Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) - Rat Genome Database

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Gene: Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) Rattus norvegicus
Symbol: Grin2b
Name: glutamate ionotropic receptor NMDA type subunit 2B
RGD ID: 2738
Description: Enables several functions, including beta-catenin binding activity; extracellular ligand-gated monoatomic ion channel activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ketone; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and synaptic cleft. Part of NMDA selective glutamate receptor complex. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Used to study attention deficit hyperactivity disorder; fetal alcohol spectrum disorder; hyperhomocysteinemia; and transient cerebral ischemia. Biomarker of several diseases, including attention deficit hyperactivity disorder; cognitive disorder (multiple); egg allergy; placental insufficiency; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B); PARTICIPATES IN excitatory synaptic transmission pathway; long term potentiation; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: GluN2B; glutamate [NMDA] receptor subunit epsilon-2; Glutamate receptor ionotropic N-methyl D-aspartate 2B; glutamate receptor ionotropic, NMDA 2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Grin2bem1Mcwi  
Genetic Models: LE-Grin2bem1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84170,297,811 - 170,775,420 (-)NCBIGRCr8
mRatBN7.24168,580,824 - 169,044,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4168,599,546 - 169,042,279 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4174,894,793 - 175,337,242 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04170,675,997 - 171,118,792 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04169,300,441 - 169,742,894 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04169,541,620 - 170,000,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04233,806,406 - 234,260,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44172,721,895 - 173,183,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14172,966,830 - 173,428,311 (-)NCBI
Celera4157,188,514 - 157,629,365 (-)NCBICelera
RH 3.4 Map41026.8RGD
Cytogenetic Map4q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
astigmatism  (ISO)
Ataxia  (ISO)
attention deficit hyperactivity disorder  (IEP,IMP)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autosomal dominant intellectual developmental disorder  (ISO)
autosomal dominant intellectual developmental disorder 6  (ISO)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (IEP)
cerebral palsy  (ISO)
chronic obstructive pulmonary disease  (ISO)
cognitive disorder  (IEP)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
developmental and epileptic encephalopathy 11  (ISO)
developmental and epileptic encephalopathy 27  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
dystonia  (ISO)
egg allergy  (IEP)
epilepsy  (IEP,ISO)
Experimental Diabetes Mellitus  (IEP)
fetal alcohol spectrum disorder  (IEP,IMP)
Fetal Growth Retardation  (IEP)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (IMP,ISO)
hyperhomocysteinemia  (IDA)
hypoglycemia  (IEP)
Hypotension  (ISO)
Hypoxia  (IEP)
intellectual disability  (ISO)
Landau-Kleffner syndrome  (ISO)
Nervous System Trauma  (IEP)
Neurodevelopmental Disorders  (ISO)
nicotine dependence  (ISO)
opioid abuse  (ISO)
phenylketonuria  (ISO)
placental insufficiency  (IEP)
Reperfusion Injury  (IEP)
retinitis pigmentosa  (IEP)
schizophrenia  (IEP,ISO)
sciatic neuropathy  (IEP)
Sleep Deprivation  (IEP)
temporal lobe epilepsy  (ISO)
transient cerebral ischemia  (IMP)
vascular dementia  (ISO)
withdrawal disorder  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamiprid  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agomelatine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
alpha-pinene  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asarone  (EXP)
astragaloside IV  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
caffeine  (EXP)
capsaicin  (EXP)
capsazepine  (EXP)
carbaryl  (EXP)
carbon dioxide  (EXP)
carbon nanotube  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
citalopram  (EXP)
clozapine  (EXP)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dextromethorphan  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP)
dizocilpine maleate  (EXP,ISO)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
Ethyl 4-methoxycinnamate  (EXP)
excitatory amino acid agonist  (ISO)
felbamate  (EXP)
Fluorocitric acid  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP,ISO)
galactose  (EXP)
glycidol  (EXP)
haloperidol  (ISO)
ionomycin  (EXP)
isoflurane  (EXP)
kainic acid  (ISO)
ketamine  (EXP)
Kukoamine B  (ISO)
L-ascorbic acid  (ISO)
lanthanum trichloride  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
leflunomide  (ISO)
linoleic acid  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (EXP)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melamine  (EXP)
melatonin  (EXP)
memantine  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
morphine  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-D-aspartic acid  (ISO)
nickel atom  (EXP)
nobiletin  (EXP)
notoginsenoside R1  (ISO)
NS-398  (EXP)
Ondansetron  (EXP)
oxidopamine  (EXP)
paclitaxel  (EXP)
paraquat  (EXP,ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
pyridine  (EXP)
remifentanil  (EXP)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP)
rimonabant  (ISO)
Ro 25-6981  (EXP)
rottlerin  (ISO)
sarin  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
spermine  (EXP)
sterigmatocystin  (EXP)
sulfur dioxide  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tannic acid  (EXP)
testosterone  (EXP)
tetrodotoxin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
tributylstannane  (EXP)
trimethyltin  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IMP)
associative learning  (IMP)
auditory behavior  (IEP)
behavioral fear response  (IMP,ISO)
behavioral response to pain  (ISO)
calcium ion transmembrane import into cytosol  (IEA,ISO,ISS)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cellular response to amino acid stimulus  (IEP)
cellular response to corticosterone stimulus  (IEP)
cellular response to curcumin  (IEP)
cellular response to dsRNA  (IEP)
cellular response to forskolin  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to lipid  (IEP)
