Il1rl1 (interleukin 1 receptor-like 1) - Rat Genome Database

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Gene: Il1rl1 (interleukin 1 receptor-like 1) Rattus norvegicus
Analyze
Symbol: Il1rl1
Name: interleukin 1 receptor-like 1
RGD ID: 2894
Description: Predicted to enable interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide; and negative regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Biomarker of acute myocardial infarction and bacterial pneumonia. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fit-1; FIT1; Fos-responsive gene 1; Interleukin 1 receptor-like 1 (Fos-responsive gene 1); interleukin-1 receptor-like 1; St2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,157,326 - 50,222,888 (+)NCBIGRCr8
mRatBN7.2942,661,694 - 42,727,266 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,697,192 - 42,727,256 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,179,169 - 51,227,104 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,301,859 - 56,349,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,577,363 - 54,625,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,133,483 - 47,184,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,134,034 - 47,182,170 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,818,236 - 46,866,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,577,879 - 39,624,781 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,610,600 - 39,618,735 (+)NCBI
Celera940,421,404 - 40,468,339 (+)NCBICelera
RH 3.4 Map9420.09RGD
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dioxane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
anthracene-1,8,9-triol  (ISO)
aripiprazole  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzoic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calycosin  (EXP)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dimethylselenide  (ISO)
dioxygen  (ISO)
endosulfan  (EXP,ISO)
ferroheme b  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
heme b  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methyltestosterone  (ISO)
Mezerein  (ISO)
Muraglitazar  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nonanoic acid  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pemetrexed  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
propionic acid  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
saccharin  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium nitrite  (ISO)
streptozocin  (EXP)
styrene oxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
WIN 55212-2  (EXP)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential production of interleukin-1 family cytokines (IL-1β, IL-18, IL-33 and IL-37) in patients with paracoccidioidomycosis: correlation with clinical form and antifungal therapy. Alves ABRM, etal., Med Mycol. 2018 Apr 1;56(3):332-343. doi: 10.1093/mmy/myx050.
2. The Alarmin IL-33 Derived from HSV-2-Infected Keratinocytes Triggers Mast Cell-Mediated Antiviral Innate Immunity. Aoki R, etal., J Invest Dermatol. 2016 Jun;136(6):1290-1292. doi: 10.1016/j.jid.2016.01.030. Epub 2016 Feb 9.
3. IL-33 receptor (ST2) deficiency downregulates myeloid precursors, inflammatory NK and dendritic cells in early phase of sepsis. Babic ZM, etal., J Biomed Sci. 2018 Jul 12;25(1):56. doi: 10.1186/s12929-018-0455-z.
4. T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses. Baumann C, etal., Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4056-61. doi: 10.1073/pnas.1418549112. Epub 2015 Mar 17.
5. Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. Bergers G, etal., EMBO J 1994 Mar 1;13(5):1176-88.
6. Asthma and genes encoding components of the vitamin D pathway. Bosse Y, etal., Respir Res. 2009 Oct 24;10:98.
7. Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33. Castanhinha S, etal., J Allergy Clin Immunol. 2015 Aug;136(2):312-22.e7. doi: 10.1016/j.jaci.2015.01.016. Epub 2015 Mar 5.
8. Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. Castano R, etal., Am J Rhinol Allergy. 2009 Jul-Aug;23(4):377-84.
9. Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice. Chuang CC, etal., J Microbiol Immunol Infect. 2016 Feb;49(1):91-6. doi: 10.1016/j.jmii.2014.01.009. Epub 2014 Mar 21.
10. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
11. Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. Ferreira MA, etal., Eur J Hum Genet. 2011 Apr;19(4):458-64. Epub 2010 Dec 8.
12. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. Franca RF, etal., J Neuroinflammation. 2016 Jun 22;13(1):159. doi: 10.1186/s12974-016-0628-1.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis. Gimenes JA, etal., Clin Sci (Lond). 2019 Apr 29;133(8):983-996. doi: 10.1042/CS20181088. Print 2019 Apr 30.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Gudbjartsson DF, etal., Nat Genet. 2009 Mar;41(3):342-7. Epub 2009 Feb 8.
17. Increased soluble serum markers caspase-cleaved cytokeratin-18, histones, and ST2 indicate apoptotic turnover and chronic immune response in COPD. Hacker S, etal., J Clin Lab Anal. 2009;23(6):372-9.
18. Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. Hayakawa H, etal., J Biol Chem. 2007 Sep 7;282(36):26369-80. Epub 2007 Jul 10.
