Il1r1 (interleukin 1 receptor type 1) - Rat Genome Database

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Gene: Il1r1 (interleukin 1 receptor type 1) Rattus norvegicus
Analyze
Symbol: Il1r1
Name: interleukin 1 receptor type 1
RGD ID: 2892
Description: Enables ionotropic glutamate receptor binding activity. Involved in several processes, including interleukin-1-mediated signaling pathway; positive regulation of neuron migration; and response to odorant. Located in axon; cell surface; and extracellular space. Part of protein-containing complex. Biomarker of pulpitis. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis; systemic scleroderma; and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1); PARTICIPATES IN interleukin-1 signaling pathway; interleukin-12 signaling pathway; apoptotic cell death pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD121 antigen-like family member A; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; interleukin 1 beta receptor type 1 short transmembrane form; interleukin 1 beta receptor type 1 soluble form; interleukin 1 bete receptor type 1 long transmembrane form; interleukin 1 receptor, type I; interleukin-1 receptor alpha; interleukin-1 receptor type 1; interleukin-1 receptor type I; p80
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Il1r1em3Mcwi   Il1r1em2Mcwi   Il1r1em1Mcwi  
Genetic Models: BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em1Mcwi BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em3Mcwi BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,000,558 - 50,076,579 (+)NCBIGRCr8
mRatBN7.2942,504,917 - 42,580,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,504,735 - 42,579,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,042,291 - 51,080,451 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,165,013 - 56,203,144 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,441,033 - 54,478,767 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0946,962,291 - 47,038,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,962,288 - 47,036,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,647,422 - 46,723,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,434,910 - 39,473,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,434,750 - 39,475,060 (+)NCBI
Celera940,285,956 - 40,323,730 (+)NCBICelera
RH 3.4 Map9396.1RGD
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(S)-nicotine  (EXP)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxycyclophosphamide  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
adenosine  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
AH23848  (ISO)
albendazole  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
asperentin  (ISO)
atrazine  (ISO)
Bardoxolone methyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brevianamide A  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carrageenan  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
ellagic acid  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
erlotinib hydrochloride  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
indirubin  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
lenalidomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
magnesium dihydroxide  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methyllycaconitine  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
naringin  (EXP)
neoechinulin A  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
o-anisidine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
sterigmatocystin  (ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP,ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
XAV939  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. High glucose and interleukin-1beta downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism. Aveleira C, etal., Cytokine. 2010 Mar;49(3):279-86. doi: 10.1016/j.cyto.2009.11.014. Epub 2010 Jan 19.
2. Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level. Bergholdt R, etal., Genes Immun. 2000 Dec;1(8):495-500.
3. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, etal., Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
4. Sensory pulpal nerve fibres and trigeminal ganglion neurons express IL-1RI: a potential mechanism for development of inflammatory hyperalgesia. Bletsa A, etal., Int Endod J. 2009 Nov;42(11):978-86. doi: 10.1111/j.1365-2591.2009.01605.x. Epub 2009 Sep 1.
5. Interleukin 1 (IL-1) and IL-1-receptor antagonist (IL-1-RA) in middle ear cholesteatoma: an analysis of protein production and biological activity. Bujia J, etal., Eur Arch Otorhinolaryngol. 1996;253(4-5):252-5.
6. Tollip is a mediator of protein sumoylation. Ciarrocchi A, etal., PLoS One. 2009;4(2):e4404. Epub 2009 Feb 9.
7. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Fernandes A, etal., Glia. 2011 Jan;59(1):14-25. doi: 10.1002/glia.21072. Epub 2010 Oct 21.
8. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Frank JA, etal., Thorax. 2008 Feb;63(2):147-53. Epub 2007 Sep 27.
9. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation. Gardoni F, etal., J Neuroinflammation. 2011 Feb 11;8(1):14.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Gamma interferon and interleukin-1 receptor 1 regulate neutrophil recruitment to the corneal stroma in a murine model of Onchocerca volvulus keratitis. Gentil K and Pearlman E, Infect Immun. 2009 Apr;77(4):1606-12. doi: 10.1128/IAI.00671-08. Epub 2009 Jan 21.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. An mRNA homologous to interleukin-1 receptor type I is expressed in cultured rat sympathetic ganglia. Hart RP, etal., J Neuroimmunol 1993 Apr;44(1):49-56.
14. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
15. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
16. Localization and characterization of interleukin-1 receptors in the islets of Langerhans from control and nonobese diabetic mice. Jafarian-Tehrani M, etal., Endocrinology. 1995 Feb;136(2):609-13.
17. Increased interleukin 1 receptor, type I, at messenger RNA and protein level in skin fibroblasts from patients with systemic sclerosis. Kawaguchi Y, etal., Biochem Biophys Res Commun. 1992 May 15;184(3):1504-10.
18. The rat intraovarian interleukin (IL)-1 system: cellular localization, cyclic variation and hormonal regulation of IL-1beta and of the type I and type II IL-1 receptors. Kol S, etal., Mol Cell Endocrinol. 1999 Mar 25;149(1-2):115-28.
19. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
20. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. Interleukin-1 beta guides the migration of cortical neurons. Ma L, etal., J Neuroinflammation. 2014 Jun 21;11:114. doi: 10.1186/1742-2094-11-114.
22. An association between type 1 diabetes and the interleukin-1 receptor type 1 gene. The DiMe Study Group. Childhood Diabetes in Finland. Metcalfe KA, etal., Hum Immunol. 1996 Nov;51(1):41-8.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Comprehensive gene review and curation RGD comprehensive gene curation
31. A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons. Sasaki M, etal., Brain Res Mol Brain Res. 2001 Apr 18;89(1-2):158-63.
32. Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice. Schafers M, etal., Neurosci Lett. 2001 Sep 14;310(2-3):113-6.
33. DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis. Shiue HS, etal., J Altern Complement Med. 2008 Jul;14(6):689-98.
34. The IL-1 family: regulators of immunity. Sims JE and Smith DE, Nat Rev Immunol. 2010 Feb;10(2):89-102. Epub 2010 Jan 18.
35. Additive anti-hyperalgesia of electroacupuncture and intrathecal antisense oligodeoxynucleotide to interleukin-1 receptor type I on carrageenan-induced inflammatory pain in rats. Song MJ, etal., Brain Res Bull. 2009 Mar 30;78(6):335-41. doi: 10.1016/j.brainresbull.2008.10.009. Epub 2008 Nov 18.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Upregulation of type I interleukin-1 receptor after traumatic spinal cord injury in adult rats. Wang XF, etal., Acta Neuropathol. 2006 Mar;111(3):220-8. Epub 2006 Feb 3.
38. Interleukin-1 contributes to an effective clearance of Mycobacterium kansasii from the respiratory tract. Wieland CW, etal., Microbes Infect. 2006 Aug;8(9-10):2409-13. Epub 2006 Jun 2.
39. Immunostaining and transcriptional enhancement of interleukin-1 receptor type I in the rat dental follicle. Wise GE and Zhao L, Arch Oral Biol. 1997 May;42(5):339-44.
40. Enhanced susceptibility to immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Xie C, etal., Clin Immunol. 2007 Jul;124(1):49-56. Epub 2007 May 17.
41. Characterization of alternatively spliced isoforms of the type I interleukin-1 receptor on iNOS induction in rat hepatocytes. Yamada M, etal., Nitric Oxide. 2007 Sep;17(2):98-105. Epub 2007 Jul 1.
42. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
43. Differential role of YiGanKang decoction in IL-1beta induction of IL-1RI and AP-1 in rat hepatic stellate cell. Zhang Y, etal., J Ethnopharmacol. 2012 Jun 1;141(2):599-602. doi: 10.1016/j.jep.2011.09.001. Epub 2011 Sep 8.
44. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
Additional References at PubMed
PMID:10383454   PMID:10653850   PMID:10854325   PMID:11880380   PMID:12135759   PMID:12627233   PMID:15024756   PMID:15030977   PMID:15292196   PMID:16477012   PMID:16757809   PMID:18996842  
PMID:19833765   PMID:22297845   PMID:23034280   PMID:23395675   PMID:23992404   PMID:26902320   PMID:27440742   PMID:28645297   PMID:33081813   PMID:33879157   PMID:35990672  


Genomics

Comparative Map Data
Il1r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8950,000,558 - 50,076,579 (+)NCBIGRCr8
mRatBN7.2942,504,917 - 42,580,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl942,504,735 - 42,579,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx951,042,291 - 51,080,451 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0956,165,013 - 56,203,144 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0954,441,033 - 54,478,767 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0946,962,291 - 47,038,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,962,288 - 47,036,670 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0946,647,422 - 46,723,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4939,434,910 - 39,473,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1939,434,750 - 39,475,060 (+)NCBI
Celera940,285,956 - 40,323,730 (+)NCBICelera
RH 3.4 Map9396.1RGD
Cytogenetic Map9q22NCBI
IL1R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382102,070,390 - 102,179,874 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2102,064,544 - 102,179,874 (+)EnsemblGRCh38hg38GRCh38
GRCh372102,686,850 - 102,796,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362102,136,834 - 102,162,766 (+)NCBINCBI36Build 36hg18NCBI36
Build 342102,228,919 - 102,254,852NCBI
Celera296,971,617 - 96,997,550 (+)NCBICelera
Cytogenetic Map2q11.2-q12.1NCBI
HuRef296,534,264 - 96,560,197 (+)NCBIHuRef
CHM1_12102,774,745 - 102,800,675 (+)NCBICHM1_1
T2T-CHM13v2.02102,528,685 - 102,638,160 (+)NCBIT2T-CHM13v2.0
Il1r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39140,261,651 - 40,355,361 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl140,264,240 - 40,356,417 (+)EnsemblGRCm39 Ensembl
GRCm38140,222,480 - 40,316,201 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl140,225,080 - 40,317,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv37140,281,925 - 40,373,022 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36140,169,626 - 40,260,723 (+)NCBIMGSCv36mm8
Celera140,033,653 - 40,127,353 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map118.81NCBI
Il1r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554707,685,498 - 7,703,374 (+)NCBIChiLan1.0ChiLan1.0
IL1R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,052,033 - 26,167,680 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A26,054,794 - 26,164,430 (-)NCBINHGRI_mPanPan1
PanPan1.12A103,151,559 - 103,230,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A103,193,131 - 103,230,005 (+)Ensemblpanpan1.1panPan2
IL1R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11040,825,986 - 40,897,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1040,827,377 - 40,897,596 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1040,751,798 - 40,823,679 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01041,692,476 - 41,764,370 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1041,692,623 - 41,811,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11041,406,689 - 41,478,437 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01041,688,685 - 41,760,634 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01041,880,427 - 41,952,281 (-)NCBIUU_Cfam_GSD_1.0
Il1r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629290,252,781 - 90,324,177 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936713808,659 - 881,076 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936713808,761 - 881,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL1R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl352,192,915 - 52,288,485 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1352,192,912 - 52,334,734 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2354,729,121 - 54,757,667 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL1R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,781,486 - 5,852,872 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,781,479 - 5,855,942 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041173,465,069 - 173,539,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il1r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,708,522 - 6,739,871 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247496,661,142 - 6,737,988 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il1r1
502 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:78
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000019673
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
