Grin1 (glutamate ionotropic receptor NMDA type subunit 1) - Rat Genome Database

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Gene: Grin1 (glutamate ionotropic receptor NMDA type subunit 1) Rattus norvegicus
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Symbol: Grin1
Name: glutamate ionotropic receptor NMDA type subunit 1
RGD ID: 2736
Description: Enables several functions, including amino acid binding activity; amyloid-beta binding activity; and monoatomic ion gated channel activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of dendritic spine maintenance; and protein heterotetramerization. Located in several cellular components, including dendrite; postsynaptic density; and synaptic cleft. Part of NMDA selective glutamate receptor complex. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Biomarker of cognitive disorder; middle cerebral artery infarction; placental insufficiency; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1); PARTICIPATES IN excitatory synaptic transmission pathway; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GluN1; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDAR1; NR1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,103,680 - 8,130,603 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,103,680 - 8,130,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,208,200 - 11,235,127 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,794,430 - 19,821,357 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0317,984,273 - 18,011,200 (-)NCBIRnor_WKY
Rnor_6.032,507,745 - 2,534,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,506,896 - 2,534,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,489,158 - 2,516,082 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,453,784 - 3,480,381 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,453,783 - 3,480,381 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(R)-lipoic acid  (EXP)
(S)-3,5-dihydroxyphenylglycine  (EXP)
(S)-colchicine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-methylcholine  (ISO)
26-hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (EXP)
agomelatine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
capsaicin  (EXP)
celecoxib  (ISO)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
D-aspartic acid  (EXP)
D-glucose  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (EXP)
dextromethorphan  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP,ISO)
dizocilpine maleate  (EXP,ISO)
dopamine  (EXP)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
excitatory amino acid agonist  (ISO)
felbamate  (EXP)
fenvalerate  (EXP,ISO)
Fluorocitric acid  (EXP)
folic acid  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP)
fumonisin B1  (ISO)
gabapentin  (ISO)
galactose  (EXP)
gamma-tocopherol  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
haloperidol  (EXP)
herbicide  (ISO)
homocysteine  (EXP)
hydroxyurea  (ISO)
imipramine  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP)
KT 5720  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lead(II) chloride  (EXP)
linuron  (EXP)
lipoic acid  (EXP)
lipoteichoic acid  (ISO)
lithium chloride  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melamine  (EXP)
melatonin  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
monosodium L-glutamate  (EXP)
morphine  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
nobiletin  (EXP)
Nonylphenol  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (ISO)
oxidopamine  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (EXP)
PCB138  (EXP)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phencyclidine  (ISO)
phenytoin  (EXP)
picloram  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
resveratrol  (EXP,ISO)
semicarbazide  (ISO)
SKF 38393  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
sulfadiazine  (ISO)
sulfur dioxide  (EXP)
sulindac  (EXP)
testosterone  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene  (ISO)
tributylstannane  (EXP)
trichlopyr  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP)
vinclozolin  (EXP)
WIN 55212-2  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
associative learning  (ISO)
calcium ion homeostasis  (ISO)
calcium ion transmembrane import into cytosol  (ISO)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to manganese ion  (IEP)
cerebral cortex development  (ISO)
chemical synaptic transmission  (IBA)
conditioned taste aversion  (ISO)
excitatory postsynaptic potential  (ISO)
intracellular calcium ion homeostasis  (ISO)
ionotropic glutamate receptor signaling pathway  (IBA,IDA,IEA,ISO,ISS)
learning  (ISO)
learning or memory  (ISO,TAS)
long-term memory  (ISO)
male mating behavior  (ISO)
memory  (ISO)
monoatomic cation transmembrane transport  (IDA,ISS)
monoatomic cation transport  (ISO)
monoatomic ion transmembrane transport  (IEA)
negative regulation of neuron apoptotic process  (ISO)
neuromuscular process  (ISO)
neuron cellular homeostasis  (ISO)
olfactory learning  (ISO)
pons maturation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion transport into cytosol  (IGI)
