Advanced Search (OLGA)

Gene: Aox2 (aldehyde oxidase 2) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Aox2

Name:

aldehyde oxidase 2

RGD ID:

1359668

Description:

Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and protein homodimerization activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol; PARTICIPATES IN monoterpenoid biosynthetic pathway; niacin metabolic pathway; phase I biotransformation pathway via cytochrome P450; .

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

aldehyde oxidase 2 pseudogene; aldehyde oxidase 3-like 1; aldehyde oxidase homolog 3; Aox2p; Aox3l1; azaheterocycle hydroxylase 2

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Alliance orthologs ³				less info ...
Mus musculus (house mouse):	Aox2 (aldehyde oxidase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aox6 (aldehyde oxidase 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ry	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	xdh-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	67,322,291 - 67,411,694 (+)	NCBI		GRCr8
mRatBN7.2	9	59,828,403 - 59,916,175 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	59,828,084 - 59,916,146 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	68,321,349 - 68,409,382 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	73,437,270 - 73,525,311 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	71,755,358 - 71,843,386 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	65,175,455 - 65,265,149 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	65,177,511 - 65,265,149 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	64,973,842 - 65,072,447 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	56,948,950 - 57,038,897 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	57,095,931 - 57,185,868 (+)	NCBI
Celera	9	57,271,035 - 57,358,789 (+)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

xenobiotic metabolic process (ISS)

Cellular Component

cytoplasm (IEA)

cytosol (ISS)

Molecular Function

2 iron, 2 sulfur cluster binding (IEA,ISS)

aldehyde oxidase activity (IBA,IEA,ISS)

FAD binding (IEA)

flavin adenine dinucleotide binding (IEA,ISS)

iron ion binding (IEA,ISS)

iron-sulfur cluster binding (IEA)

metal ion binding (IEA)

molybdopterin cofactor binding (ISS)

NAD binding (IEA)

oxidoreductase activity (IEA)

protein homodimerization activity (ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

monoterpenoid biosynthetic pathway (IEA)

niacin metabolic pathway (IEA)

phase I biotransformation pathway via cytochrome P450 (IEA)

tryptophan metabolic pathway (IEA)

tyrosine metabolic pathway (IEA)

valine, leucine and isoleucine degradation pathway (IEA)

vitamin B6 metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa.	Kurosaki M, etal., J Biol Chem 2004 Nov 26;279(48):50482-98. Epub 2004 Sep 20.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:23263164

Genomics

Variants

Variants in Aox2
440 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	202
Count of miRNA genes:	149
Interacting mature miRNAs:	160
Transcripts:	ENSRNOT00000048027
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	23754024	61381613	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	49968546	71098346	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	55847841	77026453	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56627713	78595166	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat

Markers in Region

BF398906

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	59,862,631 - 59,862,721 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	65,211,645 - 65,211,734	NCBI	Rnor6.0
Rnor_5.0	9	65,019,072 - 65,019,161	UniSTS	Rnor5.0
RGSC_v3.4	9	56,983,723 - 56,983,812	UniSTS	RGSC3.4
Celera	9	57,305,227 - 57,305,316	UniSTS
RH 3.4 Map	9	482.6	UniSTS
Cytogenetic Map	9	q31	UniSTS

BQ211911

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	59,890,877 - 59,891,047 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	65,239,884 - 65,240,053	NCBI	Rnor6.0
Rnor_5.0	9	65,047,310 - 65,047,479	UniSTS	Rnor5.0
RGSC_v3.4	9	57,013,499 - 57,013,668	UniSTS	RGSC3.4
Celera	9	57,333,530 - 57,333,699	UniSTS
RH 3.4 Map	9	483.8	UniSTS
Cytogenetic Map	9	q31	UniSTS

BQ208531

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	59,888,074 - 59,888,258 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	65,237,081 - 65,237,264	NCBI	Rnor6.0
Rnor_5.0	9	65,044,507 - 65,044,690	UniSTS	Rnor5.0
RGSC_v3.4	9	57,010,696 - 57,010,879	UniSTS	RGSC3.4
Celera	9	57,330,727 - 57,330,910	UniSTS
RH 3.4 Map	9	483.3	UniSTS
Cytogenetic Map	9	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	16	106	91	88	59	17	59	6	174	56	86	42	54	29

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596459	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY665588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000048027 ⟹ ENSRNOP00000047535

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	59,828,084 - 59,916,146 (+)	Ensembl
Rnor_6.0 Ensembl	9	65,177,511 - 65,265,149 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095499 ⟹ ENSRNOP00000079851

