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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol
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Accession:CHEBI:93829 term browser browse the term
Definition:A piperidine that has formula C21H27NO2.
Synonyms:related_synonym: Formula=C21H27NO2;   InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3;   InChIKey=UYNVMODNBIQBMV-UHFFFAOYSA-N;   SMILES=CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3;   ifenprodil tartrate
 xref: CAS:23210-56-2;   Drug_Central:1419;   LINCS:LSM-4369
 xref_mesh: MESH:C010739



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4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein] CTD PMID:24718106 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] CTD PMID:24718106 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
G Capn2 calpain 2 multiple interactions EXP ifenprodil inhibits the reaction [Isoflurane results in increased expression of CAPN2 protein] CTD PMID:31672664 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein] CTD PMID:24718106 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein] CTD PMID:24718106 NCBI chr  X:65,859,653...65,911,887
Ensembl chr  X:65,860,172...65,910,322
JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1-like 1 multiple interactions EXP ifenprodil inhibits the reaction [Isoflurane results in decreased expression of EPB41L1 protein] CTD PMID:31672664 NCBI chr 3:144,929,195...145,052,723
Ensembl chr 3:144,984,640...145,052,721
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
ifenprodil inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]
ifenprodil inhibits the reaction [Haloperidol results in increased expression of FOS protein]
CTD PMID:12807422 PMID:15140647 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIA1 protein] CTD PMID:19474322 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN1 protein] CTD PMID:19474322 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2A protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2A protein] CTD PMID:19474322 PMID:22824136 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects binding
decreases activity
multiple interactions
EXP ifenprodil binds to GRIN2B protein
ifenprodil results in decreased activity of GRIN2B protein
[Zinc co-treated with ifenprodil] results in decreased activity of GRIN2B protein; ifenprodil binds to and results in decreased activity of GRIN2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]; Magnesium inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein]; Spermine inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein]
CTD PMID:9729614 PMID:16822975 PMID:19474322 PMID:21192972 PMID:22824136 More... NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO SM 21 promotes the reaction [ifenprodil results in decreased activity of KCNH2 protein] CTD PMID:17460149 PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; ifenprodil inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein] CTD PMID:19474322 PMID:22824136 PMID:24718106 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; ifenprodil inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ifenprodil inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein] CTD PMID:19474322 PMID:22824136 PMID:24718106 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Slc12a5 solute carrier family 12 member 5 multiple interactions EXP ifenprodil inhibits the reaction [Isoflurane results in decreased expression of SLC12A5 protein] CTD PMID:31672664 NCBI chr 3:153,696,522...153,735,801
Ensembl chr 3:153,696,517...153,735,765
JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 multiple interactions EXP ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein] CTD PMID:24718106 NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              organonitrogen compound 18544
                organonitrogen heterocyclic compound 17661
                  piperidines 7587
                    4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteromonocyclic compound 17120
                                    piperidines 7587
                                      4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol 16
paths to the root