Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) - Rat Genome Database

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Gene: Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) Rattus norvegicus
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Symbol: Grin2b
Name: glutamate ionotropic receptor NMDA type subunit 2B
RGD ID: 2738
Description: Enables several functions, including beta-catenin binding activity; extracellular ligand-gated ion channel activity; and signaling receptor binding activity. Involved in several processes, including cellular response to organic cyclic compound; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including Z disc; dendrite; and synaptic cleft. Is integral component of plasma membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Used to study attention deficit hyperactivity disorder; fetal alcohol spectrum disorder; and hyperhomocysteinemia. Biomarker of several diseases, including attention deficit hyperactivity disorder; cognitive disorder (multiple); hypoglycemia; placental insufficiency; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; bipolar disorder; developmental and epileptic encephalopathy 27; and neurodegenerative disease (multiple). Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B); PARTICIPATES IN excitatory synaptic transmission pathway; long term potentiation; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GluN2B; glutamate [NMDA] receptor subunit epsilon-2; Glutamate receptor ionotropic N-methyl D-aspartate 2B; glutamate receptor ionotropic, NMDA 2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Grin2bem1Mcwi  
Genetic Models: LE-Grin2bem1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24168,580,824 - 169,044,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4168,599,546 - 169,042,279 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4174,894,793 - 175,337,242 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04170,675,997 - 171,118,792 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04169,300,441 - 169,742,894 (-)NCBIRnor_WKY
Rnor_6.04169,541,620 - 170,000,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04233,806,406 - 234,260,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44172,721,895 - 173,183,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14172,966,830 - 173,428,311 (-)NCBI
Celera4157,188,514 - 157,629,365 (-)NCBICelera
RH 3.4 Map41026.8RGD
Cytogenetic Map4q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agomelatine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
alpha-pinene  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (ISO)
amphetamine  (EXP)
arsenite(3-)  (ISO)
astragaloside IV  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
capsaicin  (EXP)
capsazepine  (EXP)
carbaryl  (EXP)
carbon dioxide  (EXP)
carbon nanotube  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
citalopram  (EXP)
clozapine  (EXP)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
crocidolite asbestos  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dextromethorphan  (EXP,ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP)
dizocilpine maleate  (EXP,ISO)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
excitatory amino acid agonist  (ISO)
felbamate  (EXP)
Fluorocitric acid  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP,ISO)
galactose  (EXP)
haloperidol  (ISO)
ionomycin  (EXP)
isoflurane  (EXP)
kainic acid  (ISO)
ketamine  (EXP)
Kukoamine B  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
linoleic acid  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lovastatin  (EXP)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melamine  (EXP)
melatonin  (EXP)
memantine  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
morphine  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-D-aspartic acid  (ISO)
nickel atom  (EXP)
nobiletin  (EXP)
notoginsenoside R1  (ISO)
NS-398  (EXP)
Ondansetron  (EXP)
oxidopamine  (EXP)
paclitaxel  (EXP)
paraquat  (EXP,ISO)
PCB138  (EXP,ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
pyridine  (EXP)
remifentanil  (EXP)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP)
rimonabant  (ISO)
Ro 25-6981  (EXP)
rottlerin  (ISO)
sarin  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
spermine  (EXP)
sterigmatocystin  (EXP)
sulfur dioxide  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
testosterone  (EXP)
tetrodotoxin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
tributylstannane  (EXP)
trimethyltin  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IMP)
associative learning  (IMP)
behavioral fear response  (IMP,ISO)
behavioral response to pain  (ISO)
calcium ion transmembrane import into cytosol  (IEA,ISO,ISS)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cation transmembrane transport  (IC)
cation transport  (ISO)
cellular response to amino acid stimulus  (IEP)
cellular response to corticosterone stimulus  (IEP)
cellular response to curcumin  (IEP)
cellular response to dsRNA  (IEP)
cellular response to forskolin  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to lipid  (IEP)
cellular response to magnesium starvation  (IEP)
cellular response to manganese ion  (IEP)
cellular response to organic cyclic compound  (IEP)
cerebral cortex development  (IEP)