positive regulation of cell death  (IDA)
positive regulation of cysteine-type endopeptidase activity  (IGI)
positive regulation of dendritic spine maintenance  (IGI)
positive regulation of excitatory postsynaptic potential  (IDA,ISS)
positive regulation of reactive oxygen species biosynthetic process  (IGI)
positive regulation of Schwann cell migration  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IDA,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
prepulse inhibition  (ISO)
propylene metabolic process  (ISO)
protein heterotetramerization  (IDA)
protein localization to postsynaptic membrane  (ISO)
protein-containing complex assembly  (IDA)
regulation of axonogenesis  (ISO)
regulation of cell communication  (ISO)
regulation of dendrite morphogenesis  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of membrane potential  (IBA,ISO)
regulation of monoatomic cation transmembrane transport  (IDA,ISS)
regulation of neuron apoptotic process  (ISO)
regulation of neuronal synaptic plasticity  (ISO,NAS)
regulation of presynaptic membrane potential  (IEA)
regulation of respiratory gaseous exchange  (ISO)
regulation of synapse assembly  (ISO)
regulation of synaptic plasticity  (ISO)
response to amine  (IEP)
response to amphetamine  (ISO)
response to calcium ion  (IEP)
response to ethanol  (ISO)
response to fungicide  (IEP)
response to glycine  (ISO)
response to morphine  (ISO)
response to organic cyclic compound  (IEP)
rhythmic process  (IDA)
sensory perception of pain  (ISO)
social behavior  (ISO)
startle response  (ISO)
suckling behavior  (ISO)
synaptic transmission, glutamatergic  (ISO)
transcription by RNA polymerase II  (ISO)
visual learning  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
Alzheimer's disease pathway  (IEA)
amyotrophic lateral sclerosis pathway  (IEA)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (IDA)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
heroin pharmacodynamics pathway  (ISO)
Huntington's disease pathway  (IEA)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (IEA)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. Abe M, etal., J Neurosci. 2004 Aug 18;24(33):7292-304. doi: 10.1523/JNEUROSCI.1261-04.2004.
2. Subunit-specific NMDA receptor trafficking to synapses. Barria A and Malinow R, Neuron. 2002 Jul 18;35(2):345-53.
3. Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses. Berg LK, etal., Neuroscience. 2013 Jan 29;230:139-50. doi: 10.1016/j.neuroscience.2012.10.061. Epub 2012 Nov 14.
4. Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus. Bersier MG and Rodriguez de Lores Arnaiz G, Neurochem Res. 2009 Sep;34(9):1650-7. Epub 2009 Mar 26.
5. Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule. Bidoret C, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14126-31. Epub 2009 Aug 4.
6. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. Burkhardt C, etal., FEBS Lett. 2005 Jul 4;579(17):3821-8.
7. Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. Chazot PL, etal., J Biol Chem. 1994 Sep 30;269(39):24403-9.
8. Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons. Chen Y and Li M, Neuropharmacology. 2005 Dec;49(7):1026-41. Epub 2005 Jul 28.
9. Control of excitatory and inhibitory synapse formation by neuroligins. Chih B, etal., Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.
10. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
11. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Cui Z, etal., Neuron. 2004 Mar 4;41(5):781-93. doi: 10.1016/s0896-6273(04)00072-8.
12. Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. De Felice FG, etal., J Biol Chem. 2007 Apr 13;282(15):11590-601. Epub 2007 Feb 16.
13. Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices. Dos-Anjos S, etal., Neuroscience. 2009 Dec 15;164(3):1119-26. Epub 2009 Sep 15.
14. The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain. Eriksson M, etal., Biochem Biophys Res Commun. 2007 Sep 14;361(1):127-32. Epub 2007 Jul 16.
15. Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1). Feliciello A, etal., FEBS Lett 1999 Dec 31;464(3):174-8.
16. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. Fu Z, etal., J Neurophysiol. 2003 Dec;90(6):3950-7. Epub 2003 Aug 20.
17. Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. Fukumori R, etal., J Pharmacol Sci. 2010 Mar 19;112(3):273-81. Epub 2010 Feb 18.
18. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation. Gardoni F, etal., J Neuroinflammation. 2011 Feb 11;8(1):14.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo. Gill I, etal., J Cell Sci. 2015 Feb 15;128(4):768-80. doi: 10.1242/jcs.162362. Epub 2014 Dec 19.
21. Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Gingrich JR, etal., Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6237-42. Epub 2004 Apr 6.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Age-related changes in hypothalamic gonadotropin-releasing hormone and N-methyl-D-aspartate receptor gene expression, and their regulation by oestrogen, in the female rat. Gore AC, etal., J Neuroendocrinol 2002 Apr;14(4):300-9.
24. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Graf ER, etal., Cell. 2004 Dec 29;119(7):1013-26.
25. The effect of ketamine on N-methyl-D-aspartate receptor subunit expression in neonatal rats. Han LC, etal., Eur J Anaesthesiol. 2010 Feb;27(2):181-6.
26. Prenatal development of NMDA receptor composition and function in trigeminal neurons. Ishihama K, etal., Arch Histol Cytol. 2005 Dec;68(4):321-35.
27. Structural insights into competitive antagonism in NMDA receptors. Jespersen A, etal., Neuron. 2014 Jan 22;81(2):366-78. doi: 10.1016/j.neuron.2013.11.033.
28. CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. Jiang X, etal., Neurobiol Aging. 2015 Feb;36(2):867-76. doi: 10.1016/j.neurobiolaging.2014.10.018. Epub 2014 Oct 16.
29. PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. Jurado S, etal., EMBO J. 2010 Aug 18;29(16):2827-40. Epub 2010 Jul 13.
30. Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size. Kalev-Zylinska ML, etal., Stroke. 2013 Aug;44(8):2212-9. doi: 10.1161/STROKEAHA.113.001235. Epub 2013 May 30.
31. Crystal structure of a heterotetrameric NMDA receptor ion channel. Karakas E and Furukawa H, Science. 2014 May 30;344(6187):992-7. doi: 10.1126/science.1251915.
32. Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Karakas E, etal., Nature. 2011 Jun 15;475(7355):249-53. doi: 10.1038/nature10180.
33. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. Ko J, etal., EMBO J. 2009 Oct 21;28(20):3244-55. doi: 10.1038/emboj.2009.249. Epub 2009 Sep 3.
34. Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. Kravchick DO, etal., EMBO J. 2016 Sep 1;35(17):1923-34. doi: 10.15252/embj.201593070. Epub 2016 Jul 25.
35. Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins. Kuryatov A, etal., Neuron. 1994 Jun;12(6):1291-300.
36. Amino terminal domains of the NMDA receptor are organized as local heterodimers. Lee CH and Gouaux E, PLoS One. 2011 Apr 22;6(4):e19180. doi: 10.1371/journal.pone.0019180.
37. Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Lee FJ, etal., Cell. 2002 Oct 18;111(2):219-30.
38. Thyroid hormone regulation of N-methyl-D-aspartic acid receptor subunit mRNA expression in adult brain. Lee PR, etal., J Neuroendocrinol 2003 Jan;15(1):87-92.
39. Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease. Leuba G, etal., Curr Alzheimer Res. 2014 Jan;11(1):86-96.
40. Regulation of NMDA receptors by cyclin-dependent kinase-5. Li BS, etal., Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12742-7.
41. NF-kappaB site interacts with Sp factors and up-regulates the NR1 promoter during neuronal differentiation. Liu A, etal., J Biol Chem 2004 Apr 23;279(17):17449-58. Epub 2004 Feb 16.
42. GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions. Mao L, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19038-43. doi: 10.1073/pnas.1013494107. Epub 2010 Oct 18.
43. Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins. Mehta SL, etal., J Neurosci. 2015 Dec 16;35(50):16443-9. doi: 10.1523/JNEUROSCI.2943-15.2015.
44. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
45. N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat. Miller BH and Gore AC, Endocrinology 2002 Sep;143(9):3568-74.
46. Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease. Mohamed NE, etal., J Alzheimers Dis. 2015;44(2):431-7. doi: 10.3233/JAD-141764.
47. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Muller BM, etal., Neuron. 1996 Aug;17(2):255-65.
48. Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Nagy J, etal., Neurochem Int 2003 Jan;42(1):35-43.
49. Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Nakatsu Y, etal., Toxicol Appl Pharmacol. 2009 Oct 15;240(2):292-8. Epub 2009 Jul 7.
50. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
51. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. Ng D, etal., PLoS Biol. 2009 Feb 24;7(2):e41. doi: 10.1371/journal.pbio.1000041.
52. Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. Ning K, etal., J Neurosci. 2004 Apr 21;24(16):4052-60.
53. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
54. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
55. Glutamatergic signaling through the N-methyl-D-aspartate receptor directly activates medial subpopulations of luteinizing hormone-releasing hormone (LHRH) neurons, but does not appear to mediate the effects of estradiol on LHRH gene expression. Ottem EN, etal., Endocrinology 2002 Dec;143(12):4837-45.
56. Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation. Pelkey KA, etal., Neuron. 2002 Mar 28;34(1):127-38.
57. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
58. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
59. Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors. Qian A and Johnson JW, J Neurosci. 2006 Oct 18;26(42):10899-910.
60. Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines. Radley JJ, etal., Brain Res. 2007 Feb 23;1134(1):87-94. Epub 2007 Jan 17.
61. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
62. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
63. An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors. Riou M, etal., PLoS One. 2012;7(4):e35134. doi: 10.1371/journal.pone.0035134. Epub 2012 Apr 6.
64. Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Schlief ML, etal., Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14919-24. Epub 2006 Sep 26.
65. Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit. Schmidt C and Hollmann M, J Mol Biol. 2008 Feb 22;376(3):658-70. doi: 10.1016/j.jmb.2007.11.105. Epub 2007 Dec 8.
66. Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi. Schober ME, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R681-92. Epub 2009 Jan 14.
67. TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5. Selamat W, etal., Neurosci Lett. 2009 Jan 30;450(2):163-6. doi: 10.1016/j.neulet.2008.12.014. Epub 2008 Dec 16.
68. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. Shankar GM, etal., J Neurosci. 2007 Mar 14;27(11):2866-75.
69. A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction. Siegler Retchless B, etal., Nat Neurosci. 2012 Jan 15;15(3):406-13, S1-2. doi: 10.1038/nn.3025.
70. Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties. Sun W, etal., Neuron. 2017 Apr 5;94(1):58-64.e3. doi: 10.1016/j.neuron.2017.03.018.
71. NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. Swanwick CC, etal., FEBS Lett. 2009 Apr 17;583(8):1226-30. Epub 2009 Mar 17.
72. Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Tajima N, etal., Nature. 2016 Jun 2;534(7605):63-8. doi: 10.1038/nature17679. Epub 2016 May 2.
73. GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activation. Talukder I, etal., Biophys J. 2011 Nov 16;101(10):2389-98. doi: 10.1016/j.bpj.2011.10.015. Epub 2011 Nov 15.
74. A novel family of adhesion-like molecules that interacts with the NMDA receptor. Wang CY, etal., J Neurosci. 2006 Feb 22;26(8):2174-83.
75. Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Wei B, etal., Brain Res. 2016 Jan 15;1631:157-64. doi: 10.1016/j.brainres.2015.11.041. Epub 2015 Dec 2.
76. Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits. Wernicke C, etal., Biol Psychiatry. 2003 Nov 1;54(9):922-8.
77. Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. Wu HY, etal., J Biol Chem. 2007 Jul 13;282(28):20075-87. doi: 10.1074/jbc.M700624200. Epub 2007 May 25.
78. Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo. Wyszynski M, etal., J Neurosci 1999 Aug 1;19(15):6528-37.
79. Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Xu B, etal., Neurotoxicology. 2009 Nov;30(6):941-9. Epub 2009 Jul 28.
80. Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 . Yoshioka T, etal., FEBS Lett. 2013 May 21;587(10):1453-9. doi: 10.1016/j.febslet.2013.03.030. Epub 2013 Apr 6.
81. Control of NMDA receptor function by the NR2 subunit amino-terminal domain. Yuan H, etal., J Neurosci. 2009 Sep 30;29(39):12045-58. doi: 10.1523/JNEUROSCI.1365-09.2009.
82. Protective effect of spleen-yin-nourishing recipe on amyloid beta-peptide-induced damage of primarily cultured rat hippocampal neurons and its mechanism. Zhan LB, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Mar;7(3):242-8.