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	59,828,084 - 59,900,790 (+)	Ensembl

RefSeq Acc Id:

NM_001008522 ⟹ NP_001008522

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	67,322,598 - 67,410,363 (+)	NCBI
mRatBN7.2	9	59,828,403 - 59,916,175 (+)	NCBI
Rnor_6.0	9	65,177,511 - 65,265,149 (+)	NCBI
Rnor_5.0	9	64,973,842 - 65,072,447 (+)	NCBI
RGSC_v3.4	9	56,948,950 - 57,038,897 (+)	RGD
Celera	9	57,271,035 - 57,358,789 (+)	RGD

Sequence:

show sequence

ATGCCTTGCCCATCCCAGAGCTCCGATGAGTTGGAGTTCTTTGTGAACGGGAAGAAGGTGACAG
AGAAGAATGTGGACCCAGAAGTCACTCTGCTGGCCTTCCTGAGAAAGAACTTACGCCTCACGGG
GACTAAGTATGCCTGTGGGACAGGAAGCTGCGGGGCCTGCACTGTGATGGTGTCCCAGCACGAT
CCGGTGTGCAAGAAGACAAGACACTTCTCTGTCATGGCATGCCTGGTGCCCCTGTGCTCCCTGC
ATGGGGCTGCTGTCACCACCGTGGAAGGTGTGGGAAGCATCAAGACCAGGCTACACCCCGTGCA
GGAGAGACTCGCCAAGAGCCACGGCACCCAGTGTGGATTCTGCAGCCCTGGGATGGTGATGTCC
ATGTATGCTCTGCTCAGGAACCACCCGCAGCCCTCAGAGGAGCAGCTCCTGGAAGCCTTGGGAG
GTAATCTCTGTCGGTGTACTGGGTATCGGCCGATTCTGGAGAGTGGCAGAACCTTCTGCATGGA
GTCAGATGGTTGTCTGCAGAAAGGAACAGGACAGTGTTGCTTGGATCAGAAGGAAGGTGACTCA
TCTGGAAGCAAAAGTGATATTTGCACGGAGCTATTTGTGAAAGACGAGTTCCAGCCCTTGGACC
CAACCCAGGAGCTCATATTTCCCCCAGAACTCCTGAGGATGGCTGAGAACCCAGAGAAGCAAAC
ACTAACCTTTTATGGAGAGAGAATTACCTGGATCGCCCCAGGAACCCTCCAAGAACTCTTGGTG
CTGAAAGCCAAGTACCCTGAAGCCCCTCTCATCTCAGGCAACACGGCTCTGGGACCAGCCATGA
AGTCTCAAGGACACTTTTACCCAGTTCTCCTGTCCCCTGCTAGAATTCCTGATCTAAGAATGGT
GACTAAAACCAGTGGTGGACTGACCATAGGTGCCTGCTGCAGCCTGGCTCAGGTGAAAGACGTC
TTAGCTGAGAGCATCTCTGAGCTCCCAGAGGAGAAAACTCAGACCTACCGAGCTCTCCTGAAAC
ACCTCCGTAGCTTGGCGGGACAGCAGATCCGGAACATGGCGTCCTTAGGTGGACATGTTATAAG
CAGGCATTACTACTCGGACCTGAATCCCATCCTCTCTGTGGGCAACGCCACACTCAATCTGCTG
TCAGAAGAAGGCCTGAGGCAGATTCCCCTCAATGGACATTTTCTTGCTGGGTTGGCAAATGAAG
ACCTGAAGCCTGAAGAGATTCTGGGGTCGGTGTACATCCCCCACTCTCAGAAGCGGGAGTTTGT
GTCTGCCTTCCGGCAGGCCCAGTGCCATCAGAACGCCTTGCCTGATGTAAATGCTGGCATGAGA
GTCCTGTTCAAAGAAGGCACAGACATCATTGAGGAGCTGAGCATTGCCTATGGAGGGGTGGGGC
CCACCACCGTCAGTGCACACAGATCCTGCCAGCAGCTCCTGGGCCGGCGTTGGAACGCACTGCT
GCTAGACGAGGCTTGCAGACTGCTCCTGGACGAAGTCTCCCTCCCAGGCTCAGCCGTGGGAGGC
AAAGTGGAATTCAGGAGGACTCTCATTGTCAGCTTCTTCTTCAAGTTCTACCTGGAGGTTCTAC
AGGAACTGAAGGCTGACAAGAGGCTGCTCCCTGAATCCACCGACAGCCAGCGTTATCCAGAGAT
CGCAGACGGGTCCCGAAGCTCTCTGGGAGATTTCCAGGTCACGCTACCCCAGGGAGTCCAAACA
TACCAGAGAGTGAATTCTCACCAACCTCTCCAAGATCCAGTTGGACGTCCCATCATGCACCTGT
CAGGTCTTAAACATGCCACGGGGGAAGCTGTATTTTGTGATGACATCCCCAGGGTGGATAAAGA
ACTTTTCATGGCTTTAGTGACCAGTACCAGAGCTCATGCAAGAATCATATCGATCGACTCATCT