chemical synaptic transmission  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
excitatory postsynaptic potential  (IBA,ISO)
fear response  (ISO)
hippocampus development  (IEP)
in utero embryonic development  (ISO)
ionotropic glutamate receptor signaling pathway  (IC,IDA,IEA)
learning  (ISO)
learning or memory  (IMP,TAS)
long-term memory  (IEP)
long-term synaptic potentiation  (IBA,ISO)
memory  (IDA,ISO)
multicellular organismal response to stress  (IEP)
negative regulation of dendritic spine maintenance  (ISO)
NMDA selective glutamate receptor signaling pathway  (IMP)
positive regulation of cell death  (IDA,IMP)
positive regulation of cysteine-type endopeptidase activity  (IGI)
positive regulation of excitatory postsynaptic potential  (IC,IDA)
positive regulation of glutamate secretion  (IDA)
positive regulation of neuron death  (ISO)
positive regulation of synaptic transmission  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IC,IDA)
protein heterotetramerization  (IDA)
receptor clustering  (IDA)
regulation of cation transmembrane transport  (IC)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of MAPK cascade  (IMP)
regulation of neuronal synaptic plasticity  (IC,IEA)
regulation of postsynaptic cytosolic calcium ion concentration  (IMP)
regulation of postsynaptic membrane potential  (ISO)
regulation of presynaptic membrane potential  (IEA)
regulation of protein kinase A signaling  (ISO)
regulation of synaptic plasticity  (ISO)
response to amine  (IEP)
response to amphetamine  (IEP)
response to calcium ion  (IEP)
response to carbohydrate  (IEP)
response to cocaine  (IEP)
response to cytokine  (IEP)
response to electrical stimulus  (IEP)
response to ethanol  (IEA,IEP,ISO)
response to fungicide  (IEP)
response to growth hormone  (IEP)
response to hypoxia  (IDA)
response to magnesium ion  (IEP)
response to manganese ion  (IEP)
response to mechanical stimulus  (IEP)
response to methylmercury  (IEP)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IMP)
response to other organism  (IEP)
response to toxic substance  (IEP)
rhythmic process  (IDA)
sensitization  (IMP)
sensory organ development  (ISO)
startle response  (ISO)
suckling behavior  (ISO)

References

References - curated
# Reference Title Reference Citation
1. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. Abe M, etal., J Neurosci. 2004 Aug 18;24(33):7292-304. doi: 10.1523/JNEUROSCI.1261-04.2004.
2. Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer's disease. Andreoli V, etal., J Neural Transm (Vienna). 2014 May;121(5):533-42. doi: 10.1007/s00702-013-1125-7. Epub 2013 Dec 1.
3. Enhanced NMDAR1, NMDA2B and mGlu5 receptors gene expression in the cerebellum of insulin induced hypoglycaemic and streptozotocin induced diabetic rats. Anu J, etal., Eur J Pharmacol. 2010 Mar 25;630(1-3):61-8. Epub 2010 Jan 6.
4. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner. Arning L, etal., Hum Genet. 2007 Sep;122(2):175-82. Epub 2007 Jun 14.
5. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. Arning L, etal., Neurogenetics. 2005 Feb;6(1):25-8. Epub 2004 Nov 17.
6. Subunit-specific NMDA receptor trafficking to synapses. Barria A and Malinow R, Neuron. 2002 Jul 18;35(2):345-53.
7. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Bartlett TE, etal., Neuropharmacology. 2007 Jan;52(1):60-70. Epub 2006 Aug 10.
8. Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses. Berg LK, etal., Neuroscience. 2013 Jan 29;230:139-50. doi: 10.1016/j.neuroscience.2012.10.061. Epub 2012 Nov 14.
9. Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus. Bersier MG and Rodriguez de Lores Arnaiz G, Neurochem Res. 2009 Sep;34(9):1650-7. Epub 2009 Mar 26.
10. Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule. Bidoret C, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14126-31. Epub 2009 Aug 4.
11. Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. Borbely S, etal., Neuroscience. 2009 Mar 3;159(1):358-68. Epub 2008 Dec 27.
12. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. Brenman JE, etal., J Neurosci. 1998 Nov 1;18(21):8805-13.
13. NR2B-containing NMDA receptors promote the neurotoxic effects of 3-nitropropionic acid but not of rotenone in the striatum. Centonze D, etal., Exp Neurol. 2006 Dec;202(2):470-9. Epub 2006 Aug 17.
14. Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. Chapman DE, etal., J Neurophysiol 2003 Jan;89(1):69-80.
15. Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia. Chen WF, etal., Exp Neurol. 2007 Mar;204(1):400-10. Epub 2007 Jan 30.
16. Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. Clapp P, etal., J Pharmacol Exp Ther. 2010 Mar;332(3):720-9. Epub 2009 Dec 14.
17. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
18. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Cui Z, etal., Neuron. 2004 Mar 4;41(5):781-93. doi: 10.1016/s0896-6273(04)00072-8.
19. Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release. Dalby NO and Mody I, J Neurophysiol 2003 Aug;90(2):786-97.
20. Effects of electroconvulsive therapy and propofol on spatial memory and glutamatergic system in hippocampus of depressed rats. Dong J, etal., J ECT. 2010 Jun;26(2):126-30.
21. Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices. Dos-Anjos S, etal., Neuroscience. 2009 Dec 15;164(3):1119-26. Epub 2009 Sep 15.
22. Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses. Dupuis JP, etal., EMBO J. 2014 Apr 16;33(8):842-61. doi: 10.1002/embj.201386356. Epub 2014 Mar 3.
23. Up-regulation of anterior cingulate cortex NR2B receptors contributes to visceral pain responses in rats. Fan J, etal., Gastroenterology. 2009 May;136(5):1732-40.e3. Epub 2009 Feb 6.
24. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. Fan MM, etal., J Neurosci. 2007 Apr 4;27(14):3768-79.
25. A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats. Ferrier J, etal., PLoS One. 2013 Oct 30;8(10):e77828. doi: 10.1371/journal.pone.0077828. eCollection 2013.
26. Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. Foster KA, etal., J Neurosci. 2010 Feb 17;30(7):2676-85.
27. Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. Fukumori R, etal., J Pharmacol Sci. 2010 Mar 19;112(3):273-81. Epub 2010 Feb 18.
28. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation. Gardoni F, etal., J Neuroinflammation. 2011 Feb 11;8(1):14.
29. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. Gardoni F, etal., J Neurosci. 2006 Mar 15;26(11):2914-22.
30. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
31. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Geng SJ, etal., Exp Neurol. 2010 Apr;222(2):256-66. Epub 2010 Jan 14.
32. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
33. Alterations in NMDA receptor expression during retinal degeneration in the RCS rat. Gründer T, etal., Vis Neurosci. 2001 Sep-Oct;18(5):781-7.
34. Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia. Gulchina Y, etal., J Neurochem. 2017 Nov;143(3):320-333. doi: 10.1111/jnc.14101. Epub 2017 Sep 5.
35. Glutamate stimulates glutamate receptor interacting protein 1 degradation by ubiquitin-proteasome system to regulate surface expression of GluR2. Guo L and Wang Y, Neuroscience. 2007 Mar 2;145(1):100-9. doi: 10.1016/j.neuroscience.2006.11.042. Epub 2007 Jan 3.
36. CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function. Guo ML, etal., EMBO J. 2010 Jun 16;29(12):2070-81. doi: 10.1038/emboj.2010.93. Epub 2010 May 11.
37. Distribution of glutamate receptor subunits in experimentally induced cortical malformations. Hagemann G, etal., Neuroscience. 2003;117(4):991-1002.
38. NR2B subunit-specific NMDA antagonist Ro25-6981 inhibits the expression of conditioned fear: a comparison with the NMDA antagonist MK-801 and fluoxetine. Haller J, etal., Behav Pharmacol. 2011 Apr;22(2):113-21. doi: 10.1097/FBP.0b013e328343d7b2.
39. The effect of ketamine on N-methyl-D-aspartate receptor subunit expression in neonatal rats. Han LC, etal., Eur J Anaesthesiol. 2010 Feb;27(2):181-6.
40. [Effect of behavioral training on learning and memory capacity and changes of hippocampal NR2B and GluR1 expressions in FGR offspring rats]. Huang P, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):708-11.
41. CASK phosphorylation by PKA regulates the protein-protein interactions of CASK and expression of the NMDAR2b gene. Huang TN, etal., J Neurochem. 2010 Mar;112(6):1562-73. doi: 10.1111/j.1471-4159.2010.06569.x. Epub 2010 Jan 7.
42. Chronic unpredictable stress before pregnancy reduce the expression of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor in hippocampus of offspring rats associated with impairment of memory. Huang Y, etal., Neurochem Res. 2010 Jul;35(7):1038-49. Epub 2010 Mar 23.
43. Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway. Huo XL, etal., PLoS One. 2014 Apr 9;9(4):e94278. doi: 10.1371/journal.pone.0094278. eCollection 2014.
44. Prenatal development of NMDA receptor composition and function in trigeminal neurons. Ishihama K, etal., Arch Histol Cytol. 2005 Dec;68(4):321-35.
45. N-methyl-D-aspartate receptor subunit dysfunction at hippocampal glutamatergic synapses in an animal model of attention-deficit/hyperactivity disorder. Jensen V, etal., Neuroscience. 2009 Jan 12;158(1):353-64. doi: 10.1016/j.neuroscience.2008.05.016. Epub 2008 May 21.
46. Association between NR2B subunit gene (GRIN2B) promoter polymorphisms and sporadic Alzheimer's disease in the North Chinese population. Jiang H and Jia J, Neurosci Lett. 2009 Feb 6;450(3):356-60. doi: 10.1016/j.neulet.2008.10.075. Epub 2008 Oct 25.
47. Alterations of NR2B and PSD-95 expression after early-life epileptiform discharges in developing neurons. Jiang Q, etal., Int J Dev Neurosci. 2007 May;25(3):165-70. Epub 2007 Feb 21.
48. CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. Jiang X, etal., Neurobiol Aging. 2015 Feb;36(2):867-76. doi: 10.1016/j.neurobiolaging.2014.10.018. Epub 2014 Oct 16.
49. Immunoblot analyses on the differential distribution of NR2A and NR2B subunits in the adult rat brain. Jin DH, etal., Mol Cells. 1997 Dec 31;7(6):749-54.
50. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. Jo K, etal., J Neurosci. 1999 Jun 1;19(11):4189-99.
51. The effect of ganglioside GQ1b on the NMDA receptor signaling pathway in H19-7 cells and rat hippocampus. Jung WR, etal., Neuroscience. 2010 Jan 13;165(1):159-67. Epub 2009 Oct 9.
52. Differential functions of NR2A and NR2B in short-term and long-term memory in rats. Jung YH and Suh YH, Neuroreport. 2010 Jun 24.
53. PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. Kalia LV, etal., EMBO J. 2006 Oct 18;25(20):4971-82. Epub 2006 Sep 21.
54. Induced tolerance to glutamate neurotoxicity through down-regulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons. Kambe Y, etal., J Neurosci Res. 2010 Aug 1;88(10):2177-87.
55. Crystal structure of a heterotetrameric NMDA receptor ion channel. Karakas E and Furukawa H, Science. 2014 May 30;344(6187):992-7. doi: 10.1126/science.1251915.
56. Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. Karakas E, etal., EMBO J. 2009 Dec 16;28(24):3910-20. doi: 10.1038/emboj.2009.338. Epub .
57. Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Karakas E, etal., Nature. 2011 Jun 15;475(7355):249-53. doi: 10.1038/nature10180.
58. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. Kaufman AM, etal., J Neurosci. 2012 Mar 21;32(12):3992-4003. doi: 10.1523/JNEUROSCI.4129-11.2012.
59. Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression. Kawashima H, etal., Neuroscience. 2010 Feb 17;165(4):1301-11. Epub 2009 Dec 1.
60. Growth hormone rescues hippocampal synaptic function after sleep deprivation. Kim E, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Jun;298(6):R1588-96. Epub 2010 Mar 17.
61. Association study of polymorphisms in N-methyl-D-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism. Kim JH, etal., Neurosci Res. 2006 Oct;56(2):220-3. Epub 2006 Sep 5.
62. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Kornau HC, etal., Science. 1995 Sep 22;269(5231):1737-40.
63. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Krapivinsky G, etal., Neuron. 2003 Nov 13;40(4):775-84.
64. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Kurschner C, etal., Mol Cell Neurosci. 1998 Jun;11(3):161-72.
65. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
66. Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: a new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. Kölker S, etal., Pediatr Res. 2000 Apr;47(4 Pt 1):495-503.
67. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. Lau LF, etal., J Biol Chem. 1996 Aug 30;271(35):21622-8.
68. Amino terminal domains of the NMDA receptor are organized as local heterodimers. Lee CH and Gouaux E, PLoS One. 2011 Apr 22;6(4):e19180. doi: 10.1371/journal.pone.0019180.
69. Thyroid hormone regulation of N-methyl-D-aspartic acid receptor subunit mRNA expression in adult brain. Lee PR, etal., J Neuroendocrinol 2003 Jan;15(1):87-92.
70. Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease. Leuba G, etal., Curr Alzheimer Res. 2014 Jan;11(1):86-96.
71. The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Levenson JM, etal., Biochim Biophys Acta. 2008 Aug;1779(8):422-31. Epub 2008 Jan 12.
72. Behavioral deficits and cellular damage following developmental ethanol exposure in rats are attenuated by CP-101,606, an NMDAR antagonist with unique NR2B specificity. Lewis B, etal., Pharmacol Biochem Behav. 2012 Jan;100(3):545-53. doi: 10.1016/j.pbb.2011.10.013. Epub 2011 Oct 20.
73. Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: a HuGE review and meta-analysis. Li D and He L, Genet Med. 2007 Jan;9(1):4-8.
74. Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity. Li R, etal., BMC Neurosci. 2007 Jul 26;8:55.
75. NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats. Li TT, etal., Pain. 2009 Nov;146(1-2):183-93. Epub 2009 Aug 19.
76. Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Li YC, etal., J Neurosci. 2009 Dec 9;29(49):15551-63.
77. Mechanisms of CaMKII action in long-term potentiation. Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192.
78. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] Liu L, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2009 Jul;43(7):622-7.
79. Effects of postnatal exposure to methylmercury on spatial learning and memory and brain NMDA receptor mRNA expression in rats. Liu W, etal., Toxicol Lett. 2009 Aug 10;188(3):230-5. Epub 2009 May 3.