19. Loss of suppression of tumorigenicity 2 (ST2) gene reverses sepsis-induced inhibition of lung host defense in mice. Hoogerwerf JJ, etal., Am J Respir Crit Care Med. 2011 Apr 1;183(7):932-40. Epub 2010 Oct 19.
20. Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. Huan SL, etal., BMC Infect Dis. 2016 May 16;16:200. doi: 10.1186/s12879-016-1543-x.
21. IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation. Huang SJ, etal., J Neuroinflammation. 2018 Jan 12;15(1):12. doi: 10.1186/s12974-017-1021-4.
22. Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue. Ishikawa K, etal., Auris Nasus Larynx. 2014 Dec;41(6):552-7. doi: 10.1016/j.anl.2014.08.007. Epub 2014 Sep 2.
23. IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha. Jackson-Jones LH, etal., Eur J Immunol. 2016 Oct;46(10):2311-2321. doi: 10.1002/eji.201646442.
24. Serum soluble ST2 is a promising prognostic biomarker in HBV-related acute-on-chronic liver failure. Jiang SW, etal., Hepatobiliary Pancreat Dis Int. 2017 Apr;16(2):181-188. doi: 10.1016/s1499-3872(16)60185-6.
25. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Kearley J, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):772-81. Epub 2009 Jan 29.
26. Could interleukin-33 and its suppressor of tumorigenicity 2 (ST2) receptor have a role in cervical human papillomavirus (HPV) infections? Kulhan NG, etal., Gynecol Endocrinol. 2019 Sep;35(9):796-802. doi: 10.1080/09513590.2019.1590699. Epub 2019 Apr 2.
27. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
28. Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression. Li ZY, etal., Parasit Vectors. 2019 Jun 14;12(1):302. doi: 10.1186/s13071-019-3542-4.
29. IL-33 Exacerbates Periodontal Disease through Induction of RANKL. Malcolm J, etal., J Dent Res. 2015 Jul;94(7):968-75. doi: 10.1177/0022034515577815. Epub 2015 Mar 25.
30. T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation. Mangan NE, etal., Eur J Immunol. 2007 May;37(5):1302-12.
31. Interleukin-33 contributes to disease severity in Dengue virus infection in mice. Marques RE, etal., Immunology. 2018 Dec;155(4):477-490. doi: 10.1111/imm.12988. Epub 2018 Sep 10.
32. A role for soluble ST2 in vascular remodeling associated with obesity in rats. Martínez-Martínez E, etal., PLoS One. 2013 Nov 12;8(11):e79176. doi: 10.1371/journal.pone.0079176. eCollection 2013.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection. Nabekura T, etal., J Immunol. 2015 Jun 15;194(12):5948-52. doi: 10.4049/jimmunol.1500424. Epub 2015 Apr 29.
35. Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Oshikawa K, etal., Am J Respir Crit Care Med. 2001 Jul 15;164(2):277-81.
36. Critical role of IL-33 receptor ST2 in experimental cerebral malaria development. Palomo J, etal., Eur J Immunol. 2015 May;45(5):1354-65. doi: 10.1002/eji.201445206. Epub 2015 Mar 20.
37. IL-33 Treatment Attenuates the Systemic Inflammation Reaction in Acinetobacter baumannii Pneumonia by Suppressing TLR4/NF-κB Signaling. Peng C, etal., Inflammation. 2018 Jun;41(3):870-877. doi: 10.1007/s10753-018-0741-7.
38. Interleukin 33 mediates type 2 immunity and inflammation in the central nervous system of mice infected with Angiostrongylus cantonensis. Peng H, etal., J Infect Dis. 2013 Mar 1;207(5):860-9. doi: 10.1093/infdis/jis682. Epub 2012 Nov 12.
39. M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection. Piñeros AR, etal., Sci Rep. 2017 Jan 27;7:41240. doi: 10.1038/srep41240.
40. Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone. Ramirez-Carrozzi V, etal., J Allergy Clin Immunol. 2017 Feb;139(2):705-708.e6. doi: 10.1016/j.jaci.2016.08.026. Epub 2016 Sep 30.
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Comprehensive gene review and curation RGD comprehensive gene curation
44. ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice. Rood JE, etal., Blood. 2016 Jan 28;127(4):426-35. doi: 10.1182/blood-2015-07-659813. Epub 2015 Oct 30.
45. The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications. Ryan N, etal., Front Cell Infect Microbiol. 2020 Apr 17;10:153. doi: 10.3389/fcimb.2020.00153. eCollection 2020.
46. IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. Sanada S, etal., J Clin Invest. 2007 Jun;117(6):1538-49. doi: 10.1172/JCI30634. Epub 2007 May 10.
47. Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. Savenije OE, etal., J Allergy Clin Immunol. 2011 Mar;127(3):750-6.e1-5. Epub 2011 Feb 1.
48. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Sedhom MA, etal., Gut. 2013 Dec;62(12):1714-23. doi: 10.1136/gutjnl-2011-301785. Epub 2012 Nov 21.
49. IL-33/ST2 contributes to severe symptoms in Plasmodium chabaudi-infected BALB/c mice. Seki T, etal., Parasitol Int. 2018 Feb;67(1):64-69. doi: 10.1016/j.parint.2017.03.008. Epub 2017 Mar 27.
50. Interleukin family member ST2 and mortality in acute dyspnoea. Socrates T, etal., J Intern Med. 2010 Nov;268(5):493-500. doi: 10.1111/j.1365-2796.2010.02263.x.
51. Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Stastna M, etal., Proteomics. 2010 Jan;10(2):245-53.
52. Modulation of IL-33/ST2 system in postinfarction heart failure: correlation with cardiac remodelling markers. Sánchez-Más J, etal., Eur J Clin Invest. 2014 Jul;44(7):643-51. doi: 10.1111/eci.12282.
53. The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis. Tajima S, etal., Chest. 2003 Oct;124(4):1206-14.
54. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
55. Genetic variability of the distal promoter of the ST2 gene is associated with angiographic severity of coronary artery disease. Tsapaki A, etal., J Thromb Thrombolysis. 2010 Oct;30(3):365-71.
56. Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology. Walzl G, etal., J Exp Med. 2001 Apr 2;193(7):785-92.
57. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. Wills-Karp M, etal., J Exp Med. 2012 Mar 12;209(3):607-22. doi: 10.1084/jem.20110079. Epub 2012 Feb 13.
58. Interleukin-33/ST2 signaling contributes to the severity of hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli. Yamada S, etal., Clin Exp Nephrol. 2019 Apr;23(4):544-550. doi: 10.1007/s10157-018-1675-y. Epub 2018 Nov 22.
59. Adenovirus-mediated overexpression of soluble ST2 provides a protective effect on lipopolysaccharide-induced acute lung injury in mice. Yin H, etal., Clin Exp Immunol. 2011 May;164(2):248-55. doi: 10.1111/j.1365-2249.2011.04326.x. Epub 2011 Feb 24.
60. IL-33/ST2 correlates with severity of haemorrhagic fever with renal syndrome and regulates the inflammatory response in Hantaan virus-infected endothelial cells. Zhang Y, etal., PLoS Negl Trop Dis. 2015 Feb 6;9(2):e0003514. doi: 10.1371/journal.pntd.0003514. eCollection 2015 Feb.
Additional References at PubMed
PMID:7883081   PMID:12714518   PMID:14643017   PMID:18268038   PMID:19666510   PMID:19841166   PMID:19919994   PMID:25815839   PMID:27455844   PMID:28274612   PMID:29045903   PMID:29653119  
PMID:30562096   PMID:30998979   PMID:31726037   PMID:32513089   PMID:32592632   PMID:36768322   PMID:38142925   PMID:38724005  


Genomics

Comparative Map Data
Il1rl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,157,326 - 50,222,888 (+)NCBIGRCr8
mRatBN7.2942,661,694 - 42,727,266 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,697,192 - 42,727,256 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,179,169 - 51,227,104 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,301,859 - 56,349,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,577,363 - 54,625,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0947,133,483 - 47,184,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,134,034 - 47,182,170 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,818,236 - 46,866,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,577,879 - 39,624,781 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,610,600 - 39,618,735 (+)NCBI
Celera940,421,404 - 40,468,339 (+)NCBICelera
RH 3.4 Map9420.09RGD
Cytogenetic Map9q22NCBI
IL1RL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,311,563 - 102,352,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2102,311,502 - 102,352,037 (+)EnsemblGRCh38hg38GRCh38
GRCh372102,928,023 - 102,968,497 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,294,394 - 102,334,929 (+)NCBINCBI36Build 36hg18NCBI36
Build 342102,412,234 - 102,419,698NCBI
Celera297,129,200 - 97,169,642 (+)NCBICelera
Cytogenetic Map2q12.1NCBI
HuRef296,692,020 - 96,732,452 (+)NCBIHuRef
CHM1_12102,932,225 - 102,972,834 (+)NCBICHM1_1
T2T-CHM13v2.02102,769,811 - 102,810,635 (+)NCBIT2T-CHM13v2.0
Il1rl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,444,105 - 40,504,575 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,468,730 - 40,504,575 (+)EnsemblGRCm39 Ensembl
GRCm38140,404,864 - 40,465,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,429,570 - 40,465,415 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,496,494 - 40,522,260 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,384,308 - 40,409,958 (+)NCBIMGSCv36mm8
