IL1RL1 (interleukin 1 receptor like 1) - Rat Genome Database
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Gene: IL1RL1 (interleukin 1 receptor like 1) Homo sapiens
Analyze
Symbol: IL1RL1
Name: interleukin 1 receptor like 1
RGD ID: 736158
HGNC Page HGNC
Description: Predicted to have interleukin-33 binding activity and interleukin-33 receptor activity. Predicted to be involved in negative regulation of I-kappaB kinase/NF-kappaB signaling. Localizes to cytosol; focal adhesion; and plasma membrane. Implicated in asthma and coronary artery disease. Biomarker of asthma; chronic obstructive pulmonary disease; idiopathic pulmonary fibrosis; and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DER4; FIT-1; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL33R; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; interleukin-1 receptor-like 1; MGC32623; ST2; ST2L; ST2V; T1
RGD Orthologs
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene, IL1RL1 (GeneID: 9173) which has the alias ST2, is found on chromosome 2. IL1RL1 encodes a member of the interleukin 1 receptor family. IL1RL1 has been confused in the published literature with ST2 (GeneID: 6761) on chromosome 11 which is a region that represents a putative locus associated with various forms of cancer. [23 Jun 2016]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2102,311,502 - 102,352,037 (+)EnsemblGRCh38hg38GRCh38
GRCh382102,311,529 - 102,352,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372102,927,962 - 102,968,497 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,294,394 - 102,334,929 (+)NCBINCBI36hg18NCBI36
Build 342102,412,234 - 102,419,698NCBI
Celera297,129,200 - 97,169,642 (+)NCBI
Cytogenetic Map2q12.1NCBI
HuRef296,692,020 - 96,732,452 (+)NCBIHuRef
CHM1_12102,932,225 - 102,972,834 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (EXP)
2,4-diaminotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
ammonium chloride  (ISO)
anthracene-1,8,9-triol  (ISO)
aripiprazole  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzoic acid  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
butanal  (EXP)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (EXP)
calycosin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dichlorine  (ISO)
dioxygen  (EXP)
endosulfan  (EXP,ISO)
ferroheme b  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
heme b  (ISO)
indometacin  (EXP)
iron dichloride  (ISO)
iron trichloride  (ISO)
ketoconazole  (EXP)
kojic acid  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methylisothiazolinone  (EXP)
methyltestosterone  (EXP)
Mezerein  (ISO)
N-Nitrosopyrrolidine  (EXP)
nickel atom  (EXP)
nonanoic acid  (ISO)
O-methyleugenol  (EXP)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
palytoxin  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pemetrexed  (EXP)
pentanal  (EXP)
perfluorononanoic acid  (EXP)
phenacetin  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
progesterone  (EXP,ISO)
propionic acid  (ISO)
quercetin  (EXP,ISO)
saccharin  (ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium nitrite  (ISO)
streptozocin  (ISO)
styrene oxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
tetrachloromethane  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
WIN 55212-2  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
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32. Peng H, etal., J Infect Dis. 2013 Mar 1;207(5):860-9. doi: 10.1093/infdis/jis682. Epub 2012 Nov 12.
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35. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. RGD automated import pipeline for gene-chemical interactions
37. Rood JE, etal., Blood. 2016 Jan 28;127(4):426-35. doi: 10.1182/blood-2015-07-659813. Epub 2015 Oct 30.
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42. Seki T, etal., Parasitol Int. 2018 Feb;67(1):64-69. doi: 10.1016/j.parint.2017.03.008. Epub 2017 Mar 27.
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44. Sánchez-Más J, etal., Eur J Clin Invest. 2014 Jul;44(7):643-51. doi: 10.1111/eci.12282.
45. Tajima S, etal., Chest. 2003 Oct;124(4):1206-14.
46. Tsapaki A, etal., J Thromb Thrombolysis. 2010 Oct;30(3):365-71.
47. Walzl G, etal., J Exp Med. 2001 Apr 2;193(7):785-92.
48. Wills-Karp M, etal., J Exp Med. 2012 Mar 12;209(3):607-22. doi: 10.1084/jem.20110079. Epub 2012 Feb 13.
49. Yamada S, etal., Clin Exp Nephrol. 2019 Apr;23(4):544-550. doi: 10.1007/s10157-018-1675-y. Epub 2018 Nov 22.
50. Yin H, etal., Clin Exp Immunol. 2011 May;164(2):248-55. doi: 10.1111/j.1365-2249.2011.04326.x. Epub 2011 Feb 24.
51. Zhang Y, etal., PLoS Negl Trop Dis. 2015 Feb 6;9(2):e0003514. doi: 10.1371/journal.pntd.0003514. eCollection 2015 Feb.