Additional References at PubMed
PMID:1352681   PMID:1374164   PMID:1377365   PMID:1385220   PMID:1386026   PMID:1388270   PMID:1532151   PMID:1834949   PMID:7524561   PMID:7531804   PMID:7679115   PMID:7684237  
PMID:7685113   PMID:7907365   PMID:8060614   PMID:8313466   PMID:8399301   PMID:8713451   PMID:8840015   PMID:8980238   PMID:8980239   PMID:9003035   PMID:9054942   PMID:9246451  
PMID:9556603   PMID:10479699   PMID:10480938   PMID:10481908   PMID:10700255   PMID:10719900   PMID:10749211   PMID:10777815   PMID:10818139   PMID:10846156   PMID:10963597   PMID:11160393  
PMID:11248114   PMID:11588171   PMID:11754835   PMID:11754836   PMID:11911857   PMID:11929923   PMID:12022233   PMID:12040087   PMID:12065411   PMID:12076738   PMID:12201628   PMID:12391275  
PMID:12414093   PMID:12586454   PMID:12646556   PMID:12657691   PMID:12663061   PMID:12676993   PMID:12687684   PMID:12697759   PMID:12699333   PMID:12718863   PMID:12764094   PMID:12805203  
PMID:12832526   PMID:12858054   PMID:12859686   PMID:12884967   PMID:12890763   PMID:14530275   PMID:14645471   PMID:14706556   PMID:14732708   PMID:14960371   PMID:15107472   PMID:15173637  
PMID:15201510   PMID:15265649   PMID:15266550   PMID:15306812   PMID:15312654   PMID:15356198   PMID:15364406   PMID:15379998   PMID:15464993   PMID:15467708   PMID:15469880   PMID:15537884  
PMID:15576450   PMID:15610162   PMID:15629447   PMID:15634765   PMID:15663482   PMID:15737435   PMID:15745956   PMID:15748150   PMID:15760935   PMID:15809437   PMID:15854589   PMID:15885982  
PMID:15888440   PMID:15908129   PMID:15967799   PMID:15996549   PMID:16025111   PMID:16049015   PMID:16076026   PMID:16101757   PMID:16126302   PMID:16228995   PMID:16281028   PMID:16299502  
PMID:16319314   PMID:16417630   PMID:16504537   PMID:16513640   PMID:16551623   PMID:16573586   PMID:16606616   PMID:16611824   PMID:16635252   PMID:16638606   PMID:16710293   PMID:16814779  
PMID:16861057   PMID:16862452   PMID:16868181   PMID:16906136   PMID:17004940   PMID:17015831   PMID:17047094   PMID:17077143   PMID:17093100   PMID:17156363   PMID:17229826   PMID:17255096  
PMID:17311919   PMID:17313573   PMID:17455306   PMID:17456392   PMID:17459877   PMID:17509768   PMID:17556551   PMID:17556843   PMID:17670980   PMID:17689191   PMID:17803966   PMID:17873364  
PMID:17933570   PMID:17942238   PMID:17969105   PMID:18033813   PMID:18041094   PMID:18055458   PMID:18095593   PMID:18272600   PMID:18272676   PMID:18279317   PMID:18385465   PMID:18390190  
PMID:18423864   PMID:18439999   PMID:18445116   PMID:18479834   PMID:18554806   PMID:18592148   PMID:18629001   PMID:18644839   PMID:18720514   PMID:18728179   PMID:18801922   PMID:18809793  
PMID:18927268   PMID:18936081   PMID:19020286   PMID:19185544   PMID:19238810   PMID:19361480   PMID:19365572   PMID:19394426   PMID:19399396   PMID:19407255   PMID:19452450   PMID:19474322  
PMID:19547699   PMID:19608740   PMID:19655413   PMID:19666081   PMID:19694907   PMID:19703901   PMID:19705939   PMID:19726645   PMID:19772634   PMID:19861419   PMID:19923273   PMID:19934647  
PMID:20008465   PMID:20016075   PMID:20056114   PMID:20064569   PMID:20146080   PMID:20414717   PMID:20427654   PMID:20448042   PMID:20463582   PMID:20623763   PMID:20688433   PMID:20844142  
PMID:20850419   PMID:20854252   PMID:20871158   PMID:20884369   PMID:20980539   PMID:21049621   PMID:21068333   PMID:21162311   PMID:21171367   PMID:21180126   PMID:21185848   PMID:21292463  
PMID:21293467   PMID:21310774   PMID:21355301   PMID:21368124   PMID:21397592   PMID:21499738   PMID:21522138   PMID:21669274   PMID:21719075   PMID:21734292   PMID:21795692   PMID:21813695  
PMID:21883149   PMID:21883211   PMID:21948527   PMID:22094385   PMID:22097734   PMID:22102472   PMID:22105219   PMID:22405206   PMID:22500715   PMID:22508518   PMID:22512920   PMID:22546338  
PMID:22652057   PMID:22681877   PMID:22743575   PMID:22762252   PMID:22871113   PMID:22891278   PMID:22952988   PMID:23110394   PMID:23164617   PMID:23221411   PMID:23381906   PMID:23383317  
PMID:23392471   PMID:23395379   PMID:23537341   PMID:23562375   PMID:23578394   PMID:23640243   PMID:23672716   PMID:23715865   PMID:23760273   PMID:23941530   PMID:23972471   PMID:24029697  