Celera140,251,783 - 40,277,425 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map119.19NCBI
Il1rl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554707,779,828 - 7,849,157 (+)NCBIChiLan1.0ChiLan1.0
IL1RL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,353,603 - 25,368,702 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A25,356,789 - 25,371,496 (-)NCBINHGRI_mPanPan1
IL1RL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,658,191 - 40,732,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,659,041 - 40,677,357 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,584,086 - 40,603,254 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01041,524,636 - 41,543,860 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,481,796 - 41,559,352 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11041,239,090 - 41,258,271 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,520,373 - 41,539,587 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,712,710 - 41,731,892 (-)NCBIUU_Cfam_GSD_1.0
Il1rl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629290,097,610 - 90,128,649 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367131,021,044 - 1,035,039 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367131,020,969 - 1,035,012 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1RL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl351,846,792 - 51,951,383 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1351,868,549 - 51,902,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2354,483,076 - 54,567,410 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL1RL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,966,551 - 6,020,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,005,061 - 6,020,265 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041173,687,571 - 173,703,287 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il1rl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,795,748 - 6,873,701 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247496,795,822 - 6,873,068 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il1rl1
515 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:93
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000020108, ENSRNOT00000020144
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
RH94829  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2942,716,530 - 42,716,759 (+)MAPPERmRatBN7.2
Rnor_6.0947,173,966 - 47,174,194NCBIRnor6.0
Rnor_5.0946,858,149 - 46,858,377UniSTSRnor5.0
RGSC_v3.4939,616,577 - 39,616,805UniSTSRGSC3.4
Celera940,460,135 - 40,460,363UniSTS
RH 3.4 Map9420.09UniSTS
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 47 113 91 90 59 25 59 6 215 94 93 45 59 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001127689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY390390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU929068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA412513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA412515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000020108   ⟹   ENSRNOP00000020108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,697,192 - 42,727,256 (+)Ensembl
Rnor_6.0 Ensembl947,134,034 - 47,182,170 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000020144   ⟹   ENSRNOP00000020144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl947,165,342 - 47,174,710 (+)Ensembl
RefSeq Acc Id: NM_001127689   ⟹   NP_001121161
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,172,306 - 50,220,358 (+)NCBI
mRatBN7.2942,676,675 - 42,724,735 (+)NCBI
Rnor_6.0947,134,034 - 47,182,170 (+)NCBI
Rnor_5.0946,818,236 - 46,866,589 (+)NCBI
RGSC_v3.4939,577,879 - 39,624,781 (+)RGD
Celera940,421,404 - 40,468,339 (+)RGD
Sequence:
RefSeq Acc Id: NM_013037   ⟹   NP_037169
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,203,638 - 50,212,898 (+)NCBI
mRatBN7.2942,708,015 - 42,717,275 (+)NCBI
Rnor_6.0947,165,342 - 47,174,710 (+)NCBI
Rnor_5.0946,818,236 - 46,866,589 (+)NCBI
RGSC_v3.4939,577,879 - 39,624,781 (+)RGD
Celera940,452,740 - 40,460,879 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244739   ⟹   XP_006244801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,190,001 - 50,222,888 (+)NCBI
mRatBN7.2942,694,405 - 42,727,266 (+)NCBI
Rnor_6.0947,153,383 - 47,184,316 (+)NCBI
Rnor_5.0946,818,236 - 46,866,589 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244740   ⟹   XP_006244802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,172,139 - 50,222,888 (+)NCBI
mRatBN7.2942,676,497 - 42,727,266 (+)NCBI
Rnor_6.0947,133,483 - 47,184,316 (+)NCBI
Rnor_5.0946,818,236 - 46,866,589 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766992   ⟹   XP_008765214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,172,139 - 50,222,888 (+)NCBI