Additional References at PubMed
PMID:1482686   PMID:8621446   PMID:9058198   PMID:9207179   PMID:9618516   PMID:9794420   PMID:9811530   PMID:10191101   PMID:10491084   PMID:10527832   PMID:10936050   PMID:11076863  
PMID:11359817   PMID:11478810   PMID:11531955   PMID:12355452   PMID:12368275   PMID:12477932   PMID:12492487   PMID:12578875   PMID:12665801   PMID:14759258   PMID:14991091   PMID:15004556  
PMID:15063762   PMID:15340161   PMID:15481335   PMID:15489334   PMID:15489336   PMID:15815621   PMID:16118232   PMID:16286016   PMID:16344560   PMID:16381901   PMID:16426569   PMID:18029348  
PMID:18226917   PMID:18311140   PMID:18375488   PMID:18774397   PMID:18794051   PMID:18802081   PMID:18827826   PMID:18941187   PMID:18995177   PMID:19017513   PMID:19074885   PMID:19169993  
PMID:19180518   PMID:19247692   PMID:19254249   PMID:19520469   PMID:19559631   PMID:19756962   PMID:19860791   PMID:19889931   PMID:19898481   PMID:19910030   PMID:20190752   PMID:20237496  
PMID:20331378   PMID:20353565   PMID:20363761   PMID:20385815   PMID:20406635   PMID:20435187   PMID:20503266   PMID:20625511   PMID:20800603   PMID:20816195   PMID:20860503   PMID:21102463  
PMID:21178018   PMID:21190867   PMID:21515743   PMID:21633527   PMID:21663467   PMID:21682736   PMID:21804549   PMID:21832049   PMID:21871564   PMID:21873635   PMID:21897866   PMID:21949719  
PMID:22035779   PMID:22104207   PMID:22105364   PMID:22155704   PMID:22203232   PMID:22233535   PMID:22494834   PMID:22542450   PMID:22634619   PMID:22819319   PMID:22824976   PMID:22828942  
PMID:22835988   PMID:22841163   PMID:22865859   PMID:22922442   PMID:23028483   PMID:23042114   PMID:23128233   PMID:23220272   PMID:23290950   PMID:23300625   PMID:23332814   PMID:23357301  
PMID:23469087   PMID:23482076   PMID:23484079   PMID:23485578   PMID:23488689   PMID:23552178   PMID:23567618   PMID:23585867   PMID:23615326   PMID:23688338   PMID:23817569   PMID:23817571  
PMID:23855553   PMID:23910012   PMID:23924003   PMID:23966867   PMID:23980170   PMID:23999434   PMID:24045639   PMID:24065602   PMID:24075188   PMID:24122812   PMID:24125409   PMID:24239955  
PMID:24263122   PMID:24304137   PMID:24385203   PMID:24385685   PMID:24388013   PMID:24401186   PMID:24413615   PMID:24467978   PMID:24564816   PMID:24568840   PMID:24603291   PMID:24636276  
PMID:24675360   PMID:24746754   PMID:24751794   PMID:24982172   PMID:25003325   PMID:25032216   PMID:25068163   PMID:25069762   PMID:25091434   PMID:25200162   PMID:25280997   PMID:25324197  
PMID:25347817   PMID:25377785   PMID:25416956   PMID:25458175   PMID:25464491   PMID:25465308   PMID:25473804   PMID:25512474   PMID:25517029   PMID:25531326   PMID:25586507   PMID:25642632  
PMID:25655003   PMID:25673187   PMID:25677987   PMID:25734941   PMID:25753178   PMID:25798875   PMID:25881899   PMID:25892854   PMID:25919009   PMID:25977120   PMID:26110635   PMID:26343805  
PMID:26365875   PMID:26493291   PMID:26679377   PMID:26835712   PMID:26919112   PMID:27001944   PMID:27023364   PMID:27097949   PMID:27223112   PMID:27882929   PMID:27900334   PMID:27918564  
PMID:28110258   PMID:28126482   PMID:28126963   PMID:28169287   PMID:28262704   PMID:28266165   PMID:28283847   PMID:28415811   PMID:28440062   PMID:28442257   PMID:28466817   PMID:28614418  
PMID:28664478   PMID:28849217   PMID:28860510   PMID:28860791   PMID:29068593   PMID:29146682   PMID:29153414   PMID:29519908   PMID:29578435   PMID:29763892   PMID:29774370   PMID:29867945  
PMID:29954670   PMID:30274001   PMID:30339898   PMID:30478965   PMID:30540645   PMID:30562096   PMID:30564243   PMID:30588853   PMID:30655611   PMID:31061143   PMID:31066119   PMID:31092701  