PMID:24040266   PMID:24069373   PMID:24072709   PMID:24184018   PMID:24278457   PMID:24360204   PMID:24388786   PMID:24442866   PMID:24607230   PMID:24663672   PMID:24916964   PMID:25041985  
PMID:25335889   PMID:25544544   PMID:25683482   PMID:25772108   PMID:25825749   PMID:25829490   PMID:25867330   PMID:25896221   PMID:25932647   PMID:25937004   PMID:26045554   PMID:26071959  
PMID:26133372   PMID:26220171   PMID:26370091   PMID:26490687   PMID:26725465   PMID:26875626   PMID:26919761   PMID:26930443   PMID:27089914   PMID:27094552   PMID:27160909   PMID:27430327  
PMID:27810863   PMID:27831563   PMID:28105280   PMID:28228639   PMID:28263869   PMID:28958939   PMID:29390057   PMID:29476059   PMID:29490264   PMID:29779156   PMID:29921713   PMID:30500536  
PMID:31277281   PMID:31444392   PMID:32015122   PMID:32320718   PMID:32553080   PMID:32749055   PMID:33075473   PMID:33122756   PMID:33339841   PMID:33393454   PMID:33759085   PMID:33811955  
PMID:36341805  


Genomics

Comparative Map Data
Grin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,103,680 - 8,130,603 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,103,680 - 8,130,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,208,200 - 11,235,127 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,794,430 - 19,821,357 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0317,984,273 - 18,011,200 (-)NCBIRnor_WKY
Rnor_6.032,507,745 - 2,534,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,506,896 - 2,534,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,489,158 - 2,516,082 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,453,784 - 3,480,381 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,453,783 - 3,480,381 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBICelera
Cytogenetic Map3p13NCBI
GRIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,139,154 - 137,168,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9137,139,154 - 137,168,756 (+)EnsemblGRCh38hg38GRCh38
GRCh379140,033,606 - 140,063,208 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,153,430 - 139,183,029 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,308,678 - 137,339,043NCBI
Celera9110,548,072 - 110,577,040 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,493,914 - 109,523,231 (+)NCBIHuRef
CHM1_19140,182,355 - 140,211,903 (+)NCBICHM1_1
T2T-CHM13v2.09149,377,044 - 149,406,436 (+)NCBIT2T-CHM13v2.0
Grin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,181,189 - 25,209,199 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,181,193 - 25,209,199 (-)EnsemblGRCm39 Ensembl
GRCm38225,291,177 - 25,319,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,291,181 - 25,319,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,146,697 - 25,174,683 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,114,256 - 25,140,988 (-)NCBIMGSCv36mm8
Celera225,018,687 - 25,046,664 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.14NCBI
Grin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,154,864 - 5,178,636 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,154,864 - 5,178,636 (+)NCBIChiLan1.0ChiLan1.0
GRIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19137,168,543 - 137,198,297 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,168,722 - 137,197,382 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09108,198,350 - 108,228,887 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,492,967 - 48,513,981 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,493,287 - 48,509,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,683,789 - 47,707,011 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,357,798 - 49,382,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,357,798 - 49,383,084 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,135,045 - 48,158,254 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,433,856 - 48,457,059 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,481,015 - 48,504,246 (-)NCBIUU_Cfam_GSD_1.0
Grin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,536,077 - 202,560,723 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669814,330 - 839,208 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936669814,330 - 838,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN1
(Sus scrofa - pig)
No map positions available.
GRIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,020,556 - 1,050,568 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,019,263 - 1,050,231 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,254,719 - 4,284,702 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760776,873 - 801,354 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760777,208 - 800,525 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grin1
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:860
Count of miRNA genes:210
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000037725, ENSRNOT00000044246, ENSRNOT00000049297
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat

Markers in Region
UniSTS:465388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,110,316 - 8,110,962 (+)MAPPERmRatBN7.2
Rnor_6.032,514,382 - 2,515,027NCBIRnor6.0
Rnor_5.032,495,795 - 2,496,440UniSTSRnor5.0
RGSC_v3.433,460,413 - 3,461,058UniSTSRGSC3.4
Celera32,936,859 - 2,937,504UniSTS
Cytogenetic Map3p13UniSTS
PMC57740P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,108,466 - 8,108,969 (+)MAPPERmRatBN7.2
Rnor_6.032,512,532 - 2,513,034NCBIRnor6.0
Rnor_5.032,493,945 - 2,494,447UniSTSRnor5.0
RGSC_v3.433,458,563 - 3,459,065UniSTSRGSC3.4
Celera32,935,009 - 2,935,511UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 56
Low 3 7 10 10
Below cutoff 4 10 3 6 3 4 4 6 13 21 11 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY090615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM039130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S39221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X63255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000037725   ⟹   ENSRNOP00000029227
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,103,680 - 8,130,603 (-)Ensembl
Rnor_6.0 Ensembl32,506,896 - 2,534,375 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000044246   ⟹   ENSRNOP00000043301
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,103,680 - 8,130,603 (-)Ensembl
Rnor_6.0 Ensembl32,507,745 - 2,534,663 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000049297   ⟹   ENSRNOP00000049198
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,103,680 - 8,130,603 (-)Ensembl
Rnor_6.0 Ensembl32,507,745 - 2,534,663 (-)Ensembl
RefSeq Acc Id: NM_001270602   ⟹   NP_001257531
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,103,680 - 8,130,603 (-)NCBI
Rnor_6.032,507,745 - 2,534,663 (-)NCBI
Rnor_5.032,489,158 - 2,516,082 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270603   ⟹   NP_001257532
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,103,680 - 8,130,603 (-)NCBI
Rnor_6.032,507,745 - 2,534,663 (-)NCBI
Rnor_5.032,489,158 - 2,516,082 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270605   ⟹   NP_001257534
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,103,680 - 8,130,603 (-)NCBI
Rnor_6.032,507,745 - 2,534,663 (-)NCBI
Rnor_5.032,489,158 - 2,516,082 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270606   ⟹   NP_001257535
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,103,680 - 8,130,603 (-)NCBI
Rnor_6.032,507,745 - 2,534,663 (-)NCBI
Rnor_5.032,489,158 - 2,516,082 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270608   ⟹   NP_001257537
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,103,680 - 8,130,603 (-)NCBI
Rnor_6.032,507,745 - 2,534,663 (-)NCBI
Rnor_5.032,489,158 - 2,516,082 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270610   ⟹   NP_001257539
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,103,680 - 8,130,603 (-)NCBI
Rnor_6.032,507,745 - 2,534,663 (-)NCBI
Rnor_5.032,489,158 - 2,516,082 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001287423   ⟹   NP_001274352
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,103,680 - 8,130,603 (-)NCBI
Rnor_6.032,507,745 - 2,534,663 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBI
Sequence:
RefSeq Acc Id: NM_017010   ⟹   NP_058706
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,103,680 - 8,130,603 (-)NCBI
Rnor_6.032,507,745 - 2,534,663 (-)NCBI
Rnor_5.032,489,158 - 2,516,082 (-)NCBI
RGSC_v3.433,453,784 - 3,480,381 (-)RGD
Celera32,930,222 - 2,957,142 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257531 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257532 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257534 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257535 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257537 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257539 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274352 (Get FASTA)   NCBI Sequence Viewer  
  NP_058706 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19659 (Get FASTA)   NCBI Sequence Viewer  
  AAB22435 (Get FASTA)   NCBI Sequence Viewer  
  AAB50926 (Get FASTA)   NCBI Sequence Viewer  
  AAB50927 (Get FASTA)   NCBI Sequence Viewer  
  AAB50928 (Get FASTA)   NCBI Sequence Viewer  
  AAB50929 (Get FASTA)   NCBI Sequence Viewer  
  AAB50930 (Get FASTA)   NCBI Sequence Viewer  
  AAB50931 (Get FASTA)   NCBI Sequence Viewer  
  AAB50932 (Get FASTA)   NCBI Sequence Viewer  
