases expression | ISO | Plcd4 (Mus musculus) | 6480464 | triptonide results in increased expression of PLCD4 mRNA | CTD | PMID:33045310 | Plcd4 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of PLCD4 mRNA | CTD | PMID:23034163 | Plcd4 | Rat | zoledronic acid | decreases expression | ISO | PLCD4 (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of PLCD4 mRNA | CTD | PMID:24714768 | |