cellular response to magnesium starvation  (IEP)
cellular response to manganese ion  (IEP)
cellular response to organic cyclic compound  (IEP)
cerebral cortex development  (IEP)
chemical synaptic transmission  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
excitatory postsynaptic potential  (IBA,ISO)
fear response  (ISO)
hippocampus development  (IEP)
in utero embryonic development  (ISO)
intracellular calcium ion homeostasis  (IMP)
ionotropic glutamate receptor signaling pathway  (IDA,IEA,ISS)
learning  (ISO)
learning or memory  (IMP,TAS)
long-term memory  (IEP)
long-term synaptic potentiation  (IBA,IEP,ISO)
memory  (IDA,ISO)
monoatomic cation transmembrane transport  (ISS)
monoatomic cation transport  (ISO)
multicellular organismal response to stress  (IEP)
negative regulation of dendritic spine maintenance  (ISO)
neuron development  (IEP)
NMDA selective glutamate receptor signaling pathway  (IMP)
positive regulation of excitatory postsynaptic potential  (IDA,IMP,ISS)
positive regulation of glutamate secretion  (IDA)
positive regulation of inhibitory postsynaptic potential  (IMP)
positive regulation of synaptic transmission  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IDA,ISS)
protein heterotetramerization  (IDA)
receptor clustering  (IDA)
regulation of ARF protein signal transduction  (IGI)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of MAPK cascade  (IMP)
regulation of monoatomic cation transmembrane transport  (ISS)
regulation of neuronal synaptic plasticity  (NAS)
regulation of postsynaptic cytosolic calcium ion concentration  (IMP)
regulation of postsynaptic membrane potential  (ISO)
regulation of presynaptic membrane potential  (IEA)
regulation of protein kinase A signaling  (ISO)
regulation of synaptic plasticity  (ISO)
response to amine  (IEP)
response to amphetamine  (IEP)
response to calcium ion  (IEP)
response to carbohydrate  (IEP)
response to cocaine  (IEP)
response to cytokine  (IEP)
response to electrical stimulus  (IEP)
response to ethanol  (IEA,IEP,ISO)
response to fungicide  (IEP)
response to growth hormone  (IEP)
response to hydrogen sulfide  (IEP)
response to hypoxia  (IDA)
response to lead ion  (IEP)
response to magnesium ion  (IEP)
response to manganese ion  (IEP)
response to mechanical stimulus  (IEP)
response to methylmercury  (IEP)
response to nicotine  (IEP)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IMP)
response to other organism  (IEP)
response to toxic substance  (IEP)
rhythmic process  (IDA)
sensitization  (IMP)
sensory organ development  (ISO)
startle response  (ISO)
suckling behavior  (ISO)
synaptic transmission, glutamatergic  (IBA)


References - curated
# Reference Title Reference Citation
1. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. Abe M, etal., J Neurosci. 2004 Aug 18;24(33):7292-304. doi: 10.1523/JNEUROSCI.1261-04.2004.
2. Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer's disease. Andreoli V, etal., J Neural Transm (Vienna). 2014 May;121(5):533-42. doi: 10.1007/s00702-013-1125-7. Epub 2013 Dec 1.
3. Enhanced NMDAR1, NMDA2B and mGlu5 receptors gene expression in the cerebellum of insulin induced hypoglycaemic and streptozotocin induced diabetic rats. Anu J, etal., Eur J Pharmacol. 2010 Mar 25;630(1-3):61-8. Epub 2010 Jan 6.
4. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner. Arning L, etal., Hum Genet. 2007 Sep;122(2):175-82. Epub 2007 Jun 14.
5. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. Arning L, etal., Neurogenetics. 2005 Feb;6(1):25-8. Epub 2004 Nov 17.
6. Oscillatory Synchronous Inhibition in the Basolateral Amygdala and its Primary Dependence on NR2A-containing NMDA Receptors. Aroniadou-Anderjaska V, etal., Neuroscience. 2018 Mar 1;373:145-158. doi: 10.1016/j.neuroscience.2018.01.021. Epub 2018 Jan 13.
7. Subunit-specific NMDA receptor trafficking to synapses. Barria A and Malinow R, Neuron. 2002 Jul 18;35(2):345-53.
8. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Bartlett TE, etal., Neuropharmacology. 2007 Jan;52(1):60-70. Epub 2006 Aug 10.
9. Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses. Berg LK, etal., Neuroscience. 2013 Jan 29;230:139-50. doi: 10.1016/j.neuroscience.2012.10.061. Epub 2012 Nov 14.
10. Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus. Bersier MG and Rodriguez de Lores Arnaiz G, Neurochem Res. 2009 Sep;34(9):1650-7. Epub 2009 Mar 26.
11. Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule. Bidoret C, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14126-31. Epub 2009 Aug 4.
12. Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. Borbely S, etal., Neuroscience. 2009 Mar 3;159(1):358-68. Epub 2008 Dec 27.
13. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. Brenman JE, etal., J Neurosci. 1998 Nov 1;18(21):8805-13.
14. NR2B-containing NMDA receptors promote the neurotoxic effects of 3-nitropropionic acid but not of rotenone in the striatum. Centonze D, etal., Exp Neurol. 2006 Dec;202(2):470-9. Epub 2006 Aug 17.
15. Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. Chapman DE, etal., J Neurophysiol 2003 Jan;89(1):69-80.
16. Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia. Chen WF, etal., Exp Neurol. 2007 Mar;204(1):400-10. Epub 2007 Jan 30.
17. Structural insights into binding of therapeutic channel blockers in NMDA receptors. Chou TH, etal., Nat Struct Mol Biol. 2022 Jun;29(6):507-518. doi: 10.1038/s41594-022-00772-0. Epub 2022 May 30.
18. Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. Clapp P, etal., J Pharmacol Exp Ther. 2010 Mar;332(3):720-9. Epub 2009 Dec 14.
19. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
20. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Cui Z, etal., Neuron. 2004 Mar 4;41(5):781-93. doi: 10.1016/s0896-6273(04)00072-8.
21. Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release. Dalby NO and Mody I, J Neurophysiol 2003 Aug;90(2):786-97.
22. NMDA receptor subunits change in the prefrontal cortex of pure-opioid and multi-drug abusers: a post-mortem study. Daneshparvar H, etal., Eur Arch Psychiatry Clin Neurosci. 2019 Apr;269(3):309-315. doi: 10.1007/s00406-018-0900-8. Epub 2018 May 16.
23. EFFECT of nicotine on hippocampal nicotinic acetylcholine alpha7 receptor and NMDA receptor subunits 2A and 2B expression in young and old rats. Delibas N, etal., Int J Neurosci. 2005 Aug;115(8):1151-63. doi: 10.1080/00207450590914437.
