Plcd4 (phospholipase C, delta 4) - Rat Genome Database

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Gene: Plcd4 (phospholipase C, delta 4) Rattus norvegicus
Analyze
Symbol: Plcd4
Name: phospholipase C, delta 4
RGD ID: 621025
Description: Enables phosphatidylinositol phospholipase C activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within acrosome reaction. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human PLCD4 (phospholipase C delta 4); PARTICIPATES IN calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4; phosphoinositide phospholipase C delta-4; phosphoinositide phospholipase C-delta-4; phospholipase C-delta-4; PLC-delta-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,564,616 - 83,613,742 (+)NCBIGRCr8
mRatBN7.2976,115,523 - 76,158,602 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,117,168 - 76,142,453 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,562,298 - 84,587,522 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,691,247 - 89,716,473 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,077,430 - 88,102,653 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,816,395 - 81,844,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,816,872 - 81,844,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,579,905 - 81,608,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,878,506 - 73,905,127 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,025,487 - 74,052,109 (+)NCBI
Celera973,690,442 - 73,715,587 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
nucleus  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Molecular cloning, splice variants, expression, and purification of phospholipase C-delta 4. Lee SB and Rhee SG, J Biol Chem 1996 Jan 5;271(1):25-31.
3. A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. Liu N, etal., J Biol Chem 1996 Jan 5;271(1):355-60.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2033248   PMID:9915823   PMID:11340203   PMID:30194280  


Genomics

Comparative Map Data
Plcd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,564,616 - 83,613,742 (+)NCBIGRCr8
mRatBN7.2976,115,523 - 76,158,602 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,117,168 - 76,142,453 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx984,562,298 - 84,587,522 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,691,247 - 89,716,473 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,077,430 - 88,102,653 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,816,395 - 81,844,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,816,872 - 81,844,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,579,905 - 81,608,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,878,506 - 73,905,127 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,025,487 - 74,052,109 (+)NCBI
Celera973,690,442 - 73,715,587 (+)NCBICelera
Cytogenetic Map9q33NCBI
PLCD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,607,899 - 218,637,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,607,855 - 218,637,184 (+)EnsemblGRCh38hg38GRCh38
GRCh372219,472,622 - 219,501,898 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,180,876 - 219,210,148 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,298,136 - 219,327,409NCBI
Celera2213,240,381 - 213,269,662 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,325,808 - 211,355,366 (+)NCBIHuRef
CHM1_12219,479,454 - 219,508,883 (+)NCBICHM1_1
T2T-CHM13v2.02219,094,436 - 219,123,729 (+)NCBIT2T-CHM13v2.0
Plcd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,581,175 - 74,605,137 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,582,047 - 74,606,953 (+)EnsemblGRCm39 Ensembl
GRCm38174,541,975 - 74,565,977 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,542,888 - 74,567,794 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,589,463 - 74,612,551 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36174,477,739 - 74,499,184 (+)NCBIMGSCv36mm8
Celera175,100,417 - 75,123,669 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
Plcd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,787,677 - 14,806,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,775,119 - 14,812,872 (-)NCBIChiLan1.0ChiLan1.0
PLCD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,228,648 - 121,267,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,243,168 - 121,282,926 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B105,864,706 - 105,895,114 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,461,261 - 224,490,345 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,461,261 - 224,490,345 (+)Ensemblpanpan1.1panPan2
PLCD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,221,329 - 25,244,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,226,244 - 25,244,914 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,041,363 - 26,064,404 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,237,345 - 25,260,497 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,237,771 - 25,260,768 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,142,268 - 25,165,298 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,076,485 - 25,099,551 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,096,641 - 25,120,171 (+)NCBIUU_Cfam_GSD_1.0
Plcd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,714,969 - 174,756,001 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,058,611 - 1,099,577 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,058,092 - 1,097,662 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,626,938 - 120,688,112 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,660,549 - 120,695,731 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,641,398 - 133,676,142 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,512,156 - 104,540,555 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,512,678 - 104,542,531 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,863,854 - 94,893,228 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,418,922 - 6,442,418 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248236,418,359 - 6,446,848 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plcd4