RH94740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2942,572,249 - 42,572,361 (+)MAPPERmRatBN7.2
Rnor_6.0947,029,433 - 47,029,544NCBIRnor6.0
Rnor_5.0946,714,686 - 46,714,797UniSTSRnor5.0
RGSC_v3.4939,467,710 - 39,467,821UniSTSRGSC3.4
Celera940,317,888 - 40,317,999UniSTS
RH 3.4 Map9396.1UniSTS
Cytogenetic Map9q21UniSTS
RH94741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2942,578,066 - 42,578,177 (+)MAPPERmRatBN7.2
Rnor_6.0947,035,248 - 47,035,358NCBIRnor6.0
Rnor_5.0946,720,501 - 46,720,611UniSTSRnor5.0
RGSC_v3.4939,473,525 - 39,473,635UniSTSRGSC3.4
Celera940,323,703 - 40,323,813UniSTS
Cytogenetic Map9q21UniSTS


Genetic Models
This gene Il1r1 is modified in the following models/strains:
BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em1Mcwi     BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em3Mcwi     BBDR.BBDP-(D4Mit6-D4Mit7)/RhwMcwi-Il1r1em2Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 34 32 31 9 31 3 25 11
Low 2 9 25 10 10 10 8 11 74 32 15 8
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001412593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB079118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB112436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB112437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB112438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M95578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019673   ⟹   ENSRNOP00000019673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,538,819 - 42,579,937 (+)Ensembl
Rnor_6.0 Ensembl946,996,156 - 47,035,369 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082146   ⟹   ENSRNOP00000073880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,504,735 - 42,579,937 (+)Ensembl
Rnor_6.0 Ensembl946,962,288 - 47,036,670 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082408   ⟹   ENSRNOP00000072248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,540,359 - 42,572,452 (+)Ensembl
Rnor_6.0 Ensembl946,997,798 - 47,035,275 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087112   ⟹   ENSRNOP00000075417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,554,961 - 42,579,937 (+)Ensembl
Rnor_6.0 Ensembl946,997,798 - 47,035,275 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101259   ⟹   ENSRNOP00000080136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,564,955 - 42,579,937 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108650   ⟹   ENSRNOP00000091937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl942,538,819 - 42,579,937 (+)Ensembl
RefSeq Acc Id: NM_001412593   ⟹   NP_001399522
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,034,383 - 50,076,579 (+)NCBI
mRatBN7.2942,538,748 - 42,580,958 (+)NCBI
RefSeq Acc Id: NM_001412594   ⟹   NP_001399523
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,034,383 - 50,076,579 (+)NCBI
mRatBN7.2942,538,748 - 42,580,958 (+)NCBI
RefSeq Acc Id: XM_006244747   ⟹   XP_006244809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,000,558 - 50,076,579 (+)NCBI
mRatBN7.2942,504,917 - 42,580,958 (+)NCBI
Rnor_6.0946,962,291 - 47,038,139 (+)NCBI
Rnor_5.0946,647,422 - 46,723,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244748   ⟹   XP_006244810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,000,558 - 50,076,579 (+)NCBI
mRatBN7.2942,504,917 - 42,580,958 (+)NCBI
Rnor_6.0946,962,291 - 47,038,139 (+)NCBI
Rnor_5.0946,647,422 - 46,723,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244749   ⟹   XP_006244811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,035,965 - 50,076,579 (+)NCBI
mRatBN7.2942,540,308 - 42,580,958 (+)NCBI
Rnor_6.0946,996,559 - 47,038,139 (+)NCBI
Rnor_5.0946,647,422 - 46,723,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244750   ⟹   XP_006244812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,013,212 - 50,076,579 (+)NCBI
mRatBN7.2942,537,005 - 42,580,958 (+)NCBI
Rnor_6.0946,994,372 - 47,038,139 (+)NCBI
Rnor_5.0946,647,422 - 46,723,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244751   ⟹   XP_006244813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,036,017 - 50,076,579 (+)NCBI
mRatBN7.2942,540,384 - 42,580,958 (+)NCBI
Rnor_6.0946,996,559 - 47,038,139 (+)NCBI
Rnor_5.0946,647,422 - 46,723,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244752   ⟹   XP_006244814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,000,558 - 50,076,579 (+)NCBI
mRatBN7.2942,504,917 - 42,580,958 (+)NCBI
Rnor_6.0946,962,291 - 47,038,139 (+)NCBI
Rnor_5.0946,647,422 - 46,723,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766993   ⟹   XP_008765215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,035,997 - 50,076,579 (+)NCBI
mRatBN7.2942,540,364 - 42,580,958 (+)NCBI
Rnor_6.0946,996,559 - 47,038,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083092   ⟹   XP_038939020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,000,573 - 50,076,579 (+)NCBI
mRatBN7.2942,504,938 - 42,580,958 (+)NCBI
