Trak2 (trafficking kinesin protein 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Trak2 (trafficking kinesin protein 2) Rattus norvegicus
Analyze
Symbol: Trak2
Name: trafficking kinesin protein 2
RGD ID: 620915
Description: Enables several functions, including GABA receptor binding activity; TPR domain binding activity; and kinesin binding activity. Involved in several processes, including dendrite morphogenesis; dendritic transport of mitochondrion; and negative regulation of axonogenesis. Located in several cellular components, including axonal growth cone; dendrite; and neuronal cell body. Colocalizes with early endosome. Orthologous to human TRAK2 (trafficking kinesin protein 2); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Als2cr3; amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog (human); amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein homolog; GABA-A receptor interacting factor-1; GABA-A receptor-interacting factor 1; GRIF-1; MGC93214; O-GlcNAc transferase-interacting protein of 98 kDa; trafficking kinesin-binding protein 2; trafficking protein, kinesin binding 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2960,348,531 - 60,414,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,350,012 - 60,413,996 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,844,354 - 68,909,801 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,960,314 - 74,025,761 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,278,580 - 72,344,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,698,706 - 65,763,351 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,698,712 - 65,763,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,505,448 - 65,570,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,474,682 - 57,540,751 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,624,566 - 57,661,312 (-)NCBI
Celera957,788,961 - 57,853,095 (-)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
iron dichloride  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP)
raloxifene  (ISO)
ranitidine  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
tungsten  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification, Molecular Cloning, and Characterization of a Novel GABAA Receptor-associated Protein, GRIF-1. Beck M, etal., J Biol Chem 2002 Aug 16;277(33):30079-90.
2. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. Brickley K, etal., J Biol Chem. 2005 Apr 15;280(15):14723-32. Epub 2005 Jan 11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. Iyer SP, etal., J Biol Chem 2003 Feb 14;278(7):5399-409.
5. GRIF1 binds Hrs and is a new regulator of endosomal trafficking. Kirk E, etal., J Cell Sci. 2006 Nov 15;119(Pt 22):4689-701. Epub 2006 Oct 24.
6. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. Li Y, etal., J Cell Biol. 2009 Jun 15;185(6):1065-81. doi: 10.1083/jcb.200811033.
7. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
8. Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons. Loss O and Stephenson FA, J Neurosci Res. 2015 Jul;93(7):1056-66. doi: 10.1002/jnr.23549. Epub 2015 Feb 4.
9. GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. MacAskill AF, etal., Mol Cell Neurosci. 2009 Mar;40(3):301-12. Epub 2008 Dec 3.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Delineation of the TRAK binding regions of the kinesin-1 motor proteins. Randall TS, etal., FEBS Lett. 2013 Nov 29;587(23):3763-9. doi: 10.1016/j.febslet.2013.09.049. Epub 2013 Oct 22.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. van Spronsen M, etal., Neuron. 2013 Feb 6;77(3):485-502. doi: 10.1016/j.neuron.2012.11.027.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16630562  


Genomics

Comparative Map Data
Trak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2960,348,531 - 60,414,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,350,012 - 60,413,996 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,844,354 - 68,909,801 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,960,314 - 74,025,761 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,278,580 - 72,344,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,698,706 - 65,763,351 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,698,712 - 65,763,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,505,448 - 65,570,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,474,682 - 57,540,751 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,624,566 - 57,661,312 (-)NCBI
Celera957,788,961 - 57,853,095 (-)NCBICelera
Cytogenetic Map9q31NCBI
TRAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382201,377,207 - 201,451,458 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2201,377,207 - 201,451,500 (-)EnsemblGRCh38hg38GRCh38
GRCh372202,241,930 - 202,316,181 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,950,175 - 202,024,499 (-)NCBINCBI36Build 36hg18NCBI36