24. Effects of electroconvulsive therapy and propofol on spatial memory and glutamatergic system in hippocampus of depressed rats. Dong J, etal., J ECT. 2010 Jun;26(2):126-30.
25. Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices. Dos-Anjos S, etal., Neuroscience. 2009 Dec 15;164(3):1119-26. Epub 2009 Sep 15.
26. Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses. Dupuis JP, etal., EMBO J. 2014 Apr 16;33(8):842-61. doi: 10.1002/embj.201386356. Epub 2014 Mar 3.
27. Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation. Elagabani MN, etal., J Biol Chem. 2016 Apr 22;291(17):9105-18. doi: 10.1074/jbc.M115.691717. Epub 2016 Feb 16.
28. Up-regulation of anterior cingulate cortex NR2B receptors contributes to visceral pain responses in rats. Fan J, etal., Gastroenterology. 2009 May;136(5):1732-40.e3. Epub 2009 Feb 6.
29. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. Fan MM, etal., J Neurosci. 2007 Apr 4;27(14):3768-79.
30. A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats. Ferrier J, etal., PLoS One. 2013 Oct 30;8(10):e77828. doi: 10.1371/journal.pone.0077828. eCollection 2013.
31. Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. Foster KA, etal., J Neurosci. 2010 Feb 17;30(7):2676-85.
32. Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. Fukumori R, etal., J Pharmacol Sci. 2010 Mar 19;112(3):273-81. Epub 2010 Feb 18.
33. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation. Gardoni F, etal., J Neuroinflammation. 2011 Feb 11;8(1):14.
34. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. Gardoni F, etal., J Neurosci. 2006 Mar 15;26(11):2914-22.
35. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
36. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Geng SJ, etal., Exp Neurol. 2010 Apr;222(2):256-66. Epub 2010 Jan 14.
37. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
38. Alterations in NMDA receptor expression during retinal degeneration in the RCS rat. Gründer T, etal., Vis Neurosci. 2001 Sep-Oct;18(5):781-7.
39. Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia. Gulchina Y, etal., J Neurochem. 2017 Nov;143(3):320-333. doi: 10.1111/jnc.14101. Epub 2017 Sep 5.
40. Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2. Guo L and Wang Y, Neuroscience. 2007 Mar 2;145(1):100-9. doi: 10.1016/j.neuroscience.2006.11.042. Epub 2007 Jan 3.
41. CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function. Guo ML, etal., EMBO J. 2010 Jun 16;29(12):2070-81. doi: 10.1038/emboj.2010.93. Epub 2010 May 11.
42. Distribution of glutamate receptor subunits in experimentally induced cortical malformations. Hagemann G, etal., Neuroscience. 2003;117(4):991-1002.
43. NR2B subunit-specific NMDA antagonist Ro25-6981 inhibits the expression of conditioned fear: a comparison with the NMDA antagonist MK-801 and fluoxetine. Haller J, etal., Behav Pharmacol. 2011 Apr;22(2):113-21. doi: 10.1097/FBP.0b013e328343d7b2.
44. The effect of ketamine on N-methyl-D-aspartate receptor subunit expression in neonatal rats. Han LC, etal., Eur J Anaesthesiol. 2010 Feb;27(2):181-6.
45. [Effect of behavioral training on learning and memory capacity and changes of hippocampal NR2B and GluR1 expressions in FGR offspring rats]. Huang P, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):708-11.
46. CASK phosphorylation by PKA regulates the protein-protein interactions of CASK and expression of the NMDAR2b gene. Huang TN, etal., J Neurochem. 2010 Mar;112(6):1562-73. doi: 10.1111/j.1471-4159.2010.06569.x. Epub 2010 Jan 7.
47. Chronic unpredictable stress before pregnancy reduce the expression of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor in hippocampus of offspring rats associated with impairment of memory. Huang Y, etal., Neurochem Res. 2010 Jul;35(7):1038-49. Epub 2010 Mar 23.
48. CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus. Huang Y, etal., Neuron. 2001 Feb;29(2):485-96.
49. Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway. Huo XL, etal., PLoS One. 2014 Apr 9;9(4):e94278. doi: 10.1371/journal.pone.0094278. eCollection 2014.
50. Prenatal development of NMDA receptor composition and function in trigeminal neurons. Ishihama K, etal., Arch Histol Cytol. 2005 Dec;68(4):321-35.
51. N-methyl-D-aspartate receptor subunit dysfunction at hippocampal glutamatergic synapses in an animal model of attention-deficit/hyperactivity disorder. Jensen V, etal., Neuroscience. 2009 Jan 12;158(1):353-64. doi: 10.1016/j.neuroscience.2008.05.016. Epub 2008 May 21.
52. Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population. Jiang H and Jia J, Neurosci Lett. 2009 Feb 6;450(3):356-60. doi: 10.1016/j.neulet.2008.10.075. Epub 2008 Oct 25.
53. Exogenous sodium hydrosulfide can attenuate naloxone-precipitated withdrawal syndromes and affect cAMP signaling pathway in heroin-dependent rat's nucleus accumbens. Jiang LH, etal., Eur Rev Med Pharmacol Sci. 2012 Dec;16(14):1974-82.
54. Alterations of NR2B and PSD-95 expression after early-life epileptiform discharges in developing neurons. Jiang Q, etal., Int J Dev Neurosci. 2007 May;25(3):165-70. Epub 2007 Feb 21.
55. CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. Jiang X, etal., Neurobiol Aging. 2015 Feb;36(2):867-76. doi: 10.1016/j.neurobiolaging.2014.10.018. Epub 2014 Oct 16.
56. Immunoblot analyses on the differential distribution of NR2A and NR2B subunits in the adult rat brain. Jin DH, etal., Mol Cells. 1997 Dec 31;7(6):749-54.
57. Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors. Jindal A, etal., Neurobiol Dis. 2019 Jul;127:287-302. doi: 10.1016/j.nbd.2019.03.012. Epub 2019 Mar 15.
58. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. Jo K, etal., J Neurosci. 1999 Jun 1;19(11):4189-99.
59. The effect of ganglioside GQ1b on the NMDA receptor signaling pathway in H19-7 cells and rat hippocampus. Jung WR, etal., Neuroscience. 2010 Jan 13;165(1):159-67. Epub 2009 Oct 9.
