Aox2 (aldehyde oxidase 2) - Rat Genome Database

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Gene: Aox2 (aldehyde oxidase 2) Rattus norvegicus
No known orthologs.
Symbol: Aox2
Name: aldehyde oxidase 2
RGD ID: 1359668
Description: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; ion binding activity; and molybdopterin cofactor binding activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol; PARTICIPATES IN monoterpenoid biosynthetic pathway; niacin metabolic pathway; phase I biotransformation pathway via cytochrome P450; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde oxidase 2 pseudogene; aldehyde oxidase 3-like 1; aldehyde oxidase homolog 3; Aox2p; Aox3l1; azaheterocycle hydroxylase 2
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2959,828,403 - 59,916,175 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl959,828,084 - 59,916,146 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,321,349 - 68,409,382 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,437,270 - 73,525,311 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0971,755,358 - 71,843,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,175,455 - 65,265,149 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,177,511 - 65,265,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0964,973,842 - 65,072,447 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4956,948,950 - 57,038,897 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,095,931 - 57,185,868 (+)NCBI
Celera957,271,035 - 57,358,789 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISS)

Molecular Function


References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. Kurosaki M, etal., J Biol Chem 2004 Nov 26;279(48):50482-98. Epub 2004 Sep 20.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed



Variants in Aox2
409 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:149
Interacting mature miRNAs:160
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2959,862,631 - 59,862,721 (+)MAPPERmRatBN7.2
Rnor_6.0965,211,645 - 65,211,734NCBIRnor6.0
Rnor_5.0965,019,072 - 65,019,161UniSTSRnor5.0
RGSC_v3.4956,983,723 - 56,983,812UniSTSRGSC3.4
Celera957,305,227 - 57,305,316UniSTS
RH 3.4 Map9482.6UniSTS
Cytogenetic Map9q31UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2959,890,877 - 59,891,047 (+)MAPPERmRatBN7.2
Rnor_6.0965,239,884 - 65,240,053NCBIRnor6.0
Rnor_5.0965,047,310 - 65,047,479UniSTSRnor5.0
RGSC_v3.4957,013,499 - 57,013,668UniSTSRGSC3.4
Celera957,333,530 - 57,333,699UniSTS
RH 3.4 Map9483.8UniSTS
Cytogenetic Map9q31UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2959,888,074 - 59,888,258 (+)MAPPERmRatBN7.2
Rnor_6.0965,237,081 - 65,237,264NCBIRnor6.0
Rnor_5.0965,044,507 - 65,044,690UniSTSRnor5.0
RGSC_v3.4957,010,696 - 57,010,879UniSTSRGSC3.4
Celera957,330,727 - 57,330,910UniSTS
RH 3.4 Map9483.3UniSTS
Cytogenetic Map9q31UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 4 4
Low 2 30 18 4 18 4 5 23 23 14 4 4
Below cutoff 1 10 23 23 3 23 4 6 44 10 21 5 4


RefSeq Acc Id: ENSRNOT00000048027   ⟹   ENSRNOP00000047535
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl959,828,084 - 59,916,146 (+)Ensembl
Rnor_6.0 Ensembl965,177,511 - 65,265,149 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095499   ⟹   ENSRNOP00000079851
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl959,828,084 - 59,900,790 (+)Ensembl
RefSeq Acc Id: NM_001008522   ⟹   NP_001008522
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2959,828,403 - 59,916,175 (+)NCBI
Rnor_6.0965,177,511 - 65,265,149 (+)NCBI
Rnor_5.0964,973,842 - 65,072,447 (+)NCBI
RGSC_v3.4956,948,950 - 57,038,897 (+)RGD
Celera957,271,035 - 57,358,789 (+)RGD
RefSeq Acc Id: XM_039083624   ⟹   XP_038939552
Rat AssemblyChrPosition (strand)Source
mRatBN7.2959,828,409 - 59,915,907 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001008522 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939552 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV68255 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047535
GenBank Protein Q5QE78 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008522   ⟸   NM_001008522
- UniProtKB: Q5QE78 (UniProtKB/Swiss-Prot),   D4A6S5 (UniProtKB/Swiss-Prot),   A0A096P6M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047535   ⟸   ENSRNOT00000048027
RefSeq Acc Id: XP_038939552   ⟸   XM_039083624
- Peptide Label: isoform X1
- UniProtKB: Q5QE78 (UniProtKB/Swiss-Prot),   D4A6S5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000079851   ⟸   ENSRNOT00000095499
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5QE78-F1-model_v2 AlphaFold Q5QE78 1-1345 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359668 AgrOrtholog
BioCyc Gene G2FUF-27455 BioCyc
Ensembl Genes ENSRNOG00000033923 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048027 ENTREZGENE
  ENSRNOT00000048027.5 UniProtKB/TrEMBL
  ENSRNOT00000095499.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.465.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  [2Fe-2S]-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO dehydrogenase flavoprotein, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 2Fe-2S-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2Fe2S_fd_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/Xan_DH_a/b_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Oxase/xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_MoCoBD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AldOxase/xan_DH_Mopterin-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_DH_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_DH_flav_C_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mopterin_DH_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:316421 UniProtKB/Swiss-Prot
Pfam Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_Xan_dh_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_binding_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoCoBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aox2 PhenoGen
PIRSF Xanthine_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 2FE2S_FER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2FE2S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033923 RatGTEx
SMART Ald_Xan_dh_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CO_deh_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47741 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AOXB_RAT UniProtKB/Swiss-Prot
UniProt Secondary D4A6S5 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-26 Aox2  aldehyde oxidase 2  Aox3l1  aldehyde oxidase 3-like 1  Name and Symbol changed 629549 APPROVED
2013-01-14 Aox2p  aldehyde oxidase 2 pseudogene  Aox3l1  aldehyde oxidase 3-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Aox3l1  aldehyde oxidase 3-like 1  Aox2  aldehyde oxidase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 Aox2  aldehyde oxidase 2      Symbol and Name status set to provisional 70820 PROVISIONAL