PMID:31132589   PMID:31153005   PMID:31235844   PMID:31279260   PMID:31285364   PMID:31291030   PMID:31561019   PMID:31659258   PMID:31673224   PMID:31870168   PMID:31897507   PMID:32246094  
PMID:32296183  


Genomics

Comparative Map Data
IL1RL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2102,311,502 - 102,352,037 (+)EnsemblGRCh38hg38GRCh38
GRCh382102,311,529 - 102,352,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372102,927,962 - 102,968,497 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,294,394 - 102,334,929 (+)NCBINCBI36hg18NCBI36
Build 342102,412,234 - 102,419,698NCBI
Celera297,129,200 - 97,169,642 (+)NCBI
Cytogenetic Map2q12.1NCBI
HuRef296,692,020 - 96,732,452 (+)NCBIHuRef
CHM1_12102,932,225 - 102,972,834 (+)NCBICHM1_1
Il1rl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,444,025 - 40,504,578 (+)NCBIGRCm39mm39
GRCm38140,404,864 - 40,465,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,429,570 - 40,465,415 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,496,494 - 40,522,260 (+)NCBIGRCm37mm9NCBIm37
MGSCv36140,384,308 - 40,409,958 (+)NCBImm8
Celera140,251,783 - 40,277,425 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map119.19NCBI
Il1rl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0947,133,483 - 47,184,316 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl947,134,034 - 47,182,170 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,818,236 - 46,866,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,577,879 - 39,624,781 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1939,610,600 - 39,618,735 (+)NCBI
Celera940,421,404 - 40,468,339 (+)NCBICelera
Cytogenetic Map9q22NCBI
RH 3.4 Map9420.09RGD
Il1rl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554707,779,828 - 7,849,157 (+)NCBIChiLan1.0ChiLan1.0
IL1RL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1040,659,041 - 40,677,357 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11040,658,191 - 40,732,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Il1rl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367131,020,969 - 1,035,012 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1RL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl351,803,165 - 51,951,383 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1351,868,549 - 51,902,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2354,483,076 - 54,567,410 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL1RL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl146,005,061 - 6,020,265 (+)Ensembl
ChlSab1.1145,966,551 - 6,020,391 (+)NCBI
Il1rl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247496,795,822 - 6,873,068 (+)NCBI

Position Markers
RH68200  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372102,959,836 - 102,960,000UniSTSGRCh37
Build 362102,326,268 - 102,326,432RGDNCBI36
Celera297,160,981 - 97,161,145RGD
Cytogenetic Map2q12UniSTS
HuRef296,723,791 - 96,723,955UniSTS
GeneMap99-GB4 RH Map2360.16UniSTS
RH94265  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372102,962,258 - 102,962,379UniSTSGRCh37
Build 362102,328,690 - 102,328,811RGDNCBI36
Celera297,163,403 - 97,163,524RGD
Cytogenetic Map2q12UniSTS
HuRef296,726,213 - 96,726,334UniSTS
GeneMap99-GB4 RH Map2360.16UniSTS
G09503  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372102,930,577 - 102,930,697UniSTSGRCh37
Build 362102,297,009 - 102,297,129RGDNCBI36
Celera297,131,732 - 97,131,855RGD
Cytogenetic Map2q12UniSTS
HuRef296,694,552 - 96,694,675UniSTS
D2S2552  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372102,959,941 - 102,960,101UniSTSGRCh37