GAGGTCCTAGACCTGCCTGGTGTGGTCGATGTGATAACAGCTGAAGACATCCCGGGCAACAATG
GTGAAGAGGATGACAAATTACTGGCTGTAGATAAGGTTCTCTGTGTGGGCCAGGTCGTCTGTGC
TGTGGTAGCAGAGACTGATGTTCAGGCAAAACGAGCAACTAAGAAGATAAAAATCACCTACGAG
GATCTGAAGCCTGTGCTCTTCACCATCGAGGATGCCATACAGCACAATTCATTCCTGTGCCCTG
AAAAAAAGCTGGAACAAGGAAACATGGAGGAGGCATTTGAAAATGTGGATCAGATAGTTGAAGG
GAAGGTTCATGTTGGAGGGCAAGAACATTTCTACATGGAAACACAGAGAGTGCTTGTCATTCCA
AAGACAGAAGACAAAGAGCTGGACATGTATGTGTCCACACAGGATCCAGCCCATGTGCAGAAAA
CGGTGTCCTCTGCTTTAAACATCCCGCTCAGCAGGATCACCTGCCACGTGAAACGTGTGGGTGG
AGGCTTTGGAGGAAAGGTGGGGAGACCAGCTGTGTTCGGAGCAATTGCTGCAGTGGGGGCTGTC
AAAACTGGCCGTCCCATTCGTCTTGTTCTGGACCGTGAGGATGACATGTTAATAACTGGGGGAA
GACACCCATTATTTGCAAAATACAAAGTGGGATTCATGAACAGTGGACGAATCAAAGCCCTAGA
CATTGAATGCTACATCAATGGAGGATGCACACTGGATGACTCGGAGCTGGTAACAGAATTTCTT
GTACTAAAACTGGAAAATGCATATAAAATCCGCAACCTCAGACTTCGAGGTCGTGCCTGCATGA
CAAATTTACCATCCAATACAGCCTTTCGTGGGTTTGGCTTCCCACAAGGAGCCCTGGTGACAGA
ATCTTGCATCACAGCTGTGGCAGCCAAATGTGGGCTTCCACCAGAGAAGATTAGGGAGAAAAAC
ATGTACAAAACAGTTGATAAAACCATCTACAAACAAGCGTTCAACCCCGAACCCCTGATAAGGT
GCTGGAACGAGTGTCTGGACAAGTCTTCCTTTGCCATTAGAAGGACAAGAGTGGACGAGTTCAA
TAAGAAGAGTTACTGGAGGAAGAGAGGCATTGCGGTCGTCCCCATGAAGTTTTCAGTTGGCTTT
GCTGCGACAAGCTATCATCAGGCAGCCGCGCTCGTTCACATCTACACCGACGGCTCTGTGTTGG
TGGCACATGGAGGCAATGAGCTGGGACAAGGCATTCACACCAAAATGTTACAGGTGGCCAGCCG
TGAATTGAAAATACCCATGTCGTACCTGCACACCAGCGAAACATGCACAGCAGCGGTGCCCAAT
ACAATTGCTACGGCCGCGTCCGTCGGAGCCGATGTCAATGGCAGAGCTGTGCAGAATGCCTGTC
AGATCCTTCTCAAACGTCTTGAGCCCGTCATTAAGAAAAACCCGGAAGGGACATGGAGAGACTG
GATAGAAGCAGCCTTTGAACAAAGGATCAGTCTTTCAGCCACCGGATACAACAGGGGCTACAAG
GCCTTCATGGACTGGGAGAAGGGAGAGGGAGACCCATTCCCATACTATGTCTATGGAGCTGCGT
GTTCTGAGGTTGAAATCGACTGCCTGACAGGTGCTCACAAGAAAATGAGAACCGACATTGTCAT
GGATGCCTGTTGCAGCCTGAATCCAGCCATCGACGTTGGGCAGATCGAAGGTGCGTTTATTCAA
GGAATGGGCCTTTATACCACAGAGGACGTGCACTACTCTCCAGAGGGCGTCCTGTACTCTCGGA
GCCCGGACAAGTACAAAATCCCAACTGTCACTGATGTCCCGGAGCAGTTTAATGTGTCCTTGCT
GCCATCATCTCAGACTCCGCTCACCATCTACTCGTCAAAGGGCCTCGGGGAGTCCGGGATGTTC
CTAGGGTCATCCGTATTTTTCGCCATTGCTGATGCGGTGGCTGCGGCACGGAGACAAAGAGACA
TAGCCGAGGACTTCACAGTGAAGAGCCCAGCAACCCCAGAGCGGGTGCGGATGGCCTGTGCAGA
CCGGTTCACCGACATGATCCCGAGAGATGACCCAAAGACATTTAAACCTTGGTCTATACCTATA
GCTTAATCTGCTCTCATTTCCTAGGAGATATTTATGAGTCAAGTGAAAAGCCGGCTTCCTAATC
CTGACTGGACTCCAAACTGTATTCATGTGCTGTTGGGTGGGAGGGAGGGTGAGCTCTGTCACAA
AATTTAGAGTCACGATTCTATATCAACCACATTAATGAGATGAAGGCATTTCTTATAAATTATT
TACTTAGTGTTCTCAGCCTAGAGACTGCCAGACAAGCACTGCAGTGTTTGAAGCTCCTTTAATG
ATTTGTCTTTGAAAAAGACAGAGTAAATGGTACTGCGGAAGGAGCAGAAAGGAGACCTGGTGTG
CATGCAGA

