Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Tbc1d8 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TBC1D8 mRNA | CTD | PMID:36331819 | (2,4,5-trichlorophenoxy)acetic acid | decreases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:18579281 | 1,2-dichloroethane | decreases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of TBC1D8 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TBC1D8 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | TBC1D8 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of TBC1D8 mRNA and EGF protein inhibits the reaction [Estradiol results in decreased expression of TBC1D8 mRNA] | CTD | PMID:24758408 and PMID:30165855 | 17beta-estradiol | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of TBC1D8 mRNA | CTD | PMID:24758408 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of TBC1D8 mRNA | CTD | PMID:29581250 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TBC1D8 mRNA | CTD | PMID:21215274 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TBC1D8 mRNA | CTD | PMID:19770486 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TBC1D8 mRNA | CTD | PMID:21570461 and PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Tbc1d8 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TBC1D8 mRNA | CTD | PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TBC1D8 mRNA | CTD | PMID:20106945 and PMID:21632981 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of TBC1D8 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | TBC1D8 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of TBC1D8 gene | CTD | PMID:31601247 | 4-hydroxyphenyl retinamide | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Fenretinide results in increased expression of TBC1D8 mRNA | CTD | PMID:28973697 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of TBC1D8 mRNA | CTD | PMID:31881176 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of TBC1D8 mRNA | CTD | PMID:30779732 | antirheumatic drug | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of TBC1D8 mRNA | CTD | PMID:24449571 | Aroclor 1254 | decreases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of TBC1D8 mRNA | CTD | PMID:23650126 | arsenite(3-) | decreases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | arsenite results in decreased expression of TBC1D8 mRNA | CTD | PMID:18929588 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of TBC1D8 gene | CTD | PMID:28931070 | benzo[a]pyrene | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of TBC1D8 mRNA | CTD | PMID:19770486 and PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | TBC1D8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of TBC1D8 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of TBC1D8 mRNA | CTD | PMID:26238291 | benzo[a]pyrene | multiple interactions | ISO | Tbc1d8 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of TBC1D8 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | affects expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TBC1D8 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of TBC1D8 gene | CTD | PMID:28505145 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TBC1D8 mRNA | CTD | PMID:30816183 and PMID:32528016 | caffeine | increases phosphorylation | ISO | TBC1D8 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of TBC1D8 protein | CTD | PMID:35688186 | calcitriol | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of TBC1D8 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | TBC1D8 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of TBC1D8 mRNA | CTD | PMID:21592394 | chloroethene | decreases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Vinyl Chloride results in decreased expression of TBC1D8 mRNA | CTD | PMID:18579281 | cisplatin | multiple interactions | ISO | TBC1D8 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of TBC1D8 mRNA | CTD | PMID:27392435 | cisplatin | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of TBC1D8 mRNA | CTD | PMID:27392435 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of TBC1D8 mRNA | CTD | PMID:24386269 | copper(II) sulfate | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of TBC1D8 mRNA | CTD | PMID:19549813 | copper(II) sulfate | decreases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Copper Sulfate results in decreased expression of TBC1D8 mRNA | CTD | PMID:18579281 | curcumin | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Curcumin results in increased expression of TBC1D8 mRNA | CTD | PMID:17999991 | cyclosporin A | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Cyclosporine results in increased expression of TBC1D8 mRNA | CTD | PMID:19770486 | cyclosporin A | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of TBC1D8 mRNA | CTD | PMID:25562108 | dibutyl phthalate | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of TBC1D8 mRNA | CTD | PMID:21266533 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of TBC1D8 mRNA | CTD | PMID:29391264 | entinostat | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | entinostat results in decreased expression of TBC1D8 mRNA | CTD | PMID:26272509 | ethanol | decreases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Ethanol results in decreased expression of TBC1D8 mRNA | CTD | PMID:19167417 | ethanol | affects splicing | ISO | Tbc1d8 (Mus musculus) | 6480464 | Ethanol affects the splicing of TBC1D8 mRNA | CTD | PMID:30319688 | etoposide | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Etoposide results in increased expression of TBC1D8 mRNA | CTD | PMID:25270620 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of TBC1D8 mRNA | CTD | PMID:24136188 | genistein | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Genistein results in increased expression of TBC1D8 mRNA | CTD | PMID:32186404 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of TBC1D8 mRNA | CTD | PMID:33387578 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of TBC1D8 mRNA | CTD | PMID:24136188 | hydrogen peroxide | affects expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of TBC1D8 mRNA | CTD | PMID:20044591 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of TBC1D8 mRNA | CTD | PMID:21396975 | inulin | multiple interactions | ISO | Tbc1d8 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of TBC1D8 mRNA | CTD | PMID:36331819 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of TBC1D8 mRNA | CTD | PMID:24136188 | lithium chloride | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Lithium Chloride results in decreased expression of TBC1D8 mRNA | CTD | PMID:15711924 | methylmercury chloride | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of TBC1D8 mRNA | CTD | PMID:28001369 | mitomycin C | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Mitomycin results in increased expression of TBC1D8 mRNA | CTD | PMID:25270620 | mitoxantrone | affects response to substance | ISO | TBC1D8 (Homo sapiens) | 6480464 | TBC1D8 protein affects the susceptibility to Mitoxantrone | CTD | PMID:16217747 | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | N more ... | CTD | PMID:12756304 | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of TBC1D8 mRNA | CTD | PMID:24136188 | panobinostat | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | panobinostat results in decreased expression of TBC1D8 mRNA | CTD | PMID:26272509 | paracetamol | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of TBC1D8 mRNA | CTD | PMID:21420995 and PMID:29067470 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of TBC1D8 mRNA | CTD | PMID:33387578 | pentachlorophenol | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of TBC1D8 mRNA | CTD | PMID:23892564 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Tbc1d8 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TBC1D8 mRNA more ... | CTD | PMID:36331819 | pirinixic acid | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of TBC1D8 mRNA | CTD | PMID:18445702 | quercetin | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Quercetin results in increased expression of TBC1D8 mRNA | CTD | PMID:21632981 | sodium arsenite | affects methylation | ISO | TBC1D8 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of TBC1D8 gene | CTD | PMID:28589171 | testosterone | multiple interactions | ISO | TBC1D8 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of TBC1D8 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Testosterone results in increased expression of TBC1D8 mRNA | CTD | PMID:21592394 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TBC1D8 mRNA | CTD | PMID:31150632 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of TBC1D8 mRNA | CTD | PMID:33387578 | trichostatin A | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of TBC1D8 mRNA | CTD | PMID:26272509 | trovafloxacin | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | trovafloxacin results in increased expression of TBC1D8 mRNA | CTD | PMID:35537566 | urethane | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Urethane results in increased expression of TBC1D8 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | Tbc1d8 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of TBC1D8 mRNA | CTD | PMID:21427059 | valproic acid | decreases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of TBC1D8 mRNA | CTD | PMID:26272509 and PMID:28001369 | valproic acid | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TBC1D8 mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of TBC1D8 mRNA | CTD | PMID:25979313 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of TBC1D8 mRNA | CTD | PMID:23034163 | zinc sulfate | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | Zinc Sulfate results in increased expression of TBC1D8 mRNA | CTD | PMID:12756304 | zoledronic acid | increases expression | ISO | TBC1D8 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of TBC1D8 mRNA | CTD | PMID:24714768 | |