Build 342202,067,436 - 202,141,760NCBI
Celera2195,993,770 - 196,068,264 (-)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2194,090,332 - 194,144,077 (-)NCBIHuRef
CHM1_12202,247,949 - 202,322,415 (-)NCBICHM1_1
T2T-CHM13v2.02201,857,884 - 201,933,333 (-)NCBIT2T-CHM13v2.0
Trak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,939,608 - 59,013,509 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,939,608 - 59,012,589 (-)EnsemblGRCm39 Ensembl
GRCm38158,900,449 - 58,974,345 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,900,449 - 58,973,430 (-)EnsemblGRCm38mm10GRCm38
MGSCv37158,957,294 - 59,030,326 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36158,844,996 - 58,891,044 (-)NCBIMGSCv36mm8
Celera159,419,476 - 59,489,206 (-)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.2NCBI
Trak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403206,146 - 261,326 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955403205,372 - 261,210 (+)NCBIChiLan1.0ChiLan1.0
TRAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B104,015,054 - 104,090,173 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B88,630,665 - 88,705,709 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B206,785,541 - 206,861,102 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,785,541 - 206,861,102 (-)Ensemblpanpan1.1panPan2
TRAK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,457,985 - 10,521,432 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,461,104 - 10,497,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3711,341,722 - 11,405,148 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03710,362,764 - 10,426,223 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3710,362,766 - 10,426,177 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13710,343,403 - 10,406,849 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03710,322,444 - 10,385,866 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03710,315,865 - 10,379,295 (-)NCBIUU_Cfam_GSD_1.0
Trak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,679,121 - 158,738,519 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726649,418 - 708,820 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936726649,413 - 708,816 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,991,726 - 105,055,025 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,991,261 - 105,056,054 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,383,936 - 116,416,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11087,022,038 - 87,096,685 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1087,022,043 - 87,096,666 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040112,322,842 - 112,398,263 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899300,096 - 332,392 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624899275,291 - 335,555 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trak2
230 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:945
Count of miRNA genes:264
Interacting mature miRNAs:358
Transcripts:ENSRNOT00000014939, ENSRNOT00000015034
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat

Markers in Region
D9Rat118  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,369,837 - 60,370,066 (+)MAPPERmRatBN7.2
Rnor_6.0965,720,011 - 65,720,239NCBIRnor6.0
Rnor_5.0965,526,753 - 65,526,981UniSTSRnor5.0
RGSC_v3.4957,496,532 - 57,496,760UniSTSRGSC3.4
RGSC_v3.4957,496,531 - 57,496,760RGDRGSC3.4
RGSC_v3.1957,643,514 - 57,643,742RGD
Celera957,810,265 - 57,810,493UniSTS
RH 3.4 Map9495.2RGD
RH 3.4 Map9495.2UniSTS
RH 2.0 Map9568.4RGD
SHRSP x BN Map942.1498RGD
Cytogenetic Map9q31UniSTS
RH127778  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,348,597 - 60,348,783 (+)MAPPERmRatBN7.2
Rnor_6.0965,698,772 - 65,698,957NCBIRnor6.0
Rnor_5.0965,505,515 - 65,505,700UniSTSRnor5.0
RGSC_v3.4957,474,745 - 57,474,930UniSTSRGSC3.4
Celera957,789,024 - 57,789,209UniSTS
RH 3.4 Map9494.69UniSTS
Cytogenetic Map9q31UniSTS
RH140019  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,350,918 - 60,351,105 (+)MAPPERmRatBN7.2
Rnor_6.0965,701,093 - 65,701,279NCBIRnor6.0
Rnor_5.0965,507,836 - 65,508,022UniSTSRnor5.0
RGSC_v3.4957,477,066 - 57,477,252UniSTSRGSC3.4
Celera957,791,345 - 57,791,531UniSTS
RH 3.4 Map9495.2UniSTS
Cytogenetic Map9q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 44 28 19 28 8 11 74 35 41 11 8
Low 13 13 13
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC133661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF474163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ288898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000014939   ⟹   ENSRNOP00000014939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl960,351,438 - 60,413,964 (-)Ensembl
Rnor_6.0 Ensembl965,701,413 - 65,737,538 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000015034   ⟹   ENSRNOP00000015035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl960,350,012 - 60,413,964 (-)Ensembl