202 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:327
Count of miRNA genes:86
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000022234, ENSRNOT00000041407, ENSRNOT00000057430
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat

Markers in Region
AI045490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,142,215 - 76,142,423 (+)MAPPERmRatBN7.2
Rnor_6.0981,844,127 - 81,844,334NCBIRnor6.0
Rnor_5.0981,608,275 - 81,608,482UniSTSRnor5.0
RGSC_v3.4973,904,890 - 73,905,097UniSTSRGSC3.4
Celera973,715,350 - 73,715,557UniSTS
RH 3.4 Map9709.9UniSTS
Cytogenetic Map9q33UniSTS
RH138080  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,141,169 - 76,141,328 (+)MAPPERmRatBN7.2
Rnor_6.0981,843,081 - 81,843,239NCBIRnor6.0
Rnor_5.0981,607,229 - 81,607,387UniSTSRnor5.0
RGSC_v3.4973,903,844 - 73,904,002UniSTSRGSC3.4
Celera973,714,304 - 73,714,462UniSTS
RH 3.4 Map9709.1UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 77 76 45 25 45 6 204 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D50455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB877140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB895774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC934549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC953183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022234   ⟹   ENSRNOP00000022234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl981,821,346 - 81,843,662 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000041407   ⟹   ENSRNOP00000039708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,117,168 - 76,142,453 (+)Ensembl
Rnor_6.0 Ensembl981,816,872 - 81,844,364 (+)Ensembl
RefSeq Acc Id: NM_080688   ⟹   NP_542419
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,566,264 - 83,591,544 (+)NCBI
mRatBN7.2976,117,168 - 76,142,453 (+)NCBI
Rnor_6.0981,816,872 - 81,844,364 (+)NCBI
Rnor_5.0981,579,905 - 81,608,512 (+)NCBI
RGSC_v3.4973,878,506 - 73,905,127 (+)RGD
Celera973,690,442 - 73,715,587 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245136   ⟹   XP_006245198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,567,868 - 83,591,540 (+)NCBI
mRatBN7.2976,118,764 - 76,142,449 (+)NCBI
Rnor_6.0981,818,706 - 81,844,360 (+)NCBI
Rnor_5.0981,579,905 - 81,608,512 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245137   ⟹   XP_006245199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,567,868 - 83,591,540 (+)NCBI
mRatBN7.2976,118,764 - 76,142,449 (+)NCBI
Rnor_6.0981,818,706 - 81,844,360 (+)NCBI
Rnor_5.0981,579,905 - 81,608,512 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245138   ⟹   XP_006245200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,567,910 - 83,591,540 (+)NCBI
mRatBN7.2976,118,764 - 76,142,449 (+)NCBI
Rnor_6.0981,818,614 - 81,844,360 (+)NCBI
Rnor_5.0981,579,905 - 81,608,512 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767182   ⟹   XP_008765404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,565,788 - 83,591,540 (+)NCBI
mRatBN7.2976,116,461 - 76,142,449 (+)NCBI
Rnor_6.0981,816,397 - 81,844,360 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767184   ⟹   XP_008765406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,617 - 83,591,540 (+)NCBI
mRatBN7.2976,115,524 - 76,142,449 (+)NCBI
Rnor_6.0981,816,397 - 81,844,360 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767187   ⟹   XP_008765409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,616 - 83,591,540 (+)NCBI
mRatBN7.2976,115,523 - 76,142,449 (+)NCBI
Rnor_6.0981,816,395 - 81,844,360 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767188   ⟹   XP_008765410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,617 - 83,591,540 (+)NCBI
mRatBN7.2976,115,524 - 76,142,449 (+)NCBI
Rnor_6.0981,816,398 - 81,844,360 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767189   ⟹   XP_008765411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,618 - 83,591,540 (+)NCBI
mRatBN7.2976,115,525 - 76,142,449 (+)NCBI
Rnor_6.0981,816,400 - 81,844,360 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767190   ⟹   XP_008765412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,618 - 83,591,540 (+)NCBI
mRatBN7.2976,115,525 - 76,142,449 (+)NCBI
Rnor_6.0981,816,401 - 81,844,360 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082973   ⟹   XP_038938901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,617 - 83,591,540 (+)NCBI
mRatBN7.2976,115,524 - 76,142,449 (+)NCBI
RefSeq Acc Id: XM_039082974   ⟹   XP_038938902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,568,514 - 83,591,540 (+)NCBI
mRatBN7.2976,119,458 - 76,142,449 (+)NCBI
RefSeq Acc Id: XM_039082975   ⟹   XP_038938903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,618 - 83,613,742 (+)NCBI
mRatBN7.2976,115,524 - 76,158,602 (+)NCBI
RefSeq Acc Id: XM_063266602   ⟹   XP_063122672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,617 - 83,591,540 (+)NCBI
RefSeq Acc Id: XM_063266603   ⟹   XP_063122673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,567,900 - 83,591,540 (+)NCBI
RefSeq Acc Id: XM_063266604   ⟹   XP_063122674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,616 - 83,591,540 (+)NCBI
RefSeq Acc Id: XM_063266605   ⟹   XP_063122675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,618 - 83,591,540 (+)NCBI
RefSeq Acc Id: XM_063266606   ⟹   XP_063122676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,618 - 83,591,540 (+)NCBI
RefSeq Acc Id: XM_063266607   ⟹   XP_063122677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,618 - 83,591,540 (+)NCBI
RefSeq Acc Id: XM_063266608   ⟹   XP_063122678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,617 - 83,591,540 (+)NCBI
RefSeq Acc Id: XM_063266609   ⟹   XP_063122679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,619 - 83,591,540 (+)NCBI