80. Modulation of D2R-NR2B interactions in response to cocaine. Liu XY, etal., Neuron. 2006 Dec 7;52(5):897-909.
81. N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels. Martucci L, etal., Schizophr Res. 2006 Jun;84(2-3):214-21. Epub 2006 Mar 20.
82. Impaired glutamatergic synaptic transmission in the PKU brain. Martynyuk AE, etal., Mol Genet Metab. 2005 Dec;86 Suppl 1:S34-42. Epub 2005 Sep 8.
83. Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy. Mathern GW, etal., Epilepsy Res. 1998 Sep;32(1-2):154-71.
84. Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha induced by cerebral ischemia immediately targets and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in hippocampus of rats. Meng F and Zhang G, Neurosci Lett 2002 Nov 15;333(1):59-63.
85. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
86. Loose ligation of the rat sciatic nerve elicits early accumulation of Shank1 protein in the post-synaptic density of spinal dorsal horn neurons. Miletic G, etal., Pain. 2010 Apr;149(1):152-9. Epub 2010 Feb 18.
87. N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat. Miller BH and Gore AC, Endocrinology 2002 Sep;143(9):3568-74.
88. Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease. Mohamed NE, etal., J Alzheimers Dis. 2015;44(2):431-7. doi: 10.3233/JAD-141764.
89. Age and meloxicam attenuate the ischemia/reperfusion-induced down-regulation in the NMDA receptor genes. Montori S, etal., Neurochem Int. 2010 Jul;56(8):878-85. Epub 2010 Mar 27.
90. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Monyer H, etal., Science 1992 May 22;256(5060):1217-21.
91. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Muller BM, etal., Neuron. 1996 Aug;17(2):255-65.
92. Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Nagy J, etal., Neurochem Int 2003 Jan;42(1):35-43.
93. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Nakatsu Y, etal., Toxicol Appl Pharmacol. 2009 Oct 15;240(2):292-8. Epub 2009 Jul 7.
94. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
95. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. Ng D, etal., PLoS Biol. 2009 Feb 24;7(2):e41. doi: 10.1371/journal.pbio.1000041.
96. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. Niethammer M, etal., J Neurosci. 1996 Apr 1;16(7):2157-63.
97. Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. Obara I, etal., Alcohol Clin Exp Res. 2009 Nov;33(11):1924-34. Epub 2009 Aug 10.
98. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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100. AMPA, kainate, and NMDA receptor densities in the hippocampus of untreated male rats and females in estrus and diestrus. Palomero-Gallagher N, etal., J Comp Neurol 2003 May 12;459(4):468-74.
101. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. Pearson-Leary J and McNay EC, J Neurosci. 2016 Nov 23;36(47):11851-11864. doi: 10.1523/JNEUROSCI.1700-16.2016.
102. Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats. Peng HY, etal., Pain. 2009 Mar;142(1-2):75-88. doi: 10.1016/j.pain.2008.11.017. Epub 2009 Jan 23.
103. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
104. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
105. Memory enhancement by targeting Cdk5 regulation of NR2B. Plattner F, etal., Neuron. 2014 Mar 5;81(5):1070-1083. doi: 10.1016/j.neuron.2014.01.022.
106. Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines. Radley JJ, etal., Brain Res. 2007 Feb 23;1134(1):87-94. Epub 2007 Jan 17.
107. GOA pipeline RGD automated data pipeline
108. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
109. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
110. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. Robison AJ, etal., J Biol Chem. 2005 Oct 21;280(42):35329-36. Epub 2005 Aug 24.
111. Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones. Rockliffe N and Gawler D, FEBS Lett. 2006 Feb 6;580(3):831-8. Epub 2006 Jan 18.
112. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Sans N, etal., Nat Cell Biol. 2003 Jun;5(6):520-30.
113. Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi. Schober ME, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R681-92. Epub 2009 Jan 14.
114. Formation of molecular complexes by N-methyl-D-aspartate receptor subunit NR2B and ryanodine receptor 2 in neonatal rat myocard. Seeber S, etal., J Biol Chem. 2004 May 14;279(20):21062-8. Epub 2004 Mar 9.
115. Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease. Seripa D, etal., Dement Geriatr Cogn Disord. 2008;25(3):287-92. doi: 10.1159/000118634. Epub 2008 Feb 26.
116. The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Sheng Z, etal., Neuropharmacology. 2009 Aug;57(2):127-36. Epub 2009 May 8.
117. Enhancement of learning and memory by elevating brain magnesium. Slutsky I, etal., Neuron. 2010 Jan 28;65(2):165-77.
118. NMDA receptor subunit-dependent [Ca2+] signaling in individual hippocampal dendritic spines. Sobczyk A, etal., J Neurosci. 2005 Jun 29;25(26):6037-46.