RefSeq Acc Id: XM_063266739   ⟹   XP_063122809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,000,558 - 50,076,579 (+)NCBI
RefSeq Acc Id: XM_063266740   ⟹   XP_063122810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,000,558 - 50,076,579 (+)NCBI
RefSeq Acc Id: XM_063266741   ⟹   XP_063122811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8950,000,558 - 50,076,579 (+)NCBI
RefSeq Acc Id: XP_006244809   ⟸   XM_006244747
- Peptide Label: isoform X1
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR1 (UniProtKB/TrEMBL),   A6INN1 (UniProtKB/TrEMBL),   F7FMA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244814   ⟸   XM_006244752
- Peptide Label: isoform X3
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244810   ⟸   XM_006244748
- Peptide Label: isoform X2
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   A0A0G2K6N4 (UniProtKB/TrEMBL),   A6INM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244812   ⟸   XM_006244750
- Peptide Label: isoform X3
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244811   ⟸   XM_006244749
- Peptide Label: isoform X3
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244813   ⟸   XM_006244751
- Peptide Label: isoform X3
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765215   ⟸   XM_008766993
- Peptide Label: isoform X3
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073880   ⟸   ENSRNOT00000082146
Ensembl Acc Id: ENSRNOP00000072248   ⟸   ENSRNOT00000082408
Ensembl Acc Id: ENSRNOP00000075417   ⟸   ENSRNOT00000087112
Ensembl Acc Id: ENSRNOP00000019673   ⟸   ENSRNOT00000019673
RefSeq Acc Id: XP_038939020   ⟸   XM_039083092
- Peptide Label: isoform X3
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091937   ⟸   ENSRNOT00000108650
Ensembl Acc Id: ENSRNOP00000080136   ⟸   ENSRNOT00000101259
RefSeq Acc Id: NP_001399523   ⟸   NM_001412594
- Peptide Label: precursor
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399522   ⟸   NM_001412593
- Peptide Label: precursor
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122809   ⟸   XM_063266739
- Peptide Label: isoform X3
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122811   ⟸   XM_063266741
- Peptide Label: isoform X3
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122810   ⟸   XM_063266740
- Peptide Label: isoform X3
- UniProtKB: Q02955 (UniProtKB/Swiss-Prot),   Q05KR0 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02955-F1-model_v2 AlphaFold Q02955 1-576 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696638
Promoter ID:EPDNEW_R7154
Type:initiation region
Name:Il1r1_1
Description:interleukin 1 receptor type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7155  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0946,962,357 - 46,962,417EPDNEW
RGD ID:13696632
Promoter ID:EPDNEW_R7155
Type:initiation region
Name:Il1r1_2
Description:interleukin 1 receptor type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7154  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0946,996,187 - 46,996,247EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2892 AgrOrtholog
BioCyc Gene G2FUF-27725 BioCyc
Ensembl Genes ENSRNOG00000014504 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019673.5 UniProtKB/TrEMBL
  ENSRNOT00000082146.2 UniProtKB/TrEMBL
  ENSRNOT00000082408.2 UniProtKB/TrEMBL
  ENSRNOT00000087112.2 UniProtKB/TrEMBL
  ENSRNOT00000101259.1 UniProtKB/TrEMBL
  ENSRNOT00000108650.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_I-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1_rcpt_I/II-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1RAcP-like_ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25663 UniProtKB/TrEMBL
NCBI Gene 25663 ENTREZGENE
PANTHER INTERLEUKIN-1 RECEPTOR TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11890 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IL1R1 RGD
PhenoGen Il1r1 PhenoGen
PRINTS INTRLEUKN1R1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLKN1R12F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLKN1R1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014504 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC236650
UniProt A0A0G2K6N4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAJ2_RAT UniProtKB/TrEMBL
  A0A8I6AFI3_RAT UniProtKB/TrEMBL
  A0A8I6G672_RAT UniProtKB/TrEMBL
  A6INM9 ENTREZGENE, UniProtKB/TrEMBL
  A6INN0_RAT UniProtKB/TrEMBL
  A6INN1 ENTREZGENE, UniProtKB/TrEMBL
  F7FMA2 ENTREZGENE, UniProtKB/TrEMBL
  IL1R1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q05KR0 ENTREZGENE, UniProtKB/TrEMBL
  Q05KR1 ENTREZGENE
  Q05KR2_RAT UniProtKB/TrEMBL
  Q62692_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0G2K2H8 UniProtKB/TrEMBL
  Q05KR1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il1r1  Interleukin 1 receptor, type I      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process involved in induction of substance P (SP) gene expression 729006