RefSeq Acc Id: XM_063266610   ⟹   XP_063122680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,619 - 83,591,540 (+)NCBI
RefSeq Acc Id: XM_063266611   ⟹   XP_063122681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,564,618 - 83,591,540 (+)NCBI
Protein Sequences
Protein RefSeqs NP_542419 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245198 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245199 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245200 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765404 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765406 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765409 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765410 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765411 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765412 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938901 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938902 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938903 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122672 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122673 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122674 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122675 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122676 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122677 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122678 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122679 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122680 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52346 (Get FASTA)   NCBI Sequence Viewer  
  BAA09046 (Get FASTA)   NCBI Sequence Viewer  
  CBF62919 (Get FASTA)   NCBI Sequence Viewer  
  CBF74633 (Get FASTA)   NCBI Sequence Viewer  
  CBU87795 (Get FASTA)   NCBI Sequence Viewer  
  CBU96742 (Get FASTA)   NCBI Sequence Viewer  
  EDL75358 (Get FASTA)   NCBI Sequence Viewer  
  EDL75359 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039708.3
GenBank Protein Q62711 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_542419   ⟸   NM_080688
- UniProtKB: Q63693 (UniProtKB/Swiss-Prot),   Q62711 (UniProtKB/Swiss-Prot),   A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245198   ⟸   XM_006245136
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245199   ⟸   XM_006245137
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245200   ⟸   XM_006245138
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765409   ⟸   XM_008767187
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765406   ⟸   XM_008767184
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765404   ⟸   XM_008767182
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765411   ⟸   XM_008767189
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765410   ⟸   XM_008767188
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765412   ⟸   XM_008767190
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039708   ⟸   ENSRNOT00000041407
Ensembl Acc Id: ENSRNOP00000022234   ⟸   ENSRNOT00000022234
RefSeq Acc Id: XP_038938903   ⟸   XM_039082975
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938901   ⟸   XM_039082973
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938902   ⟸   XM_039082974
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122674   ⟸   XM_063266604
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122672   ⟸   XM_063266602
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122678   ⟸   XM_063266608
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122675   ⟸   XM_063266605
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122677   ⟸   XM_063266607
- Peptide Label: isoform X7
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122676   ⟸   XM_063266606
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122681   ⟸   XM_063266611
- Peptide Label: isoform X10
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122680   ⟸   XM_063266610
- Peptide Label: isoform X9
- UniProtKB: Q63693 (UniProtKB/Swiss-Prot),   Q62711 (UniProtKB/Swiss-Prot),   A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122679   ⟸   XM_063266609
- Peptide Label: isoform X9
- UniProtKB: Q63693 (UniProtKB/Swiss-Prot),   Q62711 (UniProtKB/Swiss-Prot),   A0A8L2QKX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122673   ⟸   XM_063266603
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QKX9 (UniProtKB/TrEMBL)
Protein Domains
C2   EF-hand   PH   PI-PLC X-box   PI-PLC Y-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62711-F1-model_v2 AlphaFold Q62711 1-772 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621025 AgrOrtholog
BioCyc Gene G2FUF-27125 BioCyc
Ensembl Genes ENSRNOG00000016361 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041407.5 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140693 UniProtKB/Swiss-Prot
NCBI Gene 140693 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10336:SF31 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plcd4 PhenoGen
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016361 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCXc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCYc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QKX9 ENTREZGENE, UniProtKB/TrEMBL
  A6JVV0_RAT UniProtKB/TrEMBL
  A6JVV1_RAT UniProtKB/TrEMBL
  PLCD4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63693 ENTREZGENE
UniProt Secondary Q63693 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Plcd4  phospholipase C, delta 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Plcd4  phospholipase C, delta 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in testis; present in brain, skeletal muscle, thyroid gland, stomach, thymus, aorta, and heart 633664
gene_protein 772 amino acids 633664
gene_regulation activated by phosphorylation by autophosphorylated tyrosine kinases as a result of binding to these kinases via the SH2 domains 633664