119. Selective effects of neonatal handling on rat brain N-methyl-D-aspartate receptors. Stamatakis A, etal., Neuroscience. 2009 Dec 29;164(4):1457-67. Epub 2009 Sep 22.
120. A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. Stephenson JR, etal., J Neurosci. 2017 Feb 22;37(8):2216-2233. doi: 10.1523/JNEUROSCI.2068-16.2017. Epub 2017 Jan 27.
121. Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties. Sun W, etal., Neuron. 2017 Apr 5;94(1):58-64.e3. doi: 10.1016/j.neuron.2017.03.018.
122. NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. Swanwick CC, etal., FEBS Lett. 2009 Apr 17;583(8):1226-30. Epub 2009 Mar 17.
123. Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Tajima N, etal., Nature. 2016 Jun 2;534(7605):63-8. doi: 10.1038/nature17679. Epub 2016 May 2.
124. Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression. Tunc-Ozcan E, etal., Alcohol Clin Exp Res. 2013 Nov;37(11):1986-95. doi: 10.1111/acer.12183. Epub 2013 Jun 13.
125. Contribution of NMDA receptor NR2B subunit to synaptic plasticity during associative learning in behaving rats. Valenzuela-Harrington M, etal., Eur J Neurosci. 2007 Feb;25(3):830-6.
126. A novel family of adhesion-like molecules that interacts with the NMDA receptor. Wang CY, etal., J Neurosci. 2006 Feb 22;26(8):2174-83.
127. Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats. Wang F, etal., Pain. 2010 Feb;148(2):275-83. Epub 2009 Dec 11.
128. Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor. Wee XK, etal., Br J Pharmacol. 2010 Jan 1;159(2):449-61. Epub 2010 Jan 15.
129. Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Wei B, etal., Brain Res. 2016 Jan 15;1631:157-64. doi: 10.1016/j.brainres.2015.11.041. Epub 2015 Dec 2.
130. Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits. Wernicke C, etal., Biol Psychiatry. 2003 Nov 1;54(9):922-8.
131. Long-term regulation of N-methyl-D-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity. Williams JM, etal., Neuroscience. 2003;118(4):1003-13.
132. Oxygen and glucose deprivation in an organotypic hippocampal slice model of the developing rat brain: the effects on N-methyl-D-aspartate subunit composition. Wise-Faberowski L, etal., Anesth Analg. 2009 Jul;109(1):205-10.
133. Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. Wu HY, etal., J Biol Chem. 2007 Jul 13;282(28):20075-87. doi: 10.1074/jbc.M700624200. Epub 2007 May 25.
134. Manganese exposure alters the expression of N-methyl-D-aspartate receptor subunit mRNAs and proteins in rat striatum. Xu B, etal., J Biochem Mol Toxicol. 2010 Jan;24(1):1-9.
135. Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Xu B, etal., Neurotoxicology. 2009 Nov;30(6):941-9. Epub 2009 Jul 28.
136. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Xu Y, etal., Neuropharmacology. 2009 Sep;57(4):463-71. doi: 10.1016/j.neuropharm.2009.06.010. Epub 2009 Jun 21.
137. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Yaka R, etal., Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5710-5. Epub 2002 Apr 9.
138. Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats. Yang J, etal., J Neurosci. 2006 Jan 11;26(2):406-10.
139. Neuroprotective Effects of Hydroxysafflor Yellow A Against Excitotoxic Neuronal Death Partially Through Down-Regulation of NR2B-Containing NMDA Receptors. Yang Q, etal., Neurochem Res. 2010 Jun 5.
140. Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 . Yoshioka T, etal., FEBS Lett. 2013 May 21;587(10):1453-9. doi: 10.1016/j.febslet.2013.03.030. Epub 2013 Apr 6.
141. Control of NMDA receptor function by the NR2 subunit amino-terminal domain. Yuan H, etal., J Neurosci. 2009 Sep 30;29(39):12045-58. doi: 10.1523/JNEUROSCI.1365-09.2009.
142. Protective effect of spleen-yin-nourishing recipe on amyloid beta-peptide-induced damage of primarily cultured rat hippocampal neurons and its mechanism. Zhan LB, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Mar;7(3):242-8.
143. Differential expression of SLC9A9 and interacting molecules in the hippocampus of rat models for attention deficit/hyperactivity disorder. Zhang-James Y, etal., Dev Neurosci. 2012;34(2-3):218-27. Epub 2012 Jul 6.
144. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Zhao MG, etal., Neuron. 2005 Sep 15;47(6):859-72.
145. Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. Zhao X, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1173-7. Epub 2009 Jun 27.
146. Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat. Zhou JY, etal., Arch Pharm Res. 2010 Apr;33(4):557-65. Epub 2010 Apr 27.