  AAB50933 (Get FASTA)   NCBI Sequence Viewer  
  AAM09025 (Get FASTA)   NCBI Sequence Viewer  
  CAA44914 (Get FASTA)   NCBI Sequence Viewer  
  CAA46335 (Get FASTA)   NCBI Sequence Viewer  
  EDL93606 (Get FASTA)   NCBI Sequence Viewer  
  EDL93607 (Get FASTA)   NCBI Sequence Viewer  
  EDL93608 (Get FASTA)   NCBI Sequence Viewer  
  EDL93609 (Get FASTA)   NCBI Sequence Viewer  
  EDL93610 (Get FASTA)   NCBI Sequence Viewer  
  EDL93611 (Get FASTA)   NCBI Sequence Viewer  
  EDL93612 (Get FASTA)   NCBI Sequence Viewer  
  EDL93613 (Get FASTA)   NCBI Sequence Viewer  
  P35439 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058706   ⟸   NM_017010
- Peptide Label: isoform 1a precursor
- UniProtKB: Q62646 (UniProtKB/Swiss-Prot),   P35439 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257539   ⟸   NM_001270610
- Peptide Label: isoform 4a precursor
- UniProtKB: P35439 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257534   ⟸   NM_001270605
- Peptide Label: isoform 2a precursor
- UniProtKB: P35439 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257537   ⟸   NM_001270608
- Peptide Label: isoform 4b precursor
- UniProtKB: P35439 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257532   ⟸   NM_001270603
- Peptide Label: isoform 2b precursor
- UniProtKB: P35439 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257535   ⟸   NM_001270606
- Peptide Label: isoform 3b precursor
- UniProtKB: Q62648 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257531   ⟸   NM_001270602
- Peptide Label: isoform 1b precursor
- UniProtKB: P35439 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001274352   ⟸   NM_001287423
- Peptide Label: isoform 3a precursor
- UniProtKB: P35439 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043301   ⟸   ENSRNOT00000044246
RefSeq Acc Id: ENSRNOP00000049198   ⟸   ENSRNOT00000049297
RefSeq Acc Id: ENSRNOP00000029227   ⟸   ENSRNOT00000037725
Protein Domains
Lig_chan-Glu_bd   PBPe

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35439-F1-model_v2 AlphaFold P35439 1-938 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691870
Promoter ID:EPDNEW_R2395
Type:initiation region
Name:Grin1_1
Description:glutamate ionotropic receptor NMDA type subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,534,579 - 2,534,639EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2736 AgrOrtholog
BioCyc Gene G2FUF-50462 BioCyc
Ensembl Genes ENSRNOG00000011726 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000029227 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000043301 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000049198 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000037725 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000044246 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000049297 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CaM-bd_C0_NMDA_rcpt_NR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24408 UniProtKB/Swiss-Prot
NCBI Gene 24408 ENTREZGENE
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CaM_bdg_C0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grin1 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NMDZ1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62646 ENTREZGENE
  Q62648 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q62646 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin1  glutamate ionotropic receptor NMDA type subunit 1  Grin1  glutamate receptor, ionotropic, N-methyl D-aspartate 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grin1  glutamate receptor, ionotropic, N-methyl D-aspartate 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed abundantly in hypothalamus in females of all ages and present in majority of gonadotrophin releasing hormone (GnRH) neurons 625682
gene_function N-methyl-D-aspartate (NMDA) class, glutamate receptor subunit 69667
gene_function N-methyl-D-aspartate (NMDA) class, glutamate receptor subunit 628428
gene_process functions in long term potentiation, synaptic plasticity, and Ca++ influx in postsynaptic nerve cells 69667
gene_process functions in long term potentiation, synaptic plasticity, and Ca++ influx in postsynaptic nerve cells 628428
gene_process has a role in memory and learning 69667
gene_process has a role in memory and learning 628428
gene_process modulates spatial memory, synapse formation and transmission  
gene_process may play an important role in the neuronal stimulation assosicated with female reproductive physiology 625682
gene_process receptor for glutamate that influences reproductive physiology in female rats 625682
gene_process glutamatergic signaling via the receptors directly activates LH-releasing hormone (LHRH) neurons in medial nuclei of the preoptic area 625682
gene_regulation phosphorylated by different kinases such as PKC, Fyn and cdk5 69667
gene_regulation increased expression in the hippocampus occurs in response to thyroid hormone 727495
gene_regulation steroids have no effect on the mRNA levels in LH-releasing hormone (LHRH) neurons or the percentage of LHRH neurons expressing the gene 625682