RGD Reference Report - IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha. - Rat Genome Database

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IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha.

Authors: Jackson-Jones, Lucy H  Rückerl, Dominik  Svedberg, Freya  Duncan, Sheelagh  Maizels, Rick M  Sutherland, Tara E  Jenkins, Stephen J  McSorley, Henry J  Bénézech, Cécile  MacDonald, Andrew S  Allen, Judith E 
Citation: Jackson-Jones LH, etal., Eur J Immunol. 2016 Oct;46(10):2311-2321. doi: 10.1002/eji.201646442.
RGD ID: 40400889
Pubmed: PMID:27592711   (View Abstract at PubMed)
PMCID: PMC5082546   (View Article at PubMed Central)
DOI: DOI:10.1002/eji.201646442   (Journal Full-text)

IL-33 plays an important role in the initiation of type-2 immune responses, as well as the enhancement of type 2 effector functions. Engagement of the IL-33 receptor on macrophages facilitates polarization to an alternative activation state by amplifying IL-4 and IL-13 signaling to IL-4Rα. IL-4 and IL-13 also induce macrophage proliferation but IL-33 involvement in this process has not been rigorously evaluated. As expected, in vivo delivery of IL-33 induced IL-4Rα-dependent alternative macrophage activation in the serous cavities. IL-33 delivery also induced macrophages to proliferate but, unexpectedly, this was independent of IL-4Rα signaling. In a filarial nematode infection model in which IL-4Rα-dependent alternative activation and proliferation in the pleural cavity is well described, IL-33R was essential for alternative activation but not macrophage proliferation. Similarly, during Alternaria alternata induced airway inflammation, which provokes strong IL-33 responses, we observed that both IL-4Rα and IL-33R were required for alternative activation, while macrophage proliferation in the pleural cavity was still evident in the absence of either receptor alone. Our data show that IL-33R and IL-4Rα promote macrophage proliferation independently of each other, but both are essential for induction of alternative activation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
filariasis  ISOIl1rl1 (Mus musculus)40400889; 40400889 RGD 
filariasis  IMP 40400889 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1rl1  (interleukin 1 receptor-like 1)

Genes (Mus musculus)
Il1rl1  (interleukin 1 receptor-like 1)

Genes (Homo sapiens)
IL1RL1  (interleukin 1 receptor like 1)

Objects referenced in this article
Gene IL33 interleukin 33 Homo sapiens
Gene Il33 interleukin 33 Mus musculus
Gene Il33 interleukin 33 Rattus norvegicus

Additional Information