Additional References at PubMed
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Genomics

Comparative Map Data
Grin2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24168,580,824 - 169,044,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4168,599,546 - 169,042,279 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4174,894,793 - 175,337,242 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04170,675,997 - 171,118,792 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04169,300,441 - 169,742,894 (-)NCBIRnor_WKY
Rnor_6.04169,541,620 - 170,000,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04233,806,406 - 234,260,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44172,721,895 - 173,183,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14172,966,830 - 173,428,311 (-)NCBI
Celera4157,188,514 - 157,629,365 (-)NCBICelera
RH 3.4 Map41026.8RGD
Cytogenetic Map4q43NCBI
GRIN2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381213,537,337 - 13,982,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1213,437,942 - 13,982,002 (-)EnsemblGRCh38hg38GRCh38
GRCh371213,690,271 - 14,134,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361213,605,411 - 14,024,319 (-)NCBINCBI36Build 36hg18NCBI36
Build 341213,605,410 - 14,024,319NCBI
Celera1218,858,978 - 19,277,660 (-)NCBICelera
Cytogenetic Map12p13.1NCBI
HuRef1213,479,858 - 13,898,402 (-)NCBIHuRef
CHM1_11213,679,406 - 14,098,101 (-)NCBICHM1_1
T2T-CHM13v2.01213,411,758 - 13,856,016 (-)NCBIT2T-CHM13v2.0
Grin2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396135,690,219 - 136,150,658 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6135,690,231 - 136,150,509 (-)EnsemblGRCm39 Ensembl
GRCm386135,713,221 - 136,173,615 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6135,713,233 - 136,173,511 (-)EnsemblGRCm38mm10GRCm38
MGSCv376135,679,813 - 136,123,529 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366135,697,791 - 136,009,994 (-)NCBIMGSCv36mm8
Celera6138,678,301 - 139,123,902 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.38NCBI
Grin2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541310,376,597 - 10,779,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541310,358,931 - 10,780,004 (-)NCBIChiLan1.0ChiLan1.0
GRIN2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11213,943,936 - 14,272,195 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,969,387 - 14,388,799 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01213,543,104 - 13,987,437 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRIN2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12732,470,889 - 32,883,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2732,471,153 - 32,877,680 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2713,572,169 - 13,850,223 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02732,702,956 - 33,191,598 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2732,702,672 - 33,190,417 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12732,798,882 - 33,078,120 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02732,748,401 - 33,027,217 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02713,302,777 - 13,581,228 (-)NCBIUU_Cfam_GSD_1.0
Grin2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494593,677,907 - 94,094,419 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365873,406,055 - 3,806,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl558,480,528 - 58,927,558 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1558,477,862 - 58,948,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2561,874,217 - 62,275,930 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11113,444,155 - 13,873,034 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1113,456,968 - 13,873,202 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606921,440,620 - 21,872,881 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475224,135,487 - 24,459,288 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475224,008,520 - 24,480,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH94749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,599,595 - 168,599,850 (+)MAPPERmRatBN7.2
Rnor_6.04169,559,999 - 169,560,253NCBIRnor6.0
Rnor_5.04233,824,084 - 233,824,338UniSTSRnor5.0
RGSC_v3.44172,721,945 - 172,722,199UniSTSRGSC3.4
Celera4157,188,564 - 157,188,818UniSTS
RH 3.4 Map41026.8UniSTS
Cytogenetic Map4q43UniSTS
RH94750  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24169,041,996 - 169,042,191 (+)MAPPERmRatBN7.2
Rnor_6.04169,998,166 - 169,998,360NCBIRnor6.0
Rnor_5.04234,258,645 - 234,258,839UniSTSRnor5.0
RGSC_v3.44173,182,905 - 173,183,099UniSTSRGSC3.4
Celera4157,629,083 - 157,629,277UniSTS
Cytogenetic Map4q43UniSTS
RH143997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,800,230 - 168,800,345 (+)MAPPERmRatBN7.2
Rnor_6.04169,761,521 - 169,761,635NCBIRnor6.0
Rnor_5.04234,025,258 - 234,025,372UniSTSRnor5.0
RGSC_v3.44172,924,073 - 172,924,187UniSTSRGSC3.4
Celera4157,389,977 - 157,390,091UniSTS
RH 3.4 Map41026.2UniSTS
Cytogenetic Map4q43UniSTS
Grin2b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,600,099 - 168,600,280 (+)MAPPERmRatBN7.2
Rnor_6.04169,560,503 - 169,560,683NCBIRnor6.0
Rnor_5.04233,824,588 - 233,824,768UniSTSRnor5.0