mRatBN7.2942,676,497 - 42,727,266 (+)NCBI
Rnor_6.0947,133,483 - 47,184,316 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596290   ⟹   XP_017451779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,200,048 - 50,222,888 (+)NCBI
mRatBN7.2942,706,543 - 42,727,266 (+)NCBI
Rnor_6.0947,163,939 - 47,184,316 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083070   ⟹   XP_038938998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,157,326 - 50,222,888 (+)NCBI
mRatBN7.2942,661,694 - 42,727,266 (+)NCBI
RefSeq Acc Id: XM_039083071   ⟹   XP_038938999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,190,005 - 50,222,888 (+)NCBI
mRatBN7.2942,694,405 - 42,727,266 (+)NCBI
RefSeq Acc Id: XM_039083072   ⟹   XP_038939000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,157,326 - 50,222,888 (+)NCBI
mRatBN7.2942,661,694 - 42,727,266 (+)NCBI
RefSeq Acc Id: XM_039083073   ⟹   XP_038939001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,203,366 - 50,222,888 (+)NCBI
mRatBN7.2942,707,740 - 42,727,266 (+)NCBI
RefSeq Acc Id: XM_063266706   ⟹   XP_063122776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,172,139 - 50,222,888 (+)NCBI
RefSeq Acc Id: NP_037169   ⟸   NM_013037
- Peptide Label: isoform Fit-1S precursor
- UniProtKB: Q62611 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001121161   ⟸   NM_001127689
- Peptide Label: isoform Fit-1M precursor
- UniProtKB: Q62612 (UniProtKB/Swiss-Prot),   Q62611 (UniProtKB/Swiss-Prot),   F1LR63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244802   ⟸   XM_006244740
- Peptide Label: isoform X1
- UniProtKB: F1LR63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244801   ⟸   XM_006244739
- Peptide Label: isoform X1
- UniProtKB: F1LR63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765214   ⟸   XM_008766992
- Peptide Label: isoform X1
- UniProtKB: F1LR63 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451779   ⟸   XM_017596290
- Peptide Label: isoform X1
- UniProtKB: F1LR63 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020144   ⟸   ENSRNOT00000020144
Ensembl Acc Id: ENSRNOP00000020108   ⟸   ENSRNOT00000020108
RefSeq Acc Id: XP_038938998   ⟸   XM_039083070
- Peptide Label: isoform X1
- UniProtKB: F1LR63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939000   ⟸   XM_039083072
- Peptide Label: isoform X1
- UniProtKB: F1LR63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938999   ⟸   XM_039083071
- Peptide Label: isoform X1
- UniProtKB: F1LR63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939001   ⟸   XM_039083073
- Peptide Label: isoform X1
- UniProtKB: F1LR63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122776   ⟸   XM_063266706
- Peptide Label: isoform X1
Protein Domains
Ig-like   Ig-like C2-type   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62611-F1-model_v2 AlphaFold Q62611 1-566 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696631
Promoter ID:EPDNEW_R7156
Type:single initiation site
Name:Il1rl1_1
Description:interleukin 1 receptor-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0947,165,343 - 47,165,403EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2894 AgrOrtholog
BioCyc Gene G2FUF-27723 BioCyc
Ensembl Genes ENSRNOG00000014835 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055019782 UniProtKB/Swiss-Prot
  ENSRNOG00060026733 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020108.6 UniProtKB/TrEMBL
  ENSRNOT00055033792 UniProtKB/Swiss-Prot
  ENSRNOT00060046322 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_I/II-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25556 UniProtKB/Swiss-Prot
NCBI Gene Il1rl1 ENTREZGENE
PANTHER INTERLEUKIN-1 RECEPTOR-LIKE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IL1RL1 RGD
PhenoGen Il1rl1 PhenoGen
PRINTS INTRLKN1R12F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLKN1R1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014835 RatGTEx
  ENSRNOG00055019782 RatGTEx
  ENSRNOG00060026733 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC211924
UniProt A6INN5_RAT UniProtKB/TrEMBL
  A6INN7_RAT UniProtKB/TrEMBL
  F1LR63 ENTREZGENE, UniProtKB/TrEMBL
  ILRL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62612 ENTREZGENE
UniProt Secondary Q62612 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Il1rl1  interleukin 1 receptor-like 1      Symbol and Name updated 629477 APPROVED
2003-03-12 Il1rl1  interleukin 1 receptor-like 1  St2  Fos-responsive gene 1  Data merged from RGD:3769 628472 PROVISIONAL
2002-06-10 St2  Fos-responsive gene 1      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Il1rl1  interleukin 1 receptor-like 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript differential promoter usage creates two alternative transcipts 69859
gene_transcript alternative mRNAs encode for a transmembrane protein and a soluable secreted protein 69859