![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | decreases expression | ISO | RGD:731869 | 6480464 | Nicotine results in decreased expression of PLCD4 mRNA | CTD | PMID:21955143 | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of PLCD4 mRNA | CTD | PMID:27840820 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:731869 | 6480464 | Ethinyl Estradiol results in increased expression of PLCD4 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:731869 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLCD4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:731869 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLCD4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLCD4 mRNA | CTD | PMID:33387578 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:731869 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of PLCD4 mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:731869 | 6480464 | 4, 4'-diaminodiphenylmethane results in decreased expression of PLCD4 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | decreases expression | ISO | RGD:731869 | 6480464 | bis(4-hydroxyphenyl)sulfone results in decreased expression of PLCD4 mRNA | CTD | PMID:30951980 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PLCD4 mRNA | CTD | PMID:25825206 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of PLCD4 mRNA | CTD | PMID:31881176 | acetylsalicylic acid | increases expression | EXP | | 6480464 | Aspirin results in increased expression of PLCD4 mRNA | CTD | PMID:12800193 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of PLCD4 mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of PLCD4 mRNA | CTD | PMID:23630614 | Aflatoxin B2 alpha | decreases methylation | ISO | RGD:1346447 | 6480464 | aflatoxin B2 results in decreased methylation of PLCD4 intron | CTD | PMID:30157460 | amitriptyline | decreases expression | EXP | | 6480464 | Amitriptyline results in decreased expression of PLCD4 mRNA | CTD | PMID:22341215 | anthocyanin | increases expression | EXP | | 6480464 | Anthocyanins results in increased expression of PLCD4 mRNA | CTD | PMID:18803703 | aristolochic acid A | increases expression | ISO | RGD:1346447 | 6480464 | aristolochic acid I results in increased expression of PLCD4 mRNA | CTD | PMID:33212167 | arsane | multiple interactions | ISO | RGD:731869 | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PLCD4 mRNA | CTD | PMID:32045263 | arsenic atom | multiple interactions | ISO | RGD:731869 | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PLCD4 mRNA | CTD | PMID:32045263 | atrazine | decreases expression | ISO | RGD:1346447 | 6480464 | Atrazine results in decreased expression of PLCD4 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases mutagenesis | ISO | RGD:1346447 | 6480464 | Benzo(a)pyrene results in increased mutagenesis of PLCD4 gene | CTD | PMID:25435355 | benzo[a]pyrene | increases methylation | ISO | RGD:1346447 | 6480464 | Benzo(a)pyrene results in increased methylation of PLCD4 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RGD:1346447 | 6480464 | Benzo(a)pyrene affects the methylation of PLCD4 intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | RGD:731869 | 6480464 | Benzo(a)pyrene results in decreased methylation of PLCD4 intron | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | RGD:731869 | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCD4 mRNA | CTD | PMID:27858113 | benzo[a]pyrene | increases expression | ISO | RGD:731869 | 6480464 | Benzo(a)pyrene results in increased expression of PLCD4 mRNA | CTD | PMID:22610609 | benzo[b]fluoranthene | increases expression | ISO | RGD:731869 | 6480464 | benzo(b)fluoranthene results in increased expression of PLCD4 mRNA | CTD | PMID:26377693 | benzo[b]fluoranthene | multiple interactions | ISO | RGD:731869 | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCD4 mRNA | CTD | PMID:27858113 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PLCD4 mRNA | CTD | PMID:25181051 more ... | bisphenol A | decreases methylation | ISO | RGD:1346447 | 6480464 | bisphenol A results in decreased methylation of PLCD4 gene | CTD | PMID:31601247 | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of PLCD4 gene | CTD | PMID:28505145 | bisphenol F | decreases expression | ISO | RGD:731869 | 6480464 | bisphenol F results in decreased expression of PLCD4 mRNA | CTD | PMID:30951980 | butanal | decreases expression | ISO | RGD:1346447 | 6480464 | butyraldehyde results in decreased expression of PLCD4 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | RGD:1346447 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PLCD4 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | RGD:1346447 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PLCD4 mRNA | CTD | PMID:35301059 | chlordecone | decreases expression | ISO | RGD:731869 | 6480464 | Chlordecone results in decreased expression of PLCD4 mRNA | CTD | PMID:29980752 | chrysene | multiple