RGSC_v3.44172,722,449 - 172,722,629UniSTSRGSC3.4
Celera4157,189,068 - 157,189,248UniSTS
Cytogenetic Map4q43UniSTS
UniSTS:465389  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24168,601,222 - 168,601,681 (+)MAPPERmRatBN7.2
Rnor_6.04169,561,626 - 169,562,084NCBIRnor6.0
Rnor_5.04233,825,711 - 233,826,169UniSTSRnor5.0
RGSC_v3.44172,723,572 - 172,724,030UniSTSRGSC3.4
Celera4157,190,191 - 157,190,649UniSTS
Cytogenetic Map4q43UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat


Genetic Models
This gene Grin2b is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:72
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000011697
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34
Low 1 30 5 2
Below cutoff 2 6 17 4 14 4 6 6 8 20 30 9 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011697   ⟹   ENSRNOP00000011697
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4168,599,546 - 169,042,279 (-)Ensembl
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108335   ⟹   ENSRNOP00000083097
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4168,739,363 - 169,042,279 (-)Ensembl
RefSeq Acc Id: NM_012574   ⟹   NP_036706
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24168,599,546 - 169,042,279 (-)NCBI
Rnor_6.04169,559,949 - 169,998,448 (-)NCBI
Rnor_5.04233,806,406 - 234,260,360 (-)NCBI
RGSC_v3.44172,721,895 - 173,183,187 (-)RGD
Celera4157,188,514 - 157,629,365 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592436   ⟹   XP_017447925
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24168,580,824 - 169,043,806 (-)NCBI
Rnor_6.04169,558,166 - 169,999,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592437   ⟹   XP_017447926
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24168,599,546 - 169,044,110 (-)NCBI
Rnor_6.04169,558,166 - 170,000,216 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592438   ⟹   XP_017447927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24168,599,546 - 169,044,002 (-)NCBI
Rnor_6.04169,558,166 - 170,000,138 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592439   ⟹   XP_017447928
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24168,580,824 - 169,043,803 (-)NCBI
Rnor_6.04169,541,620 - 169,999,881 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036706   ⟸   NM_012574
- Peptide Label: precursor
- UniProtKB: Q00960 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447928   ⟸   XM_017592439
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017447926   ⟸   XM_017592437
- Peptide Label: isoform X1
- UniProtKB: G3V746 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447927   ⟸   XM_017592438
- Peptide Label: isoform X1
- UniProtKB: G3V746 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447925   ⟸   XM_017592436
- Peptide Label: isoform X1
- UniProtKB: G3V746 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011697   ⟸   ENSRNOT00000011697
RefSeq Acc Id: ENSRNOP00000083097   ⟸   ENSRNOT00000108335
Protein Domains
ANF_receptor   Lig_chan-Glu_bd   PBPe

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00960-F1-model_v2 AlphaFold Q00960 1-1482 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2738 AgrOrtholog
BioCyc Gene G2FUF-42625 BioCyc
Ensembl Genes ENSRNOG00000008766 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011697 ENTREZGENE
  ENSRNOP00000011697.3 UniProtKB/TrEMBL
  ENSRNOP00000083097.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011697 ENTREZGENE
  ENSRNOT00000011697.5 UniProtKB/TrEMBL
  ENSRNOT00000108335.1 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24410 UniProtKB/Swiss-Prot
NCBI Gene 24410 ENTREZGENE
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grin2b PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZW91_RAT UniProtKB/TrEMBL
  G3V746 ENTREZGENE, UniProtKB/TrEMBL
  NMDE2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q62684 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin2b  glutamate ionotropic receptor NMDA type subunit 2B  Grin2b  glutamate receptor, ionotropic, N-methyl D-aspartate 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Grin2b  glutamate receptor, ionotropic, N-methyl D-aspartate 2B    glutamate receptor, ionotropic, NMDA2B   Name updated 1299863 APPROVED
2002-11-06 Grin2b  glutamate receptor, ionotropic, NMDA2B     Glutamate receptor, ionotropic, N-methyl D-aspartate 2B  Name updated 625702 APPROVED
2002-06-10 Grin2b  Glutamate receptor, ionotropic, N-methyl D-aspartate 2B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA expression in the dorsal hippocampus decreases during hyperthyroidism 728772
gene_expression expression increases significantly in hypothalami of older femals compared to the younger ones 625682
gene_expression expressed in majority of gonadotrophin releasing hormone (GnRH) neurons 625682
gene_function subunit of pentameric N-methyl-D-aspartate receptor (NMDAR) 625682
gene_process receptor for glutamate that influences reproductive physiology in female rats 625682
gene_process may play an important role in the neuronal stimulation assosicated with female reproductive physiology 625682
gene_regulation age-dependent increase in expression in hypothalamus may be involved in altered neuroendocrine function 625682