Build 362102,326,373 - 102,326,533RGDNCBI36
Celera297,161,086 - 97,161,246RGD
Cytogenetic Map2q12UniSTS
HuRef296,723,896 - 96,724,056UniSTS
Stanford-G3 RH Map24420.0UniSTS
GeneMap99-G3 RH Map25333.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2734
Count of miRNA genes:1047
Interacting mature miRNAs:1276
Transcripts:ENST00000233954, ENST00000311734, ENST00000393393, ENST00000404917, ENST00000409584, ENST00000427077, ENST00000447231, ENST00000463990, ENST00000473175, ENST00000482701
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 21
Medium 408 436 410 65 88 64 504 222 420 130 62 675 2 587 180 1
Low 1775 2194 983 349 1022 211 3056 1436 1792 173 918 660 145 616 2113 1
Below cutoff 150 351 285 167 285 147 584 491 1359 63 376 129 23 1 1 495 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001282408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006712839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011512151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB012701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB022176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB029084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL553735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ012352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA884586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB063031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU181431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU181432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000233954   ⟹   ENSP00000233954
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,311,563 - 102,352,037 (+)Ensembl
RefSeq Acc Id: ENST00000311734   ⟹   ENSP00000310371
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,337,148 - 102,346,100 (+)Ensembl
RefSeq Acc Id: ENST00000404917   ⟹   ENSP00000384822
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,311,502 - 102,346,099 (+)Ensembl
RefSeq Acc Id: ENST00000409584   ⟹   ENSP00000386618
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,337,258 - 102,344,951 (+)Ensembl
RefSeq Acc Id: ENST00000427077   ⟹   ENSP00000391120
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,337,288 - 102,343,756 (+)Ensembl
RefSeq Acc Id: ENST00000447231   ⟹   ENSP00000409437
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,311,568 - 102,338,891 (+)Ensembl
RefSeq Acc Id: ENST00000463990
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,337,250 - 102,339,466 (+)Ensembl
RefSeq Acc Id: ENST00000473175
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,311,529 - 102,340,196 (+)Ensembl
RefSeq Acc Id: ENST00000482701
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2102,337,281 - 102,343,109 (+)Ensembl
RefSeq Acc Id: NM_001282408   ⟹   NP_001269337
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,311,563 - 102,346,100 (+)NCBI
HuRef296,692,020 - 96,732,452 (+)NCBI
CHM1_12102,932,225 - 102,966,898 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003856   ⟹   NP_003847
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,337,257 - 102,346,100 (+)NCBI
GRCh372102,927,962 - 102,968,497 (+)ENTREZGENE
Build 362102,320,149 - 102,327,615 (+)NCBI Archive
HuRef296,692,020 - 96,732,452 (+)ENTREZGENE
CHM1_12102,958,048 - 102,966,898 (+)NCBI
Sequence:
RefSeq Acc Id: NM_016232   ⟹   NP_057316
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,311,563 - 102,352,037 (+)NCBI
GRCh372102,927,962 - 102,968,497 (+)ENTREZGENE
Build 362102,294,394 - 102,334,929 (+)NCBI Archive
HuRef296,692,020 - 96,732,452 (+)ENTREZGENE
CHM1_12102,932,225 - 102,972,834 (+)NCBI
Sequence:
RefSeq Acc Id: NR_104167
