RGD Reference Report - Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. - Rat Genome Database

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Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence.

Authors: Peregud, D I  Yakovlev, A A  Stepanichev, M Yu  Onufriev, M V  Panchenko, L F  Gulyaeva, N V 
Citation: Peregud DI, etal., Bull Exp Biol Med. 2012 Oct;153(6):835-8. doi: 10.1007/s10517-012-1838-x.
RGD ID: 401938657
Pubmed: PMID:23113297   (View Abstract at PubMed)
DOI: DOI:10.1007/s10517-012-1838-x   (Journal Full-text)

We studied the expression of mRNA for genes, whose protein products regulate the glutamate/NO/cGMP signal cascade in the frontal cortex, striatum, midbrain, and hippocampus of rats with various degrees of spontaneous morphine withdrawal syndrome. The concentration of Grin2a mRNA (subunit of the NMDA glutamate receptor) in the frontal cortex increased mainly in animals with severe abstinence. By contrast, the expression of mRNA for the Grin2b subunit in the striatum decreased in animals with mild abstinence. Variations in the content of mRNA for other products of the cascade (isoforms of NO-dependent guanylate cyclase and cGMP-dependent protein kinase) after morphine withdrawal were not related to the degree of abstinence. Our results suggest that the region-specific expression of mRNA for certain subunits of the NMDA glutamate receptor after morphine withdrawal can determine the degree of abstinence.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GRIN2AHumanwithdrawal disorder severityISOGrin2a (Rattus norvegicus) RGD 
Grin2aRatwithdrawal disorder severityIEP  RGD 
Grin2aMousewithdrawal disorder severityISOGrin2a (Rattus norvegicus) RGD 
Grin2bRatwithdrawal disorder severityIEP  RGD 
Gucy1a1Ratwithdrawal disorder severityIEP  RGD 
Gucy1b1Ratwithdrawal disorder severityIEP  RGD 
Prkg2Ratwithdrawal disorder severityIEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grin2a  (glutamate ionotropic receptor NMDA type subunit 2A)
Grin2b  (glutamate ionotropic receptor NMDA type subunit 2B)
Gucy1a1  (guanylate cyclase 1 soluble subunit alpha 1)
Gucy1b1  (guanylate cyclase 1 soluble subunit beta 1)
Prkg2  (protein kinase cGMP-dependent 2)

Genes (Mus musculus)
Grin2a  (glutamate receptor, ionotropic, NMDA2A (epsilon 1))

Genes (Homo sapiens)
GRIN2A  (glutamate ionotropic receptor NMDA type subunit 2A)


Additional Information