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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol
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Accession:CHEBI:93829 term browser browse the term
Definition:A piperidine that has formula C21H27NO2.
Synonyms:related_synonym: Formula=C21H27NO2;   InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3;   InChIKey=UYNVMODNBIQBMV-UHFFFAOYSA-N;   SMILES=CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3;   ifenprodil tartrate
 xref: CAS:23210-56-2;   Drug_Central:1419;   LINCS:LSM-4369
 xref_mesh: MESH:C010739

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4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein] CTD PMID:24718106 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] CTD PMID:24718106 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652 		JBrowse link
G Capn2 calpain 2 multiple interactions EXP ifenprodil inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:31672664 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein] CTD PMID:24718106 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein] CTD PMID:24718106 NCBI chr  X:70,596,246...70,648,529
Ensembl chr  X:70,596,576...70,648,532 		JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1-like 1 multiple interactions EXP ifenprodil inhibits the reaction [Isoflurane results in decreased expression of EPB41L1 protein] CTD PMID:31672664 NCBI chr 3:152,492,725...152,622,047
Ensembl chr 3:152,552,822...152,619,722 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO		 ifenprodil inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]
ifenprodil inhibits the reaction [Haloperidol results in increased expression of FOS protein]		 CTD PMID:12807422 PMID:15140647 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIA1 protein] CTD PMID:19474322 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN1 protein] CTD PMID:19474322 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2A protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein] CTD PMID:19474322 PMID:22824136 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects binding
decreases activity
multiple interactions		 EXP ifenprodil binds to GRIN2B protein
ifenprodil results in decreased activity of GRIN2B protein
[Zinc co-treated with ifenprodil] results in decreased activity of GRIN2B protein; ifenprodil binds to and results in decreased activity of GRIN2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; Magnesium inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein]; Spermine inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein]		 CTD PMID:9729614 PMID:16822975 PMID:19474322 PMID:21192972 PMID:22824136 PMID:24718106 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO SM 21 promotes the reaction [ifenprodil results in decreased activity of KCNH2 protein] CTD PMID:17460149 PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; ifenprodil inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein] CTD PMID:19474322 PMID:22824136 PMID:24718106 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; ifenprodil inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein] CTD PMID:19474322 PMID:22824136 PMID:24718106 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 multiple interactions EXP ifenprodil inhibits the reaction [Isoflurane results in decreased expression of SLC12A5 protein] CTD PMID:31672664 NCBI chr 3:161,433,303...161,465,078
Ensembl chr 3:161,425,988...161,462,879 		JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein] CTD PMID:24718106 NCBI chr20:5,535,434...5,564,657
Ensembl chr20:5,535,432...5,564,437 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      atom 19873
        nonmetal atom 19751
          nitrogen atom 18640
            nitrogen molecular entity 18640
              organonitrogen compound 18414
                organonitrogen heterocyclic compound 17579
                  piperidines 7567
                    4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organic heteromonocyclic compound 16621
                                    piperidines 7567
                                      4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol 16
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