hide sequence

RefSeq Acc Id:

XM_063267188 ⟹ XP_063123258

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	67,322,291 - 67,411,694 (+)	NCBI

RefSeq Acc Id:

XM_063267189 ⟹ XP_063123259

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	67,322,291 - 67,358,850 (+)	NCBI

RefSeq Acc Id:

XM_063267190 ⟹ XP_063123260

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	67,322,435 - 67,395,800 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001008522	(Get FASTA)	NCBI Sequence Viewer
	XP_063123258	(Get FASTA)	NCBI Sequence Viewer
	XP_063123259	(Get FASTA)	NCBI Sequence Viewer
	XP_063123260	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAV68255	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000047535
	ENSRNOP00000047535.4
	ENSRNOP00000079851.1
GenBank Protein	Q5QE78	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008522 ⟸ NM_001008522

- UniProtKB:

Q5QE78 (UniProtKB/Swiss-Prot), D4A6S5 (UniProtKB/Swiss-Prot), A0A096P6M6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPCPSQSSDELEFFVNGKKVTEKNVDPEVTLLAFLRKNLRLTGTKYACGTGSCGACTVMVSQHD
PVCKKTRHFSVMACLVPLCSLHGAAVTTVEGVGSIKTRLHPVQERLAKSHGTQCGFCSPGMVMS
MYALLRNHPQPSEEQLLEALGGNLCRCTGYRPILESGRTFCMESDGCLQKGTGQCCLDQKEGDS
SGSKSDICTELFVKDEFQPLDPTQELIFPPELLRMAENPEKQTLTFYGERITWIAPGTLQELLV
LKAKYPEAPLISGNTALGPAMKSQGHFYPVLLSPARIPDLRMVTKTSGGLTIGACCSLAQVKDV
LAESISELPEEKTQTYRALLKHLRSLAGQQIRNMASLGGHVISRHYYSDLNPILSVGNATLNLL
SEEGLRQIPLNGHFLAGLANEDLKPEEILGSVYIPHSQKREFVSAFRQAQCHQNALPDVNAGMR
VLFKEGTDIIEELSIAYGGVGPTTVSAHRSCQQLLGRRWNALLLDEACRLLLDEVSLPGSAVGG
KVEFRRTLIVSFFFKFYLEVLQELKADKRLLPESTDSQRYPEIADGSRSSLGDFQVTLPQGVQT
YQRVNSHQPLQDPVGRPIMHLSGLKHATGEAVFCDDIPRVDKELFMALVTSTRAHARIISIDSS
EVLDLPGVVDVITAEDIPGNNGEEDDKLLAVDKVLCVGQVVCAVVAETDVQAKRATKKIKITYE
DLKPVLFTIEDAIQHNSFLCPEKKLEQGNMEEAFENVDQIVEGKVHVGGQEHFYMETQRVLVIP
KTEDKELDMYVSTQDPAHVQKTVSSALNIPLSRITCHVKRVGGGFGGKVGRPAVFGAIAAVGAV
KTGRPIRLVLDREDDMLITGGRHPLFAKYKVGFMNSGRIKALDIECYINGGCTLDDSELVTEFL
VLKLENAYKIRNLRLRGRACMTNLPSNTAFRGFGFPQGALVTESCITAVAAKCGLPPEKIREKN
MYKTVDKTIYKQAFNPEPLIRCWNECLDKSSFAIRRTRVDEFNKKSYWRKRGIAVVPMKFSVGF
AATSYHQAAALVHIYTDGSVLVAHGGNELGQGIHTKMLQVASRELKIPMSYLHTSETCTAAVPN
TIATAASVGADVNGRAVQNACQILLKRLEPVIKKNPEGTWRDWIEAAFEQRISLSATGYNRGYK
AFMDWEKGEGDPFPYYVYGAACSEVEIDCLTGAHKKMRTDIVMDACCSLNPAIDVGQIEGAFIQ
GMGLYTTEDVHYSPEGVLYSRSPDKYKIPTVTDVPEQFNVSLLPSSQTPLTIYSSKGLGESGMF
LGSSVFFAIADAVAAARRQRDIAEDFTVKSPATPERVRMACADRFTDMIPRDDPKTFKPWSIPI
A