60. Differential functions of NR2A and NR2B in short-term and long-term memory in rats. Jung YH and Suh YH, Neuroreport. 2010 Jun 24.
61. PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. Kalia LV, etal., EMBO J. 2006 Oct 18;25(20):4971-82. Epub 2006 Sep 21.
62. Induced tolerance to glutamate neurotoxicity through down-regulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons. Kambe Y, etal., J Neurosci Res. 2010 Aug 1;88(10):2177-87.
63. Crystal structure of a heterotetrameric NMDA receptor ion channel. Karakas E and Furukawa H, Science. 2014 May 30;344(6187):992-7. doi: 10.1126/science.1251915.
64. Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. Karakas E, etal., EMBO J. 2009 Dec 16;28(24):3910-20. doi: 10.1038/emboj.2009.338. Epub .
65. Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Karakas E, etal., Nature. 2011 Jun 15;475(7355):249-53. doi: 10.1038/nature10180.
66. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. Kaufman AM, etal., J Neurosci. 2012 Mar 21;32(12):3992-4003. doi: 10.1523/JNEUROSCI.4129-11.2012.
67. Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression. Kawashima H, etal., Neuroscience. 2010 Feb 17;165(4):1301-11. Epub 2009 Dec 1.
68. Growth hormone rescues hippocampal synaptic function after sleep deprivation. Kim E, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Jun;298(6):R1588-96. Epub 2010 Mar 17.
69. Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism. Kim JH, etal., Neurosci Res. 2006 Oct;56(2):220-3. Epub 2006 Sep 5.
70. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Kornau HC, etal., Science. 1995 Sep 22;269(5231):1737-40.
71. [Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]. Korytina GF, etal., Mol Biol (Mosk). 2017 Jul-Aug;51(4):603-614. doi: 10.7868/S0026898417040127.
72. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Krapivinsky G, etal., Neuron. 2003 Nov 13;40(4):775-84.
73. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Kurschner C, etal., Mol Cell Neurosci. 1998 Jun;11(3):161-72.
74. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
75. Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: a new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. Kölker S, etal., Pediatr Res. 2000 Apr;47(4 Pt 1):495-503.
76. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. Lau LF, etal., J Biol Chem. 1996 Aug 30;271(35):21622-8.
77. Amino terminal domains of the NMDA receptor are organized as local heterodimers. Lee CH and Gouaux E, PLoS One. 2011 Apr 22;6(4):e19180. doi: 10.1371/journal.pone.0019180.
78. Thyroid hormone regulation of N-methyl-D-aspartic acid receptor subunit mRNA expression in adult brain. Lee PR, etal., J Neuroendocrinol 2003 Jan;15(1):87-92.
79. Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease. Leuba G, etal., Curr Alzheimer Res. 2014 Jan;11(1):86-96.
80. The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Levenson JM, etal., Biochim Biophys Acta. 2008 Aug;1779(8):422-31. Epub 2008 Jan 12.
81. Behavioral deficits and cellular damage following developmental ethanol exposure in rats are attenuated by CP-101,606, an NMDAR antagonist with unique NR2B specificity. Lewis B, etal., Pharmacol Biochem Behav. 2012 Jan;100(3):545-53. doi: 10.1016/j.pbb.2011.10.013. Epub 2011 Oct 20.
82. Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: a HuGE review and meta-analysis. Li D and He L, Genet Med. 2007 Jan;9(1):4-8.
83. Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity. Li R, etal., BMC Neurosci. 2007 Jul 26;8:55.
84. NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats. Li TT, etal., Pain. 2009 Nov;146(1-2):183-93. Epub 2009 Aug 19.
85. Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Li YC, etal., J Neurosci. 2009 Dec 9;29(49):15551-63.
86. Mechanisms of CaMKII action in long-term potentiation. Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192.
87. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] Liu L, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2009 Jul;43(7):622-7.
88. Effects of postnatal exposure to methylmercury on spatial learning and memory and brain NMDA receptor mRNA expression in rats. Liu W, etal., Toxicol Lett. 2009 Aug 10;188(3):230-5. Epub 2009 May 3.
89. Auditory Training Reverses Lead (Pb)-Toxicity-Induced Changes in Sound-Azimuth Selectivity of Cortical Neurons. Liu X, etal., Cereb Cortex. 2019 Jul 22;29(8):3294-3304. doi: 10.1093/cercor/bhy199.
90. Modulation of D2R-NR2B interactions in response to cocaine. Liu XY, etal., Neuron. 2006 Dec 7;52(5):897-909.
91. N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels. Martucci L, etal., Schizophr Res. 2006 Jun;84(2-3):214-21. Epub 2006 Mar 20.
92. Impaired glutamatergic synaptic transmission in the PKU brain. Martynyuk AE, etal., Mol Genet Metab. 2005 Dec;86 Suppl 1:S34-42. Epub 2005 Sep 8.
93. Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy. Mathern GW, etal., Epilepsy Res. 1998 Sep;32(1-2):154-71.
94. Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats. Meng F and Zhang G, Neurosci Lett 2002 Nov 15;333(1):59-63.
95. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
96. Loose ligation of the rat sciatic nerve elicits early accumulation of Shank1 protein in the post-synaptic density of spinal dorsal horn neurons. Miletic G, etal., Pain. 2010 Apr;149(1):152-9. Epub 2010 Feb 18.
97. N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat. Miller BH and Gore AC, Endocrinology 2002 Sep;143(9):3568-74.
98. Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease. Mohamed NE, etal., J Alzheimers Dis. 2015;44(2):431-7. doi: 10.3233/JAD-141764.
99. Age and meloxicam attenuate the ischemia/reperfusion-induced down-regulation in the NMDA receptor genes. Montori S, etal., Neurochem Int. 2010 Jul;56(8):878-85. Epub 2010 Mar 27.
100. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Monyer H, etal., Science 1992 May 22;256(5060):1217-21.
101. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Muller BM, etal., Neuron. 1996 Aug;17(2):255-65.
102. Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Nagy J, etal., Neurochem Int 2003 Jan;42(1):35-43.
103. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Nakatsu Y, etal., Toxicol Appl Pharmacol. 2009 Oct 15;240(2):292-8. Epub 2009 Jul 7.
104. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
105. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. Ng D, etal., PLoS Biol. 2009 Feb 24;7(2):e41. doi: 10.1371/journal.pbio.1000041.
106. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. Niethammer M, etal., J Neurosci. 1996 Apr 1;16(7):2157-63.
107. Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. Obara I, etal., Alcohol Clin Exp Res. 2009 Nov;33(11):1924-34. Epub 2009 Aug 10.
108. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
109. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
110. AMPA, kainate, and NMDA receptor densities in the hippocampus of untreated male rats and females in estrus and diestrus. Palomero-Gallagher N, etal., J Comp Neurol 2003 May 12;459(4):468-74.
111. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. Pearson-Leary J and McNay EC, J Neurosci. 2016 Nov 23;36(47):11851-11864. doi: 10.1523/JNEUROSCI.1700-16.2016.
112. Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats. Peng HY, etal., Pain. 2009 Mar;142(1-2):75-88. doi: 10.1016/j.pain.2008.11.017. Epub 2009 Jan 23.
113. Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. Peregud DI, etal., Bull Exp Biol Med. 2012 Oct;153(6):835-8. doi: 10.1007/s10517-012-1838-x.
114. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
115. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
116. Memory enhancement by targeting Cdk5 regulation of NR2B. Plattner F, etal., Neuron. 2014 Mar 5;81(5):1070-1083. doi: 10.1016/j.neuron.2014.01.022.
117. Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines. Radley JJ, etal., Brain Res. 2007 Feb 23;1134(1):87-94. Epub 2007 Jan 17.
118. GOA pipeline RGD automated data pipeline
119. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
120. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
121. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. Robison AJ, etal., J Biol Chem. 2005 Oct 21;280(42):35329-36. Epub 2005 Aug 24.
122. Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones. Rockliffe N and Gawler D, FEBS Lett. 2006 Feb 6;580(3):831-8. Epub 2006 Jan 18.
123. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Sans N, etal., Nat Cell Biol. 2003 Jun;5(6):520-30.
124. Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi. Schober ME, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R681-92. Epub 2009 Jan 14.
125. Formation of molecular complexes by N-methyl-D-aspartate receptor subunit NR2B and ryanodine receptor 2 in neonatal rat myocard. Seeber S, etal., J Biol Chem. 2004 May 14;279(20):21062-8. Epub 2004 Mar 9.
126. Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease. Seripa D, etal., Dement Geriatr Cogn Disord. 2008;25(3):287-92. doi: 10.1159/000118634. Epub 2008 Feb 26.
127. The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Sheng Z, etal., Neuropharmacology. 2009 Aug;57(2):127-36. Epub 2009 May 8.
128. Enhancement of learning and memory by elevating brain magnesium. Slutsky I, etal., Neuron. 2010 Jan 28;65(2):165-77.
129. NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines. Sobczyk A, etal., J Neurosci. 2005 Jun 29;25(26):6037-46.
130. Selective effects of neonatal handling on rat brain N-methyl-D-aspartate receptors. Stamatakis A, etal., Neuroscience. 2009 Dec 29;164(4):1457-67. Epub 2009 Sep 22.
131. A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. Stephenson JR, etal., J Neurosci. 2017 Feb 22;37(8):2216-2233. doi: 10.1523/JNEUROSCI.2068-16.2017. Epub 2017 Jan 27.
132. Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties. Sun W, etal., Neuron. 2017 Apr 5;94(1):58-64.e3. doi: 10.1016/j.neuron.2017.03.018.
133. NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. Swanwick CC, etal., FEBS Lett. 2009 Apr 17;583(8):1226-30. Epub 2009 Mar 17.
134. Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Tajima N, etal., Nature. 2016 Jun 2;534(7605):63-8. doi: 10.1038/nature17679. Epub 2016 May 2.
135. Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. Tunc-Ozcan E, etal., Alcohol Clin Exp Res. 2013 Nov;37(11):1986-95. doi: 10.1111/acer.12183. Epub 2013 Jun 13.
136. Contribution of NMDA receptor NR2B subunit to synaptic plasticity during associative learning in behaving rats. Valenzuela-Harrington M, etal., Eur J Neurosci. 2007 Feb;25(3):830-6.
137. A novel family of adhesion-like molecules that interacts with the NMDA receptor. Wang CY, etal., J Neurosci. 2006 Feb 22;26(8):2174-83.
138. Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats. Wang F, etal., Pain. 2010 Feb;148(2):275-83. Epub 2009 Dec 11.
139. Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor. Wee XK, etal., Br J Pharmacol. 2010 Jan 1;159(2):449-61. Epub 2010 Jan 15.
140. Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Wei B, etal., Brain Res. 2016 Jan 15;1631:157-64. doi: 10.1016/j.brainres.2015.11.041. Epub 2015 Dec 2.
141. Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits. Wernicke C, etal., Biol Psychiatry. 2003 Nov 1;54(9):922-8.
142. Long-term regulation of N-methyl-D-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity. Williams JM, etal., Neuroscience. 2003;118(4):1003-13.
143. Oxygen and glucose deprivation in an organotypic hippocampal slice model of the developing rat brain: the effects on N-methyl-D-aspartate subunit composition. Wise-Faberowski L, etal., Anesth Analg. 2009 Jul;109(1):205-10.
144. Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. Wu HY, etal., J Biol Chem. 2007 Jul 13;282(28):20075-87. doi: 10.1074/jbc.M700624200. Epub 2007 May 25.
145. Manganese exposure alters the expression of N-methyl-D-aspartate receptor subunit mRNAs and proteins in rat striatum. Xu B, etal., J Biochem Mol Toxicol. 2010 Jan;24(1):1-9.
146. Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Xu B, etal., Neurotoxicology. 2009 Nov;30(6):941-9. Epub 2009 Jul 28.
147. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Xu Y, etal., Neuropharmacology. 2009 Sep;57(4):463-71. doi: 10.1016/j.neuropharm.2009.06.010. Epub 2009 Jun 21.
148. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Yaka R, etal., Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5710-5. Epub 2002 Apr 9.
149. Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats. Yang J, etal., J Neurosci. 2006 Jan 11;26(2):406-10.
150. Neuroprotective Effects of Hydroxysafflor Yellow A Against Excitotoxic Neuronal Death Partially Through Down-Regulation of NR2B-Containing NMDA Receptors. Yang Q, etal., Neurochem Res. 2010 Jun 5.
151. Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 . Yoshioka T, etal., FEBS Lett. 2013 May 21;587(10):1453-9. doi: 10.1016/j.febslet.2013.03.030. Epub 2013 Apr 6.
152. Control of NMDA receptor function by the NR2 subunit amino-terminal domain. Yuan H, etal., J Neurosci. 2009 Sep 30;29(39):12045-58. doi: 10.1523/JNEUROSCI.1365-09.2009.
153. Protective effect of spleen-yin-nourishing recipe on amyloid beta-peptide-induced damage of primarily cultured rat hippocampal neurons and its mechanism. Zhan LB, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Mar;7(3):242-8.
154. Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory. Zhang XM, etal., Cell Res. 2015 Jul;25(7):818-36. doi: 10.1038/cr.2015.75. Epub 2015 Jun 19.
155. Differential expression of SLC9A9 and interacting molecules in the hippocampus of rat models for attention deficit/hyperactivity disorder. Zhang-James Y, etal., Dev Neurosci. 2012;34(2-3):218-27. Epub 2012 Jul 6.
156. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Zhao MG, etal., Neuron. 2005 Sep 15;47(6):859-72.
157. Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. Zhao X, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1173-7. Epub 2009 Jun 27.
158. Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat. Zhou JY, etal., Arch Pharm Res. 2010 Apr;33(4):557-65. Epub 2010 Apr 27.
Additional References at PubMed
PMID:1377365   PMID:7524561   PMID:7531804   PMID:8789948   PMID:8840015   PMID:8940188   PMID:9003035   PMID:9147327   PMID:9458051   PMID:9581762   PMID:9670010   PMID:10479680  
PMID:10480938   PMID:10485705   PMID:10634899   PMID:10846156   PMID:10939335   PMID:11160393   PMID:11488959   PMID:11530236   PMID:11588171   PMID:11711849   PMID:11719203   PMID:11897109  
PMID:11911857   PMID:11929923   PMID:12147342   PMID:12391275   PMID:12486601   PMID:12579524   PMID:12586431   PMID:12676993   PMID:12684439   PMID:12716944   PMID:12764094   PMID:12816890  
PMID:12832518   PMID:12890763   PMID:14503841   PMID:14645471   PMID:14672996   PMID:15016095   PMID:15143284   PMID:15146049   PMID:15201510   PMID:15356193   PMID:15356198   PMID:15483135  
PMID:15537897   PMID:15574735   PMID:15580338   PMID:15610162   PMID:15629447   PMID:15634765   PMID:15649985   PMID:15673434   PMID:15748150   PMID:15790561   PMID:15804717   PMID:15885982  
PMID:15908129   PMID:15924861   PMID:15967799   PMID:16045501   PMID:16141268   PMID:16155008   PMID:16190898   PMID:16221859   PMID:16300633   PMID:16436603   PMID:16540573   PMID:16710293  
PMID:16741178   PMID:16794574   PMID:16901514   PMID:16980547   PMID:17047094   PMID:17114649   PMID:17124177   PMID:17156360   PMID:17196527   PMID:17229826   PMID:17255096   PMID:17331654  
PMID:17451646   PMID:17509768   PMID:17545075   PMID:17670980   PMID:17706601   PMID:17717018   PMID:17986236   PMID:18006154   PMID:18025808   PMID:18033811   PMID:18033813   PMID:18048007  
PMID:18230675   PMID:18272676   PMID:18339694   PMID:18342306   PMID:18356833   PMID:18378405   PMID:18445116   PMID:18468585   PMID:18538939   PMID:18673451   PMID:18688011   PMID:18694808  
PMID:18706452   PMID:18751892   PMID:18765272   PMID:18826591   PMID:18922773   PMID:18927268   PMID:18936081   PMID:18952054   PMID:19088076   PMID:19106110   PMID:19164281   PMID:19187438  
PMID:19193935   PMID:19275891   PMID:19302193   PMID:19335206   PMID:19376094   PMID:19428647   PMID:19520065   PMID:19531642   PMID:19543280   PMID:19587283   PMID:19625512   PMID:19656178  
PMID:19694907   PMID:19726645   PMID:19857555   PMID:19864302   PMID:20107120   PMID:20418887   PMID:20427654   PMID:20508838   PMID:20569495   PMID:20625810   PMID:20661302   PMID:20698836  
PMID:20831617   PMID:20850419   PMID:20887777   PMID:20974938   PMID:21029094   PMID:21144999   PMID:21171386   PMID:21177185   PMID:21182900   PMID:21364640   PMID:21384157   PMID:21397592  
PMID:21427228   PMID:21439793   PMID:21470075   PMID:21575722   PMID:21608225   PMID:21664258   PMID:21669274   PMID:21762679   PMID:21795692   PMID:21862938   PMID:21880917   PMID:21895803  
PMID:22027786   PMID:22055014   PMID:22084102   PMID:22089426   PMID:22100849   PMID:22177709   PMID:22179603   PMID:22335236   PMID:22359056   PMID:22364833   PMID:22366650   PMID:22375001  
PMID:22377595   PMID:22543102   PMID:22558458   PMID:22610100   PMID:22681877   PMID:22740692   PMID:22743575   PMID:22759925   PMID:22776695   PMID:22820466   PMID:22824136   PMID:22833681  
PMID:22871113   PMID:22902837   PMID:22906554   PMID:22931702   PMID:22965452   PMID:22982438   PMID:23022504   PMID:23069667   PMID:23091164   PMID:23146303   PMID:23219940   PMID:23221411  
PMID:23313317   PMID:23429044   PMID:23431156   PMID:23497405   PMID:23516288   PMID:23584669   PMID:23585298   PMID:23611155   PMID:23660833   PMID:23672716   PMID:23676200   PMID:23811393  
PMID:23839940   PMID:23981041   PMID:24032403   PMID:24041503   PMID:24069373   PMID:24120858   PMID:24189275   PMID:24336715   PMID:24388786   PMID:24431445   PMID:24440698   PMID:24487031  
PMID:24491052   PMID:24562683   PMID:24607230   PMID:24631206   PMID:24705401   PMID:24761931   PMID:24824341   PMID:25122884   PMID:25393018   PMID:25404733   PMID:25496357   PMID:25521238  
PMID:25772108   PMID:25838242   PMID:25917873   PMID:26027736   PMID:26190171   PMID:26197883   PMID:26204818   PMID:26229100   PMID:26343542   PMID:26391783   PMID:26401567   PMID:26440419  
