RGD Reference Report - Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease. - Rat Genome Database

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Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease.

Authors: Mohamed, Nur-Ezan  Lee, Jasinda H  Francis, Paul T  Esiri, Margaret M  Chen, Christopher P  Lai, Mitchell K P 
Citation: Mohamed NE, etal., J Alzheimers Dis. 2015;44(2):431-7. doi: 10.3233/JAD-141764.
RGD ID: 13792687
Pubmed: PMID:25261450   (View Abstract at PubMed)
DOI: DOI:10.3233/JAD-141764   (Journal Full-text)


BACKGROUND: Glutamatergic deficits are well-established neurochemical findings in Alzheimer's disease (AD) and are thought to underlie both cognitive and behavioral symptoms of the disease. However, it is unclear whether subcortical ischemic vascular dementia (SIVD) and mixed SIVD/AD (MixD) manifest similar changes in the glutamatergic system.
OBJECTIVE: To measure the immunoreactivities of NMDA receptor GluN1, GluN2A, and GluN2B subunits in SIVD and MixD.
METHODS: Postmortem neocortical tissues from a cohort of well-characterized, longitudinally followed-up patients with SIVD and MixD, together with age-matched controls, were processed for immunoblotting with GluN subunit-specific antibodies.
RESULTS: There was a significant reduction of GluN1 only in MixD, while significant increases of GluN2A and GluN2B were found only in SIVD. Furthermore, GluN1 loss and GluN2A/2B upregulation was associated respectively with higher Braak stages and lacunar infarct scores.
CONCLUSIONS: Our data suggest that the differential alterations of GluN subunits in SIVD and MixD may result from separate, interacting disease processes, and point to the potential utility of glutamatergic approaches for pharmacotherapy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
vascular dementia  IEP 13792687associated with Alzheimer's diseaseRGD 
vascular dementia  IEP 13792687 RGD 
vascular dementia severityIEP 13792687 RGD 
vascular dementia  ISOGRIN1 (Homo sapiens)13792687; 13792687associated with Alzheimer's diseaseRGD 
vascular dementia  ISOGRIN2A (Homo sapiens)13792687; 13792687 RGD 
vascular dementia severityISOGRIN2B (Homo sapiens)13792687; 13792687 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grin1  (glutamate ionotropic receptor NMDA type subunit 1)
Grin2a  (glutamate ionotropic receptor NMDA type subunit 2A)
Grin2b  (glutamate ionotropic receptor NMDA type subunit 2B)

Genes (Mus musculus)
Grin1  (glutamate receptor, ionotropic, NMDA1 (zeta 1))
Grin2a  (glutamate receptor, ionotropic, NMDA2A (epsilon 1))
Grin2b  (glutamate receptor, ionotropic, NMDA2B (epsilon 2))

Genes (Homo sapiens)
GRIN1  (glutamate ionotropic receptor NMDA type subunit 1)
GRIN2A  (glutamate ionotropic receptor NMDA type subunit 2A)
GRIN2B  (glutamate ionotropic receptor NMDA type subunit 2B)


Additional Information