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Gene: Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) Rattus norvegicus
Symbol: Grin2b
Name: glutamate ionotropic receptor NMDA type subunit 2B
Description: Exhibits several functions, including beta-catenin binding activity; extracellular ligand-gated ion channel activity; and signaling receptor binding activity. Involved in several processes, including cellular response to organic cyclic compound; learning or memory; and pallium development. Localizes to several cellular components, including dendrite; hippocampal mossy fiber to CA3 synapse; and integral component of plasma membrane. Used to study attention deficit hyperactivity disorder; fetal alcohol spectrum disorder; and hyperhomocysteinemia. Biomarker of several diseases, including attention deficit hyperactivity disorder; cognitive disorder (multiple); hypoglycemia; placental insufficiency; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant non-syndromic intellectual disability 6; bipolar disorder; early infantile epileptic encephalopathy 27; and neurodegenerative disease (multiple). Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B); PARTICIPATES IN excitatory synaptic transmission pathway; long term potentiation; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: GluN2B; glutamate [NMDA] receptor subunit epsilon-2; Glutamate receptor ionotropic N-methyl D-aspartate 2B; glutamate receptor ionotropic, NMDA 2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B
Allele / Splice: Grin2bem1Mcwi  
Genetic Models: LE-Grin2bem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04169,541,620 - 170,000,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04233,806,406 - 234,260,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44172,721,895 - 173,183,187 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14172,966,830 - 173,428,311 (-)NCBI
Celera4157,188,514 - 157,629,365 (-)NCBICelera
Cytogenetic Map4q43NCBI
RH 3.4 Map41026.8RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Grin2b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2738
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.