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,337,257 - 102,346,100 (+)NCBI
HuRef296,692,020 - 96,732,452 (+)NCBI
CHM1_12102,958,048 - 102,966,898 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006712839   ⟹   XP_006712902
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,337,250 - 102,352,367 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011512151   ⟹   XP_011510453
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,311,529 - 102,346,100 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057316   ⟸   NM_016232
- Peptide Label: isoform 1 precursor
- UniProtKB: Q01638 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_003847   ⟸   NM_003856
- Peptide Label: isoform 2 precursor
- UniProtKB: Q01638 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001269337   ⟸   NM_001282408
- Peptide Label: isoform 3
- UniProtKB: Q01638 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006712902   ⟸   XM_006712839
- Peptide Label: isoform X2
- UniProtKB: Q01638 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011510453   ⟸   XM_011512151
- Peptide Label: isoform X1
- UniProtKB: Q01638 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000391120   ⟸   ENST00000427077
RefSeq Acc Id: ENSP00000384822   ⟸   ENST00000404917
RefSeq Acc Id: ENSP00000310371   ⟸   ENST00000311734
RefSeq Acc Id: ENSP00000233954   ⟸   ENST00000233954
RefSeq Acc Id: ENSP00000409437   ⟸   ENST00000447231
RefSeq Acc Id: ENSP00000386618   ⟸   ENST00000409584
Protein Domains
Ig-like   Ig-like C2-type   TIR

Promoters
RGD ID:6797639
Promoter ID:HG_KWN:34199
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:NM_016232,   OTTHUMT00000329224,   OTTHUMT00000329227,   UC002TBW.2
Position:
Human AssemblyChrPosition (strand)Source
Build 362102,294,006 - 102,294,506 (+)MPROMDB
RGD ID:6861206
Promoter ID:EPDNEW_H3768
Type:initiation region
Name:IL1RL1_2
Description:interleukin 1 receptor like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3769  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,311,563 - 102,311,623EPDNEW
RGD ID:6861208
Promoter ID:EPDNEW_H3769
Type:initiation region
Name:IL1RL1_1
Description:interleukin 1 receptor like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3768  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382102,337,257 - 102,337,317EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q11.2-12.3(chr2:100378510-108472871)x3 copy number gain See cases [RCV000050836] Chr2:100378510..108472871 [GRCh38]
Chr2:100994972..109089327 [GRCh37]
Chr2:100361404..108455759 [NCBI36]
Chr2:2q11.2-12.3
pathogenic
GRCh38/hg38 2q11.1-12.1(chr2:94817406-103252396)x3 copy number gain See cases [RCV000052946] Chr2:94817406..103252396 [GRCh38]
Chr2:95618109..103868854 [GRCh37]
Chr2:94846878..103235286 [NCBI36]
Chr2:2q11.1-12.1
pathogenic
GRCh38/hg38 2q11.2-13(chr2:97672522-110211318)x3 copy number gain See cases [RCV000052947] Chr2:97672522..110211318 [GRCh38]
Chr2:98288985..110968895 [GRCh37]
Chr2:97655417..110326184 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2p11.2-q11.2(chr2:91443218-102334856)x3 copy number gain See cases [RCV000052945] Chr2:91443218..102334856 [GRCh38]
Chr2:91617683..102951316 [GRCh37]
Chr2:90981410..102317748 [NCBI36]
Chr2:2p11.2-q11.2
pathogenic
NM_016232.4(IL1RL1):c.109C>T (p.Pro37Ser) single nucleotide variant Malignant melanoma [RCV000060279] Chr2:102338884 [GRCh38]
Chr2:102955344 [GRCh37]
Chr2:102321776 [NCBI36]
Chr2:2q12.1
not provided
NM_016232.4(IL1RL1):c.181G>A (p.Glu61Lys) single nucleotide variant Malignant melanoma [RCV000064988] Chr2:102338956 [GRCh38]
Chr2:102955416 [GRCh37]
Chr2:102321848 [NCBI36]
Chr2:2q12.1
not provided