PMID:26548659   PMID:26554229   PMID:26609151   PMID:26627310   PMID:26875626   PMID:26881126   PMID:26919761   PMID:26930443   PMID:27217103   PMID:27430327   PMID:27457929   PMID:27487820  
PMID:27497478   PMID:27523302   PMID:27531837   PMID:27839871   PMID:27865917   PMID:27926876   PMID:28160495   PMID:28326942   PMID:28358367   PMID:28393079   PMID:28497343   PMID:28682239  
PMID:28916627   PMID:29335819   PMID:29353374   PMID:29476059   PMID:29490264   PMID:30054528   PMID:30142538   PMID:30176218   PMID:30269991   PMID:30350722   PMID:30400767   PMID:30639357  
PMID:31080121   PMID:31213568   PMID:31245854   PMID:31277281   PMID:31424425   PMID:31672664   PMID:31840160   PMID:32032782   PMID:32386416   PMID:32606037   PMID:32816128   PMID:32929031  
PMID:33420399   PMID:33485963   PMID:33550485   PMID:33843051   PMID:34360755   PMID:34445376   PMID:35181828   PMID:35183034   PMID:35257794   PMID:36085433   PMID:36344756   PMID:36521778  
PMID:36527595   PMID:36563833   PMID:37085778   PMID:37394125   PMID:37700085   PMID:38037367   PMID:38416255   PMID:38471625  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84170,297,811 - 170,775,420 (-)NCBIGRCr8
mRatBN7.24168,580,824 - 169,044,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4168,599,546 - 169,042,279 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4174,894,793 - 175,337,242 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04170,675,997 - 171,118,792 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04169,300,441 - 169,742,894 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04169,541,620 - 170,000,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04233,806,406 - 234,260,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44172,721,895 - 173,183,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14172,966,830 - 173,428,311 (-)NCBI
Celera4157,188,514 - 157,629,365 (-)NCBICelera
RH 3.4 Map41026.8RGD
Cytogenetic Map4q43NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381213,537,337 - 13,982,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1213,437,942 - 13,982,002 (-)EnsemblGRCh38hg38GRCh38
GRCh371213,690,271 - 14,134,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361213,605,411 - 14,024,319 (-)NCBINCBI36Build 36hg18NCBI36
Build 341213,605,410 - 14,024,319NCBI
Celera1218,858,978 - 19,277,660 (-)NCBICelera
Cytogenetic Map12p13.1NCBI
HuRef1213,479,858 - 13,898,402 (-)NCBIHuRef
CHM1_11213,679,406 - 14,098,101 (-)NCBICHM1_1
T2T-CHM13v2.01213,411,758 - 13,856,548 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396135,690,219 - 136,150,658 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6135,690,231 - 136,150,509 (-)EnsemblGRCm39 Ensembl
GRCm386135,713,221 - 136,173,615 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6135,713,233 - 136,173,511 (-)EnsemblGRCm38mm10GRCm38
MGSCv376135,679,813 - 136,123,529 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366135,697,791 - 136,009,994 (-)NCBIMGSCv36mm8
Celera6138,678,301 - 139,123,902 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.38NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541310,376,597 - 10,779,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541310,358,931 - 10,780,004 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21018,992,799 - 19,432,314 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11218,972,796 - 19,429,075 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01213,543,104 - 13,987,437 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11213,943,936 - 14,272,195 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,969,387 - 14,388,799 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12732,470,889 - 32,883,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2732,471,153 - 32,877,680 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2713,572,169 - 13,850,223 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02732,702,956 - 33,191,598 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2732,702,672 - 33,190,417 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12732,798,882 - 33,078,120 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02732,748,401 - 33,027,217 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02713,302,777 - 13,581,228 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494593,677,907 - 94,094,419 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365873,405,698 - 3,804,664 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365873,406,055 - 3,806,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl558,480,528 - 58,927,558 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1558,477,862 - 58,948,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2561,874,217 - 62,275,930 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11113,444,155 - 13,873,034 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1113,456,968 - 13,873,202 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606921,440,620 - 21,872,881 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475224,135,487 - 24,459,288 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475224,008,520 - 24,480,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Grin2b
1861 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:72
Interacting mature miRNAs:87
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,599,595 - 168,599,850 (+)MAPPERmRatBN7.2
Rnor_6.04169,559,999 - 169,560,253NCBIRnor6.0
Rnor_5.04233,824,084 - 233,824,338UniSTSRnor5.0
RGSC_v3.44172,721,945 - 172,722,199UniSTSRGSC3.4
Celera4157,188,564 - 157,188,818UniSTS
RH 3.4 Map41026.8UniSTS
Cytogenetic Map4q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24169,041,996 - 169,042,191 (+)MAPPERmRatBN7.2
Rnor_6.04169,998,166 - 169,998,360NCBIRnor6.0
Rnor_5.04234,258,645 - 234,258,839UniSTSRnor5.0
RGSC_v3.44173,182,905 - 173,183,099UniSTSRGSC3.4
Celera4157,629,083 - 157,629,277UniSTS