interactions | ISO | RGD:731869 | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCD4 mRNA | CTD | PMID:27858113 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of PLCD4 mRNA | CTD | PMID:26033743 | copper atom | multiple interactions | ISO | RGD:1346447 | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of PLCD4 mRNA | CTD | PMID:30911355 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of PLCD4 mRNA | CTD | PMID:26033743 | copper(0) | multiple interactions | ISO | RGD:1346447 | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of PLCD4 mRNA | CTD | PMID:30911355 | dexamethasone | decreases expression | EXP | | 6480464 | Dexamethasone results in decreased expression of PLCD4 mRNA | CTD | PMID:14618091 | dibenz[a,h]anthracene | increases expression | ISO | RGD:731869 | 6480464 | 1 more ... | CTD | PMID:26377693 | dichloroacetic acid | decreases expression | ISO | RGD:731869 | 6480464 | Dichloroacetic Acid results in decreased expression of PLCD4 mRNA | CTD | PMID:28962523 | dicrotophos | increases expression | ISO | RGD:1346447 | 6480464 | dicrotophos results in increased expression of PLCD4 mRNA | CTD | PMID:28302478 | diuron | decreases expression | EXP | | 6480464 | Diuron metabolite results in decreased expression of PLCD4 mRNA | CTD | PMID:24172598 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of PLCD4 mRNA | CTD | PMID:29391264 | ethanol | increases expression | ISO | RGD:731869 | 6480464 | Ethanol results in increased expression of PLCD4 mRNA | CTD | PMID:21955143, PMID:30319688 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of PLCD4 mRNA | CTD | PMID:30307764 | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of PLCD4 mRNA | CTD | PMID:18035473 | folic acid | decreases expression | ISO | RGD:731869 | 6480464 | Folic Acid results in decreased expression of PLCD4 mRNA | CTD | PMID:25629700 | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of PLCD4 gene | CTD | PMID:22079235 | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of PLCD4 mRNA | CTD | PMID:21782745 | genistein | increases expression | ISO | RGD:731869 | 6480464 | Genistein results in increased expression of PLCD4 mRNA | CTD | PMID:32186404 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PLCD4 mRNA | CTD | PMID:33387578 | glufosinate | decreases expression | ISO | RGD:731869 | 6480464 | phosphinothricin results in decreased expression of PLCD4 mRNA | CTD | PMID:34597628 | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of PLCD4 mRNA | CTD | PMID:20080153 | morphine | decreases expression | ISO | RGD:731869 | 6480464 | Morphine results in decreased expression of PLCD4 mRNA | CTD | PMID:21955143 | N-Nitrosopyrrolidine | increases expression | ISO | RGD:1346447 | 6480464 | N-Nitrosopyrrolidine results in increased expression of PLCD4 mRNA | CTD | PMID:32234424 | nicotine | decreases expression | ISO | RGD:731869 | 6480464 | Nicotine results in decreased expression of PLCD4 mRNA | CTD | PMID:21955143 | paracetamol | increases expression | ISO | RGD:1346447 | 6480464 | Acetaminophen results in increased expression of PLCD4 mRNA | CTD | PMID:26690555 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PLCD4 mRNA | CTD | PMID:33387578 | perfluorooctane-1-sulfonic acid | decreases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased expression of PLCD4 mRNA | CTD | PMID:20136073 | pirinixic acid | multiple interactions | ISO | RGD:1346447 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLCD4 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | RGD:731869 | 6480464 | pirinixic acid results in increased expression of PLCD4 mRNA | CTD | PMID:20813756 | resveratrol | multiple interactions | ISO | RGD:1346447 | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of PLCD4 mRNA | CTD | PMID:23557933 | silicon dioxide | decreases expression | ISO | RGD:1346447 | 6480464 | Silicon Dioxide analog results in decreased expression of PLCD4 mRNA | CTD | PMID:25895662 | sodium arsenite | multiple interactions | ISO | RGD:731869 | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PLCD4 mRNA | CTD | PMID:32045263 | tetraphene | multiple interactions | ISO | RGD:731869 | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLCD4 mRNA | CTD | PMID:27858113 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PLCD4 mRNA | CTD | PMID:34492290 | topiramate | decreases expression | EXP | | 6480464 | topiramate results in decreased expression of PLCD4 mRNA | CTD | PMID:16979414 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of PLCD4 mRNA | CTD | PMID:33387578 | triptonide | increases expression | ISO | RGD:731869 | 6480464 | triptonide results in increased expression of PLCD4 mRNA | CTD | PMID:33045310 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of PLCD4 mRNA | CTD | PMID:23034163 | zoledronic acid | decreases expression | ISO | RGD:1346447 | 6480464 | zoledronic acid results in decreased expression of PLCD4 mRNA | CTD | PMID:24714768 | |