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Gene: Idh1 (isocitrate dehydrogenase (NADP(+)) 1) Rattus norvegicus
Symbol: Idh1
Name: isocitrate dehydrogenase (NADP(+)) 1
RGD ID: 2862
Description: Exhibits NADP binding activity and isocitrate dehydrogenase (NADP+) activity. Involved in female gonad development; isocitrate metabolic process; and response to steroid hormone. Localizes to peroxisome. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and malignant glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: cytosolic NADP-isocitrate dehydrogenase; IDH; IDP; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase 1; isocitrate dehydrogenase 1 (NADP+); isocitrate dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase 1 soluble; isocitrate dehydrogenase 1, soluble; isocitrate dehydrogenase [NADP] cytoplasmic; NADP(+)-specific ICDH; oxalosuccinate decarboxylase
Homo sapiens (human) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)  HGNC  Alliance
Mus musculus (house mouse) : Idh1 (isocitrate dehydrogenase 1 (NADP+), soluble)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Canis lupus familiaris (dog) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
Sus scrofa (pig) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Chlorocebus sabaeus (African green monkey) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Heterocephalus glaber (naked mole-rat) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0971,882,108 - 71,911,645 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,882,105 - 71,900,044 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,660,443 - 70,689,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,769,401 - 63,790,622 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1963,916,382 - 63,937,604 (-)NCBI
Celera963,929,810 - 63,951,008 (-)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Idh1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2862
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.