RGD Reference Report - Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue. - Rat Genome Database

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Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue.

Authors: Ishikawa, Kazuya  Yagi-Nakanishi, Sayaka  Nakanishi, Yosuke  Kondo, Satoru  Tsuji, Akira  Endo, Kazuhira  Wakisaka, Naohiro  Murono, Shigeyuki  Yoshizaki, Tomokazu 
Citation: Ishikawa K, etal., Auris Nasus Larynx. 2014 Dec;41(6):552-7. doi: 10.1016/j.anl.2014.08.007. Epub 2014 Sep 2.
RGD ID: 39938972
Pubmed: PMID:25193287   (View Abstract at PubMed)
DOI: DOI:10.1016/j.anl.2014.08.007   (Journal Full-text)


OBJECTIVE: The aim of this study was to clarify the role of IL-33 in tumor progression.
METHODS: Surgical specimens from 81 patients with squamous cell carcinoma of the tongue were studied using immunohistochemistry. Primary tumor sections were analyzed for IL-33 and ST2 expression. To examine the influence of IL-33 on the microenvironment of the tumor, we determined the mast cell density (MCD) and microvessel density of the stroma.
RESULTS: Patients with high IL-33 expression had a significantly worse prognosis (p=0.004). IL-33 expression was significantly elevated in patients with local and nodal recurrence (p=0.014 and p=0.019). ST2 expression was also associated with a worse prognosis (p=0.024) and was significantly elevated in patients with nodal recurrence (p=0.004). MCD was associated with worse prognosis (p=0.038) and correlated significantly with IL-33 expression (r=0.626, p<0.001). Micovessels in the stroma were significantly increased in the high IL-33 group (p<0.001).
CONCLUSION: These data suggest that the IL-33/ST2 axis contributes to tumor aggressiveness and affects the tumor microenvironment. Immunohistochemical evaluation of IL-33 and ST2 is useful for identifying patients at a high risk for poor prognosis.



Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Il1rl1  (interleukin 1 receptor-like 1)
Il33  (interleukin 33)

Genes (Mus musculus)
Il1rl1  (interleukin 1 receptor-like 1)
Il33  (interleukin 33)

Genes (Homo sapiens)
IL1RL1  (interleukin 1 receptor like 1)
IL33  (interleukin 33)


Additional Information