Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) - Rat Genome Database
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Gene: Grin2b (glutamate ionotropic receptor NMDA type subunit 2B) Ictidomys tridecemlineatus
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Symbol: Grin2b
Name: glutamate ionotropic receptor NMDA type subunit 2B
RGD ID: 12661197
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); calcium channel activity (ortholog); cation channel activity (ortholog); INVOLVED IN action potential (ortholog); associative learning (ortholog); behavioral fear response (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; ASSOCIATED WITH alcohol use disorder (ortholog); astigmatism (ortholog); Ataxia (ortholog); FOUND IN apical dendrite (ortholog); cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: glutamate receptor ionotropic, NMDA 2B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365873,406,055 - 3,806,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (ISO)
associative learning  (ISO)
behavioral fear response  (ISO)
behavioral response to pain  (ISO)
calcium ion transmembrane import into cytosol  (ISO)
calcium ion transport  (ISO)
cation transport  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to corticosterone stimulus  (ISO)
cellular response to curcumin  (ISO)
cellular response to dsRNA  (ISO)
cellular response to forskolin  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to lipid  (ISO)
cellular response to magnesium starvation  (ISO)
cellular response to manganese ion  (ISO)
cellular response to organic cyclic compound  (ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (ISO)
detection of mechanical stimulus involved in sensory perception of pain  (ISO)
excitatory postsynaptic potential  (ISO)
fear response  (ISO)
hippocampus development  (ISO)
in utero embryonic development  (ISO)
ionotropic glutamate receptor signaling pathway  (ISO)
learning  (ISO)
learning or memory  (ISO)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
memory  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
NMDA selective glutamate receptor signaling pathway  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of glutamate secretion  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of synaptic transmission  (ISO)
protein heterotetramerization  (ISO)
receptor clustering  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of MAPK cascade  (ISO)
regulation of postsynaptic cytosolic calcium ion concentration  (ISO)
regulation of postsynaptic membrane potential  (ISO)
regulation of protein kinase A signaling  (ISO)
regulation of synaptic plasticity  (ISO)
response to amine  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
response to carbohydrate  (ISO)
response to cocaine  (ISO)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to ethanol  (ISO)
response to fungicide  (ISO)
response to growth hormone  (ISO)
response to hypoxia  (ISO)
response to magnesium ion  (ISO)
response to manganese ion  (ISO)
response to mechanical stimulus  (ISO)
response to methylmercury  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to other organism  (ISO)
response to toxic substance  (ISO)
rhythmic process  (ISO)
sensitization  (ISO)
sensory organ development  (ISO)
startle response  (ISO)
suckling behavior  (ISO)

References

Genomics

Comparative Map Data
Grin2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365873,406,055 - 3,806,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1213,437,942 - 13,981,957 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1213,437,942 - 13,982,002 (-)EnsemblGRCh38hg38GRCh38
GRCh381213,537,337 - 13,982,012 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371213,690,271 - 14,134,536 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361213,605,411 - 14,024,319 (-)NCBINCBI36hg18NCBI36
Build 341213,605,410 - 14,024,319NCBI
Celera1218,858,978 - 19,277,660 (-)NCBI
Cytogenetic Map12p13.1NCBI
HuRef1213,479,858 - 13,898,402 (-)NCBIHuRef
CHM1_11213,679,406 - 14,098,101 (-)NCBICHM1_1
Grin2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396135,690,219 - 136,150,658 (-)NCBIGRCm39mm39
GRCm39 Ensembl6135,690,231 - 136,150,509 (-)Ensembl
GRCm386135,713,221 - 136,173,615 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6135,713,233 - 136,173,511 (-)EnsemblGRCm38mm10GRCm38
MGSCv376135,679,813 - 136,123,529 (-)NCBIGRCm37mm9NCBIm37
MGSCv366135,697,791 - 136,009,994 (-)NCBImm8
Celera6138,678,301 - 139,123,902 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.38NCBI
Grin2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24168,580,824 - 169,044,110 (-)NCBI
Rnor_6.0 Ensembl4169,560,387 - 169,999,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04169,541,620 - 170,000,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04233,806,406 - 234,260,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44172,721,895 - 173,183,187 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14172,966,830 - 173,428,311 (-)NCBI
Celera4157,188,514 - 157,629,365 (-)NCBICelera
RH 3.4 Map41026.8RGD
Cytogenetic Map4q43NCBI
Grin2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541310,376,597 - 10,779,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541310,358,931 - 10,780,004 (-)NCBIChiLan1.0ChiLan1.0
GRIN2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11213,943,936 - 14,272,195 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,969,387 - 14,388,799 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01213,543,104 - 13,987,437 (-)NCBIMhudiblu_PPA_v0panPan3
GRIN2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2732,471,153 - 32,877,680 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12732,470,889 - 32,883,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
GRIN2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl558,480,526 - 58,927,583 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1558,477,862 - 58,948,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2561,874,217 - 62,275,930 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11113,444,155 - 13,873,034 (-)NCBI
ChlSab1.1 Ensembl1113,456,968 - 13,873,202 (-)Ensembl
Grin2b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475224,008,520 - 24,480,834 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005331895   ⟹   XP_005331952
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365873,406,055 - 3,806,956 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005331952 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005331952   ⟸   XM_005331895
- UniProtKB: I3LXL2 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
ANF_receptor   Lig_chan-Glu_bd   PBPe


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000924 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000000825 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000026638 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000921 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOT00000031305 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
NCBI Gene Grin2b ENTREZGENE
Pfam ANF_receptor UniProtKB/TrEMBL
  Lig_chan UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/TrEMBL
  NMDAR2_C UniProtKB/TrEMBL
PRINTS NMDARECEPTOR UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/TrEMBL
  PBPe UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A0A287CZD3_ICTTR UniProtKB/TrEMBL
  I3LXL2 ENTREZGENE, UniProtKB/TrEMBL