Cytogenetic Map4q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,800,230 - 168,800,345 (+)MAPPERmRatBN7.2
Rnor_6.04169,761,521 - 169,761,635NCBIRnor6.0
Rnor_5.04234,025,258 - 234,025,372UniSTSRnor5.0
RGSC_v3.44172,924,073 - 172,924,187UniSTSRGSC3.4
Celera4157,389,977 - 157,390,091UniSTS
RH 3.4 Map41026.2UniSTS
Cytogenetic Map4q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,600,099 - 168,600,280 (+)MAPPERmRatBN7.2
Rnor_6.04169,560,503 - 169,560,683NCBIRnor6.0
Rnor_5.04233,824,588 - 233,824,768UniSTSRnor5.0
RGSC_v3.44172,722,449 - 172,722,629UniSTSRGSC3.4
Celera4157,189,068 - 157,189,248UniSTS
Cytogenetic Map4q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,601,222 - 168,601,681 (+)MAPPERmRatBN7.2
Rnor_6.04169,561,626 - 169,562,084NCBIRnor6.0
Rnor_5.04233,825,711 - 233,826,169UniSTSRnor5.0
RGSC_v3.44172,723,572 - 172,724,030UniSTSRGSC3.4
Celera4157,190,191 - 157,190,649UniSTS
Cytogenetic Map4q43UniSTS

Genetic Models
This gene Grin2b is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 34
Low 1 30 5 2
Below cutoff 2 6 17 4 14 4 6 6 8 20 30 9 6


RefSeq Acc Id: ENSRNOT00000011697   ⟹   ENSRNOP00000011697
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4168,599,546 - 169,042,279 (-)Ensembl
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108335   ⟹   ENSRNOP00000083097
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4168,739,363 - 169,042,279 (-)Ensembl
RefSeq Acc Id: NM_012574   ⟹   NP_036706
Rat AssemblyChrPosition (strand)Source
GRCr84170,330,865 - 170,773,570 (-)NCBI
mRatBN7.24168,599,546 - 169,042,279 (-)NCBI
Rnor_6.04169,559,949 - 169,998,448 (-)NCBI
Rnor_5.04233,806,406 - 234,260,360 (-)NCBI
RGSC_v3.44172,721,895 - 173,183,187 (-)RGD
Celera4157,188,514 - 157,629,365 (-)RGD
RefSeq Acc Id: XM_017592436   ⟹   XP_017447925
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,774,841 (-)NCBI
mRatBN7.24168,580,824 - 169,043,806 (-)NCBI
Rnor_6.04169,558,166 - 169,999,881 (-)NCBI
RefSeq Acc Id: XM_017592437   ⟹   XP_017447926
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,775,420 (-)NCBI
mRatBN7.24168,599,546 - 169,044,110 (-)NCBI
Rnor_6.04169,558,166 - 170,000,216 (-)NCBI
RefSeq Acc Id: XM_017592438   ⟹   XP_017447927
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,775,301 (-)NCBI
mRatBN7.24168,599,546 - 169,044,002 (-)NCBI
Rnor_6.04169,558,166 - 170,000,138 (-)NCBI
RefSeq Acc Id: XM_017592439   ⟹   XP_017447928
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,775,289 (-)NCBI
mRatBN7.24168,580,824 - 169,043,803 (-)NCBI
Rnor_6.04169,541,620 - 169,999,881 (-)NCBI
RefSeq Acc Id: XM_063285520   ⟹   XP_063141590
Rat AssemblyChrPosition (strand)Source
GRCr84170,297,811 - 170,774,443 (-)NCBI
RefSeq Acc Id: NP_036706   ⟸   NM_012574
- Peptide Label: precursor
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447928   ⟸   XM_017592439
- Peptide Label: isoform X2
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447926   ⟸   XM_017592437
- Peptide Label: isoform X1
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot),   G3V746 (UniProtKB/TrEMBL),   A6IMH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447927   ⟸   XM_017592438
- Peptide Label: isoform X1
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot),   G3V746 (UniProtKB/TrEMBL),   A6IMH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447925   ⟸   XM_017592436
- Peptide Label: isoform X1
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot),   G3V746 (UniProtKB/TrEMBL),   A6IMH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011697   ⟸   ENSRNOT00000011697
RefSeq Acc Id: ENSRNOP00000083097   ⟸   ENSRNOT00000108335
RefSeq Acc Id: XP_063141590   ⟸   XM_063285520
- Peptide Label: isoform X1
- UniProtKB: Q62684 (UniProtKB/Swiss-Prot),   Q00960 (UniProtKB/Swiss-Prot),   A6IMH0 (UniProtKB/TrEMBL),   G3V746 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00960-F1-model_v2 AlphaFold Q00960 1-1482 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2738 AgrOrtholog
BioCyc Gene G2FUF-42625 BioCyc
Ensembl Genes ENSRNOG00000008766 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011697.5 UniProtKB/TrEMBL
  ENSRNOT00000108335.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Solute-binding_3/MltF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24410 UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SBP_bac_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grin2b PhenoGen
RatGTEx ENSRNOG00000008766 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZW91_RAT UniProtKB/TrEMBL
UniProt Secondary Q62684 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin2b  glutamate ionotropic receptor NMDA type subunit 2B  Grin2b  glutamate receptor, ionotropic, N-methyl D-aspartate 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Grin2b  glutamate receptor, ionotropic, N-methyl D-aspartate 2B    glutamate receptor, ionotropic, NMDA2B   Name updated 1299863 APPROVED
2002-11-06 Grin2b  glutamate receptor, ionotropic, NMDA2B     Glutamate receptor, ionotropic, N-methyl D-aspartate 2B  Name updated 625702 APPROVED
2002-06-10 Grin2b  Glutamate receptor, ionotropic, N-methyl D-aspartate 2B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA expression in the dorsal hippocampus decreases during hyperthyroidism 728772
gene_expression expression increases significantly in hypothalami of older femals compared to the younger ones 625682
gene_expression expressed in majority of gonadotrophin releasing hormone (GnRH) neurons 625682
gene_function subunit of pentameric N-methyl-D-aspartate receptor (NMDAR) 625682
gene_process receptor for glutamate that influences reproductive physiology in female rats 625682
gene_process may play an important role in the neuronal stimulation assosicated with female reproductive physiology 625682
gene_regulation age-dependent increase in expression in hypothalamus may be involved in altered neuroendocrine function 625682