NM_016232.4(IL1RL1):c.880G>A (p.Glu294Lys) single nucleotide variant Malignant melanoma [RCV000064989] Chr2:102343325 [GRCh38]
Chr2:102959785 [GRCh37]
Chr2:102326217 [NCBI36]
Chr2:2q12.1
not provided
NM_016232.4(IL1RL1):c.1640G>C (p.Ser547Thr) single nucleotide variant Malignant melanoma [RCV000064990] Chr2:102351890 [GRCh38]
Chr2:102968350 [GRCh37]
Chr2:102334782 [NCBI36]
Chr2:2q12.1
not provided
GRCh38/hg38 2q11.2-12.2(chr2:102084275-106085903)x1 copy number loss See cases [RCV000134974] Chr2:102084275..106085903 [GRCh38]
Chr2:102700735..106702359 [GRCh37]
Chr2:102067167..106068791 [NCBI36]
Chr2:2q11.2-12.2
likely pathogenic
GRCh38/hg38 2q11.2-13(chr2:101710825-110791418)x3 copy number gain See cases [RCV000138645] Chr2:101710825..110791418 [GRCh38]
Chr2:102327287..111548995 [GRCh37]
Chr2:101693719..111265466 [NCBI36]
Chr2:2q11.2-13
pathogenic
GRCh38/hg38 2q11.1-13(chr2:94678532-110602409)x3 copy number gain See cases [RCV000141075] Chr2:94678532..110602409 [GRCh38]
Chr2:95344257..111359986 [GRCh37]
Chr2:94707984..111076455 [NCBI36]
Chr2:2q11.1-13
pathogenic
GRCh38/hg38 2q11.2-12.2(chr2:100478285-106498909)x3 copy number gain See cases [RCV000141445] Chr2:100478285..106498909 [GRCh38]
Chr2:101094747..107115365 [GRCh37]
Chr2:100461179..106481797 [NCBI36]
Chr2:2q11.2-12.2
uncertain significance
GRCh38/hg38 2q11.2-12.2(chr2:101234070-105679157)x1 copy number loss See cases [RCV000142969] Chr2:101234070..105679157 [GRCh38]
Chr2:101850532..106295614 [GRCh37]
Chr2:101216964..105662046 [NCBI36]
Chr2:2q11.2-12.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q11.1-12.3(chr2:95529039-108518266) copy number gain See cases [RCV000449270] Chr2:95529039..108518266 [GRCh37]
Chr2:2q11.1-12.3
pathogenic
GRCh37/hg19 2q11.1-13(chr2:95327499-111370025)x4 copy number gain See cases [RCV000446842] Chr2:95327499..111370025 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q11.1-12.2(chr2:95518497-107186127) copy number gain See cases [RCV000511158] Chr2:95518497..107186127 [GRCh37]
Chr2:2q11.1-12.2
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
Single allele inversion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3 copy number gain not provided [RCV000682168] Chr2:96353030..114045463 [GRCh37]
Chr2:2q11.1-13
pathogenic
GRCh37/hg19 2q12.1(chr2:102964268-102969807)x1 copy number loss not provided [RCV000753066] Chr2:102964268..102969807 [GRCh37]
Chr2:2q12.1
benign
GRCh37/hg19 2q12.1(chr2:102968356-102972799)x1 copy number loss not provided [RCV000753070] Chr2:102968356..102972799 [GRCh37]
Chr2:2q12.1
benign
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q12.1(chr2:102964742-102968824)x1 copy number loss not provided [RCV000753067] Chr2:102964742..102968824 [GRCh37]
Chr2:2q12.1
benign
GRCh37/hg19 2q12.1(chr2:102967430-102967857)x0 copy number loss not provided [RCV000753068] Chr2:102967430..102967857 [GRCh37]
Chr2:2q12.1
benign
GRCh37/hg19 2q12.1(chr2:102967587-102968824)x1 copy number loss not provided [RCV000753069] Chr2:102967587..102968824 [GRCh37]
Chr2:2q12.1
benign
NM_016232.5(IL1RL1):c.19G>T (p.Ala7Ser) single nucleotide variant not provided [RCV000962950] Chr2:102338283 [GRCh38]
Chr2:102954743 [GRCh37]
Chr2:2q12.1
likely benign
NM_016232.5(IL1RL1):c.458C>T (p.Ala153Val) single nucleotide variant not provided [RCV000948605] Chr2:102340676 [GRCh38]
Chr2:102957136 [GRCh37]
Chr2:2q12.1
benign
NM_016232.5(IL1RL1):c.1329G>A (p.Arg443=) single nucleotide variant not provided [RCV000968452] Chr2:102351579 [GRCh38]
Chr2:102968039 [GRCh37]
Chr2:2q12.1
benign
NM_016232.5(IL1RL1):c.369T>C (p.Ser123=) single nucleotide variant not provided [RCV000946623] Chr2:102340194 [GRCh38]
