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Gene: Grin1 (glutamate ionotropic receptor NMDA type subunit 1) Rattus norvegicus
Symbol: Grin1
Name: glutamate ionotropic receptor NMDA type subunit 1
Description: Exhibits several functions, including amino acid binding activity; amyloid-beta binding activity; and ligand-gated ion channel activity. Predicted to contribute to calcium channel activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of dendritic spine maintenance; and protein heterotetramerization. Localizes to several cellular components, including dendrite; hippocampal mossy fiber to CA3 synapse; and integral component of plasma membrane. Biomarker of cognitive disorder; middle cerebral artery infarction; placental insufficiency; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1); PARTICIPATES IN excitatory synaptic transmission pathway; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; (S)-3,5-dihydroxyphenylglycine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GluN1; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDAR1; NR1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.032,507,745 - 2,534,664 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,506,896 - 2,534,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,489,158 - 2,516,082 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,453,784 - 3,480,381 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.133,453,783 - 3,480,381 (-)NCBI
Celera32,930,222 - 2,957,142 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Grin1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2736
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.