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Gene: Idh1 (isocitrate dehydrogenase (NADP(+)) 1) Rattus norvegicus
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Symbol: Idh1
Name: isocitrate dehydrogenase (NADP(+)) 1
Description: Exhibits NADP binding activity and isocitrate dehydrogenase (NADP+) activity. Involved in female gonad development; isocitrate metabolic process; and response to steroid hormone. Localizes to the peroxisome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; glioblastoma multiforme; hepatocellular clear cell carcinoma; malignant glioma; and myelodysplastic syndrome. Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; (RS)-amphetamine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cytosolic NADP-isocitrate dehydrogenase; IDH; IDP; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase 1; isocitrate dehydrogenase 1 (NADP+); isocitrate dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase 1 soluble; isocitrate dehydrogenase 1, soluble; isocitrate dehydrogenase [NADP] cytoplasmic; NADP(+)-specific ICDH; oxalosuccinate decarboxylase
Orthologs:
Homo sapiens (human) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)  HGNC  Alliance
Mus musculus (house mouse) : Idh1 (isocitrate dehydrogenase 1 (NADP+), soluble)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Canis lupus familiaris (dog) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
Sus scrofa (pig) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0971,882,108 - 71,911,645 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,882,105 - 71,900,044 (-)Ensembl
Rnor_5.0970,660,443 - 70,689,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,769,401 - 63,790,622 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1963,916,382 - 63,937,604 (-)NCBI
Celera963,929,810 - 63,951,008 (-)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Idh1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2862
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.