Tuba4a (tubulin, alpha 4A) - Rat Genome Database

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Gene: Tuba4a (tubulin, alpha 4A) Rattus norvegicus
Analyze
Symbol: Tuba4a
Name: tubulin, alpha 4A
RGD ID: 1359623
Description: Predicted to enable GTP binding activity and protein kinase binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22. Orthologous to human TUBA4A (tubulin alpha 4a); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-tubulin 4; MGC94628; similar to Tubulin alpha-4 chain (Alpha-tubulin 4); Tuba4; tubulin alpha-4 chain; tubulin alpha-4A chain; tubulin, alpha 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,158,871 - 84,174,041 (-)NCBIGRCr8
mRatBN7.2976,709,617 - 76,714,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,709,614 - 76,713,918 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,155,014 - 85,158,697 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,283,905 - 90,287,588 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,670,120 - 88,673,803 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,415,599 - 82,419,918 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,415,605 - 82,419,288 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,184,860 - 82,189,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,496,508 - 74,500,192 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,643,490 - 74,647,174 (-)NCBI
Celera974,280,623 - 74,284,307 (-)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
7,12-dimethyltetraphene  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bromoacetate  (ISO)
buspirone  (EXP)
butanal  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenamidone  (ISO)
ferroheme b  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
heme b  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP)
phytoestrogen  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenic acid  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A revised nomenclature for the human and rodent alpha-tubulin gene family. Khodiyar VK, etal., Genomics. 2007 May 31;.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Villasante A, etal., Mol Cell Biol 1986 Jul;6(7):2409-19.
Additional References at PubMed
PMID:19199708   PMID:20458337   PMID:21525035   PMID:22082260   PMID:22871113   PMID:23874210   PMID:24327345   PMID:25002582   PMID:25931508   PMID:26316108   PMID:29476059  


Genomics

Comparative Map Data
Tuba4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,158,871 - 84,174,041 (-)NCBIGRCr8
mRatBN7.2976,709,617 - 76,714,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,709,614 - 76,713,918 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,155,014 - 85,158,697 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,283,905 - 90,287,588 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,670,120 - 88,673,803 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,415,599 - 82,419,918 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,415,605 - 82,419,288 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,184,860 - 82,189,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,496,508 - 74,500,192 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,643,490 - 74,647,174 (-)NCBI
Celera974,280,623 - 74,284,307 (-)NCBICelera
Cytogenetic Map9q33NCBI
TUBA4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,249,710 - 219,254,740 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,249,710 - 219,277,902 (-)EnsemblGRCh38hg38GRCh38
GRCh372220,114,432 - 220,119,462 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,823,245 - 219,826,882 (-)NCBINCBI36Build 36hg18NCBI36
Build 342219,940,505 - 219,944,143NCBI
Celera2213,884,708 - 213,888,345 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,967,348 - 211,972,245 (-)NCBIHuRef
CHM1_12220,120,276 - 220,125,176 (-)NCBICHM1_1
T2T-CHM13v2.02219,734,477 - 219,739,787 (-)NCBIT2T-CHM13v2.0
Tuba4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,190,867 - 75,197,905 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,190,872 - 75,196,509 (-)EnsemblGRCm39 Ensembl
GRCm38175,214,972 - 75,221,261 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,214,228 - 75,219,865 (-)EnsemblGRCm38mm10GRCm38
MGSCv37175,211,549 - 75,215,828 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36175,098,122 - 75,102,401 (-)NCBIMGSCv36mm8
Celera175,705,885 - 75,710,164 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.63NCBI
Tuba4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,175,866 - 14,182,023 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,177,043 - 14,180,814 (+)NCBIChiLan1.0ChiLan1.0
TUBA4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,880,718 - 121,884,443 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,895,683 - 121,899,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,507,842 - 106,512,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,098,446 - 225,102,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,093,643 - 225,102,188 (-)Ensemblpanpan1.1panPan2
TUBA4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,799,075 - 25,803,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,796,107 - 25,802,892 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,624,976 - 26,629,142 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,814,305 - 25,818,478 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,813,707 - 25,818,101 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,718,693 - 25,722,858 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,653,811 - 25,657,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,674,711 - 25,678,885 (-)NCBIUU_Cfam_GSD_1.0
Tuba4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,325,485 - 175,329,806 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,668,878 - 1,672,514 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,668,265 - 1,672,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUBA4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,288,957 - 121,294,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115121,290,149 - 121,294,048 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,324,536 - 134,329,577 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103217904
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,154,928 - 105,159,340 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,153,933 - 105,158,655 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,236,773 - 94,241,516 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tuba4a
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:29
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000004797
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97665062976771824Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat

Markers in Region
RH132688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,709,631 - 76,709,815 (+)MAPPERmRatBN7.2
Rnor_6.0982,415,026 - 82,415,209NCBIRnor6.0
Rnor_5.0982,184,287 - 82,184,470UniSTSRnor5.0
RGSC_v3.4974,495,930 - 74,496,113UniSTSRGSC3.4
Celera974,280,045 - 74,280,228UniSTS
RH 3.4 Map9711.2UniSTS
Cytogenetic Map9q33UniSTS
RH78682  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04209,800,159 - 209,800,341UniSTSRnor5.0
Rnor_5.02218,687,079 - 218,687,261UniSTSRnor5.0
Cytogenetic Map7q36UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004797   ⟹   ENSRNOP00000004797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,709,614 - 76,713,918 (-)Ensembl
Rnor_6.0 Ensembl982,415,605 - 82,419,288 (-)Ensembl
RefSeq Acc Id: NM_001007004   ⟹   NP_001007005
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,871 - 84,162,584 (-)NCBI
mRatBN7.2976,710,205 - 76,713,918 (-)NCBI
Rnor_6.0982,415,604 - 82,419,288 (-)NCBI
Rnor_5.0982,184,860 - 82,189,155 (-)NCBI
RGSC_v3.4974,496,508 - 74,500,192 (-)RGD
Celera974,280,623 - 74,284,307 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245227   ⟹   XP_006245289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,876 - 84,163,451 (-)NCBI
mRatBN7.2976,710,205 - 76,714,327 (-)NCBI
Rnor_6.0982,415,599 - 82,419,918 (-)NCBI
Rnor_5.0982,184,860 - 82,189,155 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083681   ⟹   XP_038939609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,876 - 84,161,897 (-)NCBI
mRatBN7.2976,709,617 - 76,713,282 (-)NCBI
RefSeq Acc Id: XM_063267230   ⟹   XP_063123300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,876 - 84,174,041 (-)NCBI
RefSeq Acc Id: XM_063267231   ⟹   XP_063123301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,158,876 - 84,161,993 (-)NCBI
RefSeq Acc Id: NP_001007005   ⟸   NM_001007004
- UniProtKB: Q5XIF6 (UniProtKB/Swiss-Prot),   A6JVZ9 (UniProtKB/TrEMBL),   A0A8I6ALV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245289   ⟸   XM_006245227
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALV8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004797   ⟸   ENSRNOT00000004797
RefSeq Acc Id: XP_038939609   ⟸   XM_039083681
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123300   ⟸   XM_063267230
- Peptide Label: isoform X1
- UniProtKB: Q5XIF6 (UniProtKB/Swiss-Prot),   A6JVZ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123301   ⟸   XM_063267231
- Peptide Label: isoform X2
Protein Domains
Tubulin/FtsZ 2-layer sandwich   Tubulin/FtsZ GTPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIF6-F1-model_v2 AlphaFold Q5XIF6 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696775
Promoter ID:EPDNEW_R7299
Type:single initiation site
Name:Tuba4a_1
Description:tubulin, alpha 4A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0982,419,312 - 82,419,372EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359623 AgrOrtholog
BioCyc Gene G2FUF-27088 BioCyc
Ensembl Genes ENSRNOG00000003597 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000053468 UniProtKB/TrEMBL
  ENSRNOG00055010434 UniProtKB/Swiss-Prot
  ENSRNOG00060007884 UniProtKB/Swiss-Prot
  ENSRNOG00065008885 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004797.6 UniProtKB/Swiss-Prot
  ENSRNOT00000107560.1 UniProtKB/TrEMBL
  ENSRNOT00055017667 UniProtKB/Swiss-Prot
  ENSRNOT00060013034 UniProtKB/Swiss-Prot
  ENSRNOT00065014198 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.600 UniProtKB/Swiss-Prot
  3.30.1330.20 UniProtKB/Swiss-Prot
  3.40.50.1440 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/TrEMBL
  Tubulin/FtsZ, C-terminal domain UniProtKB/TrEMBL
  Tubulin/FtsZ, GTPase domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191229 IMAGE-MGC_LOAD
InterPro Alpha_tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tub_FtsZ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin/FtsZ-like_C UniProtKB/TrEMBL
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin/FtsZ_C_sf UniProtKB/Swiss-Prot
  Tubulin/FtsZ_GTPase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_FtsZ_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:316531 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94628 IMAGE-MGC_LOAD
NCBI Gene 316531 ENTREZGENE
PANTHER PTHR11588 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBULIN ALPHA-1A CHAIN UniProtKB/TrEMBL
  TUBULIN ALPHA-4A CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TUBA4A RGD
PhenoGen Tuba4a PhenoGen
PRINTS ALPHATUBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TUBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003597 RatGTEx
  ENSRNOG00000053468 RatGTEx
  ENSRNOG00055010434 RatGTEx
  ENSRNOG00060007884 RatGTEx
  ENSRNOG00065008885 RatGTEx
SMART Tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52490 UniProtKB/Swiss-Prot
  SSF55307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin nucleotide-binding domain-like UniProtKB/TrEMBL
UniProt A0A8I6ALV8 ENTREZGENE, UniProtKB/TrEMBL
  A6JVZ9 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIF6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-05-17 Tuba4a  tubulin, alpha 4A  Tuba4  tubulin, alpha 4  Symbol and Name updated 1624988 APPROVED
2005-11-17 Tuba4  tubulin, alpha 4  MGC94628  similar to Tubulin alpha-4 chain (Alpha-tubulin 4)  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC94628  similar to Tubulin alpha-4 chain (Alpha-tubulin 4)      Symbol and Name status set to provisional 70820 PROVISIONAL