Ccdc168 (coiled-coil domain containing 168) - Rat Genome Database

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Gene: Ccdc168 (coiled-coil domain containing 168) Rattus norvegicus
Analyze
Symbol: Ccdc168
Name: coiled-coil domain containing 168
RGD ID: 7680407
Description: Predicted to be located in membrane. Orthologous to human CCDC168 (coiled-coil domain containing 168); INTERACTS WITH aristolochic acid A (ortholog); benzo[a]pyrene (ortholog); coumarin (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: coiled-coil domain-containing protein 168; hypothetical protein LOC100360458; leucine-rich repeat transmembrane protein CCDC168; LOC100360458; LOC102548013; uncharacterized LOC102548013
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,690,704 - 53,728,801 (-)NCBIGRCr8
mRatBN7.2946,198,234 - 46,236,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,198,635 - 46,235,936 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0950,814,067 - 50,851,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0950,481,044 - 50,518,666 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,137,470 - 43,174,323 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera943,902,861 - 43,940,217 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ccdc168
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,690,704 - 53,728,801 (-)NCBIGRCr8
mRatBN7.2946,198,234 - 46,236,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,198,635 - 46,235,936 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0950,814,067 - 50,851,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0950,481,044 - 50,518,666 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,137,470 - 43,174,323 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera943,902,861 - 43,940,217 (-)NCBICelera
Cytogenetic Map9q22NCBI
CCDC168
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,729,367 - 102,759,072 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13102,729,367 - 102,759,072 (-)EnsemblGRCh38hg38GRCh38
GRCh3713103,381,717 - 103,411,422 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1384,226,147 - 84,255,852 (-)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1383,974,010 - 84,003,709 (-)NCBIHuRef
CHM1_113103,351,137 - 103,380,855 (-)NCBICHM1_1
T2T-CHM13v2.013101,947,434 - 101,977,110 (-)NCBIT2T-CHM13v2.0
Ccdc168
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,095,031 - 44,118,906 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,095,032 - 44,118,906 (-)EnsemblGRCm39 Ensembl
GRCm38144,055,869 - 44,082,447 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl144,055,872 - 44,079,746 (-)EnsemblGRCm38mm10GRCm38
MGSCv37144,113,655 - 44,136,065 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv37144,113,655 - 44,136,065 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36144,001,356 - 44,023,766 (-)NCBIMGSCv36mm8
Celera144,406,678 - 44,423,218 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.54NCBI
Ccdc168
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554048,401,713 - 8,425,519 (+)NCBIChiLan1.0ChiLan1.0
CCDC168
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214104,248,302 - 104,280,140 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113102,916,255 - 102,948,102 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01383,891,331 - 83,921,047 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113103,027,195 - 103,056,282 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13103,027,230 - 103,056,282 (-)Ensemblpanpan1.1panPan2
CCDC168
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,228,429 - 52,257,920 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2252,008,103 - 52,035,693 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02252,676,100 - 52,703,684 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12252,328,682 - 52,356,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,344,737 - 52,372,325 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,385,952 - 52,413,524 (-)NCBIUU_Cfam_GSD_1.0
Ccdc168
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,609,247 - 187,648,049 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364728,305,760 - 8,337,456 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC168
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11171,047,611 - 71,069,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,361,285 - 78,368,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCDC168
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,291,027 - 81,321,907 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604637,828,041 - 37,859,028 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccdc168
149 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000106735   ⟹   ENSRNOP00000081759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,198,635 - 46,235,936 (-)Ensembl
RefSeq Acc Id: XM_017596796   ⟹   XP_017452285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,690,704 - 53,728,801 (-)NCBI
mRatBN7.2946,198,234 - 46,236,325 (-)NCBI
Rnor_6.0950,814,067 - 50,851,997 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596797   ⟹   XP_017452286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,690,704 - 53,728,801 (-)NCBI
mRatBN7.2946,198,234 - 46,236,325 (-)NCBI
Rnor_6.0950,814,067 - 50,851,997 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_017452285 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452286 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081759.1
RefSeq Acc Id: XP_017452286   ⟸   XM_017596797
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452285   ⟸   XM_017596796
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000081759   ⟸   ENSRNOT00000106735
Protein Domains
Coiled-coil

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7680407 AgrOrtholog
BioCyc Gene G2FUF-27656 BioCyc
Ensembl Genes ENSRNOG00000063478 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000106735.1 UniProtKB/TrEMBL
InterPro CCDC168_N UniProtKB/TrEMBL
KEGG Report rno:102548013 UniProtKB/TrEMBL
NCBI Gene LOC102548013 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING PROTEIN 168 UniProtKB/TrEMBL
  COILED-COIL DOMAIN-CONTAINING PROTEIN 168 UniProtKB/TrEMBL
Pfam CCDC168_N UniProtKB/TrEMBL
PhenoGen Ccdc168 PhenoGen
RatGTEx ENSRNOG00000063478 RatGTEx
UniProt A0A8I5ZTR5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-01 Ccdc168  coiled-coil domain containing 168  Ccdc168  coiled-coil domain containing 168  Data merged from RGD:149736214 737654 PROVISIONAL
2021-08-09 Ccdc168  coiled-coil domain containing 168      Symbol and Name status set to provisional 45752 PROVISIONAL
2017-08-24 Ccdc168  coiled-coil domain containing 168  LOC102548013  uncharacterized LOC102548013  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 LOC102548013  uncharacterized LOC102548013  LOC100360458  hypothetical protein LOC100360458  Data merged from RGD:2322098 737654 PROVISIONAL
2013-12-18 LOC102548013  uncharacterized LOC102548013      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-06 LOC100360458  hypothetical protein LOC100360458      Symbol and Name status set to provisional 70820 PROVISIONAL