RGD Reference Report - Heteromeric NMDA receptors: molecular and functional distinction of subtypes. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Heteromeric NMDA receptors: molecular and functional distinction of subtypes.

Authors: Monyer, H  Sprengel, R  Schoepfer, R  Herb, A  Higuchi, M  Lomeli, H  Burnashev, N  Sakmann, B  Seeburg, PH 
Citation: Monyer H, etal., Science 1992 May 22;256(5060):1217-21.
RGD ID: 727540
Pubmed: PMID:1350383   (View Abstract at PubMed)

The N-methyl D-aspartate (NMDA) receptor subtype of glutamate-gated ion channels possesses high calcium permeability and unique voltage-dependent sensitivity to magnesium and is modulated by glycine. Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% identical in sequence. These are structurally related, with less than 20% sequence identity, to other excitatory amino acid receptor subunits, including the NMDA receptor subunit NMDAR1 (NR1). Upon expression in cultured cells, the new subunits yielded prominent, typical glutamate- and NMDA-activated currents only when they were in heteromeric configurations with NR1. NR1-NR2A and NR1-NR2C channels differed in gating behavior and magnesium sensitivity. Such heteromeric NMDA receptor subtypes may exist in neurons, since NR1 messenger RNA is synthesized throughout the mature rat brain, while NR2 messenger RNA show a differential distribution.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
NMDA selective glutamate receptor complex  IDA 727540 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
extracellularly glutamate-gated ion channel activity  IDA 727540 RGD 
NMDA glutamate receptor activity  IDA 727540 RGD 
protein-containing complex binding  IDA 727540heterodimerizationRGD 

Objects Annotated

Genes (Rattus norvegicus)
Grin2b  (glutamate ionotropic receptor NMDA type subunit 2B)

Objects referenced in this article
Gene GRIN1 glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens
Gene GRIN2B glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens
Gene Grin2a glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus
Gene Grin2c glutamate ionotropic receptor NMDA type subunit 2C Rattus norvegicus

Additional Information