hide sequence

Ensembl Acc Id:

ENSRNOP00000047535 ⟸ ENSRNOT00000048027

Ensembl Acc Id:

ENSRNOP00000079851 ⟸ ENSRNOT00000095499

RefSeq Acc Id:	XP_063123258 ⟸ XM_063267188
- Peptide Label:	isoform X1
- UniProtKB:	Q5QE78 (UniProtKB/Swiss-Prot), D4A6S5 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063123259 ⟸ XM_063267189
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063123260 ⟸ XM_063267190
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5ZNK8 (UniProtKB/TrEMBL)

Protein Domains

2Fe-2S ferredoxin-type FAD-binding PCMH-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5QE78-F1-model_v2	AlphaFold	Q5QE78	1-1345	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359668	AgrOrtholog
BioCyc Gene	G2FUF-27455	BioCyc
Ensembl Genes	ENSRNOG00000033923	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000048027	ENTREZGENE
	ENSRNOT00000048027.5	UniProtKB/TrEMBL
	ENSRNOT00000095499.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.20.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.43.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.465.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	[2Fe-2S]-binding domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CO dehydrogenase flavoprotein, C-terminal domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	2Fe-2S-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2Fe-2S-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2Fe-2S_ferredoxin-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2Fe-2S_ferredoxin-type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2Fe2S_fd_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_Oxase/Xan_DH_a/b	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_Oxase/Xan_DH_a/b_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_Oxase/xanthine_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldehyde_oxidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AldOxase/xan_DH_MoCoBD2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AldOxase/xan_DH_Mopterin-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AldOxase/xan_DH_Mopterin-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Beta-grasp_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CO_DH_flav_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CO_DH_flav_C_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FAD-bd_PCMH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FAD-bd_PCMH-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FAD-bd_PCMH_sub1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FAD-bd_PCMH_sub2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mopterin_DH_FAD-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:316421	UniProtKB/Swiss-Prot
NCBI Gene	316421	ENTREZGENE
PANTHER	XANTHINE DEHYDROGENASE	UniProtKB/Swiss-Prot
	XANTHINE DEHYDROGENASE	UniProtKB/Swiss-Prot
	XANTHINE DEHYDROGENASE	UniProtKB/TrEMBL
	XANTHINE DEHYDROGENASE	UniProtKB/TrEMBL
Pfam	Ald_Xan_dh_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ald_Xan_dh_C2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CO_deh_flav_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FAD_binding_5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fer2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fer2_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MoCoBD_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Aox2	PhenoGen
PIRSF	Xanthine_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	2FE2S_FER_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2FE2S_FER_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FAD_PCMH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000033923	RatGTEx
SMART	Ald_Xan_dh_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CO_deh_flav_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47741	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54292	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54665	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55447	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56003	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56176	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A096P6M6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZNK8	ENTREZGENE, UniProtKB/TrEMBL
	AOXB_RAT	UniProtKB/Swiss-Prot
	D4A6S5	ENTREZGENE
	Q5QE78	ENTREZGENE
UniProt Secondary	D4A6S5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-09-26	Aox2	aldehyde oxidase 2	Aox3l1	aldehyde oxidase 3-like 1	Name and Symbol changed	629549	APPROVED
2013-01-14	Aox2p	aldehyde oxidase 2 pseudogene	Aox3l1	aldehyde oxidase 3-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-12	Aox3l1	aldehyde oxidase 3-like 1	Aox2	aldehyde oxidase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-29	Aox2	aldehyde oxidase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)