Chr2:102956654 [GRCh37]
Chr2:2q12.1
benign
NM_016232.5(IL1RL1):c.1557T>C (p.Asn519=) single nucleotide variant not provided [RCV000916793] Chr2:102351807 [GRCh38]
Chr2:102968267 [GRCh37]
Chr2:2q12.1
likely benign
NM_016232.5(IL1RL1):c.1187G>A (p.Arg396His) single nucleotide variant not provided [RCV000946625] Chr2:102349148 [GRCh38]
Chr2:102965608 [GRCh37]
Chr2:2q12.1
benign
NM_016232.5(IL1RL1):c.646G>A (p.Ala216Thr) single nucleotide variant not provided [RCV000882908] Chr2:102342258 [GRCh38]
Chr2:102958718 [GRCh37]
Chr2:2q12.1
benign
NM_016232.5(IL1RL1):c.985A>G (p.Ile329Val) single nucleotide variant not provided [RCV000882909] Chr2:102347959 [GRCh38]
Chr2:102964419 [GRCh37]
Chr2:2q12.1
benign
NM_016232.5(IL1RL1):c.873C>T (p.Asp291=) single nucleotide variant not provided [RCV000946624] Chr2:102343318 [GRCh38]
Chr2:102959778 [GRCh37]
Chr2:2q12.1
benign
GRCh37/hg19 2q12.1-12.2(chr2:102917327-106755564)x1 copy number loss not provided [RCV000848959] Chr2:102917327..106755564 [GRCh37]
Chr2:2q12.1-12.2
uncertain significance
GRCh37/hg19 2q11.2-12.1(chr2:102248064-103361749)x3 copy number gain not provided [RCV000848462] Chr2:102248064..103361749 [GRCh37]
Chr2:2q11.2-12.1
uncertain significance
NM_016232.5(IL1RL1):c.1449G>C (p.Glu483Asp) single nucleotide variant not provided [RCV000901358] Chr2:102351699 [GRCh38]
Chr2:102968159 [GRCh37]
Chr2:2q12.1
likely benign
NM_016232.5(IL1RL1):c.1533G>A (p.Lys511=) single nucleotide variant not provided [RCV000885724] Chr2:102351783 [GRCh38]
Chr2:102968243 [GRCh37]
Chr2:2q12.1
benign
NM_016232.5(IL1RL1):c.603G>T (p.Thr201=) single nucleotide variant not provided [RCV000933887] Chr2:102340821 [GRCh38]
Chr2:102957281 [GRCh37]
Chr2:2q12.1
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5998 AgrOrtholog
COSMIC IL1RL1 COSMIC
Ensembl Genes ENSG00000115602 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000233954 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000310371 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000384822 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000386618 UniProtKB/TrEMBL
  ENSP00000391120 UniProtKB/Swiss-Prot
  ENSP00000409437 UniProtKB/TrEMBL
Ensembl Transcript ENST00000233954 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000311734 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000404917 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000409584 UniProtKB/TrEMBL
  ENST00000427077 UniProtKB/Swiss-Prot
  ENST00000447231 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000115602 GTEx
HGNC ID HGNC:5998 ENTREZGENE
Human Proteome Map IL1RL1 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_I/II-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9173 UniProtKB/Swiss-Prot
NCBI Gene 9173 ENTREZGENE
OMIM 601203 OMIM
PANTHER PTHR11890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IL1RL1 RGD, PharmGKB
PRINTS INTRLKN1R12F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.66 ENTREZGENE
  Hs.731651 ENTREZGENE
UniProt A8VPW9_HUMAN UniProtKB/TrEMBL
  A8VPX0_HUMAN UniProtKB/TrEMBL
  C9JSY6_HUMAN UniProtKB/TrEMBL
  E9PC41_HUMAN UniProtKB/TrEMBL
  ILRL1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A8K6B3 UniProtKB/Swiss-Prot
  B4E0I3 UniProtKB/Swiss-Prot
  Q53TU7 UniProtKB/Swiss-Prot
  Q8NEJ3 UniProtKB/Swiss-Prot
  Q9ULV7 UniProtKB/Swiss-Prot
  Q9UQ44 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 IL1RL1  interleukin 1 receptor like 1    interleukin 1 receptor-like 1  Symbol and/or name change 5135510 APPROVED
2011-08-16 IL1RL1  interleukin 1 receptor-like 1  IL1RL1  interleukin 1 receptor-like 1  Symbol and/or name change 5135510 APPROVED