Rnor_6.0 Ensembl965,698,712 - 65,763,273 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087458   ⟹   ENSRNOP00000072887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl960,350,403 - 60,413,996 (-)Ensembl
Rnor_6.0 Ensembl965,701,612 - 65,736,852 (-)Ensembl
RefSeq Acc Id: NM_133560   ⟹   NP_598244
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,348,535 - 60,414,018 (-)NCBI
Rnor_6.0965,698,709 - 65,763,273 (-)NCBI
Rnor_5.0965,505,448 - 65,570,090 (-)NCBI
RGSC_v3.4957,474,682 - 57,540,751 (-)RGD
Celera957,788,961 - 57,853,095 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767072   ⟹   XP_008765294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,348,531 - 60,413,996 (-)NCBI
Rnor_6.0965,698,706 - 65,763,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596256   ⟹   XP_017451745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,351,137 - 60,414,032 (-)NCBI
Rnor_6.0965,698,706 - 65,763,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082996   ⟹   XP_038938924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2960,351,952 - 60,414,036 (-)NCBI
RefSeq Acc Id: NP_598244   ⟸   NM_133560
- UniProtKB: Q8R2H6 (UniProtKB/Swiss-Prot),   Q8R4G3 (UniProtKB/Swiss-Prot),   Q8R2H7 (UniProtKB/Swiss-Prot),   A6IP87 (UniProtKB/TrEMBL),   A6IP85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765294   ⟸   XM_008767072
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K434 (UniProtKB/TrEMBL),   A6IP85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451745   ⟸   XM_017596256
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K434 (UniProtKB/TrEMBL),   A6IP85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014939   ⟸   ENSRNOT00000014939
RefSeq Acc Id: ENSRNOP00000072887   ⟸   ENSRNOT00000087458
RefSeq Acc Id: ENSRNOP00000015035   ⟸   ENSRNOT00000015034
RefSeq Acc Id: XP_038938924   ⟸   XM_039082996
- Peptide Label: isoform X2
- UniProtKB: A6IP86 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2H7-F1-model_v2 AlphaFold Q8R2H7 1-913 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696695
Promoter ID:EPDNEW_R7220
Type:initiation region
Name:Trak2_1
Description:trafficking kinesin protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,763,201 - 65,763,261EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620915 AgrOrtholog
BioCyc Gene G2FUF-27429 BioCyc
Ensembl Genes ENSRNOG00000010881 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014939 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000015034 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000087458 ENTREZGENE
  ENSRNOT00000087458.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124967 IMAGE-MGC_LOAD
InterPro HAP1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Traffickng_kinesin-bd_prot_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171086 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93214 IMAGE-MGC_LOAD
NCBI Gene 171086 ENTREZGENE
PANTHER TRAFFICKING KINESIN-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAFFICKING KINESIN-BINDING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HAP1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Milton UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trak2 PhenoGen
RatGTEx ENSRNOG00000010881 RatGTEx
SMART HAP1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Milton UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K434 ENTREZGENE, UniProtKB/TrEMBL
  A6IP85 ENTREZGENE, UniProtKB/TrEMBL
  A6IP86 ENTREZGENE, UniProtKB/TrEMBL
  A6IP87 ENTREZGENE, UniProtKB/TrEMBL
  Q8R2H6 ENTREZGENE
  Q8R2H7 ENTREZGENE
  Q8R4G3 ENTREZGENE
  TRAK2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8R2H6 UniProtKB/Swiss-Prot
  Q8R4G3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Trak2  trafficking kinesin protein 2  Trak2  trafficking protein, kinesin binding 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Trak2  trafficking protein, kinesin binding 2  Als2cr3  amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog (human)  Symbol and Name updated 1299863 APPROVED
2004-12-14 Als2cr3  amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog (human)    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3  Name updated 1299863 APPROVED
2002-08-07 Als2cr3  amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains consensus sequences for phosphorylation by protein kinase A, protein kinase C and casein kinase and contains a proline-rich domain 625504
gene_expression mRNA expressed in a variety of tissues but protein expression is predominantly in excitable tissues 625504
gene_homology has 47% homology over 297 aa with the rat huntingtin-associated protein (HAP-1) 625504
gene_product 913 amino acid protein 625504
gene_transcript expressed as two alternative splicing forms 625504